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Arnesen lab

The eukaryotic NAT-machinery

Protein N-terminal acetylation

From molecular mechanisms to human disease

Most proteins are chemically modified in the cell and such modifications are often crucial for the protein’s ability to carry out a function. N-terminal acetylation one of the most common modifications in eukaryotes. It is catalyzed by N-terminal acetyltransferases (NATs) which are linked to cancer, genetic syndromes, and regulation of human metabolism.

The Arnesen lab is part of the Translational Cell Signaling and Metabolism research group at the Department of biomedicine.

Master’s degree
The image shows a stained cell with adhesion patches in red and actin cytoskeleton in yellow/white

TIRFing the Master’s degree to shore

Monica Hellesvik has been one of the pioneers to test the new TIRF microscope at the department. She needed to look closely at cell adhesive properties and the TIRF microscope was the perfect tool for it since it is particularly well suited for studying structures closest to the glass slides.

Award
To forskningsartikkler stemplet med Best paper 2018

Paper of the year 2018

Two PNAS articles from the Arnesen lab are elected as the best publication of the year 2018 at the Faculty of Medicine. The prize will be awarded at the Faculty Day on 13 June 2019.

New Research
Impaired function of the NAA10 R83H variant

A novel pathological variant of the acetyltransferase NAA10 causes disabilities

N-terminal acetylation is a very common protein modification and NAA10 is the major responsible enzyme in human cells. Here we found a novel pathological NAA10 variant, NAA10 p. (R83H), in two boys with developmental delay and intellectual disabilities.

Technology
Master student med laptop

Cellular espionage in the NAT cell lab

As the first lab in Norway, the NAT lab recently installed a HoloMonitor system for 3D live cell microscopy. This novel instrument allows us to spy on the cells in a gentle and non-invasive way.

New research
Hunger is not a hindrance for N-terminal acetylation

Hunger is not a hindrance for N-terminal acetylation

Arnesen Lab reveals that the global level of N-terminal acetylation, a highly abundant protein modification in eukaryotes, remains stable in starving yeast cells despite an overall decrease in the cellular level of acetyl-CoA. The findings, described in the December issue of Molecular & Cellular...