- E-postmette.vesterhus@uib.no
- Telefon+47 55 97 52 69
- BesøksadresseHaraldsplass Diakonale SykehusRom5.etg. SMU-bygget
- PostadressePostboks 78045020 Bergen
Mette Vesterhus er ansatt som professor ved UiB (100%) og er utdanningsleder ved K2. Som spesialist i fordøyelsessykdommer med spesiell interesse for leversykdommer, har hun en bistilling som overlege ved Haraldsplass diakonale sykehus. Forskningen hennes fokuserer på autoimmune leversykdommer, med særlig vekt på leverelastografi og biomarkører for fibrose, og for sykdomsaktivitet og prognose ved primær skleroserende cholangitt. Knyttet til forskningen, leder hun leverforskningsgruppen ved Haraldsplass, NoPSC Bergen Clinical Research Group, og er prosjektleder for ScandPSC - Strategic Prospective Scandinavian PSC Biobank & Cohort og Nasjonalt nettverk for autoimmune leversykdommer. For øvrig er hun er leder av Norsk Gastroenterologisk Forening (NGF) og medlem av NGFs Interessegruppe for leversykdommer, som bl.a. arrangerer det årlige Nasjonalt levermøte.
Vitenskapelig artikkel
- (2023). Whole blood RNA sequencing identifies transcriptional differences between primary sclerosing cholangitis and ulcerative colitis. JHEP Reports.
- (2023). Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis. Hepatology. 269-288.
- (2023). Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma. Journal of Hepatology. 93-108.
- (2023). Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation. Journal of Hepatology. 955-966.
- (2023). A global action agenda for turning the tide on fatty liver disease. Hepatology.
- (2022). Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis. JHEP Reports. 1-10.
- (2022). Improvement of cholestatic episodes in patients with benign recurrent intrahepatic cholestasis (BRIC) treated with rifampicin. A long-term follow-up. Scandinavian Journal of Gastroenterology.
- (2022). Impact on follow-up strategies in patients with primary sclerosing cholangitis. Liver international (Print). 12 sider.
- (2022). Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases. Journal of Clinical and Translational Hepatology (JCTH). 796-802.
- (2022). Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis. European Radiology Experimental. 9 sider.
- (2021). Fluctuating biomarkers in primary sclerosing cholangitis: A longitudinal comparison of alkaline phosphatase, liver stiffness, and ELF. JHEP Reports. 1-10.
- (2021). Controlled Attenuation Parameter in Healthy Individuals Aged 8-70 Years. Ultrasound International Open. E6-E13.
- (2021). Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease. JHEP Reports. 1-11.
- (2021). Circulating Macrophage Activation Markers Predict Transplant-Free Survival in Patients With Primary Sclerosing Cholangitis. Clinical and Translational Gastroenterology. e00315-e00315.
- (2021). Associations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitis. Scandinavian Journal of Gastroenterology. 443-452.
- (2020). Point shear wave elastography and the effect of physical exercise, alcohol consumption, and respiration in healthy adults. Ultrasound International Open. E54-E61.
- (2020). Liver elastography in healthy children using three different systems - how many measurements are necessary? Ultraschall in der Medizin. 1-10.
- (2020). Liver Elastography in Primary Sclerosing Cholangitis Patients Using Three Different Scanner Systems. Ultrasound in Medicine and Biology. 1854-1864.
- (2020). Effects of Tumor Necrosis Factor Antagonists in Patients With Primary Sclerosing Cholangitis. Clinical Gastroenterology and Hepatology. 2295-2304.e2.
- (2020). Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation. Hepatology.
- (2020). Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis. Gastroenterology.
- (2019). Normal Liver Stiffness Values in Children: A Comparison of Three Different Elastography Methods. Journal of Pediatric Gastroenterology and Nutrition - JPGN. 706-712.
- (2019). Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis. Liver international (Print). 371-381.
- (2019). Cholangiocarcinoma is associated with a raised enhanced liver fibrosis score independent of primary sclerosing cholangitis. European Journal of Clinical Investigation.
- (2019). Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis. Scientific Reports.
- (2018). Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis. Alimentary Pharmacology and Therapeutics. 179-189.
- (2018). Primary sclerosing cholangitis risk estimate tool (PREsTo) predicts outcomes of the disease: A derivation and validation study using machine learning. Hepatology. 1-11.
- (2018). Liver elasticity in healthy individuals by two novel shear-wave elastography systems-Comparison by age, gender, BMI and number of measurements. PLOS ONE. 1-16.
- (2018). Follow-up magnetic resonance imaging/3D-magnetic resonance cholangiopancreatography in patients with primary sclerosing cholangitis: challenging for experts to interpret. Alimentary Pharmacology and Therapeutics. 169-178.
- (2018). Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System. Hepatology. 2120-2135.
- (2017). Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner. Gut. 1135-1145.
- (2017). Repeatability of shear wave elastography in liver fibrosis phantoms—Evaluation of five different systems. PLOS ONE. 1-16.
- (2017). Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. Journal of Hepatology. 1214-1222.
- (2017). Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study. Liver international (Print). 1554-1561.
- (2017). Assessing liver stiffness by 2-D shear wave elastography in a healthy cohort. Ultrasound in Medicine and Biology. 332-341.
- (2017). Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis. Liver international (Print). 458-465.
- (2017). Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis. Hepatology. 137-144.
- (2016). Ultrasound and point shear wave elastography in livers of patients with primary sclerosing cholangitis. Ultrasound in Medicine and Biology. 2146-2155.
- (2016). The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls. Gut. 611-619.
- (2016). Prognostic biomarkers and surrogate end points in PSC. Liver international (Print). 1748-1751.
- (2016). In vitro comparison of five different elastography systems for clinical applications, using strain and shear wave technology. Ultrasound in Medicine and Biology. 2572-2588.
- (2016). In Vitro Comparison of Five Different Elastography Systems for Clinical Applications, Using Strain and Shear Wave Technology. Ultrasound in Medicine and Biology. 2572-2588.
- (2016). Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function. United European Gastroenterology Journal (UEG Journal). 532-541.
- (2016). Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis. Liver international (Print). 1370-1377.
- (2016). Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation. Mucosal Immunology.
- (2015). Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis. Hepatology. 188-197.
- (2014). Review article: Controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis. Alimentary Pharmacology and Therapeutics. 282-301.
- (2014). Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. Diabetes. 259-269.
- (2013). Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (Maturity-Onset Diabetes of the young). PLOS ONE. 11 sider.
- (2011). The role of pancreatic imaging in monogenic diabetes. Nature Reviews Endocrinology.
- (2011). Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. Journal of Biological Chemistry. 34593-34605.
- (2010). Pancreatic Function in Carboxyl-Ester Lipase Knockout Mice. Pancreatology (Print). 467-476.
- (2008). Reduced pancreatic volume in hepatocyte nuclear factor 1A-maturity-onset diabetes of the young. Journal of Clinical Endocrinology and Metabolism (JCEM). 3505-3509.
- (2008). Pancreatic Exocrine Dysfunction in Maturity-Onset Diabetes of the Young Type 3. Diabetes Care. 306-310.
- (2008). Neurological features and enzyme therapy in patients with endocrine and exocrine pancreas dysfunction due to CEL mutations. Diabetes Care. 1738-1740.
- (2008). Lack of pancreatic body and tail in HNF1B mutation carriers. Diabetic Medicine. 782-787.
Faglig foredrag
- (2021). ULTRASOUND EVALUATION OF PSC.
- (2021). PSC - What is that disease exactly?
- (2021). Juvenile PSC/ASC: The adult side.
- (2021). ELF Test in PSC - should we start using it?
- (2021). 2.linjebehandling ved PBC og AIH.
- (2017). Ultralyd Elastografi.
- (2017). Måling av vevsstivhet på fantomer med fire ulike «shear wave» elastografisystemer.
Vitenskapelig foredrag
- (2016). Quantification of tissue elasticity in vitro using three clinical shear wave elastography platforms on liver fibrosis phantoms.
- (2016). Elastography of the Liver in Primary Sclerosing Cholangitis.
- (2015). O082 : THE GUT MICROBIOTA IN PRIMARY SCLEROSING CHOLANGITIS DIFFERS FROM THAT OF HEALTHY CONTROLS AND ULCERATIVE COLITIS PATIENTS WITHOUT BILIARY DISEASE.
- (2015). In vitro quantification and reproducibility of elasticity measurements using five different elastography systems.
Leder
- (2022). Gode TIPS ved alvorlig leversykdom. Tidsskrift for Den norske legeforening.
Kronikk
- (2022). Vi trenger en ny strategi for leversykdom. Tidsskrift for Den norske legeforening. 6 sider.
Brev til redaktøren
- (2023). FIB-4-testen som beslutningsverktøy. Tidsskrift for Den norske legeforening.
- (2021). Reply to: "Both tacrolimus and mycophenylate mophetil should be considered second-line therapy for autoimmune hepatitis". Journal of Hepatology. 755-756.
Doktorgradsavhandling
- (2009). Monogenic diabetes and pancreatic exocrine dysfunction in mouse and man.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
- (2015). Point shear wave elastography of the liver in primary sclerosing cholangitis. 2 sider.
Sammendrag/abstract
- (2015). Elasticity Mearsurements Using Four Different Ultrasound Scanners. Ultrasound in Medicine and Biology. 148-149.
- (2007). Pancreatic exocrine deficiency is common in MODY 3. Diabetologia. S123-S123.
Poster
- (2020). P117 Biomarkers of extracellular matrix remodelling are associated with intestinal fibrosis assessed by magnetic resonance enterography and accumulated intestinal damage (Lémann index): the IBSEN study.
- (2017). ASSESSING LIVER STIFFNESS USING 2D-SHEAR WAVE ELASTOGRAPHY IN A HEALTHY COHORT.
- (2015). Point shear wave elastography of the liver in primary sclerosing cholangitis.
- (2015). P1174: Microbiota-dependent marker trimethylamine-N-oxide (TMAO) is associated with the severity of primary sclerosing cholangitis.
- (2015). MICROBIOTA-DEPENDENT MARKER TRIMETHYLAMINE-N-OXIDE (TMAO) IS ASSOCIATED WITH THE SEVERITY OF PRIMARY SCLEROSING CHOLANGITIS.
- (2015). In vitro quantification and reproducibility of elasticity measurements using four different ultrasound scanners.
Vitenskapelig oversiktsartikkel/review
- (2023). Noninvasive evaluation of fibrosis in adult biliary diseases. Current Opinion in Gastroenterology. 83-88.
- (2021). Klinisk oversiktsartikkel: Diagnostikk og behandling av autoimmun hepatitt. Tidsskrift for Den norske legeforening. 8 sider.
- (2021). Advancing the global public health agenda for NAFLD: a consensus statement. Nature reviews: Gastroenterology & hepatology.
- (2020). Second-line and third-line therapy for autoimmune hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group. Journal of Hepatology. 1-12.
- (2020). Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities. Journal of gastroenterology. 588-614.
- (2017). Primary sclerosing cholangitis - a comprehensive review. Journal of Hepatology. 1298-1323.
- (2012). The role of pancreatic imaging in monogenic diabetes mellitus. Nature Reviews Endocrinology. 148-159.
Fagartikkel
- (2023). Primær skleroserende kolangitt. Tidsskrift for Den norske legeforening.
- (2020). Prioriteringsråd for fordøyelsessykdommer under korona-pandemien. NGF-nytt. 16-17.
- Strategic Prospective Scandinavian PSC Biobank (National PI)
- Nasjonalt nettverk for autoimmune leversykdommer (PI)
- Biomarkers of prognosis and disease activity in primary sclerosing cholangitis (Hovedveileder for PhD-prosjekt)
Kompetansefelt