Klinisk institutt 2

Midtveisevaluering - Vegard Lysne



This project aims to investigate the role of the nuclear receptor peroxisome proliferator-activated receptor (PPAR) α in the regulation of one-carbon metabolism and B-vitamin status, and explore whether these metabolites can predict future acute myocardial infarction and mortality.

In the two first studies of the project, data from two animal experiments are used to investigate the effect of PPAR activation on the plasma concentration of one-carbon metabolites and B-vitamin status. In the first paper (1) pronounced increases were observed for several metabolites, including dimethylglycine, vitamin B3, vitamin B6 and methylmalonic acid. Preliminary results from the second paper confirms the findings from the first paper.

In the final paper, the metabolites that responded most profoundly to PPAR activation in the two animal models will be explored as predictors of acute myocardial infarction and mortality in the Western Norway Coronary Angiography Cohort (WECAC), consisting of 4166 patients with suspected coronary heart disease at baseline.


1.           Lysne V, Strand E, Svingen GF, Bjorndal B, Pedersen ER, Midttun O, et al. Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats. Nutrients. 2016;8(1).