Styrt vevsbygging og regenerasjon


There has not been added a translated version of this content. You can either try searching or go to the "area" home page to see if you can find the information there
Phd defense

Doctoral thesis defense

Tissue Engineering group member Sushma Bartaula-Brevik successfully defended her PhD thesis "Vascularization and Host Response in Bone Tissue Engineering" on 07.12.16.

Jørgen Barth



The major hurdle in the survival of a tissue-engineered construct after implantation is vascularization. Pre-vascularization is one of the proposed methods to achieve vascularization in tissue-engineered constructs. This thesis is centered on prevascularization of the tissue-engineered construct and local host response upon implantation in vivo.

In her thesis, Sushma has shown that mesenchymal stem cells (MSC) in combination with endothelial cells (EC) developed microvessels-like structures before implantation in vivo. Hypoxia, a common consequence after implantation of constructs, accelerated wound healing and tube formation via paracrine effect of MSC. Combining these two effects might lead to inosculation and survival of a graft. Addition of EC improved the immunomodulatory property of MSC.

Acting as opponents were Professor Susanna Miettinen, University of Tampere, Finland, and Professor Xuebin Yang, University of Leeds, UK.