Lymphangiogenesis during development of apical periodontitis
Main content
Apical periodontitis is a common inflammatory disease that dentists either prevent or treat when they give patients a root canal treatment. This condition is caused by bacteria in the root canal system of the tooth and is characterized by inflammatory reaction around the root tip with concomitant bone resorption.
This project would like to investigate the role of various inflammatory mediators during disease development with main focus on vascular endothelial growth factors (VEGFs). These factors are closely related to vasculogenesis, namely blood and lymphatic vessels' growth but their involvement in apical periodontitis and inflammatory bone resorption has not yet been investigated.
In this project, animal (rat/mouse) models of apical periodontitis, as well as biopsies from patients with apical periodontitis will be used.
People:
Professor Ellen Berggreen, Department of Biomedicine - Physiology, University of Bergen
Associate Professor Nancy Bletsa, Department of Clinical Dentristry-Endodontics and Department of Biomedicine, University of Bergen
PhD candidate Anca Virtej, Department of Biomedicine - Physiology, University of Bergen
https://www.uib.no/personer/Nancy.Bletsa
