Home
University of Bergen
TargetRNA

PhD projects in TargetRNA

The MSCA doctoral network TargetRNA will train a cohort of 16 doctoral candidates (DCs) in an intersectoral, international and interdisciplinary setting with the aim to advance the field of RNA-ligand design.

Main content

Overview of the doctoral projects - click to read more!

 

  • Host
Project title
  • AZ
DC 1: AI-guided design of preQ1-II and SAM-III riboswitch ligands (WP2)
  • DTU
DC 2: Fragment-based ligand discovery for the preQ1-II and SAM-III riboswitches (WP2)
  • DTU
DC 3: Discovery of recruiters of bacterial endoribonucleases (WP2, 3)
  • DTU
DC 4: Hit discovery and structural studies of riboswitch-ligand complexes using NMR and X-ray crystallography (WP1 and 2)
  • GUF
DC 5: Targeting RNA to reshape the gut microbiome (WP3)
  • GUF
DC 6: Characterization of riboswitch-ligand interactions using NMR spectroscopy and other biophysical methods (WP1, 2 and 3)
  • IIT
DC 7: Design of compounds targeting the group II intron of Enterobacteriales and Candida (WP2)
  • MUAS
DC 8: Mode of action studies (WP3)
  • RU
DC 9: Methods to study ligand-RNA target engagement in cellulo (WP3)
  • UB
DC 10: Lead finding and structural characterization of the 5’-UTR of ompA of A. baumannii using fragment screening and application of paramagnetic NMR restraints (WP1 and 2)
  • UniCA
DC 11: Design, synthesis and biological evaluation of RNA ligands targeting the SAM-I/IV riboswitch (WP2, 3)
  • UiB
DC 12: Characterization of RNA-ligand interactions using X-ray crystallography and other biophysical methods (WP1, 2 and 3)
  • UiB
DC 13: Virtual screening and design of riboswitch ligands (WP2)
  • UiB
DC 14: Design and synthesis of ligands for the FMN riboswitch and the 5’-UTR of ompA (WP2)
  • UiB
DC 15: Establishing a toolbox of warheads for covalent targeting of RNA(WP2)
  • UU
DC 16: Structural characterization of group II introns from Enterobacterales and Candida species and the 5’UTR of ompA bound to inhibitors using cryo-EM (WP1, 3)

 

Work package structure of TargetRNA.
What is TargetRNA about | TargetRNA | UiB

Work package structure of TargetRNA.
Photo:
Work package structure of TargetRNA. Ruth Brenk
EU flag
Photo:
This project has received funding from the European Union's Horizon Europe research and innovation programme under the Marie Skłodowska-Curie grant agreement 101168667.
10.01.2025