Protein N-terminal acetylation
From molecular mechanisms to human disease
Most proteins are chemically modified in the cell and such modifications are often crucial for the protein’s ability to carry out a function. N-terminal acetylation one of the most common modifications in eukaryotes. It is catalyzed by N-terminal acetyltransferases (NATs) which are linked to cancer, genetic syndromes, and regulation of human metabolism.
The Arnesen lab is part of the Translational Cell Signaling and Metabolism research group at the Department of biomedicine.