Hjem
Annette Brenners bilde

Annette Brenner

Forsker, i hematologi
  • E-postAnnette.Brenner@uib.no
  • Telefon+47 469 23 798
  • Besøksadresse
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
Tidsskriftartikler
  • Aasebø, Elise; Hernandez-Valladares, Maria; Selheim, Frode; Berven, Frode; Brenner, Annette; Bruserud, Øystein. 2019. Proteomic profiling of primary human acute myeloid leukemia cells does not reflect their constitutive release of soluble mediators. Proteomes. 7: 1-10. doi: 10.3390/proteomes7010001
  • Bjørnstad, Ronja; Aesoy, Reidun; Bruserud, Øystein; Brenner, Annette; Giraud, Francis; Dowling, Tara Helen; Gausdal, Gro; Moreau, Pascale; Doskeland, Stein Ove; Anizon, Fabrice; Herfindal, Lars. 2019. A kinase inhibitor with anti-Pim kinase activity is a potent and selective cytotoxic agent toward acute myeloid leukemia. Molecular Cancer Therapeutics. 18: 567-578. doi: 10.1158/1535-7163.MCT-17-1234
  • Brenner, Annette; Aasebø, Elise; Hernandez-Valladares, Maria; Selheim, Frode; Berven, Frode; Grønningsæter, Ida Sofie; Bartaula-Brevik, Sushma; Bruserud, Øystein. 2019. The capacity of long-term in vitro proliferation of acute myeloid leukemia cells supported only by exogenous cytokines is associated with a patient subset with adverse outcome. Cancers. 11:73: 1-22. doi: 10.3390/cancers11010073
  • Brenner, Annette; Bruserud, Øystein. 2019. Functional toll-like receptors (TLRs) are expressed by a majority of primary human acute myeloid leukemia cells and inducibility of the TLR signaling pathway is associated with a more favorable phenotype. Cancers. 11.
  • Reikvam, Håkon; Aasebø, Elise; Brenner, Annette; Bartaula-Brevik, Sushma; Grønningsæter, Ida Sofie; Forthun, Rakel Brendsdal; Hovland, Randi; Bruserud, Øystein. 2019. High constitutive cytokine release by primary human acute myeloid leukemia cells is associated with a specific intercellular communication phenotype. Journal of clinical medicine. 8.
  • Brenner, Annette; Bruserud, Øystein. 2018. S100 proteins in acute myeloid leukemia. Neoplasia. 20: 1175-1186. doi: 10.1016/j.neo.2018.09.007
  • Johansen, Silje; Brenner, Annette; Bartaula-Brevik, Sushma; Reikvam, Håkon; Bruserud, Øystein. 2018. The possible importance of β3 integrins for leukemogenesis and chemoresistance in acute myeloid leukemia. International Journal of Molecular Sciences. 19:251: 1-17. doi: 10.3390/ijms19010251
  • Nepstad, Ina; Hatfield, Kimberley Joanne; Aasebø, Elise; Hernandez-Valladares, Maria; Brenner, Annette; Bartaula-Brevik, Sushma; Berven, Frode; Selheim, Frode; Skavland, Jørn; Gjertsen, Bjørn Tore; Reikvam, Håkon; Bruserud, Øystein. 2018. Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic and transcriptomic comparison. Expert opinion on therapeutic targets. 22: 639-653. doi: 10.1080/14728222.2018.1487401
  • Nepstad, Ina; Reikvam, Håkon; Brenner, Annette; Bruserud, Øystein; Hatfield, Kimberley Joanne. 2018. Resistance to the antiproliferative in vitro effect of PI3K-Akt-mTOR inhibition in primary human acute myeloid leukemia cells is associated with altered cell metabolism. International Journal of Molecular Sciences. 19:382: 1-18. doi: 10.3390/ijms19020382
  • Tvedt, Tor Henrik Anderson; Melve, Guro Kristin; Tsykunova, Galina; Ahmed, Aymen B; Brenner, Annette; Bruserud, Øystein. 2018. Immunological heterogeneity of healthy peripheral blood stem cell donors - Effects of granulocyte colony-stimulating factor on inflammatory responses. International Journal of Molecular Sciences. 19:2886: 1-16. doi: 10.3390/ijms19102886
  • Brenner, Annette; Aasebø, Elise; Hernandez-Valladares, Maria; Selheim, Frode; Berven, Frode; Bruserud, Øystein. 2017. Rethinking the role of osteopontin in human acute myeloid leukemia. Leukemia and Lymphoma. 58: 1494-1497. doi: 10.1080/10428194.2016.1243682
  • Brenner, Annette; Nepstad, Ina; Bruserud, Øystein. 2017. Mesenchymal stem cells support survival and proliferation of primary human acute myeloid leukemia cells through heterogeneous molecular mechanisms. Frontiers in Immunology. 8:106: 1-17. doi: 10.3389/fimmu.2017.00106
  • Brenner, Annette; Reikvam, Håkon; Rye, Kristin Paulsen; Hagen, Karen Marie; Lavecchia, Antonio; Bruserud, Øystein. 2017. CDC25 inhibition in acute myeloid leukemia - A study of patient heterogeneity and the effects of different inhibitors. Molecules. 22:446: 1-18. doi: 10.3390/molecules22030446
  • Brenner, Annette; Tvedt, Tor Henrik Anderson; Nepstad, Ina; Rye, Kristin Paulsen; Hagen, Karen Marie; Reikvam, Håkon; Bruserud, Øystein. 2017. Patients with acute myeloid leukemia can be subclassified based on the constitutive cytokine release of the leukemic cells; the possible clinical relevance and the importance of cellular iron metabolism. Expert opinion on therapeutic targets. 21: 357-369. doi: 10.1080/14728222.2017.1300255
  • Honnemyr, Maria; Bruserud, Øystein; Brenner, Annette. 2017. The constitutive protease release by primary human acute myeloid leukemia cells. Journal of Cancer Research and Clinical Oncology. Published ahead of print: 1-14. doi: 10.1007/s00432-017-2458-7
  • Brenner, Annette; Reikvam, Håkon; Bruserud, Øystein. 2016. A subset of patients with acute myeloid leukemia has leukemia cells characterized by chemokine responsiveness and altered expression of transcriptional as well as angiogenic regulators. Frontiers in Immunology. 7. doi: 10.3389/fimmu.2016.00205
  • Brenner, Annette; Tvedt, Tor Henrik Anderson; Bruserud, Øystein. 2016. The complexity of targeting PI3K-Akt-mTOR signalling in human acute myeloid leukaemia: The importance of leukemic cell heterogeneity, neighbouring mesenchymal stem cells and immunocompetent cells. Molecules. 21:1512. 32 sider. doi: 10.3390/molecules21111512
  • Kittang, Astrid Marta Olsnes; Sand, Kristoffer; Brenner, Annette; Rye, Kristin Paulsen; Bruserud, Øystein. 2016. The systemic profile of soluble immune mediators in patients with myelodysplastic syndromes. International Journal of Molecular Sciences. 17:1080. doi: 10.3390/ijms17071080
  • Bruserud, Øystein; Reikvam, Håkon; Fredly, Hanne Kristin; Skavland, Jørn; Hagen, Karen Marie; Hoang, Tuyen; Brenner, Annette; Kadi, Amir; Astori, Audrey; Gjertsen, Bjørn Tore; Pendino, Frederic. 2015. Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation. OncoTarget. 6: 2794-2811.
  • Ersvær, Elisabeth; Brenner, Annette; Vetås, Kristin; Reikvam, Håkon; Bruserud, Øystein. 2015. Effects of cytarabine on activation of human T cells - cytarabine has concentration-dependent effects that are modulated both by valproic acid and all-trans retinoic acid. BMC Pharmacology & Toxicology. 16:12. doi: 10.1186/s40360-015-0012-2
  • Reikvam, Håkon; Brenner, Annette; Hagen, Karen Marie; Liseth, Knut; Skrede, Silje; Hatfield, Kimberley Joanne; Bruserud, Øystein. 2015. The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cells. Stem Cell Research. 15: 530-541. doi: 10.1016/j.scr.2015.09.008
  • Reikvam, Håkon; Hauge, Michelle Victoria; Brenner, Annette; Hatfield, Kimberley Joanne; Bruserud, Øystein. 2015. Emerging therapeutic targets for the treatment of human acute myeloid leukemia (part 1) - gene transcription, cell cycle regulation, metabolism and intercellular communication. Expert Review of Hematology. 8: 299-313. doi: 10.1586/17474086.2015.1032935
  • Tvedt, Tor Henrik Anderson; Rye, Kristin Paulsen; Reikvam, Håkon; Brenner, Annette; Bruserud, Øystein. 2015. The importance of sample collection when using single cytokine levels and systemic cytokine profiles as biomarkers - a comparative study of serum versus plasma samples. JIM - Journal of Immunological Methods. 418: 19-28. doi: 10.1016/j.jim.2015.01.006
  • Brenner, Annette; Frøystein, Nils Åge. 2014. Using MUSIC and CC(CO)NH for Backbone Assignment of Two Medium-Sized Proteins Not Fully Accessible to Standard 3D NMR. Molecules. 19: 8890-8903. doi: 10.3390/molecules19078890
  • Brenner, Annette; Reikvam, Håkon; Lavecchia, Antonio; Bruserud, Øystein. 2014. Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid Leukemia - The possibility to target several kinases through inhibition of the various CDC25 isoforms. Molecules. 19: 18414-18447. doi: 10.3390/molecules191118414
  • Reikvam, Håkon; Brenner, Annette; Nepstad, Ina; Sulen, Andre; Bruserud, Øystein. 2014. Heat shock protein 70 - the next chaperone to target in the treatment of human acute myelogenous leukemia? Expert opinion on therapeutic targets. 18: 929-944. doi: 10.1517/14728222.2014.924925
  • Reikvam, Håkon; Forthun, Rakel Brendsdal; Brenner, Annette; Ersvær, Elisabeth; Hatfield, Kimberley Joanne; Bruserud, Øystein. 2014. Heat shock protein 90 – a potential target in the treatment of human acute myelogenous leukemia. Advances in cancer drug targets. 2: 3-53. doi: 10.2174/9781608059386114020003
  • Brenner, Annette; Kieffer, Bruno; Trave, Gilles Michel; Frøystein, Nils Åge; Raae, Arnt Johan. 2012. Thermal stability of chicken brain alpha-spectrin repeat 17: a spectroscopic study. Journal of Biomolecular NMR. 53: 71-83. doi: 10.1007/s10858-012-9620-y
  • Evjenth, Rune Henrik; Brenner, Annette; Thompson, Paul R.; Arnesen, Thomas; Frøystein, Nils Åge; Lillehaug, Johan R. 2012. Human Protein N-terminal Acetyltransferase hNaa50p (hNAT5/hSAN) Follows Ordered Sequential Catalytic Mechanism (combined kinetic and NMR study). Journal of Biological Chemistry. 287: 10081-10088. doi: 10.1074/jbc.M111.326587
  • Karlsen, Odd Andre; Ramsevik, Linda; Bruseth, Live J.; Larsen, Øivind; Brenner, Annette Katharina; Berven, Frode; Jensen, Harald B; Lillehaug, Johan. 2005. Characterisation of a prokaryotic hemerythrin from the methanotrophic bacterium Methylococcus capsulatus (Bath). The FEBS Journal. 272: 2428-2440.
Rapporter/avhandlinger
  • Brenner, Annette. 2012. Revealing the secrets of proteins – a triple-nuclear and multi-dimensional high-resolution NMR study. University of Bergen.
  • Brenner, Annette Katharina. 2006. The haemerythrin of Methylococcus capsulatus ( Bath ); a structutal study using physical-chemical methods. Molekylærbiologisk insitutt, Universitetet i Bergen. 72 sider.

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