Brain metastasis is a complication occurring in one third of all cancer patients. The most common cancers giving rise to brain metastases are lung cancer, breast cancer, skin cancer (melanoma) and cancers from the gastrointestinal tract. The prognosis is poor. Treatment strategies available today show minimal effects, as current chemotherapeutic agents are ineffective. The Brain Metastasis Research Lab at the Translational Cancer Research focuses on determining molecular mechanisms which drive metastasis to the brain, in order to find new therapeutic strategies.