Neural Microcircuits

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Coupled A II amacrine cells in the retina

Retinal Microcircuits

Synaptic interactions in the retina: receptors, mechanisms, circuits and networks

Our lab is interested in the cellular and molecular basis of synaptic transmission and synaptic integration in the central nervous system. Our main goal is to understand the synaptic and cellular mechanisms employed by identified neurons and specific microcircuits for signal processing. The primary techniques we use are targeted patch-clamp recording of visually-identified neurons, 2-photon imaging and computational modeling. 

Figure: Two retinal interneurons (AII amacrines) imaged with 2-photon microscopy. Copyright: Espen Hartveit

Current projects include:

  1. Multiphoton excitation imaging combined with patch-clamp recording to elucidate the mechanisms of retinal signal processing
  2. Quantitative morphological reconstructions of single neurons by computer-aided manual tracing of image stacks acquired with multiphoton excitation microscopy 
  3. Development of compartmental models of single neurons to study passive and active properties involved in signal processing
  4. Simultaneous multi-electrode recordings from neurons in specific microcircuits within the inner retina 
  5. Confocal and STED microscopy to localize receptors and synaptic proteins to individual neurons and circuits
More LASER power with funding from NORBRAIN3

NORBRAIN3: New 2-photon microscope with simultaneous 2-photon uncaging

We multiply our 2-photon microscopy power with a new custom-built microscope for 3D scanning with simultaneous photo-stimulation and 2-photon uncaging. Available soon as a core facility for researchers in Norway.

New paper published

Student work pays off!

Congratulations to David (Medical Student Research Programme) and Maren, Kaykobad and Yola (8-week BMED320 students)! Their concentrated work resulted in a shared second author position on a new paper from our lab. Congratulations also to first author Jian Hao, an MD/PhD student soon finishing in...

Mikroskopisk bilde av en nervecelle i netthinnen

Extrasynaptic glutamate receptors in the retina

The Retinal Microcircuits Research Group investigates how neurons in the retina communicate to produce vision. In their latest study, they looked outside the conventional neural circuits and found some unexpected receptor molecules in unexpected locations.

Visionaries of the Quarter
Meg and Espen have been chosen as Visionaries of the Quarter

European Vision Institute selects Meg and Espen as Visionaries of the Quarter for summer 2021

Meg Veruki and Espen Hartveit from the Retinal Microcircuits Research Group at the Department of Biomedicine have been chosen to be the Visionaries of the Quarter for the European Vision Institute.

Prof. Meg Veruki

Top List of Excellent Women in European Vision Research and Ophthalmology 2021

Prof. Meg Veruki of the Retinal Microcircuits research group has been selected to the "Top List" of Excellent Women in European Vision Research and Ophthalmology 2021

Our research is supported by the Research Council of Norway, the Mohn Research Center for the Brain, NORBRAIN, the European Commission's Horizon 2020 programme Marie Curie Actions ITN, and the University of Bergen.


We are partners in switchBoard - In the Eye of the Observer: Visual Processing at the Heart of the Retina

switchBoard is an In Innovative Training Network (ITN) funded by the European Commission's Horizon 2020 programme under the Marie Curie Actions.