Ziegler lab

Selected publications

Main content


Strømland Ø, Kallio JP, Pschibul A, Skoge RH, Harðardóttir HM, Sverkeli LJ, Heinekamp T, Kniemeyer O, Migaud ME, Makarov MV, Gossmann TI, Brakhage AA, Ziegler M (2021): Discovery of fungal surface NADases predominantly present in pathogenic species. Nat. Commun. 12, doi: 10.1038/s41467-021-21307-z.

Bockwoldt M, Houry D, Niere M, Gossmann TI, Reinartz I, Schug A, Ziegler M, Heiland I (2019): Identification of evolutionary and kinetic drivers of NAD-dependent signaling. Proc. Natl. Acad. Sci. U. S. A. 116, doi: 10.1073/pnas.1902346116.

Buonvicino D, Mazzola F, Zamporlini F, Resta F, Ranieri G, Camaioni E, Muzzi M, Zecchi R, Pieraccini G, Dölle C, Calamante M, Bartolucci G, Ziegler M, Stecca B, Raffaelli N, Chiarugi A (2018): Identification of the nicotinamide salvage pathway as a new toxification route for antimetabolites. Cell. Chem. Biol. 25, doi: 10.1016/j.chembiol.2018.01.012.

Skoge RH, Ziegler M (2016): SIRT2 inactivation reveals a subset of hyperacetylated perinuclear microtubules inaccessible to HDAC6. J. Cell Sci. 129, doi: 10.1242/jcs.187518.

VanLinden MR, Dölle C, Pettersen IK, Kulikova VA, Niere M, Agrimi G, Dyrstad SE, Palmieri F, Nikiforov AA, Tronstad KJ, Ziegler M (2015): Subcellular distribution of NAD+ between cytosol and mitochondria determines the metabolic profile of human cells. J. Biol. Chem. 290, doi: 10.1074/jbc.M115.654129.

Love NR, Pollak N, Dölle C, Niere M, Chen Y, Oliveri P, Amaya E, Patel S, Ziegler M (2015): NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms. Proc. Natl. Acad. Sci. U. S. A. 112, doi: 10.1073/pnas.1417290112.

Rack JG, VanLinden MR, Lutter T, Aasland R, Ziegler M (2014): Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform. J. Mol. Biol. 426, doi: 10.1016/j.jmb.2013.10.027.

Stavrum AK, Heiland I, Schuster S, Puntervoll P, Ziegler M (2013): Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data. J. Biol. Chem. 288, doi: 10.1074/jbc.M113.474908.

Niere M, Mashimo M, Agledal L, Dölle C, Kasamatsu A, Kato J, Moss J, Ziegler M (2012): ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose). J. Biol. Chem. 287, doi: 10.1074/jbc.M112.349183.

Nikiforov A, Dölle C, Niere M, Ziegler M (2011): Pathways and subcellular compartmentation of NAD biosynthesis in human cells: From entry of extracellular precursors to mitochondrial NAD generation. J. Biol. Chem. 286, doi: 10.1074/jbc.M110.213298.

Dölle C, Niere M, Lohndal E, Ziegler M (2010): Visualization of subcellular NAD pools and intra-organellar protein localization by poly-ADP-ribose formation. Cell. Mol. Life Sci. 67, doi: 10.1007/s00018-009-0190-4.

Lau C, Dölle C, Gossmann TI, Agledal L, Niere M, Ziegler M (2010): Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases. J. Biol. Chem. 285, doi: 10.1074/jbc.M110.107631.

Dölle C, Ziegler M (2009): Application of a coupled enzyme assay to characterize nicotinamide riboside kinases. Anal. Biochem. 385, doi: 10.1016/j.ab.2008.10.033.

Niere M, Kernstock S, Koch-Nolte F, Ziegler M (2008). Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix. Mol Cell Biol. 28, doi: 10.1128/MCB.01766-07.

Pollak N, Niere M, Ziegler M (2007): NAD kinase levels control the NADPH concentration in human cells. J. Biol. Chem. 282, doi: 10.1074/jbc.M704442200.

Berger F, Lau C, Ziegler M (2007): Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1. Proc. Natl. Acad. Sci. U. S. A. 104, doi: 10.1073/pnas.0609211104.

Berger F, Lau C, Dahlmann M, Ziegler M (2005): Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms. J. Biol. Chem. 280, doi: 10.1074/jbc.M508660200.


Strømland Ø, Niere M, Nikiforov AA, VanLinden MR, Heiland I, Ziegler M (2019): Keeping the balance in NAD metabolism. Biochem. Soc. Trans. 47, doi: 10.1042/BST20180417. Review

Nikiforov A, Kulikova V, Ziegler M (2015): The human NAD metabolome: Functions, metabolism and compartmentalization. Crit. Rev. Biochem. Mol. Biol. 50, doi: 10.3109/10409238.2015.1028612.

Dölle C, Skoge RH, Vanlinden MR, Ziegler M (2013): NAD biosynthesis in humans - Enzymes, metabolites and therapeutic aspects. Curr. Top. Med. Chem. 13, doi: 10.2174/15680266113136660206.

Koch-Nolte F, Ziegler M (2013): Physiology of ADP-ribosylation. FEBS J. 280, doi: 10.1111/febs.12389.

Schüler H, Ziegler M (2013): Pharmacology of ADP-ribosylation. FEBS J. 280, doi: 10.1111/febs.12388.

Dölle C, Rack JG, Ziegler M (2013): NAD and ADP-ribose metabolism in mitochondria. FEBS J. 280, doi: 10.1111/febs.12304.

Chiarugi A, Dölle C, Felici R, Ziegler M (2012): The NAD metabolome - A key determinant of cancer cell biology. Nat. Rev. Cancer 12, doi: 10.1038/nrc3340.

Koch-Nolte F, Fischer S, Haag F, Ziegler M (2011): Compartmentation of NAD+-dependent signalling. FEBS Lett. 585, doi:10.1016/j.febslet.2011.03.045.

Agledal L, Niere M, Ziegler M (2010): The phosphate makes a difference: Cellular functions of NADP. Redox Rep. 15, doi: 10.1179/174329210X12650506623122.

Lau C, Niere M, Ziegler M (2009): The NMN/NaMN adenylyltransferase (NMNAT) protein family. Front. Biosci. 14, doi: 10.2741/3252.

Koch-Nolte F, Haag F, Guse AH, Lund F, Ziegler M (2009): Emerging roles of NAD+ and its metabolites in cell signaling. Sci. Signal. 2, doi: 10.1126/scisignal.257mr1.

Pollak N, Dölle C, Ziegler M (2007): The power to reduce: pyridine nucleotides - small molecules with a multitude of functions. Biochem J. 402, doi: 10.1042/BJ20061638.

Billington RA, Bruzzone S, De Flora A, Genazzani AA, Koch-Nolte F, Ziegler M, Zocchi E (2006): Emerging functions of extracellular pyridine nucleotides. Mol Med. 12, doi: 10.2119/2006–00075.Billington

Ziegler M (2005): A vital link between energy and signal transduction. FEBS J. 272, doi: 10.1111/j.1742-4658.2005.04893.x.

Oei SL, Keil C, Ziegler M (2005): Poly(ADP-ribosylation) and genomic stability. Biochem Cell Biol. 83, doi: 10.1139/o05-039.

Berger F, Ramírez-Hernández MH, Ziegler M (2004): The new life of a centenarian: signalling functions of NAD(P). Trends Biochem Sci. 29, doi: 10.1016/j.tibs.2004.01.007.