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Epimutations in the BRCA1 gene results in increased risk of developing triple negative breast cancer and ovarian cancer
Germline mutations in one of the two so-called breast cancer genes (BRCA1 and BRCA2) is the most frequent cause of inherited breast (and ovarian) cancers. While other genes have been shown associated with breast cancer risk, their contribution is small.
Most genes contains one or more “on-off switches” regulating their activity. Such switching, on and off, is a normal procedure during life, and plays a pivotal role at the prenatal stage (before birth). Aberrant silencing or activation of genes by errors in this “button function” is well known, and may act like gene mutations. Such aberrant silencing is termed “epimutations”, or “hyper-methylation”, and may play serious effects in many diseases, including cancer.
An important question is whether such epimutations, affecting normal cells, may actually be cancer-triggering events. In a recent study now in the well-known medical journal JAMA Oncology we actually show this to happen. In collaboration with US investigators in the famous Women Health Initiative (WHI), we found such epimutations affecting the BRCA1 gene in the blood of about 5% of healthy women. As for those carrying such epimutations, the risk to develop a so-called triple negative breast cancer (TNBC), was nearly 2.5 times higher than for women not carrying such methylations. TNBC accounts for about 15% of all breast cancers and is characterized by the lack of receptors for estrogen, progesterone and HER2 in the cancer cells. TNBC is often affecting younger women, and in general carries a more serious prognosis compared to other breast cancer subtypes. Moreover, women carrying these BRCA1 epimutations had an 80% increased risk also of malignant ovarian cancer.
For today, we do not know the cause of these epimutations, but based on previous data, we know they happen before birth. And we are currently studying different mechanisms aiming at elucidating the cause of these epimutations, hopefully being able to reduce this cancer risk.
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Stian Knappskog/BioRender.com
Research articles associated with these findings (link to article in image):