Styrt vevsbygging og regenerasjon

Peer-reviewed publications

I tillegg til tidsskriftpublikasjoner, presenteres vårt arbeid jevnlig i lokale, nasjonale og internasjonale møter.



  1. Yamada S, Yassin MA, Schwarz T, Mustafa K, Hansmann J. Optimization and Validation of a Custom-Designed Perfusion Bioreactor for Bone Tissue Engineering: Flow Assessment and Optimal Culture Environmental Conditions. Front Bioeng Biotechnol. 25;10:811942. doi: 10.3389/fbioe.2022.811942. (2022).

  2. Suliman S, Mieszkowska A, Folkert J, Rana N, Mohamed-Ahmed S, Fuoco T, Finne-Wistrand A, Dirscherl K, Jørgensen B, Mustafa K, Gurzawska-Comis K. Immune-instructive copolymer scaffolds using plant-derived nanoparticles to promote bone regeneration. Inflamm Regen. 3;42(1):12. doi: 10.1186/s41232-022-00196-9. (2022).

  3. Hara K, Hellem E, Yamada S, Sariibrahimoglu K, Mølster A, Gjerdet NR, Hellem S, Mustafa K, Yassin MA. Efficacy of treating segmental bone defects through endochondral ossification: 3D printed designs and bone metabolic activities. Mater Today Bio. 7;14:100237. doi: 10.1016/j.mtbio.2022.100237. (2022)

  4. Shanbhag S, Kampleitner C, Mohammed Ahmed S, Yassin MA, Dongre H, Costea DE, Tangl S, Stavropoulos A, Bolstad AI, Suliman S, Mustafa K. Ectopic bone tissue engineering in mice using human gingiva or bone marrow-derived stromal/progenitor cells in scaffold-hydrogel constructs. Front Bioeng Biotechnol. 4;9:831669. doi: 10.3389/fbioe.2021.831669. (2022).

  5. Rana N, Suliman S, Mohamed-Ahmed S, Gavasso S, Gjertsen BT, Mustafa K. Systemic and local innate immune responses to surgical co-transplantation of mesenchymal stromal cells and biphasic calcium phosphate for bone regeneration. Acta Biomater. 28:S1742-7061(21)00841-2. doi: 10.1016/j.actbio.2021.12.02 (2022).

  6. Rana N, Suliman S, Al-sharabi N, Mohamed-Ahmed S, Mustafa K. Extracellular vesicles derived from primed mesenchymal stromal cells loaded on biphasic calcium phosphate biomaterial exhibit enhanced macrophage polarization. Cells. 29;11(3):470. doi: 10.3390/cells11030470. (2022).

  7. Saleem R, Mohamed-Ahmed S, Elnour R, Berggreen E, Mustafa K, Al-Sharabi N. Conditioned Medium from Bone Marrow Mesenchymal Stem Cells Restored Oxidative Stress-Related Impaired Osteogenic Differentiation. Int J Mol Sci 15:13458. doi: 10.3390/ijms222413458 (2022).


  1. Shanbhag S, Suliman S, Mohamed Ahmed S, Campleitner C, Hasan MN, Heimel P, Tangl S, Bolstad AI, Mustafa K. Bone regeneration in rat calvarial defects using dissociated or spheroid mesenchymal stromal cells. Stem Cell Res Ther. 14:575 https://doi.org/10.1186/s13287-021-02642-w (2021).

  2. Yamada S, Yassin MA, Weigel T, Schmitz T, Hansmann J, Mustafa K. Surface activation with oxygen plasma promotes osteogenesis with enhanced extracellular matrix formation in three-dimensional microporous scaffolds. J Biomed Mater Res Part A, doi:10.1002/.37151. (2021).

  3. Yamada S, Yassin MA, Schmitz T, Hansmann J, Mustafa K. Induction of osteogenic differentiation of bone marrow stromal cells on 3D polyester-based scaffolds solely by subphysiological fluidic stimulation in a laminar flow bioreactor. J Tissue Eng, doi:10.117720417314211019375 (2021).

  4. Shanbhag S, Rashad A, Nymark EH, Suliman S, Davies CL, Stavropoulos A, Bolstad AI, Mustafa K. Spheroid coculture of human gingiva-derived progenitor cells with endothelial cells in modified platelet lysate hydrogels. Front Bioeng Biotechnol doi.org/10.3389/fbioe.2021.739225  (2021).

  5. Yamada S, Shanbhag S, Mustafa K. Scaffolds in Periodontal Regenerative Treatment. Dental Clinics of North America. https://doi.org/10.1016/j.cden.2021.06.004 (2021).

  6. Helgeland E, Mohamed_Ahmed S, Shanbhag S, Pedersen TØ, Rosén A, Mustafa K, Rashad A. 3D printed gelatin scaffolds for temporomandibular joint cartilage regeneration. Biomed Phys Eng Express, doi: 10.1088/2057-1976/ac1e68 (2021).

  7. Xing Z, Jiang X, Si Q, Finne-Wistrand A, Liu B, Xue Y, Mustafa K. Endochondral ossification induced by cell transplantation of endothelial cells and bone marrow stromal cells with copolymer scaffold using a rat calvarial defect model. Polymers (Basel), 9;13(9):1521. doi: 10.3390/polym13091521. (2021).

  8. Jain S, Yassin MA, Fuoco T, Liu H, Vindenes H, Mustafa K, Finne-Wistrand A. Understanding of how the properties of medical grade lactide based copolymer scaffolds influence adipose tissue regeneration: Sterilization and a systematic in vitro assessment. Materials Science & Engineering C, doi.org/10.1006/j.msec.112020. (2021).

  9. Helgeland E, Rashad A, Campodoni E, Goksoyr O, Pedersen TØ, Sandri M, Rosén A, Mustafa K. Dual-crosslinked 3D printed gelatin scaffolds with potential for temporomandibular joint cartilage regeneration. Biomed Mater, 16. doi: 10.1088/1748-605X/abe6d9. (2021).

  10. Vakilian S, Jamshidi-adegani F, Al Yahmadi A, Al-Broumi M, Ur Rehman N, Anwar MU, Alam K, Al-Wahaibi N, Shalaby A, Sausan A, Al-Harrasi A, Mustafa K, Al-Hashmi S. A competitive nature-derived multilayered scaffold based on chitosan and alginate, for full-thickness wound healing. Carbohydrate Polymers, 262: doi.org/10.1016/j.carbpol.117921. (2021).

  11. Mohamed-Ahmed S, Yassin MA, Rashad A, Espedal H, Idris SB, Finne-Wistrand A, Mustafa K, Vindenes H, Fristad I. Comparison of bone regenerative capacity of donor-matched human adipose-derived and bone marrow mesenchymal stem cells. Cell Tissue Res, 383: 1061 – 1075 (2021).


  1. Shanbhag S, Suliman S, Bolstad AI, Stavropoulos A, Mustafa K. Xeno-free spheroids of human gingiva-derived progenitor cells for bone tissue engineering. Frontiers Bioengineering and Biotechnology, 8: 968 (2020).

  2. Jain S, Yassin MA, Fuoco T, Liu H, Mohamed-Ahmed S, Mustafa K, Finne-Wistrand A. Engineering 3D Degradable, Pliable Scaffolds Toward Adipose Tissue Regeneration; Optimized Printability, Simulations and Surface Modification. J Tissue Eng, 16: doi: 10.1177/2041731420954316. eCollection (2020).

  3. Shanbhag S, Mohamed-Ahmed S, Lunde T, Suliman S, Bolstad AI, Hervig T, Mustafa K. Influence of platelet storage time on human platelet lysates and platelet lysate-expanded mesenchymal stromal cells for bone tissue engineering. Stem Cell Res Ther. 183; 13287-9 (2020).

  4. Gjerde CG, Shanbhag S, Neppelberg E, Mustafa K, Gjengedal H. Patient experience following iliac crest-derived alveolar bone grafting and implant placement. Int J Implant Dent. 5;6(1):4. doi: 10.1186/s40729-019-0200-8 (2020).

  5. Fuoco T, Ahlinder A, Jain S, Mustafa K, Finne-Wistrand A. Poly(ε-caprolactone-co-p-dioxanone): a Degradable and Printable Copolymer for Pliable 3D Scaffolds Fabrication toward Adipose Tissue Regeneration. Biomacromolecules 13;21:188-198  (2020).

  6. Jain S, Fuoco T, Yassin MA, Mustafa K, Wistrand AF. Printability and critical insight into polymer properties during direct- extrusion based 3D printing of medical grade polylactide and copolyesters. Biomacromolecules 10;21: 388-396 (2020).

  7. Azarudeen RS, Hassan MN, Yassin MA, Thirumarimuruganb M, Muthukumarasamyc N, Velauthapillaid D, Mustafa K. 3D printable Polycaprolactone-gelatin blends characterized for in vitro osteogenic potency. Reactive and Functional Polymers 146: 104445 (2020).

  8. Helgeland E, Pedersen TO, Rashad A, Johannessen AC, Mustafa K, Rosén A. Angiostatin-functionalized collagen scaffolds suppress angiogenesis but do not induce chondrogenesis by mesenchymal stromal cells in vivo. J Oral Sci. 2020 Jul 17. doi: 10.2334/josnusd.19-0327. (2020).

  9. Omer A, Al-Sharabi N, Qiu Y, Xue Y, Li Y, Fujio M, Mustafa K, Xing Z. Biological responses of dental pulp cells to surfaces modified by collagen 1 and fibronectin. J Biomed Mater Res A. 108(6):1369-1379. doi: 10.1002/jbm.a.36908 (2020).


  1. Hassan MN, Yassin MA, Suliman S, Lie SA, Gjengedal H, Mustafa K. The Bone Regeneration Capacity of 3D-Printed Templates in Calvarial Defect Models: A Systematic Review and Meta-Analysis. Acta Biomaterialia 91:1-23. doi: 10.1016/j.actbio.2019.04.017 (2019).

  2. Suliman S, Hassan A, Karlsen T, Amiaud J, Mohamed-Ahmed S, Costea DE, Brinchmann JE, Mustafa K. Impact of humanised isolation and culture conditions on stemness and osteogenic potential of mesenchymal stromal cells. Sci Rep 5;9(1):16031. (2019).

  3. Munir A, Døskeland A, Avery SJ, Fuoco T, Mohamed-Ahmed S, Lygre H, Finne-Wistrand A, Sloan AJ , Waddington RJ, Mustafa K, Suliman S. Journal of Tissue Engineering 31;10:2041731419852703. doi: 10.1177/2041731419852703 (2019).

  4. Sharma S, Xue Y, Xing Z, Yassin MA, Sun Y, Lorens JB, Finne-Wistrand A, Sapkota D, Mustafa K. Adenoviral mediated mono delivery of BMP2 is superior to the combined delivery of BMP2 and VEGFA in bone regeneration in a critical-sized rat calvarial bone defect. Bone Reports 11;10:100205. doi: 10.1016/j.bonr.2019.100205. (2019).  

  5. Sanz M, Dahlin C, Apatzidou D, Artzi Z, Bozic D, Calciolari E, De Bruyn H, Dommisch H, Donos N, Eickholz P, Ellingsen JE, Haugen HJ, Herrera D, Lambert F, Layrolle P, Montero E, Mustafa K, Omar O, Schliephake H. Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration. J Clin Periodontol 46 Suppl 21:82-91. doi: 10.1111/jcpe.13123 (2019).

  6. Yassin MA, Fuoco T, Mohamed-Ahmed S, Mustafa K, Finne-Wistrand A. 3D and Porous RGDC-Functionalized Polyester-Based Scaffolds as a Niche to Induce Osteogenic Differentiation of Human Bone Marrow Stem Cells. Macromol Biosci. 2019 May 3:e1900049. doi: 10.1002/mabi.201900049 (2019).

  7. Rojewski MT, Lotfi R, Gjerde C, Mustafa K, Veronesi E, Ahmed AB, Wiesneth M, Körper S, Sensebé L, Layrolle P, Hellem S, Schrezenmeier H. Translation of a standardized manufacturing protocol for mesenchymal stromal cells: A systematic comparison of validation and manufacturing data.  Cytotherapy 21: 468-482 (2019).

  8. Ojansivu M, Rashad A, Ahlinder AE, Massera J, Mishra A, Syverud K, Finne-Wistrand A, Miettinen S, Mustafa K. Wood-based nanocellulose and bioactive glass modified gelatin-alginate bioinks for 3D bioprinting of bone cells. Biofabrication. doi: 10.1088/1758-5090/ab0692 (2019).

  9. Rashad A, Suliman S, Mustafa M, Pedersen TO, Campodoni E, Sandri M, Syverud K, Mustafa K. Inflammatory Responses and Host Tissue Reactions to Wood-Based Nanocellulose Scaffolds. Materials Science & Engineering C Mater Biol Appl. 97:208-221 (2019).

  10. Sanz M, Dahlin C, Apatzidou D, Artzi Z, Bozic D, Calciolari E, De Bruyn H, Dommisch H, Donos N, Eickholz P, Ellingsen JE, Haugen HJ, Herrera D, Lambert F, Layrolle P, Montero E, Mustafa K, Omar O, Schliephake H. Biomaterials and regenerative technologies used in bone regeneration in craniomaxillo-facial region. Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration. Accepted in J Clin Periodontol (2019).  

  11. Shanbhag S, Suliman S, Pandis N, Stavropoulos A, Sanz M, Mustafa K. Cell therapy for orofacial bone regeneration: a systematic review and meta-analysis. J Clin Periodontol doi: 10.1111/jcpe.13049 (2019).

  12. Campodoni E, Heggset EB, Rashad A, Ramírez-Rodríguez GB, Mustafa K, Syverud K, Tampieri A, Sandri M. Polymeric 3D scaffolds for tissue regeneration: Evaluation of biopolymer nanocomposite reinforced with cellulose nanofibrils. Materials Science & Engineering C 94: 867 – 878. doi: 10.1016/j.msec (2019).


  1. Gjerde CG, Mustafa K et al…2018. Cell therapy induced regeneration of severely atrophied mandibular bone - Part II: Clinical outcome. Stem Cell Res Ther. 9;9(1):213. doi: 10.1186/s13287-018-0951-9 (2018).

  2. Rashad A, Mohamed-Ahmed S, Ojansivu M, Berstad K, Yassin MA, Kivijärvi T, Heggset EB, Syverud K, Mustafa K. Coating 3D Printed Polycaprolactone Scaffolds with Nanocellulose Promotes Growth and Differentiation of Mesenchymal Stem Cells. Biomacromolecules. 12: 4307-4319. doi: 10.1021/acs.biomac.8b01194. (2018).

  3. Weigel T, Schmitz T, Pfister T, Gaetzner S, Jannasch M, Al-Hijailan R, Schürlein S, Suliman S, Mustafa K, Hansmann J. A three-dimensional hybrid pacemaker electrode seamlessly integrates into engineered, functional human cardiac tissue in vitro. Sci Rep. 28: 14545. doi: 10.1038/s41598-018-32790-8. (2018).

  4. Mohamed-Ahmed S, Fristad I, Lie SA, Suliman S, Mustafa K, Vindenes H, Idris SB. Adipose-derived and bone marrow mesenchymal stem cells: a donor-matched comparison. Stem Cell Res Ther. 19:168. doi: 10.1186/s13287-018-0914-1. (2018).

  5. Ibrahim M, Schoelermann J, Mustafa K, Cimpan MR. TiO2 nanoparticles disrupt cell adhesion and the architecture of cytoskeletal networks of human osteoblast-like cells in a size dependent manner. J Biomed Mater Res A. 30. doi: 10.1002/jbm.a.36448 (2018).

  6. Gharaei MA, Xue Y, Mustafa K, Lie SA, Fristad I. Human dental pulp stromal cell conditioned medium alters endothelial cell behaviour. Stem Cell Res Ther. 21;9(1):69. doi: 10.1186/s13287-018-0815-3 (2018).

  7. Ibrahim M, Xue Y, Ostermann M, Sauter A, Steinmueller-Nethl D, Schweeberg S, Krueger A, Cimpan MR, Mustafa K. In vitro cytotoxicity assessment of nanodiamond particles and their osteogenic potential. J Biomed Mater Res, Feb 16. doi: 10.1002/jbm.a.36369 (2018).

  8. Sharma S, Sapkota D, Xue Y, Rajthala S, Yassin MA, Finne-Wistrand A, Mustafa K. Delivery of VEGFA in bone marrow stromal cells seeded in copolymer scaffold enhances angiogenesis, but is inadequate for osteogenesis as compared with the dual delivery of VEGFA and BMP2 in a subcutaneous mouse model. Stem Cell Res Ther, 31;23. doi: 10.1186/s13287-018-0778-4 (2018).

  9. Helgeland E, Shanbhag S, Pedersen TO, Mustafa K, Rosén A. Scaffold-based TMJ tissue regeneration in experimental animal models: a systematic review. Tissue Eng Part B Rev, Feb 5. doi: 10.1089/ten.TEB.2017.0429 (2018).


  1. Gjerde CG, Santis DD,  Dominici M et al…, Mustafa K, Veronesi E. Autologous porcine bone marrow mesenchymal cells for reconstruction of a resorbed alveolar bone: a preclinical model in mini-pigs. Int J Stem Cell Res Ther, 4:050, DOI: 10.23937/2469-570X/1410050 (2017).

  2. Rashad A, Mustafa K, Heggset EB, Syverud K. Cytocompatibility of Wood-Derived Cellulose Nanofibril Hydrogels with Different Surface Chemistry. Biomacromolecules 2017 Apr 10;18(4):1238-1248. doi: 10.1021/acs.biomac.6b01911. Epub (2017).

  3. Yassin MA, Mustafa K et el…. A Copolymer Scaffold Functionalized with Nanodiamond Particles Enhances Osteogenic Metabolic Activity and Bone Regeneration. Macromolecular Bioscience 2017, Jan 24. doi: 10.1002/mabi.201600427, (2017).

  4. Shanbhag S, Suliman S, Stavropoulos A, Hervig T, Mustafa K. Efficacy of humanized mesenchymal stem cell cultures for bone tissue engineering: a systematic review with a focus on platelet-derivatives. Accepted in Tissue Engineering Part B (2017).

  5. Lynds R, Lyu C, Lyu G-W, Shi X-Q, Rosen A, Mustafa K, Shi T-J. Neuronal plasticity of trigeminal ganglia in mice following nerve injury. J pain Research 2017, 2017 Feb 9;10:349-357. doi: 10.2147/JPR.S120092. (2017).

  6. Shanbhag S, Pandis N, Mustafa K, Nyengaard JR, Stavropoulos A. Bone tissue engineering in oral peri-implant defects in preclinical in vivo research: a systematic review and meta-analysis. J Tissue Eng Regen Med, doi: 10.1002/term.2412. (2017).

  7. Bartaula S, Bolstad AI, Mustafa K, Pedersen TO. Secretome of mesenchymal stem cells grown in hypoxia accelerates wound healing and vessel formation in vitro. Int J Stem Cell Res Ther 2017, 4:045 DOI: 10.23937/2469-570X/1410045 (2017).

  8. Mohamed HG, Mustafa K, Ibrahim SO, Åstrøm AN. Dietary habits, oral impact on daily performance and type 2 diabetes: a matched case-control study from Sudan.  Health and Quality of Life Outcomes. 15:111. doi: 10.1186/s12955-017-0686-9, (2017).

  9. Shanbhag S, Pandis N, Mustafa K, Nyengaard JR, Stavropoulos A. Cell co-transplantation strategies for vascularized craniofacial bone tissue engineering: a systematic review and meta-analysis. Tissue Engineering, Part B, 23:101-117 (2017).  


  1. Suliman S, Mustafa K, Krueger A, Steinmüller-Nethl D, Finne-Wistrand A, Osdal T, Hamza AO, Sun Y, Parajuli H, Waag T, Nickel J, Johannessen A-Ch, Cormack EM, Costea DE. Nanodiamond modified copolymer scaffolds affects tumour progression. Biomaterials 2016, 95:11-21.

  2. Suliman S, Sun Y,Pedersen TO, Xue Y, Nickel J, Finne-Wistrand A, Steinmüller-Nethl D, Krueger A, Costea DE, Mustafa K. Host response and degradation of copolymer scaffolds functionalised with nanodiamonds and BMP2. Adv. Healthc. Mater., 2016, 5 (6), 730-742.   

  3. Galli S, Andersson M, Jinno Y, Karlsson J, He W, Xue Y, Mustafa K, Wennerberg A, Jimbo R. Magnesium release from mesoporous carriers on endosseus implants does not influence bone maturation at 6 weeks in rabbit bone. J Biomed Mater Res B Appl Biomater. 2016 13. doi: 10.1002/jbm.b.33752.

  4. Shanbhag S, Pandis N, Mustafa K, Nyengaard JR, Stavropoulos A. Alveolar bone tissue engineering in critical-size defects of experimental animal models: a systematic review and meta-analysis. (2016), J Tissue Eng Regen Med, 2016 doi: 10.1002/term.2198. Review

  5. Bartaula S, Pedersen TO, Finne-Winstrand A, Bolstad AI, Mustafa K. Angiogenic and Immunomodulatory Properties of Endothelial and Mesenchymal Stem Cells. Tissue Eng Part A. (2016), 22(3-4), 244-252, DOI: 10.1089/ten.tea.2015.0316

  6. Sharma S, Sapkota D, Xue Y, Sun Y, Finne-Wistrand A, Bruland O, Mustafa K. Adenoviral Mediated Expression of BMP2 by Bone Marrow Stromal Cells cultured in 3D Copolymer Scaffolds Enhances Bone Formation. PLoS ONE (2016). 2016 25;11(1):e0147507. doi: 10.1371/journal.pone.0147507. eCollection 2016.

  7. Yassin MA, Leknes KN, Pedersen TO, Xing Z, SunY, Lie SA, Finne-WistrandA, Mustafa K. Surfactant Tuning of Hydrophilicity of Porous Degradable Copolymer Scaffolds Promotes Cellular Proliferation and Enhances Bone Formation. J Biomed Mater Res A 2016, doi: 10.1002/jbm.a.35741

  8. Al-Sharabi N, Xue Y, Mustafa M, Udea M, Xue Y, Mustafa K, Fristad I. Conditioned media from human bone marrow stromal cells attenuate initial inflammatory reactions in dental pulp tissue. Dental Traumatology 2016; doi: 10.1111/edt. 12277.

  9. Mohamed HG, Idris SB, Mustafa M, Ahmed MF, Åstrøm AN, Mustafa K, Ibrahim SO. Influence of type 2 diabetes on prevalence of key periodontal pathogens, salivary matrix metalloproteinases and bone remodeling markers in adults with and without chronic periodontitis. Int J Dent. 2016;2016:6296854. doi: 10.1155/2016/6296854. Epub 2016

  10. Dagmar F Bunæs DF, Lie SA, Aastrøm AN, Mustafa K, Leknes KN. Site-specific effect of smoking following 12 months of supportive periodontal therapy, J Clin Periodontol. 2016 Dec;43(12):1086-1093. doi: 10.1111/jcpe.12619. (2016).