- E-postchristian.doelle@uib.no
- BesøksadresseHaukeland Universitetssykehus Laboratoriebygget, 7. etg. Heis øst5009 Bergen
- PostadressePostboks 78045020 Bergen
Vitenskapelig artikkel
- (2023). Nicotinamide riboside supplementation is not associated with altered methylation homeostasis in Parkinson's disease. iScience.
- (2023). NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson’s disease. Nature Communications.
- (2022). Ultra-deep whole genome bisulfite sequencing reveals a single methylation hotspot in human brain mitochondrial DNA. Epigenetics. 16 sider.
- (2022). The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease. Cell Metabolism. 396-407.e6.
- (2021). Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain. Molecular Neurodegeneration. 1-20.
- (2020). Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease. Acta neuropathologica communications. 1-13.
- (2020). Meta-analysis of whole-exome sequencing data from two independent cohorts finds no evidence for rare variant enrichment in Parkinson disease associated loci. PLOS ONE. 1-9.
- (2020). Differential transcript usage in the Parkinson’s disease brain. PLoS Genetics. 1-24.
- (2019). Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or α-synuclein, is localized to the mitochondrial matrix. PLOS ONE. 1-14.
- (2018). Ultradeep mapping of neuronal mitochondrial deletions in Parkinson's disease. Neurobiology of Aging. 120-127.
- (2018). Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites. Cell Chemical Biology. 471-482.e7.
- (2018). 3,3'-Diaminobenzidine staining interferes with PCR-based DNA analysis. Scientific Reports. 1-8.
- (2017). Neuronal complex I deficiency occurs throughout the Parkinson's disease brain, but is not associated with neurodegeneration or mitochondrial DNA damage. Acta Neuropathologica. 409-425.
- (2017). Glitazone use associated with reduced risk of Parkinson's disease. Movement Disorders. 1594-1599.
- (2017). Compartment-Specific Poly-ADP-Ribose Formation as a Biosensor for Subcellular NAD Pools. Methods in molecular biology. 45-56.
- (2017). ADP-ribosylation of DNA moving into focus. The FEBS Journal. 3999-4001.
- (2016). Novel SLC19A3 promoter deletion and allelic silencing in biotin-thiamine-responsive basal ganglia encephalopathy. PLOS ONE.
- (2016). Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease. Nature Communications. 11 sider.
- (2015). Subcellular distribution of NAD+ between cytosol and mitochondria determines the metabolic profile of human cells. Journal of Biological Chemistry. 27644-27659.
- (2015). NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 1386-1391.
- (2015). Generation, release, and uptake of the NAD precursor nicotinic acid riboside by human cells. Journal of Biological Chemistry. 27124-27137.
- (2014). Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels. DNA Repair. 33-38.
- (2012). ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose)glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose). Journal of Biological Chemistry. 16088-16102.
- (2011). Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells FROM ENTRY OF EXTRACELLULAR PRECURSORS TO MITOCHONDRIAL NAD GENERATION. Journal of Biological Chemistry. 21767-21778.
- (2010). Visualization of subcellular NAD pools and intra-organellar protein localization by poly-ADP-ribose formation. Cellular and Molecular Life Sciences (CMLS). 433-443.
- (2010). Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases. Journal of Biological Chemistry. 18868-18876.
Vitenskapelig foredrag
- (2012). Identification of the pathways generating organellar NAD pools using targeted poly-ADP ribose formation.
- (2010). Dissection of candidate enzymes involved in mitochondrial poly-ADP-ribose degradation.
- (2009). Alteration of compartment-specific NAD biosynthesis by reduction of individual subcellular NAD pools.
- (2007). Visualization of an enzymatic activity to determine the suborganellar location of mitochondrial proteins.
Leder
- (2009). Application of a coupled enzyme assay to characterize nicotinamide riboside kinases. Analytical Biochemistry. 377-379.
Mastergradsoppgave
- (2017). High-resolution subcellular localization of pathogenic proteins in Parkinson's disease.
Doktorgradsavhandling
- (2019). Mitochondrial mechanisms in neurodegeneration.
Sammendrag/abstract
- (2013). Potential role of cytosolic 5'- nucleotidases in human NAD metabolism. The FEBS Journal. 181-181.
Poster
- (2008). Alteration of isoform-specific NMNAT expression by reduction of subcellular NAD pools.
- (2007). Expression of NAD biosynthetic enzymes in response to decreased mitochondrial and cytosolic NAD levels.
- (2005). A new potential ADP-ribose acceptor protein in mitochondria.
- (2005). A new potential ADP-ribose acceptor protein in mitochondria.
Vitenskapelig oversiktsartikkel/review
- (2013). NAD biosynthesis in humans - enzymes, metabolites and therapeutic aspects. Current Topics in Medicinal Chemistry. 2907-2917.
- (2013). NAD and ADP-ribose metabolism in mitochondria. The FEBS Journal. 3530-3541.
- (2012). The NAD metabolome - a key determinant of cancer cell biology. Nature Reviews Cancer. 741-752.
- (2007). The power to reduce: pyridine nucleotides - small molecules with a multitude of functions. Biochemical Journal. 205-218.