Karl-Henning Kalland: Tumour Virology and Regulatory Patterns of Carcinogenesis
Kalland’s research group has developed methodology and models in order to understand global gene expression and regulatory patterns in cancer.
The aim is to identify molecular mechanisms involved in carcinogenesis and next to target critical mechanisms in order to control cancer progression. Both patient materials and experimental cell culture models are used and the most interesting results are followed up in animal models and eventually in clinical trials. A novel cell culture model of stepwise prostate carcinogenesis and a new drug screening program are parts of this enterprise.
Most recent exciting scientific results show evidence for coordinated regulation of entire functional and structural gene expression modules in our cell culture model and patient materials during carcinogenesis (Ke et al., 2008; Ke et al., 2009).
The group has established national and international collaboration in translational research projects.
Previous significant results include the mechanism of function of the essential HIV-1 regulatory protein Rev and studies of differential gene expression in measles virus infected cells.