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Bjørn Blombergs bilde

Bjørn Blomberg

Førsteamanuensis
  • E-postBjorn.Blomberg@uib.no
  • Telefon+47 55 97 29 60
  • Besøksadresse
    5021 Bergen
  • Postadresse
    Postboks 7804
    5020 Bergen

I work in the infectious diseases research group at UoB and Haukeland University Hospital. Recently focus has been on COVID-19, and our article in Nature Medicine, Long COVID in a prospective cohort of home-isolated patients (Blomberg et al, Nat Med 2021, 27:1607-1613) has been cited 120 times, downloaded 145000 times, and recently got the prices for "article of the year" 2021 from both the Norwegian Infectious Diseases Association and the Faculty of Medicine, UoB. 

My PhD-research in Tanzania on antimicrobial resistance (AMR) in severe pediatric infections documented for the first time the excessive mortality in children with sepsis caused by of multidrug-resistant ESBL (extended-spectrum beta-lactamase) producing bacteria. Later we have done follow-up studies in Tanzania, including Zanzibar, and in India. I worked for WHO in the group researching and promoting 4-drug fixed-dose combination drugs world-wide to counteract emerging multidrug-resistant tuberculosis (MDR-TB). I have planned and supervised a randomized clinical trial (COTRIMRESIST, clinicaltrials.gov ID NCT03087890) on antibiotic chemotherapy and AMR in HIV-patients in Tanzania.  I am co-investigator of an ongoing RCT on probiotic use in newborns in rural Tanzania to prevent AMR and increase survival (PRORIDE, clinicaltrials.gov ID NCT04172012). 

I am an enthusiastic user of R for statistical analysis.

Indremedisin, infeksjonssykdommer, fokus på global helse / tropemedisin, inkl. HIV, tuberkulose, malaria, ebola m.m. Underviser på internasjonalt tropemedisinkurs ved CMC, Vellore, India.

 

I teach medical students at the University of Bergen since 2008. In 2018 I received the final year students' price for best teacher at medical studies. Apart from that I have been teaching at the international short course in clinical tropical medicine at Christian Medical College, Vellore, India, since its start in 2007,  and for a five-years period at the Union's international tuberculosis course in Arusha, Tanzania (www.theunion.org). 

I teach various topics in internal medicine and infectious diseases, global health and tropical medicine, including antimicrobial resistance, sepsis, malaria, ebola, tuberculosis

I have have over 80 articles on pubmed, including 15 as first author and 16 as last author.

My most cited articles include [1-5]

 

1.         Blomberg B, Mohn KG, Brokstad KA, Zhou F, Linchausen DW, Hansen BA, Lartey S, Onyango TB, Kuwelker K, Saevik M, et al: Long COVID in a prospective cohort of home-isolated patients. Nat Med 2021, 27:1607-1613.

2.         Blomberg B, Manji KP, Urassa WK, Tamim BS, Mwakagile DS, Jureen R, Msangi V, Tellevik MG, Holberg-Petersen M, Harthug S, et al: Antimicrobial resistance predicts death in Tanzanian children with bloodstream infections: a prospective cohort study. BMC Infect Dis 2007, 7:43.

3.         Blomberg B, Jureen R, Manji KP, Tamim BS, Mwakagile DS, Urassa WK, Fataki M, Msangi V, Tellevik MG, Maselle SY, Langeland N: High rate of fatal cases of pediatric septicemia caused by gram-negative bacteria with extended-spectrum beta-lactamases in Dar es Salaam, Tanzania. J Clin Microbiol 2005, 43:745-749.

4.         Blomberg B, Fourie B: Fixed-dose combination drugs for tuberculosis: application in standardised treatment regimens. Drugs 2003, 63:535-553.

5.         Blomberg B, Spinaci S, Fourie B, Laing R: The rationale for recommending fixed-dose combination tablets for treatment of tuberculosis. Bull World Health Organ 2001, 79:61-68.

Vitenskapelig artikkel
  • Vis forfatter(e) (2022). Weight gain during treatment course of allogenic hematopoietic stem cell transplantation, in patients with hematological malignancies, affects treatment outcome. Cytotherapy.
  • Vis forfatter(e) (2022). Symptom burden and immune dynamics 6 to 18 months following mild SARS-CoV-2 infection -a case-control study. Clinical Infectious Diseases.
  • Vis forfatter(e) (2022). Malaria prevalence and performance of diagnostic tests among patients hospitalized with acute undifferentiated fever in Zanzibar. Malaria Journal. 8 sider.
  • Vis forfatter(e) (2022). Intermittent left bundle branch block with septal flash and postural orthostatic tachycardia syndrome in a young woman with long COVID-19. BMJ Case Reports.
  • Vis forfatter(e) (2022). Gastrointestinal colonization of extended-spectrum beta-lactamase-producing bacteria among children below five years of age hospitalized with fever in Dar es Salaam, Tanzania. Journal of Global Antimicrobial Resistance. 107-114.
  • Vis forfatter(e) (2022). First identification of bla<inf>NDM-5</inf>producing Escherichia coli from neonates and a HIV infected adult in Tanzania. Journal of Medical Microbiology. 11 sider.
  • Vis forfatter(e) (2022). Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses. Cell Chemical Biology.
  • Vis forfatter(e) (2021). Use of probiotics to reduce infections and death and prevent colonization with extended-spectrum beta-lactamase (ESBL)-producing bacteria among newborn infants in Tanzania (ProRIDE Trial): study protocol for a randomized controlled clinical trial. Trials.
  • Vis forfatter(e) (2021). Predominance of PVL-negative community-associated methicillin-resistant Staphylococcus aureus sequence type 8 in newly diagnosed HIV-infected adults, Tanzania. European Journal of Clinical Microbiology and Infectious Diseases. 1-9.
  • Vis forfatter(e) (2021). Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9. Scientific Reports. 1-12.
  • Vis forfatter(e) (2021). Molecular characterisation of the first New Delhi metallo-β-lactamase 1-producing Acinetobacter baumannii from Tanzania. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1080-1085.
  • Vis forfatter(e) (2021). Lower antibiotic prescription rates in hospitalized COVID-19 patients than influenza patients, a prospective study. Infectious Diseases. 1-12.
  • Vis forfatter(e) (2021). Long-term echocardiographic follow-up of a patient with constrictive pericarditis treated with antituberculosis drugs and pericardiectomy. BMJ Case Reports. 1-7.
  • Vis forfatter(e) (2021). Long COVID in a prospective cohort of home-isolated patients. Nature Medicine. 1607-1613.
  • Vis forfatter(e) (2021). Leishmaniasis i Norge. Tidsskrift for Den norske legeforening. 1-9.
  • Vis forfatter(e) (2021). Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial. Annals of Internal Medicine. 1261-1269.
  • Vis forfatter(e) (2021). COVID-19 myocarditis and postinfection Bell's palsy. BMJ Case Reports. 1-4.
  • Vis forfatter(e) (2021). Attack rates amongst household members of outpatients with confirmed COVID-19 in Bergen, Norway: A case-ascertained study. The Lancet Regional Health - Europe. 9 sider.
  • Vis forfatter(e) (2021). Adherence to community versus facility-based delivery of monthly malaria chemoprevention with dihydroartemisinin-piperaquine for the post-discharge management of severe anemia in Malawian children: A cluster randomized trial. PLOS ONE. 1-16.
  • Vis forfatter(e) (2021). A cohort analysis of survival and outcomes in severely anaemic children with moderate to severe acute malnutrition in Malawi. PLOS ONE. 1-11.
  • Vis forfatter(e) (2020). SARS-CoV-2-specific neutralizing antibody responses in Norwegian healthcare workers after the first wave of COVID-19 pandemic: a prospective cohort study. Journal of Infectious Diseases.
  • Vis forfatter(e) (2020). Point-of-care influenza testing impacts clinical decision, patient flow and length of stay in hospitalized adults. Journal of Infectious Diseases.
  • Vis forfatter(e) (2020). Horizontal plasmid transfer among klebsiella pneumoniae isolates is the key factor for dissemination of extended-spectrum β-lactamases among children in Tanzania. mSphere. 1-13.
  • Vis forfatter(e) (2020). High rate of antimicrobial resistance and multiple mutations in the dihydrofolate reductase gene among Streptococcus pneumoniae isolated from HIV-infected adults in a community setting in Tanzania. Journal of Global Antimicrobial Resistance. 749-753.
  • Vis forfatter(e) (2020). High prevalence of fecal carriage of extended spectrum β-lactamase-producing enterobacteriaceae among newly HIV-diagnosed adults in a community setting in Tanzania. Microbial Drug Resistance. 1540-1545.
  • Vis forfatter(e) (2020). Hemophagocytic lymphohistiocytosis and miliary tuberculosis in a previously healthy individual: a case report. Journal of Medical Case Reports. 1-9.
  • Vis forfatter(e) (2020). Bacteraemia, malaria, and case fatality among children hospitalized with fever in Dar es Salaam, Tanzania. Frontiers in Microbiology. 1-10.
  • Vis forfatter(e) (2019). En mann i 80-årene med leddgikt og vedvarende feber. Tidsskrift for Den norske legeforening. 6 sider.
  • Vis forfatter(e) (2019). Assessment of malaria real-time PCR methods and application with focus on lowlevel parasitaemia. PLOS ONE. 1-15.
  • Vis forfatter(e) (2018). Introducing post-discharge malaria chemoprevention (PMC) for management of severe anemia in Malawian children: a qualitative study of community health workers’ perceptions and motivation. BMC Health Services Research. 1-15.
  • Vis forfatter(e) (2018). Delivery strategies for malaria chemoprevention with monthly dihydroartemisinin-piperaquine for the post-discharge management of severe anaemia in children aged less than 5 years old in Malawi: a protocol for a cluster randomized trial. BMC Pediatrics. 1-8.
  • Vis forfatter(e) (2018). Aortic valve endocarditis with Erysipelothrix rhusiopathiae: A rare zoonosis. Infectious Disease Reports. 47-49.
  • Vis forfatter(e) (2017). Molecular Characterization of Cotrimoxazole Resistance Genes and Their Associated Integrons in Clinical Isolates of Gram-Negative Bacteria from Tanzania. Microbial Drug Resistance. 37-43.
  • Vis forfatter(e) (2017). Detection of CTX-M-15 beta-lactamases in Enterobacteriaceae causing hospital- and community-acquired urinary tract infections as early as 2004, in Dar es Salaam, Tanzania. BMC Infectious Diseases. 1-7.
  • Vis forfatter(e) (2017). Comprehensive analysis of prevalence, epidemiologic characteristics, and clinical characteristics of monoinfection and coinfection in diarrheal diseases in children in Tanzania. American Journal of Epidemiology. 1074-1083.
  • Vis forfatter(e) (2017). Acute undifferentiated fever in India: A multicentre study of aetiology and diagnostic accuracy. BMC Infectious Diseases. 1-11.
  • Vis forfatter(e) (2016). Multidrug-resistant tuberculosis in Norway: a nationwide study, 1995-2014. The International Journal of Tuberculosis and Lung Disease. 786-792.
  • Vis forfatter(e) (2016). High prevalence of faecal carriage of esbl-producing enterobacteriaceae among children in Dar es Salaam, Tanzania. PLOS ONE.
  • Vis forfatter(e) (2016). Clinical features of suspected Ebola cases referred to the Moyamba ETC, Sierra Leone: Challenges in the later stages of the 2014 outbreak. BMC Infectious Diseases.
  • Vis forfatter(e) (2016). Clinical features of and risk factors for fatal Ebola virus disease, Moyamba District, Sierra Leone, December 2014–February 2015. Emerging Infectious Diseases. 1537-1544.
  • Vis forfatter(e) (2016). A high malaria prevalence identified by PCR among patients with acute undifferentiated fever in India. PLOS ONE.
  • Vis forfatter(e) (2015). Prevalence of Cryptosporidium parvum/hominis, Entamoeba histolytica and Giardia lamblia among Young Children with and without Diarrhea in Dar es Salaam, Tanzania. PLoS Neglected Tropical Diseases.
  • Vis forfatter(e) (2015). Prevalence and antimicrobial resistance of microbes causing bloodstream infections in unguja, Zanzibar. PLOS ONE.
  • Vis forfatter(e) (2015). Genetic relatedness and risk factor analysis of ampicillin-resistant and high-level gentamicin-resistant enterococci causing bloodstream infections in Tanzanian children. BMC Infectious Diseases.
  • Vis forfatter(e) (2015). Beredskap ved alvorlig malaria. Tidsskrift for Den norske legeforening. 533-535.
  • Vis forfatter(e) (2014). Prevalence and molecular characterisation of human adenovirus in diarrhoeic children in Tanzania; a case control study. BMC Infectious Diseases. 9 sider.
  • Vis forfatter(e) (2014). PCR targeting Plasmodium mitochondrial genome of DNA extracted from dried blood on filter paper compared to whole blood. Malaria Journal.
  • Vis forfatter(e) (2014). Identification of VIM-2-producing Pseudomonas aeruginosa from Tanzania is associated with sequence types 244 and 640 and the location of blaVIM-2 in a TniC integron. Antimicrobial Agents and Chemotherapy. 682-685.
  • Vis forfatter(e) (2014). High nasal carriage of methicillin-resistant staphylococcus aureus among healthy tanzanian under-5 children. Microbial Drug Resistance. 82-88.
  • Vis forfatter(e) (2014). Genetic diversity of norovirus in hospitalised diarrhoeic children and asymptomatic controls in Dar es Salaam, Tanzania. Infection, Genetics and Evolution. 340-347.
  • Vis forfatter(e) (2014). Genetic diversity of circulating rotavirus strains in Tanzania prior to the introduction of vaccination. PLOS ONE.
  • Vis forfatter(e) (2014). Education and knowledge helps combating malaria, but not degedege: A cross-sectional study in Rufiji, Tanzania. Malaria Journal.
  • Vis forfatter(e) (2014). Comparison of four methods for extracting DNA from dried blood on filter paper for PCR targeting the mitochondrial Plasmodium genome. Transactions of the Royal Society of Tropical Medicine and Hygiene. 488-494.
  • Vis forfatter(e) (2013). No asymptomatic malaria parasitaemia found among 108 young children at one health facility in Dar es Salaam, Tanzania. Malaria Journal.
  • Vis forfatter(e) (2013). Challenges in diagnosing paediatric malaria in Dar es Salaam, Tanzania. Malaria Journal.
  • Vis forfatter(e) (2013). A novel, single-amplification PCR targeting mitochondrial genome highly sensitive and specific in diagnosing malaria among returned travellers in Bergen, Norway. Malaria Journal. 8 sider.
  • Vis forfatter(e) (2012). Penicillin resistance and serotype distribution of Streptococcus pneumoniae in nasopharyngeal carrier children under 5 years of age in Dar es Salaam, Tanzania. Journal of Medical Microbiology. 952-959.
  • Vis forfatter(e) (2011). CNS involvement and treatment with interferon-alpha are independent prognostic factors in Erdheim-Chester disease: a multicenter survival analysis of 53 patients. Blood. 2778-2782.
  • Vis forfatter(e) (2010). Tuberculous meningitis and resistance to isoniazid. BMJ. British Medical Journal.
  • Vis forfatter(e) (2010). Diagnosis and follow-up of treatment of latent tuberculosis; the utility of the QuantiFERON-TB Gold In-tube assay in outpatients from a tuberculosis low-endemic country. BMC Infectious Diseases. 9 sider.
  • Vis forfatter(e) (2008). Falciparum malaria and HIV-1 in hospitalized adults in Maputo, Mozambique: does HIV-infection obscure the malaria diagnosis? Malaria Journal.
  • Vis forfatter(e) (2007). Extended-spectrum beta-lactamase-type SHV-12-producing Enterobacteriaceae causing septicemia in Tanzanian children: vectors for horizontal transfer of antimicrobial resistance. Diagnostic microbiology and infectious disease. 351-354.
  • Vis forfatter(e) (2007). Antimicrobial resistance predicts death in Tanzanian children with bloodstream infections: a prospective cohort study. BMC Infectious Diseases.
  • Vis forfatter(e) (2005). High rate of fatal cases of pediatric septicemia caused by gram-negative bacteria with extended-spectrum beta-lactamases in Dar es Salaam, Tanzania. Journal of Clinical Microbiology. 745-749.
  • Vis forfatter(e) (2005). Antimicrobial resistance in urinary bacterial isolates from pregnant women in rural Tanzania: Implications for public health. Scandinavian Journal of Infectious Diseases. 262-268.
  • Vis forfatter(e) (2004). Surveillance of antimicrobial resistance at a tertiary hospital in Tanzania. BMC Public Health. 45.
  • Vis forfatter(e) (2004). Nosocomial outbreak of neonatal Salmonella enterica serotype Enteritidis meningitis in a rural hospital in northern Tanzania. BMC Infectious Diseases. 35.
  • Vis forfatter(e) (2004). Fixed dose combinations for tuberculosis: Lessons learned from clinical, formulation and regulatory perspective. Methods and Findings in Experimental and Clinical Pharmacology. 703-721.
  • Vis forfatter(e) (2003). Effects of zinc deficiency and pneumococcal surface protein A immunization on zinc status and the risk of severe infection in mice. Infection and Immunity. 2009-2013.
Vitenskapelig foredrag
  • Vis forfatter(e) (2021). Effectiveness of community versus facility delivery of dihydroartemisinin-peraquine for post-discharge malaria chemoprevention in management of severe anaemia in Malawian children.
  • Vis forfatter(e) (2017). Delivery strategies of malaria chemoprevention for post-discharge management of children with severe anemia in Malawi (oral).
Fagbok
  • Vis forfatter(e) (2009). Management of side effects of antituberculosis drugs (book chapter) in Tuberculosis - a comprehensive review (edited by H. Simon Schaaf, Alimuddin Zumla). Elsevier.
Kronikk
  • Vis forfatter(e) (2018). Mann i 20-årene med svimmelhet, dobbeltsyn og perifer facialisparese. Tidsskrift for Den norske legeforening. 7 sider.
Brev til redaktøren
  • Vis forfatter(e) (2013). Aminoglykosider ved alvorlig sepsis. Tidsskrift for Den norske legeforening. 1553-1554.
Intervju
  • Vis forfatter(e) (2018). Epidemiene som truer verden.
Sammendrag/abstract
  • Vis forfatter(e) (2013). Erdheim-Chester Disease: A Monocentric Series Of 96 Patients. Arthritis and Rheumatism. S858-S858.
Poster
  • Vis forfatter(e) (2019). Effectiveness Of Community Versus Facility Delivery Strategies On Adherence To Dihydroartemesinin-Piperaquine For Post-Discharge Malaria Chemoprevention In Management Of Severe Anaemia In Malawian Children.
  • Vis forfatter(e) (2019). Effectiveness Of Community Versus Facility Delivery Strategies On Adherence To Dihydroartemesinin-Piperaquine For Post-Discharge Malaria Chemoprevention In Management Of Severe Anaemia In Malawian Children.
  • Vis forfatter(e) (2017). Delivery strategies of malaria chemoprevention for post-discharge management of children with severe anemia in Malawi (poster) .
  • Vis forfatter(e) (2005). Prevalence and characterization of extended spectrum beta-lactamase (ESBL) producing isolates from children with bacteraemia in Tanzania.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) (2008). Antibiotikaresistens i utviklingsland. Tidsskrift for Den norske legeforening. 2462-2466.
  • Vis forfatter(e) (2003). Fixed-dose combination drugs for tuberculosis: application in standardised treatment regimens. Drugs. 535-553.

Se fullstendig oversikt over publikasjoner i CRIStin.

MD, PhD, spesialist i infeksjonssykdommer og indremedisin

I am a medical doctor, specialist in infectious diseases and internal medicine at Haukeland University Hospital, and an associate professor at the Dept of Clinical Science, University of Bergen. 

I studied at the University of Bergen, MD (1994), PhD (2007). My PhD work was on antimicrobial resistance in severe infections in children in Tanzania, and have continued with research on antimicrobial resistance later on. 

Apart from that, some of my interests are

- tropical medicine, major global infections such as TB, HIV and malaria

- viral infections outbreaks, Ebola, Covid-19