Klinisk institutt 2

Karl-Henning Kalland: Tumour Virology and Regulatory Patterns of Carcinogenesis

Kalland’s research group has developed methodology and models in order to understand global gene expression and regulatory patterns in cancer.

Kalland's research group, 2010. From upper left corner: Kristo Marvyin, Jan...
Kalland's research group, 2010. From upper left corner: Kristo Marvyin, Jan Roger Olsen, Karl-Henning Kalland, Kari Rostad, Margrete Hellem. From lower left corner: Xisong Ke, Beth Johannessen, Anne Margrete Øyan, Yi Qu, Hoang My Hua
Kristian Jensen

The aim is to identify molecular mechanisms involved in carcinogenesis and next to target critical mechanisms in order to control cancer progression. Both patient materials and experimental cell culture models are used and the most interesting results are followed up in animal models and eventually in clinical trials. A novel cell culture model of stepwise prostate carcinogenesis and a new drug screening program are parts of this enterprise.

Most recent exciting scientific results show evidence for coordinated regulation of entire functional and structural gene expression modules in our cell culture model and patient materials during carcinogenesis (Ke et al., 2008; Ke et al., 2009).
The group has established national and international collaboration in translational research projects.

Previous significant results include the mechanism of function of the essential HIV-1 regulatory protein Rev and studies of differential gene expression in measles virus infected cells.

More information

Cell Culture Model

Drug Screening Program

Scientific Results

Collaborative Partners

Discovery of HIV-1 Rev Nucleocytoplasmic Shuttling and Signald Mediated Active Export from the Nucleus

Measles Virus