Hjem
Mathias Zieglers bilde

Mathias Ziegler

Professor
  • E-postmathias.ziegler@uib.no
  • Telefon+47 55 58 45 91+47 992 05 986
  • Besøksadresse
    Jonas Lies vei 91
    5009 Bergen
  • Postadresse
    Postboks 7804
    5020 Bergen

The NAD(P) Metabolome: Cell Biology, Enzymology and Signalling Functions

  • Vis forfatter(e) (2023). Screening for inhibitors in a path for developing novel antifungal agents.
  • Vis forfatter(e) (2023). POLG genotype influences degree of mitochondrial dysfunction in iPSC derived neural progenitors, but not the parent iPSC or derived glia. Experimental Neurology. 16 sider.
  • Vis forfatter(e) (2023). Novel Calcium-Binding Motif Stabilizes and Increases the Activity of Aspergillus fumigatus Ecto-NADase. Biochemistry.
  • Vis forfatter(e) (2023). NAD as target for microbial attack.
  • Vis forfatter(e) (2023). Identification of structural determinants of nicotinamide phosphoribosyl transferase (NAMPT) activity and substrate selectivity. Journal of Structural Biology. 10 sider.
  • Vis forfatter(e) (2023). Dynamics of SLC25A51 reveal preference for oxidized NAD<sup>+</sup> and substrate led transport. EMBO Reports. 14 sider.
  • Vis forfatter(e) (2022). The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease. Cell Metabolism. 396-407.e6.
  • Vis forfatter(e) (2022). Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells. Journal of Biological Chemistry. 15 sider.
  • Vis forfatter(e) (2022). POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition. Cell Cycle. 1178-1193.
  • Vis forfatter(e) (2022). NAD - much more than a coenzyme and a target for pathogenic microorganisms.
  • Vis forfatter(e) (2022). Functional consequences of modulated expression of SLC25A51 on cellular NAD metabolism.
  • Vis forfatter(e) (2022). Enzymology and dynamics of cellular NAD metabolism .
  • Vis forfatter(e) (2022). Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria. Metabolites. 1-13.
  • Vis forfatter(e) (2022). Comparing the mitochondrial signatures in ESCs and iPSCs and their neural derivations. Cell Cycle. 2206-2221.
  • Vis forfatter(e) (2022). Characterization of the NAD metabolome in breast cancer cell models treated with fulvestrant.
  • Vis forfatter(e) (2022). Cellular NAD sensing and homeostasis.
  • Vis forfatter(e) (2021). Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25. Biomolecules.
  • Vis forfatter(e) (2021). The balance between NAD + biosynthesis and consumption in ageing. Mechanisms of Ageing and Development.
  • Vis forfatter(e) (2021). Stem cell derived astrocytes with POLG mutations and mitochondrial dysfunction including abnormal NAD+ metabolism is toxic for neurons. bioRxiv.
  • Vis forfatter(e) (2021). Natural isotope correction improves analysis of protein modification dynamics. Analytical and Bioanalytical Chemistry. 7333-7340.
  • Vis forfatter(e) (2021). Instability in nad+ metabolism leads to impaired cardiac mitochondrial function and communication. eLIFE. 1-23.
  • Vis forfatter(e) (2021). Equilibrative nucleoside transporters mediate the import of nicotinamide riboside and nicotinic acid riboside into human cells. International Journal of Molecular Sciences. 1-13.
  • Vis forfatter(e) (2021). Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD. Biomolecules.
  • Vis forfatter(e) (2021). Discovery of fungal surface NADases predominantly present in pathogenic species. Nature Communications. 12 sider.
  • Vis forfatter(e) (2021). Combined metabolic and chemical (CoMetChem) labeling using stable isotopes - A strategy to reveal site-specific histone acetylation and deacetylation rates by LC-MS. Analytical Chemistry. 12872-12880.
  • Vis forfatter(e) (2021). Author Correction: Discovery of fungal surface NADases predominantly present in pathogenic species (Nature Communications, (2021), 12, 1, (1631), 10.1038/s41467-021-21307-z). Nature Communications.
  • Vis forfatter(e) (2021). ADP-ribosyltransferases, an update on function and nomenclature . The FEBS Journal. 12 sider.
  • Vis forfatter(e) (2020). Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing. Mechanisms of Ageing and Development. 1-6.
  • Vis forfatter(e) (2020). SLC25A51 is a mammalian mitochondrial NAD+ transporter. Nature. 1-25.
  • Vis forfatter(e) (2020). Kinetic and oligomeric study of Leishmania braziliensis nicotinate/nicotinamide mononucleotide adenylyltransferase. Heliyon. 1-7.
  • Vis forfatter(e) (2020). Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations. EMBO Molecular Medicine. 1-26.
  • Vis forfatter(e) (2019). Sirtuin 2 enhances allergic asthmatic inflammation. JCI Insight.
  • Vis forfatter(e) (2019). Keeping the balance in NAD metabolism. Biochemical Society Transactions. 119-130.
  • Vis forfatter(e) (2019). Identification of evolutionary and kinetic drivers of NAD-dependent signaling. Proceedings of the National Academy of Sciences of the United States of America. 15957-15966.
  • Vis forfatter(e) (2019). Degradation of Extracellular NAD+ Intermediates in Cultures of Human HEK293 Cells. Metabolites. 1-14.
  • Vis forfatter(e) (2019). Analysis of an alternative splicing-derived NRK1 isoform for mitochondrial localization.
  • Vis forfatter(e) (2018). The generation and maintenance of the mitochondrial NAD pool is independent of mitochondrial NAD biosynthetic enzymes.
  • Vis forfatter(e) (2018). NAD Metabolome Analysis in Human Cells Using 1H NMR Spectroscopy. International Journal of Molecular Sciences. 3906.
  • Vis forfatter(e) (2018). N-terminal acetylation levels are maintained during acetyl-CoA deficiency in Saccharomyces cerevisiae. Molecular & Cellular Proteomics. 2309-2323.
  • Vis forfatter(e) (2018). Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites. Cell Chemical Biology. 471-482.e7.
  • Vis forfatter(e) (2018). Cooperation between subcellular NAD pools in the maintenance of NAD-dependent processes.
  • Vis forfatter(e) (2017). Insights into the peroxisomal NAD pool.
  • Vis forfatter(e) (2017). Compartment-Specific Poly-ADP-Ribose Formation as a Biosensor for Subcellular NAD Pools. Methods in molecular biology. 45-56.
  • Vis forfatter(e) (2017). ADP-ribosylation of DNA moving into focus. The FEBS Journal. 3999-4001.
  • Vis forfatter(e) (2016). Tissue specific models of Tryptohan-metabolism — insights into metabolic crosstalk.
  • Vis forfatter(e) (2016). SIRT2 inactivation reveals a subset of hyperacetylated perinuclear microtubules inaccessible to HDAC6. Journal of Cell Science. 2972-2982.
  • Vis forfatter(e) (2016). Phylogenetic and simulation-based analysis of NAD metabolism.
  • Vis forfatter(e) (2016). NAD-dependent and NAD-independent α-tubulin deacetylation.
  • Vis forfatter(e) (2016). Dynamic aspects of protein N-terminal acetylation in response to changes in nutrient availability.
  • Vis forfatter(e) (2015). The human NAD metabolome: Functions, metabolism and compartmentalization. Critical reviews in biochemistry and molecular biology. 284-297.
  • Vis forfatter(e) (2015). Subcellular distribution of NAD+ between cytosol and mitochondria determines the metabolic profile of human cells. Journal of Biological Chemistry. 27644-27659.
  • Vis forfatter(e) (2015). NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 1386-1391.
  • Vis forfatter(e) (2015). Insights into NAD homeostasis in the compartmentalized cell.
  • Vis forfatter(e) (2015). Generation, release, and uptake of the NAD precursor nicotinic acid riboside by human cells. Journal of Biological Chemistry. 27124-27137.
  • Vis forfatter(e) (2015). Dynamics of NAD-metabolism - everything but constant.
  • Vis forfatter(e) (2015). Discovery, metabolism and functions of NAD and NADP. Biochemist. 9-13.
  • Vis forfatter(e) (2015). An organellar Nα-acetyltransferase, Naa60, acetylates cytosolic n termini of transmembrane proteins and maintains golgi integrity. Cell reports. 1362-1374.
  • Vis forfatter(e) (2014). The PHD finger of p300 influences its ability to acetylate histone and non-histone targets. Journal of Molecular Biology (JMB). 3960-3972.
  • Vis forfatter(e) (2014). Sequence divergence and diversity suggests ongoing functional diversification of vertebrate NAD metabolism. DNA Repair. 39-48.
  • Vis forfatter(e) (2014). Separating NADH and NADPH fluorescence in live cells and tissues using FLIM. Nature Communications.
  • Vis forfatter(e) (2014). Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels. DNA Repair. 33-38.
  • Vis forfatter(e) (2014). Predicting pathological metabolic changes using a kinetic model of tryptophan metabolism.
  • Vis forfatter(e) (2014). NAD-metabolism and the circadian clock -- Unraveling contradictions.
  • Vis forfatter(e) (2014). Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform. Journal of Molecular Biology (JMB). 1677-1691.
  • Vis forfatter(e) (2014). Carbohydrate metabolism during vertebrate appendage regeneration: What is its role? How is it regulated? A postulation that regenerating vertebrate appendages facilitate glycolytic and pentose phosphate pathways to fuel macromolecule biosynthesis. Bioessays. 27-33.
  • Vis forfatter(e) (2013). Potential role of cytosolic 5'- nucleotidases in human NAD metabolism. The FEBS Journal. 181-181.
  • Vis forfatter(e) (2013). Physiology of ADP-ribosylation. The FEBS Journal. 3483-3483.
  • Vis forfatter(e) (2013). Pharmacology of ADP-ribosylation. The FEBS Journal. 3542-3542.
  • Vis forfatter(e) (2013). PAR-degrading, but not PAR-generating activities support the idea of PAR metabolism in mitochondria.
  • Vis forfatter(e) (2013). NAD-metabolism and the circadian clock.
  • Vis forfatter(e) (2013). NAD biosynthesis in humans - enzymes, metabolites and therapeutic aspects. Current Topics in Medicinal Chemistry. 2907-2917.
  • Vis forfatter(e) (2013). NAD and ADP-ribose metabolism in mitochondria. The FEBS Journal. 3530-3541.
  • Vis forfatter(e) (2013). Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data. Journal of Biological Chemistry. 34555-34566.
  • Vis forfatter(e) (2012). The NAD metabolome - a key determinant of cancer cell biology. Nature Reviews Cancer. 741-752.
  • Vis forfatter(e) (2012). Separation of NADPH and NADH Fluorescence Emission in Live Cells using Flim. Biophysical Journal. 196A-196A.
  • Vis forfatter(e) (2012). NAD(+) biosynthesis and salvage - a phylogenetic perspective. The FEBS Journal. 3355-3363.
  • Vis forfatter(e) (2012). Identification of the pathways generating organellar NAD pools using targeted poly-ADP ribose formation.
  • Vis forfatter(e) (2012). ARH3 catalyzes degradation of mitochondrial matrix-accumulated Poly (ADP-ribose). The FASEB Journal. 1 sider.
  • Vis forfatter(e) (2012). ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose)glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose). Journal of Biological Chemistry. 16088-16102.
  • Vis forfatter(e) (2011). Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells FROM ENTRY OF EXTRACELLULAR PRECURSORS TO MITOCHONDRIAL NAD GENERATION. Journal of Biological Chemistry. 21767-21778.
  • Vis forfatter(e) (2011). Pathway analysis of NAD(+) metabolism. Biochemical Journal. 341-348.
  • Vis forfatter(e) (2011). NAD(+) - a key molecule in cellular signalling. The FEBS Journal. 15-15.
  • Vis forfatter(e) (2011). Molecular mechanisms behind Chlamydia-induced reactive oxygen species production and inflammasome activation. International Journal of Medical Microbiology. 86-87.
  • Vis forfatter(e) (2011). Compartmentation of NAD(+)-dependent signalling. FEBS Letters. 1651-1656.
  • Vis forfatter(e) (2011). ARH3, not PARG isoforms, is responsible for degrading mitochondrial poly-ADP-ribose (PAR), consistent with roles for PARG isoforms different from PAR degradation.
  • Vis forfatter(e) (2010). Visualization of subcellular NAD pools and intra-organellar protein localization by poly-ADP-ribose formation. Cellular and Molecular Life Sciences (CMLS). 433-443.
  • Vis forfatter(e) (2010). The phosphate makes a difference: cellular functions of NADP. Redox report. 2-10.
  • Vis forfatter(e) (2010). The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation. The FEBS Journal. 185-185.
  • Vis forfatter(e) (2010). Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases. Journal of Biological Chemistry. 18868-18876.
  • Vis forfatter(e) (2010). Human Naa50p (Nat5/San) displays both protein N-alpha- and N-epsilon-Acetyltransferase activity. The FEBS Journal. 182-182.
  • Vis forfatter(e) (2010). Human Naa50p (Nat5/San) Displays Both Protein Na-and Ne-Acetyltransferase activity.
  • Vis forfatter(e) (2010). Dissection of candidate enzymes involved in mitochondrial poly-ADP-ribose degradation.
  • Vis forfatter(e) (2010). Application of reverse-phase HPLC to quantify oligopeptide acetylation eliminates interference from unspecific acetyl CoA hydrolysis. The FEBS Journal. 265-266.
  • Vis forfatter(e) (2009). The NMN/NaMN adenylyltransferase (NMNAT) protein family. Frontiers in Bioscience. 410-431.
  • Vis forfatter(e) (2009). Reconstitution of yeast silent chromatin: Multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro. Molecular Cell. 323-334.
  • Vis forfatter(e) (2009). Proteomic response of human neuroblastoma cells to azaspiracid-1. Journal of Proteomics. 695-707.
  • Vis forfatter(e) (2009). Is there a poly-ADP-ribose glycohydrolase isoform in mitochondria?
  • Vis forfatter(e) (2009). Human Naa50p (Nat5/San) Displays Both Protein N-alpha- and N-epsilon-Acetyltransferase Activity. Journal of Biological Chemistry. 31122-31129.
  • Vis forfatter(e) (2009). Emerging Roles of NAD(+) and Its Metabolites in Cell Signaling. Science Signaling. 5 sider.
  • Vis forfatter(e) (2009). Application of a coupled enzyme assay to characterize nicotinamide riboside kinases. Analytical Biochemistry. 377-379.
  • Vis forfatter(e) (2009). Alteration of compartment-specific NAD biosynthesis by reduction of individual subcellular NAD pools.
  • Vis forfatter(e) (2008). NAD kinase levels control the NADPH concentration in human cells. Free radical research. S37-S37.
  • Vis forfatter(e) (2008). Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix. Molecular and Cellular Biology. 814-824.
  • Vis forfatter(e) (2008). Biosynthesis and Degradation of NAD in Mitochondria.
  • Vis forfatter(e) (2008). Alteration of isoform-specific NMNAT expression by reduction of subcellular NAD pools.
  • Vis forfatter(e) (2007). The power to reduce: pyridine nucleotides - small molecules with a multitude of functions. Biochemical Journal. 205-218.
  • Vis forfatter(e) (2007). Regulation of Poly(ADP-ribose)polymerase 1 Activity by the Phosphorylation State of the Nuclear NAD Biosynthetic Enzyme NMN Adenylyl Transferase 1. Proceedings of the National Academy of Sciences of the United States of America. 3765-3770.
  • Vis forfatter(e) (2007). Refinement of a radioreceptor binding assay for nicotinic acid adenine dinucleotide phosphate. Analytical Biochemistry. 26-36.
  • Vis forfatter(e) (2007). NAD kinase levels control the NADPH concentration in human cells. Journal of Biological Chemistry. 33562-33571.
  • Vis forfatter(e) (2007). Expression of NAD biosynthetic enzymes in response to decreased mitochondrial and cytosolic NAD levels.
  • Vis forfatter(e) (2006). Time sensing by NAADP receptors. Biochemical Journal. 313-320.
  • Vis forfatter(e) (2006). The utility of PARP-1 activity to modulate subcellular NAD levels.
  • Vis forfatter(e) (2006). The making of NAD: How, When and Why.
  • Vis forfatter(e) (2006). Suborganellar localisation of proteins involved in mitochondrial energy metabolism.
  • Vis forfatter(e) (2006). Overexpression of human NAD kinase and its effect on oxidative stress in HEK293 cells.
  • Vis forfatter(e) (2006). Nuclear NAD+ Synthesis: Linking bioenergetics to DNA repair.
  • Vis forfatter(e) (2006). NAD: metabolism and regulatory functions. 8 sider.
  • Vis forfatter(e) (2006). NAD signalling and biosynthesis: many functions, many places, many questions.
  • Vis forfatter(e) (2006). Life and death with NAD(P): Signalling functions of the pyridine nucleotides.
  • Vis forfatter(e) (2006). From bioenergetics to signal transduction: Life and death with NAD.
  • Vis forfatter(e) (2006). Biochemistry and pharmacology of enzymes involved in NAD metabolism. Acta Pharmacologica Sinica. 37-37.
  • Vis forfatter(e) (2006). Biochemistry and pharmacology of enzymes involved in NAD metabolism.
  • Vis forfatter(e) (2006). An approach to modulate cellular poly(ADP-ribose) levels by means of RNA interference.
  • Vis forfatter(e) (2006). Amplification of poly(ADP-ribosyl)ation in sites of PARP-1 activation by the NAD biosynthetic enzyme NMN adenylyltransferase-1.
  • Vis forfatter(e) (2005). Triplicate NAD synthesis: Catalytic properties and subcellular compartmentation of the human NMN adenylyltransferase isoforms.
  • Vis forfatter(e) (2005). The new life of a centenarian - Signaling functions of NAD.
  • Vis forfatter(e) (2005). The adenine nucleotide translocase - a carrier protein potentially required for mitochondrial generation of NAD. Biochemistry (Moscow). 173-177.
  • Vis forfatter(e) (2005). Subcellular Compartmentation and Differential Catalytic Properties of the Three Human Nicotinamide Mononucleotide Adenylyltransferase Isoforms. Journal of Biological Chemistry. 36334-36341.
  • Vis forfatter(e) (2005). Regulation of PARP-1 by the NAD biosynthetic enzyme NMN adenylyltransferase-1.
  • Vis forfatter(e) (2005). Poly(ADP-ribosylation) and genomic stability. Biochemistry and Cell Biology. 263-269.
  • Vis forfatter(e) (2005). Importance of NAD metabolism for cancer development and treatment.
  • Vis forfatter(e) (2005). Functional interaction between PARP-1 and NMN adenylyltransferase-1.
  • Vis forfatter(e) (2005). An endogenous activator of poly-ADP-ribose polymerase-1: The NAD+ biosynthetic enzyme NMN Adenylyltransferase-1.
  • Vis forfatter(e) (2005). A vital link between energy and signal transduction - Regulatory functions of NAD(P). The FEBS Journal. 4561-4564.
  • Vis forfatter(e) (2004). The new life of a centenarian: signalling functions of NAD(P). TIBS -Trends in Biochemical Sciences. Regular ed.. 111-118.
  • Vis forfatter(e) (2004). NAD+ surfaces again. Biochemical Journal. 2 sider.
  • Vis forfatter(e) (2004). NAD � new roles in signalling and gene regulation in plants. New Phytologist. 31-44.
  • Vis forfatter(e) (2004). Dynamics of some postreplication DNA repair proteins in carcinogen-damaged mammalian cells. Tsitologia. 43-52.

Se fullstendig oversikt over publikasjoner i CRIStin.

Biochemistry, Cell biology, Bioenergetics, Enzymology, Nucleotide metabolism, Compartmentation