Hjem
Dag Rune Olsens bilde

Dag Rune Olsen

Professor
  • E-postDag.Rune.Olsen@uib.no
  • Telefon+47 930 85 881
  • Besøksadresse
    Kalfarveien 31, 2. etasje
  • Postadresse
    Postboks 7800
    5020 Bergen

Adaptive radiation therapy of cancer - molecular imaging and biophysical modelling

Radiation therapy is a critical component in modern management of cancer. Still, approximately 1 out of 5 cancer patients die due to loco-regional failure. Radiation oncology is developing into the paradigm of focused biology, and radiobiological factors may be incorporated into optimization of radiation therapy.

Radiation therapy of tumours aims traditionally at delivering a homogeneous dose to the entire target volume, although intra-tumour variations in cellular and physiological factors of importance for response to therapy have been demonstrated. Biological adaptive radiation therapy (BioART) aims at tailoring the radiation dose distribution on a sub-regional level in the tumour according regional variations in radiobiological factors, like hypoxia.


It has been suggested that non-invasive biological imaging (like MRI, MRSi and PET) may provide the pertinent information to guide the painting or sculpting of the optimal dose distribution to the tumour. Simulations of tumour control probability (TCP) have demonstrated that increasing the dose to hypoxic regions, while keeping the mean dose constant may increase TCP. Moreover, tailored dose distribution is feasible with modern irradiation techniques like intensitymodulated radiation therapy (IMRT) and computer-controlled HDR brachytherapy. The aims of this project are:

- To utilize biological imaging (cedMRI, MRSi and PET) in visualizing cellular and tumour physiological factors of importance for radiation response

- Design models for optimizing dose distribution with respect to tumour control probability, based on biological imaging

- Demonstrate enhanced local control in experimental and clinical studies

 

Selected publications 

Søvik A, Malinen E, Olsen DR. Adapting biological feedback in radiotherapy. Semin Radiat Oncol. 2010 Apr;20(2):138-46.

Søvik A, Malinen E, Olsen DR. Strategies for biologic image-guided dose escalation: a review. Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):650-8.

Malinen E, Søvik A, Hristov D, Bruland ØS, Olsen DR. Adapting radiotherapy to hypoxic tumours. Phys Med Biol. 2006 Oct 7;51(19):4903-21.

 

 

Utdanning: Fakultetet tilbyr en rekke forskningsbaserte studier på bachelor- og master-nivå inne matematikk, naturvitenskap og teknologi. Som dekan er det mitt ansvar å legge til rette for undervisning av høy kvalitet til beste for studentene og samfunnet.

 

Forskning er én av våre kjerneaktiviteter – dekanen ønsker å legge til rette for et internasjonalt konkurransedyktig forskningsmiljø innen matematikk, naturvitenskap og teknologi.

  

Helse, miljø og sikkerhet for våre ansatte og studenter er et prioritert område for denne fakultetsledelsen.

 

Økonomi: Finansiering, optimal resursutnyttelse og resurstildeling anses som et viktig virkemiddel for å realisere våre strategiske planer.

 

Andre funksjoner:

styremedlem i L.Meltzers Høyskolefond

styremedlem i Nansensenteret

styremedlem i Bjerknessenteret

 

Vitenskapelig artikkel
  • Vis forfatter(e) 2018. Radiation treatment monitoring with DCE-US in CWR22 prostate tumor xenografts. Acta Radiologica. 1-10.
  • Vis forfatter(e) 2015. Radiation treatment monitoring using multimodal functional imaging: PET/CT (18F-Fluoromisonidazole & 18F-Fluorocholine) and DCE-US. Journal of Translational Medicine. 10 sider.
  • Vis forfatter(e) 2015. Multimodal approach to assess tumour vasculature and potential treatment effect with DCE-US and DCE-MRI quantification in CWR22 prostate tumour xenografts. Contrast Media & Molecular Imaging. 428-437.
  • Vis forfatter(e) 2014. Associations between tumor vascularization assessed by in vivo DCE-MRI and the presence of disseminated tumor cells in bone marrow in breast cancer patients at the time of diagnosis. Journal of Magnetic Resonance Imaging. 1382-1391.
  • Vis forfatter(e) 2013. The clinical impact of mean vessel size and solidity in breast carcinoma patients. PLOS ONE. 11 sider.
  • Vis forfatter(e) 2013. Routine pelvic MRI using phased-array coil for detection of extraprostatic tumour extension: accuracy and clinical significance. European Radiology. 1158-1166.
  • Vis forfatter(e) 2013. Hypoxic tumor kinase signaling mediated by STAT5A in development of castration-resistant prostate cancer. PLOS ONE. 11 sider.
  • Vis forfatter(e) 2012. Vascular responses to radiotherapy and androgen-deprivation therapy in experimental prostate cancer. Radiation Oncology. 13 sider.
  • Vis forfatter(e) 2012. The updated ESTRO core curricula 2011 for clinicians, medical physicists and RTTs in radiotherapy/radiation oncology. Radiotherapy and Oncology. 103-108.
  • Vis forfatter(e) 2012. Low dose hyper-radiosensitivity is eliminated during exposure to cycling hypoxia but returns after reoxygenation. International Journal of Radiation Biology. 311-319.
  • Vis forfatter(e) 2012. Iterative reconstruction reduces abdominal CT dose. European Journal of Radiology. 1483-1487.
  • Vis forfatter(e) 2012. Assessment of liposome biodistribution by non-invasive optical imaging: a feasibility study in tumour-bearing mice. Journal of Nanoscience and Nanotechnology. 2912-2918.
  • Vis forfatter(e) 2011. Ultrasound enhanced antitumor activity of liposomal doxorubicin in mice. Journal of drug targeting (Print). 701-708.
  • Vis forfatter(e) 2011. Quantification of Angiogenesis in Breast Cancer by Automated Vessel Identification in CD34 Immunohistochemical Sections. Anticancer Research. 4053-4060.
  • Vis forfatter(e) 2011. Predicted Risk of Radiation-Induced Cancers After Involved Field and Involved Node Radiotherapy With or Without Intensity Modulation for Early-Stage Hodgkin Lymphoma in Female Patients. International Journal of Radiation Oncology, Biology, Physics. 490-497.
  • Vis forfatter(e) 2011. Neoadjuvant chemotherapy in breast cancer-response evaluation and prediction of response to treatment using dynamic contrast-enhanced and diffusion-weighted MR imaging. European Radiology. 1188-1199.
  • Vis forfatter(e) 2011. Liposomal doxorubicin improves radiotherapy response in hypoxic prostate cancer xenografts. Radiation Oncology. 10 sider.
  • Vis forfatter(e) 2011. Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical study. Radiation Oncology.
  • Vis forfatter(e) 2011. Dose evaluation and risk estimation for secondary cancer in contralateral breast and a study of correlation between thorax shape and dose to organs at risk following tangentially breast irradiation during deep inspiration breath-hold and free breathing. Acta Oncologica. 563-568.
  • Vis forfatter(e) 2011. Dose distribution in the thyroid gland following radiation therapy of breast cancer-a retrospective study. Radiation Oncology. 7 sider.
  • Vis forfatter(e) 2010. Preclinical dynamic F-18-FDG PET - tumor characterization and radiotherapy response assessment by kinetic compartment analysis. Acta Oncologica. 914-921.
  • Vis forfatter(e) 2010. Longitudinal magnetic resonance imaging-based assessment of vascular changes and radiation response in androgen-sensitive prostate carcinoma xenografts under androgen-exposed and androgen-deprived conditions. Neoplasia. 818-825.
  • Vis forfatter(e) 2010. LATE EFFECTS AFTER RADIOTHERAPY FOR LOCALLY ADVANCED CERVICAL CANCER: COMPARISON OF TWO BRACHYTHERAPY SCHEDULES AND EFFECT OF DOSE DELIVERED WEEKLY. International Journal of Radiation Oncology, Biology, Physics. 713-718.
  • Vis forfatter(e) 2010. Improved image quality of low-dose thoracic CT examinations with a new postprocessing software. Journal of Applied Clinical Medical Physics. 250-258.
  • Vis forfatter(e) 2010. Diffusion-weighted magnetic resonance imaging for pretreatment prediction and monitoring of treatment response of patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy. Acta Oncologica. 354-360.
  • Vis forfatter(e) 2010. CT Density in Lung Cancer Patients After Radiotherapy Sensitized by Metoclopramide A Subgroup Analysis of a Randomized Trial. Strahlentherapie und Onkologie (Print). 163-168.
  • Vis forfatter(e) 2010. Adapting Biological Feedback in Radiotherapy. Seminars in Radiation Oncology. 138-146.
  • Vis forfatter(e) 2009. The elimination of low dose hyper-radiosensitivity by transfer of irradiated-cell conditioned medium depends on dose rate. Radiation Research. 22-32.
  • Vis forfatter(e) 2009. Pediatric digital chest radiography, comparison of grid vs. non-grid techniques. European Journal of Radiography. 201-206.
  • Vis forfatter(e) 2009. Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming. International Journal of Radiation Biology. 1157-1165.
  • Vis forfatter(e) 2009. Late regional density changes of the lung after radiotherapy for breast cancer. Radiotherapy and Oncology. 148-152.
  • Vis forfatter(e) 2009. Hybrid intelligent modeling and prediction of texture segmented lesion from 4DCT scans of thorax. 2009. IEEE International Fuzzy Systems conference proceedings. 1801-1805.
  • Vis forfatter(e) 2009. DCEMRI of spontaneous canine tumors during fractionated radiotherapy: A pharmacokinetic analysis. Radiotherapy and Oncology. 618-624.
  • Vis forfatter(e) 2009. DCEMRI of spontaneous canine tumors during fractionated radiotherapy: A pharmacokinetic analysis. Radiotherapy and Oncology. 618-624.
  • Vis forfatter(e) 2009. Cancer treatment by radiotherapy in Western Nepal: a hospital-based study. Asian Pacific Journal of Cancer Prevention.
  • Vis forfatter(e) 2009. Cancer Treatment by Radiotherapy in Western Nepal: A Hospital-based Retrospective study. Asian Pacific Journal of Cancer Prevention. 205-208.
  • Vis forfatter(e) 2009. Automatic segmentation and recognition of lungs and lesion from CT scans of thorax. Computerized Medical Imaging and Graphics. 72-82.
  • Vis forfatter(e) 2009. Artificial neural networks for prediction of response to chemoradiation in ht29 xenografts. International Journal of Radiation Oncology, Biology, Physics. 506-511.
  • Vis forfatter(e) 2009. Artificial neural networks for prediction of response to chemoradiation in HT29 xenografts. International Journal of Radiation Oncology, Biology, Physics. 506-511.
  • Vis forfatter(e) 2009. A planning comparison of dose patterns in organs at risk and predicted risk for radiation induced malignancy in the contralateral breast following radiation therapy of primary breast using conventional, IMRT and volumetric modulated arc treatment techniques. Acta Oncologica.
  • Vis forfatter(e) 2009. A planning comparison of dose patterns in organs at risk and predicted risk for radiation induced malignancy in the contralateral breast following radiation therapy of primary breast using conventional, IMRT and Volumetric modulated arc treatment techniques. Acta Oncologica. 495-503.
  • Vis forfatter(e) 2008. Teleradiology with satellite units - six years experience at the norwegian radium hospital. Studies in Health Technology and Informatics. 209-216.
  • Vis forfatter(e) 2008. Reduction in dose from CT examinations of liver lesions with a new postprocessing filter: A ROC phantom study. Acta Radiologica.
  • Vis forfatter(e) 2008. Radiological and functional assessment of radiation-induced pulmonary damage following breast irradiation. Acta Oncologica. 248-254.
  • Vis forfatter(e) 2008. Quality assurance of dosimetry and the impact on sample size in randomized clinical trials. Radiotherapy and Oncology.
  • Vis forfatter(e) 2008. Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high–resolution magic angle spinning 1H magnetic resonance spectroscopy. Molecular Cancer. 33.
  • Vis forfatter(e) 2008. Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high-resolution magic angle spinning 1H magnetic resonance spectroscopy. Molecular Cancer. 33.
  • Vis forfatter(e) 2008. Kreftterapi med lette ioner. HMT - Helsetjenesten Medisinsk Teknikk : helse, medisin, teknikk. 7-8.
  • Vis forfatter(e) 2008. Inclusion of Biological Information in Treatment Plan Optimization. Medical Physics (Lancaster). 2873-2874.
  • Vis forfatter(e) 2008. Estimated risk for secondary cancer in the contra-lateral breast following radiation therapy of breast cancer. Acta Oncologica.
  • Vis forfatter(e) 2008. Estimated risk for secondary cancer in the contra-lateral breast following radiation therapy of breast cancer. Acta Oncologica.
  • Vis forfatter(e) 2008. Dynamic contrast enhanced magnetic resonance imaging of bladder cancer and implications for biological image-adapted radiotherapy. Acta Oncologica. 1257-1264.
  • Vis forfatter(e) 2008. Dynamic contrast enhanced magnetic resonance imaging of bladder cancer and implications for biological image-adapted radiotherapy. Acta Oncologica. 1257-1264.
  • Vis forfatter(e) 2008. DCEMRI monitoring of canine tumors during fractionated radiotherapy. Acta Oncologica. 1249-1256.
  • Vis forfatter(e) 2008. DCEMRI monitoring of canine tumors during fractionated radiotherapy. Acta Oncologica. 1249-1256.
  • Vis forfatter(e) 2008. DCEMRI monitoring of canine tumors during fractionated radiotherapy. Acta Oncologica. 1249-1256.
  • Vis forfatter(e) 2007. Recovery of low-dose hyper-radiosensitivity following a small priming dose depends on priming dose-rate. International Journal of Low Radiation. 69-86.
  • Vis forfatter(e) 2007. Reconstruction of a ring applicator using CT imaging: impact of the reconstruction method and applicator orientation. Physics in Medicine and Biology. 4893-4904.
  • Vis forfatter(e) 2007. Radiotherapy adapted to spatial and temporal variability in tumor hypoxia. International Journal of Radiation Oncology, Biology, Physics. 1496-1504.
  • Vis forfatter(e) 2007. Radiotherapy Adapted to Spatial and Temporal Variability in Tumor Hypoxia. International Journal of Radiation Oncology, Biology, Physics. 1496-1504.
  • Vis forfatter(e) 2007. Radiobiological responses for two cell lines following continuous low dose-rate (CLDR) and pulsed dose rate (PDR) brachytherapy. Acta Oncologica. 602-611.
  • Vis forfatter(e) 2007. Optimization of tumour control probability in hypoxic tumours by radiation dose redistribution: a modelling study. Physics in Medicine and Biology. 499-513.
  • Vis forfatter(e) 2007. On the parameter describing the generalised equivalent uniform dose (gEUD) for tumours. Physica Medica. 100-106.
  • Vis forfatter(e) 2007. Noninvasive monitoring of radiation-induced treatment respons using proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging in a colorectal tumor model. Radiotherapy and Oncology. 187-194.
  • Vis forfatter(e) 2007. Early changes in apparent diffusion coefficient predict the quantitative antitumoral activity of capecitabine, oxaliplatin, and irradiation in HT29 xenografts in athymic nude mice. Neoplasia. 392-400.
  • Vis forfatter(e) 2007. Early changes in apparent diffusion coefficient predict the quantitative antitumoral activity of capecitabene, oxaliplatin, and irradiation in HT29 xenografts in athymic nude mice. Neoplasia. 392-400.
  • Vis forfatter(e) 2007. Contralateral breast doses following radiotherapy of the breast and regional lymph nodes: Measurements and treatment planning calculations. Radiotherapy and Oncology.
  • Vis forfatter(e) 2007. Consequences of leaf calibration errors on IMRT delivery. Physics in Medicine and Biology. 1147-1156.
  • Vis forfatter(e) 2006. EPR dosimetry of radiotherapy photon beams in inhomogeneous media using alanine films. Physics in Medicine and Biology. 6315-6328.
  • Vis forfatter(e) 2006. Dose optimisation in single plane interstitial brachytherapy. Radiotherapy and Oncology. 105-111.
  • Vis forfatter(e) 2006. Analysis of normal tissue complication probability of the lung using a reliability model. Acta Oncologica. 610-617.
  • Vis forfatter(e) 2006. Adapting radiotherapy to hypoxic tumours. Physics in Medicine and Biology. 4903-4921.
  • Vis forfatter(e) 2005. Telemedicine in radiotherapy: A study exploring remote treatment planning, supervision and economics. Journal of Telemedicine and Telecare. 245-250.
  • Vis forfatter(e) 2005. Respiratory motion prediction by using the adaptive neuro fuzzy inference system (ANFIS). Physics in Medicine and Biology. 4721-4278.
  • Vis forfatter(e) 2005. Image quality preferences among radiographers and radiologists. A conjoint analysis. Radiography. 191-197.
  • Vis forfatter(e) 2005. Comparative analyses of the dynamic properties of the bladder wall studied by repetitive pelvic CT scans of patients and cryo-sections of cadavers. British Journal of Radiology (BJR). 528-532.
  • Vis forfatter(e) 2004. Electron paramagnetic resonance (EPR) dosimetry using lithium formate in radiotherapy: comparison with thermoluminescence (TL) dosimetry using lithium fluoride rods. Physics in Medicine and Biology. 4701-4715.
  • Vis forfatter(e) 2003. Definitive radiotherapy of prostate cancer: the possible role of staging lymphdenectomy. International Journal of Radiation Oncology, Biology, Physics. 33-41.
  • Vis forfatter(e) 2003. Changes in treatment volume of hormonally treated and untreated cancerous prostate and its impact on rectal dose. Acta Oncologica. 10-14.
  • Vis forfatter(e) 2003. Brachytherapy for prostate cancer: A systematic review of clinical and cost effectiveness. European Urology. 40-46.
  • Vis forfatter(e) 2002. Side effects and quality of life after inadvertent radiation overdosage in brachytherapy of head-and-neck cancer. International Journal of Radiation Oncology, Biology, Physics. 944-952.
  • Vis forfatter(e) 2002. Relationship between normal tissue complication probabilities and lung function in patients with lung cancer receiving radiotherapy. International Journal of Cancer. 457-457.
  • Vis forfatter(e) 2002. Preoperative irradiation and surgery for recurrent rectal cancer. Will intraoperative radiotherapy (IORT)be of additional benefit? A prospective study. Radiotherapy and Oncology. 207-213.
  • Vis forfatter(e) 2002. Preoperative irradiation and surgery for recurrent rectal cancer. Will intraoperative radiotherapy (IORT) be of additional benefit? A prospective study. Radiotherapy and Oncology. 207-213.
  • Vis forfatter(e) 2002. Modelling volume effects of experimental brachytherapy in the rat rectum: uncovering the limitations of a radiologic concept. International Journal of Radiation Oncology, Biology, Physics. 1014-1022.
  • Vis forfatter(e) 2002. Modelling volume effects of experimental brachytherapy in the rat rectum: uncovering the limitations of a radiobiological concept. International Journal of Radiation Oncology, Biology, Physics. 1014-1022.
  • Vis forfatter(e) 2002. Long-term renal function after treatment for malignant germ-cell tumours. Annals of Oncology. 222-228.
  • Vis forfatter(e) 2002. Imaging for radiotherapy treatment planning. Radiotherapy and Oncology. 03-13.
  • Vis forfatter(e) 2002. Dynamic properties of the rectum wall with implications for radiotherapy planning. Comparative studies using cryosections of human cadavers and pelvic CT-scans of patients. British Journal of Radiology (BJR).
  • Vis forfatter(e) 2002. Cell Cycle Inhibitors and Outcome after Radiotherapy in Bladder Cancer Patients. Acta Oncologica. 463-470.
  • Vis forfatter(e) 2002. Brakyterapi ved prostatakreft. Tidsskrift for Den norske legeforening. 2795-2798.
  • Vis forfatter(e) 2002. Brachytherapy for prostate cancer - a systematic review of the evidence. International Journal of Cancer. 124.
  • Vis forfatter(e) 2001. Stråleterapisatellittenheten i Kristiansand ¿ en modell for norske regionsykehus. Tidsskrift for Den norske legeforening. 2179-2182.
  • Vis forfatter(e) 2001. Inter-fraction variations in rectum and bladder volumes and dose distribution during HDR brachytherapy treatment of the uterine cervix investigated by repetitive CT-examinations. Radiotherapy and Oncology. 273-280.
  • Vis forfatter(e) 1999. Normal tissue complication probabilities correlated with late effects in the rectum after prostate conformal radiotherapy. International Journal of Radiation Oncology, Biology, Physics. 385-391.
  • Vis forfatter(e) 1999. Measurement of dose rate at the interfase of cell culture medium and glass dishes by means of ESR dosimetry using thin films of alanine. Radiation Research. 76-82.
  • Vis forfatter(e) 1999. Long-term morbidity and Quality of Life in patients with localised prostate cancer undergoing definitive radiotherapy or radical prostatectomy. International Journal of Radiation Oncology, Biology, Physics. 735-743.
  • Vis forfatter(e) 1999. Inverse dose-rate effect due to pre-mitotic accumulation during continuous low dose rate irradiation of cervix carcinoma cells. International Journal of Radiation Biology. 699-707.
  • Vis forfatter(e) 1999. Comparison of radiation side-effects in prostate cancer. The Lancet.
  • Vis forfatter(e) 1997. Strålebiologisk forskning vil gi framskritt for strålebehandlingen. Kreftnytt. 9-12.
  • Vis forfatter(e) 1997. Strålebehandling mot år 2000. Langs nye veier, eller "paa gjengrodde stier". Kreftnytt. 4-8.
  • Vis forfatter(e) 1997. Radiotherapy in the Management of Bladder Cancer. European urology update series. 80-85.
  • Vis forfatter(e) 1997. External beam abdominal radiotherapy in patients with seminoma stage I: Field type, testicular dose and spermatogenesis. International Journal of Radiation Oncology, Biology, Physics. 95-102.
  • Vis forfatter(e) 1997. Combined modality treatment including intraoperative radiotherapy in locally advanced and recurrent rectal cancer. Radiotherapy and Oncology. 277-282.
Rapport
  • Vis forfatter(e) 2006. Protonterapi. 11. 11. .
  • Vis forfatter(e) 2002. Brachyterapy ved prostatakreft. Medisinsk metodevurdering basert på egen litteraturgjennomgang. 2. 2. .
Populærvitenskapelig foredrag
  • Vis forfatter(e) 2014. Innlegg og debatt om Universitetet før, nå og i fremtiden. Debattleder: Per Buvik.
  • Vis forfatter(e) 2001. Planlagt opplegg for utdanning av medisinske fysikere ved Fysisk Institutt, Universietet i Oslo.
Vitenskapelig foredrag
  • Vis forfatter(e) 2012. Particle therapy – leveraging clinical performance?
  • Vis forfatter(e) 2009. Diffusion-weighted MRI for pretreatment prediction and monitoring of treatment response for patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy.
  • Vis forfatter(e) 2009. Chest image interpretation: Quality improvement.
  • Vis forfatter(e) 2008. Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming.
  • Vis forfatter(e) 2008. Klaas Breur Lecture 2008:ADAPTIVE RADIATION ONCOLOGY BASED ON MOLECULAR AND FUNCTIONAL IMAGING.
  • Vis forfatter(e) 2008. Inclusion of Biological Information in Treatment Plan Optimization.
  • Vis forfatter(e) 2007. LOW DOSE HYPER-RADIOSENSITIVITY IN T-47D CELLS.
  • Vis forfatter(e) 2006. Lav-dosis hypersensitivitet hos T-47D brystkræftceller.
  • Vis forfatter(e) 2006. Intracellular signalling through medium transfer and low dose hyper-radiosensitivity.
  • Vis forfatter(e) 2005. When is grid technique required in paediatric chest radiography?
  • Vis forfatter(e) 2005. Recovery of low-dose HRS following a small priming dose depends on priming dose rate.
  • Vis forfatter(e) 2005. Radiation-induced late effects after breast cancer treatment.
  • Vis forfatter(e) 2005. Proton therapy: current evidence challenge evidence based for implementation of new methods and strengthens the importance of integrating ethical and juridical considerations into the HTA process.
  • Vis forfatter(e) 2005. Predicting treatment outcome of biologically optimized IMRT for hypoxic tumors.
  • Vis forfatter(e) 2005. Modellering av behandlingsutfall ved biologisk optimalisert IMRT av hypoksiske tumorer.
  • Vis forfatter(e) 2004. Optimization of TCP in hypoxic tumors by dose redistribution.
  • Vis forfatter(e) 2004. Analysis of NTCP of the lung using a reliability model.
  • Vis forfatter(e) 2002. The role of modern radiobiology in optimized radiation therapy.
  • Vis forfatter(e) 2002. Non-uniform tumour dose based on tumour-physiological imaging - a novel strategy for improved tumour control.
  • Vis forfatter(e) 2001. The benefit of NTCP modelling in predicting rectal complications.
  • Vis forfatter(e) 2001. Telemedicine in oncology.
  • Vis forfatter(e) 2001. Non-invasive monitoring of tumor reoxygenation following irradiation by 31P MR spectroscopy.
  • Vis forfatter(e) 2001. Intensitetsmodulert stråleterapi (IMRT) - "Keiserens nye klær" eller stråleterapi langs nye veier ? - en strålebiologisk vurdering.
  • Vis forfatter(e) 2001. Ein Strahlentherapiesatellit fur ein dezentralisiertes/zentralisiertes telemedizinisches Diagnose- und Therapieangebot.
Leder
  • Vis forfatter(e) 2010. Leveraging clinical performance by technological excellence - The case of particle therapy. Radiotherapy and Oncology. 1-2.
  • Vis forfatter(e) 2010. Biology-guided adaptive radiation therapy - presence or future? Acta Oncologica. 884-887.
Leserinnlegg
  • Vis forfatter(e) 2020. Ingen forskning, ingen omstilling. Dagens næringsliv.
  • Vis forfatter(e) 2015. Samarbeid om fremragende og innovativ forskning. Forskningspolitikk. 4-5.
  • Vis forfatter(e) 2013. Akademia og næringsliv i skjønn forening. Morgenbladet. 19-19.
  • Vis forfatter(e) 2011. Styrk finansieringen! Aftenposten (morgenutg. : trykt utg.).
Fagbok
  • Vis forfatter(e) 2008. Targeted high-LET therapy of bone metastases. Springer Science+Business Media B.V..
Hovedfagsoppgave
  • Vis forfatter(e) 1998. Matematiske modellering av seneffekter ved strålebehandling.
Kronikk
  • Vis forfatter(e) 2011. Kunnskap-nøkkelen til fremtidens verdiskapning. Bergens Tidende.
  • Vis forfatter(e) 2008. Protonterapi – men hva så? Dagsavisen.
Doktorgradsavhandling
  • Vis forfatter(e) 2012. Treatment response evaluation in experimental prostate cancer by functional magnetic resonance imaging and molecular profiling.
  • Vis forfatter(e) 2010. Late side effects and modern radiotherapy techniques in the tratment of breast cancer.
  • Vis forfatter(e) 2008. Pulmonary changes following thoracic irradiation. 695.
  • Vis forfatter(e) 2008. Magnetic resoncance spectroscopy and diffusion for prediction and monitoring of treatment response in rectal cancer. 711.
  • Vis forfatter(e) 2007. Biologically adapted radiotherapy and evaluation of non-uniform dose distributions. 625.
  • Vis forfatter(e) 1999. 31P NMR Sepctroscopy in measurements of physiological parameters and response to therapy of human melanoma xenografts.
Intervju
  • Vis forfatter(e) 2020. No får dei første 16.000 studentane kome tilbake.
  • Vis forfatter(e) 2020. Fortsatt høy beredskap og kriseledelse flere steder.
  • Vis forfatter(e) 2019. Rektorer på Vestlandet tenker høyt om en strukturprosess 2.0.
  • Vis forfatter(e) 2013. Venstres miljøpris til Bjerknessenteret og CICERO.
  • Vis forfatter(e) 2013. Klimaforskinga og tusenkroners-spørsmålet / Klimaforskinga og tusenkronersspørsmålet.
  • Vis forfatter(e) 2012. Roper på næringslivet.
  • Vis forfatter(e) 2010. Startskot for klimasenter.
  • Vis forfatter(e) 2010. Kreftbehandling og protonterapi.
  • Vis forfatter(e) 2009. Kvantemedisin - Mirakelmaskin eller bedrageri?
  • Vis forfatter(e) 2009. Dag Rune Olsen, stråleekspert om ny lungekreftbehandling.
  • Vis forfatter(e) 2008. Protonterapi ved kreft - ikke et tilbud i Norge ?
Dokumentar
  • Vis forfatter(e) 2016. En banebrytende sosialantropolog ved veis ende. Professor Fredrik Barth som døde 24. januar i år, har hatt en internasjonal posisjon som svært få andre norske samfunnsforskere.
Programdeltagelse
  • Vis forfatter(e) 2009. Debatt om 'kvantemedisin' i Kveldsåpent, NRK P1.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
  • Vis forfatter(e) 2009. Radiation therapy- ionizing radiation in the treatment of cancer. 8 sider.
  • Vis forfatter(e) 2005. Fysikk og medisin. 15 sider.
Sammendrag/abstract
  • Vis forfatter(e) 2014. DCE-MRI and DCE-US quantification in CWR22 prostate tumour xenografts. Radiotherapy and Oncology. S4.
  • Vis forfatter(e) 2012. DCEMRI IN ASSESSMENT OF TUMOR NEOVASCULARIZATION AFTER ANDROGEN-DEPRIVATION IN EXPERIMENTAL PROSTATE CANCER: CORRELATION TO QUANTITATIVE IMMUNOHISTOCHEMISTRY. Radiotherapy and Oncology. S68.
  • Vis forfatter(e) 2010. Prediction of response to cancer therapy from functional magnetic resonance image parameters - an artificial neural network approach. European Journal of Cancer. 39-40.
  • Vis forfatter(e) 2010. Predicted Risk of Radiation-Induced Cancers after Involved Field- and Involved-Node Radiotherapy with or without Intensity Modulation for Early Stage Hodgkin Lymphoma in Female Patients. International Journal of Radiation Oncology, Biology, Physics. S546-S546.
  • Vis forfatter(e) 2009. Chest image interpretation: Quality improvement. European Radiology.
  • Vis forfatter(e) 2008. Klaas Breur Lecture 2008:ADAPTIVE RADIATION ONCOLOGY BASED ON MOLECULAR AND FUNCTIONAL IMAGING. Radiotherapy and Oncology. S120-S120.
  • Vis forfatter(e) 2007. Treatment response following combined capecitabine, oxaliplatin and radiation therapy monitored by diffusion weighted magnetic resonance imaging (DW-MRI) in a xenograft model. European Journal of Cancer Supplements. 62-62.
  • Vis forfatter(e) 2007. The influence of rectal movement on dose during fractionated radiotherapy. Radiotherapy and Oncology.
  • Vis forfatter(e) 2006. Automated texture based CT segmentation by Gabor filtering and fuzzy clustering. Medical Physics (Lancaster). 2170-2170.
  • Vis forfatter(e) 2006. Automated texture based CT segmentation by Gabor filtering and Fuzzy clustering. AAPM 48th Annual meeting , Florida.
  • Vis forfatter(e) 2005. Dose measurements in heterogeneous media using alanine film dosimetry. Radiotherapy and Oncology. s205-s206.
Poster
  • Vis forfatter(e) 2010. Quantitative in vivo DCE MRI of prostate cancer xenografts: assessment of ADT and RT efficacy.
  • Vis forfatter(e) 2010. Early prediction of treatment response in xenografts using quantitative diffusion weighted MRI.
  • Vis forfatter(e) 2007. Treatment response following combined capecitabine, oxaliplatin and radiation therapy monitored by diffusion weighted magnetic resonance imaging (DW-MRI) in a xenograft model.
  • Vis forfatter(e) 2006. ESR-dosimetri med alaninfilm i heterogene medier.
  • Vis forfatter(e) 2005. Dose measurements in heterogeneous media using alanine film dosimetry.
  • Vis forfatter(e) 2000. Inter-fraction variations of doses to organs at risk and NTCP-calculations for patients treated with gynaecological HDR brachytherapy-.
Errata
  • Vis forfatter(e) 2016. Erratum to: Radiation treatment monitoring using multimodal functional imaging: PET/CT (18F-Fluoromisonidazole F-Fluorocholine) and DCE-US. Journal of Translational Medicine.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) 2010. Optimal Use of Automatic Exposure Control in CT: a Literature Review. Radiologic Technology. 309-317.
  • Vis forfatter(e) 2009. STRATEGIES FOR BIOLOGIC IMAGE-GUIDED DOSE ESCALATION: A REVIEW. International Journal of Radiation Oncology, Biology, Physics. 650-658.
  • Vis forfatter(e) 2007. Proton therapy - A systematic review of clinical effectiveness. Radiotherapy and Oncology. 123-132.
Intervju tidsskrift
  • Vis forfatter(e) 2010. Jukset på etikkeksamen. Bergens Tidende.

Se fullstendig oversikt over publikasjoner i CRIStin.

Artikler i internationale 'peer-review' tidsskrift 2005-dd

2012:

Kathrine Røe, Lars TG Mikalsen, Albert J van der Kogel, Johan Bussink, Heidi Lyng, Anne H Ree, Laure Marignol and Dag R Olsen. (2012) Vascularresponses to radiotherapy and androgendeprivation therapy in experimental prostate cancer.  Radiation Oncology 2012, 7:75 

Eriksen JG, Beavis AW, Coffey MA, Leer JW, Magrini SM, Benstead K, Boelling T, Hjälm-Eriksson M, Kantor G, Maciejewski B, Mezeckis M, Oliveira A, Thirion P, Vitek P, Olsen DR, Eudaldo T, Enghardt W, François P, Garibaldi C, Heijmen B, Josipovic M, Major T, Nikoletopoulos S, Rijnders A, Waligorski M, Wasilewska-Radwanska M, Mullaney L, Boejen A, Vaandering A, Vandevelde G, Verfaillie C, Pötter R. (2012) The updated ESTRO core curricula2011 for clinicians, medical physicists and RTTs in radiotherapy/radiation oncology. Radiother Oncol. 103(1):103-8

Edin NJ, Olsen DR, Sandvik JA, Malinen E, Pettersen EO. (2011) Low dose
hyper-radiosensitivity is eliminated during exposure to cycling hypoxia but
returns after reoxygenation. Int J Radiat Biol.  88(4):311-9.

2011:

Mikalsen LT, Dhakal HP, Bruland OS, Nesland JM, Olsen DR. (2011 Quantification of angiogenesis in breast cancer by automated vessel identification in CD34 immunohistochemical sections. Anticancer Res. 31(12):4053-60.

Hagtvet E, Roe K, Olsen DR. (2011) Liposomal doxorubicin improves radiotherapy response in hypoxic prostate cancer xenografts. Radiat Oncol. 6(1):135.

Johansen S, Reinertsen K, Knutstad K, Olsen D, Fossa S. (2011) Dose distribution in the thyroid gland following radiation therapy of breast cancer-a retrospective study. Radiat Oncol. 6:68.

Roe K, Kakar M, Seierstad T, Ree AH, Olsen DR. (2011) Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical study. Radiation Oncology  6:65.

Martinsen AC, Sæther HK, Hol PK, Olsen DR, Skaane  (2011). Iterative reconstruction reduces abdominal CT dose. Eur J Radiol. [Epub ahead of print]

Hagtvet E, Evjen TJ, Olsen DR, Fossheim SL, Nilssen EA (2011). Ultrasound enhanced antitumor activity of liposomal doxorubicin in mice. J Drug Target. 19(8):701-8 

Johansen S, Vikström J, Hjelstuen MH, Mjaaland I, Dybvik KI, Olsen DR (2011). Dose evaluation and risk estimation for secondary cancer in contralateral breast and a study of correlation between thorax shape and dose to organs at risk following tangentially breast irradiation during deep inspiration breath-hold and free breathing. Acta Oncol. 50(4):563-8.

Fangberget A, Nilsen LB, Hole KH, Holmen MM, Engebraaten O, Naume B, Smith HJ, Olsen DR, Seierstad T (2011). Neoadjuvant chemotherapy in breast cancer-response evaluation and prediction of response to treatment using dynamic contrast-enhanced and diffusion weighted MR imaging. Eur Radiol. 21(6):1188-99.

 

Weber DC, Johanson S, Peguret N, Cozzi L, Olsen DR (2011). Predicted Risk of Radiation-Induced Cancers after Involved Field and Involved Node Radiotherapy with or without Intensity Modulation for Early-Stage Hodgkin Lymphoma in Female Patients.  Int J Radiat Oncol Biol Phys. 81(2):490-7

2010:

Røe K, Seierstad T, Kristian A, Mikalsen LTG, Mælamdsmo GM, van der Kogel AJ, Ree AH, Olsen DR (2010). Longitudinal MRI-based assessment of vascular changes and radiation response in androgen-sensitive prostate carcinoma xenografts under androgen-exposed and androgen-deprived conditions. Neoplasia 12(10):818-25.

Røe K, Aleksandersen TB, Kristian A, Nilsen LB, Seierstad T, Qu H, Ree AH,
Olsen DR, Malinen E. (2010) Preclinical dynamic (18)F-FDG PET - tumor characterization and radiotherapy response assessment by kinetic compartment analysis. Acta Oncol. 49(7):914-21.

Grau C, Olsen DR, Overgaard J, Høyer M, Lindegaard JC, Muren LP (2010).
Biology-guided adaptive radiation therapy - presence or future? Acta Oncol. 49(7):884-7.

Martinsen AC, Saether HK, Olsen DR, Wolff PA, Skaane P. Improved image quality of low-dose thoracic CT examinations with a new postprocessing software. J Appl Clin Med Phys. 2010 May 25;11(3):3242.

Nilsen L, Fangberget A, Geier O, Olsen DR and Seierstad T. Diffusion-weighted magnetic resonance imaging for pretreatment prediction and monitoring of treatment response of patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy. Acta Oncol. (2010) Apr;49(3):354-60.

Gudjónsdóttir J, Ween B, Olsen DR (2010). Optimal use of AEC in CT: a literature review. Radiol Technol. 81(4):309-17.

Søvik A, Malinen E, Olsen DR (2010). Adapting biological feedback in radiotherapy. Semin Radiat Oncol. 20(2):138-46.

Olsen DR, Overgaard J (2010). Leveraging clinical performance by technological excellence - The case of particle therapy. Radiother Oncol. 95(1):1-2. (editorial)

Dale,E, Harsaker,V, Kristoffersen,DT, Bruland,O, and Olsen,DR (2010). CT Density in Lung Cancer Patients After Radiotherapy Sensitized by Metoclopramide A Subgroup Analysis of a Randomized Trial. Strahlentherapie und Onkologie 186(3):163-168.

Hellebust,TP, Kristensen,GB, and Olsen,DR (2010). Late Effects After Radiotherapy for Locally Advanced Cervical Cancer: Comparison of Two Brachytherapy Schedules and Effect of Dose Delivered Weekly. International Journal of Radiation Oncology Biology Physics 76(3):713-718.

2009:

Edin,NJ, Olsen,DR, Stokke,T, Sandvik,JA, Ebbesen,P, and Pettersen,EO (2009). Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming. International Journal of Radiation Biology 85(12):1157-1165.

Sovik,A, Skogmo,HK, Andersen,EKF, Bruland,OS, Olsen,DR, and Malinen,E (2009). DCEMRI of spontaneous canine tumors during fractionated radiotherapy: A pharmacokinetic analysis. Radiotherapy and Oncology 93(3):618-624.

Kakar,M, Seierstad,T, Roe,K, and Olsen,DR (2009). Artificial Neural Networks for Prediction of Response to Chemoradiation in Ht29 Xenografts. International Journal of Radiation Oncology Biology Physics 75(2):506-511.

Johansen,S, Cozzi,L, and Olsen,DR (2009). A planning comparison of dose patterns in organs at risk and predicted risk for radiation induced malignancy in the contralateral breast following radiation therapy of primary breast using conventional, IMRT and Volumetric modulated arc treatment techniques. Acta Oncologica 48(4):495-503.

Sovik,A, Malinen,E, and Olsen,DR (2009). Strategies for Biologic Image-Guided Dose Escalation: A Review. International Journal of Radiation Oncology Biology Physics 73(3):650-658.

Vagane,R, Danielsen,T, Fossa,SD, Lokkevik,E, and Olsen,DR (2009). Late regional density changes of the lung after radiotherapy for breast cancer. Radiotherapy and Oncology 90(1):148-152.

Kakar,M and Olsen,DR (2009). Automatic segmentation and recognition of lungs and lesion from CT scans of thorax. Computerized Medical Imaging and Graphics 33(1):72-82.

Edin,NJ, Sandvik,JA, Olsen,DR, and Pettersen,EO (2009). The Elimination of Low-Dose Hyper-radiosensitivity by Transfer of Irradiated-Cell Conditioned Medium Depends on Dose Rate. Radiation Research 171(1):22-32.

2008:

Sovik,A, Skogmo,HK, Bruland,OS, Olsen,DR, and Malinen,E (2008). DCEMRI monitoring of canine tumors during fractionated radiotherapy. Acta Oncologica 47(7):1249-1256.

Roe,K, Muren,LP, Rorvik,J, Olsen,DR, Dahl,O, Bakke,A et al. (2008). Dynamic contrast enhanced magnetic resonance imaging of bladder cancer and implications for biological image-adapted radiotherapy. Acta Oncologica 47(7):1257-1264.

Seierstad,T, Roe,K, Sitter,B, Halgunset,J, Flatmark,K, Ree,AH et al. (2008). Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high-resolution magic angle spinning H-1 magnetic resonance spectroscopy. Molecular Cancer 7.

Martinsen,ACT, Saether,HK, Olsen,DR, Skaane,P, and Olerud,HM (2008). Reduction in dose from CT examinations of liver lesions with a new postprocessing filter: A ROC phantom study. Acta Radiologica 49(3):303-309.

Vagane,R, Bruland,OS, Fossa,SD, and Olsen,DR (2008). Radiological and functional assessment of radiation-induced pulmonary damage following breast irradiation. Acta Oncologica 47(2):248-254.

Johansen,S, Danielsen,T, and Olsen,DR (2008). Estimated risk for secondary cancer in the contra-lateral breast following radiation therapy of breast cancer. Acta Oncologica 47(3):391-396.

Pettersen,MN, Aird,E, and Olsen,DR (2008). Quality assurance of dosimetry and the impact on sample size in randomized clinical trials. Radiotherapy and Oncology 86(2):195-199.

2007:

Sovik,A, Ovrum,J, Olsen,DR, and Malinen,E (2007). On the parameter describing the generalised equivalent uniform dose (gEUD) for tumours. Physica Medica 23(3-4):100-106. 

Olsen,DR and Thwaites,DI (2007). Now you see it... Imaging in radiotherapy treatment planning and delivery. Radiotherapy and Oncology 85(2):173-175.

Seierstad,T, Roe,K, and Olsen,DR (2007). Noninvasive monitoring of radiation-induced treatment response using proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging in a colorectal tumor model. Radiotherapy and Oncology 85(2):187-194.

Sovik,A, Malinen,E, Skogmo,HK, Bentzen,SM, Bruland,OS, and Olsen,DR (2007). Radiotherapy adapted to spatial and temporal variability in tumor hypoxia. International Journal of Radiation Oncology Biology Physics 68(5):1496-1504.

Hellebust,TP, Tanderup,K, Bergstrand,ES, Knutsen,BH, Roislien,J, and Olsen,DR (2007). Reconstruction of a ring applicator using CT imaging: impact of the reconstruction method and applicator orientation. Physics in Medicine and Biology 52(16):4893-4904.

Hanisch,PH, Furre,T, Olsen,DR, and Pettersen,EO (2007). Radiobiological responses for two cell lines following continuous low dose-rate (CLDR) and pulsed dose rate (PDR) brachytherapy. Acta Oncologica 46(5):602-611.

Olsen,DR, Bruland,OS, Frykholm,G, and Norderhaug,IN (2007). Proton therapy - A systematic review of clinical effectiveness. Radiotherapy and Oncology 83(2):123-132.

Seierstad,T, Folkvord,S, Roe,K, Flatmark,K, Skretting,A, and Olsen,DR (2007). Early changes in apparent diffusion coefficient predict the quantitative antitumoral activity of capecitabine, oxaliplatin, and irradiation in HT29 xenografts in athymic nude mice. Neoplasia 9(5):392-400.

Johansen,S, Olsen,DR, Danielsen,T, and Malinen,E (2007). Contralateral breast doses following radiotherapy of the breast and regional lymph nodes: Measurements and treatment planning calculations. Radiotherapy and Oncology 82(3):332-336.

Sastre-Padro,M, Welleweerd,J, Malinen,E, Eilertsen,K, Olsen,DR, and van der Heide,UA (2007). Consequences of leaf calibration errors on IMRT delivery. Physics in Medicine and Biology 52(4):1147-1156.

2006:

Sovik,A, Malinen,E, Bruland,OS, Bentzen,SM, and Olsen,DR (2007). Optimization of tumour control probability in hypoxic tumours by radiation dose redistribution: a modelling study. Physics in Medicine and Biology 52(2):499-513.

Osteras,BH, Hole,EO, Olsen,DR, and Malinen,E (2006). EPR dosimetry of radiotherapy photon beams in inhomogeneous media using alanine films. Physics in Medicine and Biology 51(24):6315-6328.

Tanderup,K, Hellebust,TP, Honore,HB, Nielsen,SK, Olsen,DR, Grau,C et al. (2006). Dose optimisation in single plane interstitial brachytherapy. Radiotherapy and Oncology 81(1):105-111.

Malinen,E, Sovik,A, Hristov,D, Bruland,OS, and Olsen,DR (2006). Adapting radiotherapy to hypoxic tumours. Physics in Medicine and Biology 51(19):4903-4921.

Tanderup,K, Olsen,DR, and Grau,C (2006). Dose painting: Art or science? Radiotherapy and Oncology 79(3):245-248.

Vagane,R and Olsen,DR (2006). Analysis of normal tissue complication probability of the lung using a reliability model. Acta Oncologica 45(5):610-617.

Dahle,J, Borrebaek,J, Melhus,KB, Bruland,OS, Salberg,G, Olsen,DR et al. (2006). Initial evaluation of Th-227-p-benzyl-DOTA-rituximab for low-dose rate alpha-particle radioimmunotherapy. Nuclear Medicine and Biology 33(2):271-279.

2005:

Brurberg,KG, Skogmo,HK, Graff,BA, Olsen,DR, and Rofstad,EK (2005). Fluctuations in pO(2) in poorly and well-oxygenated spontaneous canine tumors before and during fractionated radiation therapy. Radiotherapy and Oncology 77(2):220-226.

Kakar,M, Nystrom,H, Aarup,LR, Nottrup,TJ, and Olsen,DR (2005). Respiratory motion prediction by using the adaptive neuro fuzzy inference system (ANFIS). Physics in Medicine and Biology 50(19):4721-4728.

Norum,J, Bruland,OS, Spanne,O, Bergmo,T, Green,T, Olsen,DR et al. (2005). Telemedicine in radiotherapy: a study exploring remote treatment planning., supervision and economics. Journal of Telemedicine and Telecare 11(5):245-250.

Dale,E, Hellebust,TP, Bruland,OS, and Olsen,DR (2005). Comparative analyses of the dynamic properties of the bladder wall studied by repetitive pelvic CT scans of patients and cryo-sections of cadavers. British Journal of Radiology 78(930):528-532.

Book chapters

 Eilertsen K, Olsen DR. Data format, Networking, Archiving and Telemedicine.  In: New Technologies in Radiation Therapy. Schlegel W, Bortfeld T and Grosu AL. (eds.). Springer Verlag, ISBN 3-540-00321-5, pp. 53-65 (2006).  

Bruland, Ø.S., Dahle, J., Olsen, D.R., and Larsen, R.H.: Targeted high-LET therapy of bone metastases. In: Tageted radionuclide tumor therapy - Biological aspects. Stigbrand, Adams & Carlsson (eds.). Springer Verlag. ISBN 978 1 4020 8695 3, pp. 181-194 (2008). 

Bokkapitler på norsk:

Moan JE, Olsen DR. Fysikk og medisin, In: Naturens kode, Einevoll GT & Newth E (eds.). Gyldendal Akademisk ISBN/EAN: 9788205345393 (2005).

Aviskronikker/innlegg/TV:

'Still de store spørsmålene', Bergens Tidende, 28 nov 2011

'Kunnskapsbasert politikk', Dagens Næringsliv, april 2011.

'Kunnskap – nøkkelen til fremtidens verdiskapning', Bergens Tidende/På Høyden 2011

'Styrk finansieringen!', Aftenposten, 2011

'For dårlig kreftbehandling?', Schrödingers katt 2010

'Kvantemedisin': Schrödingers katt 2009

'Kreft, en global utfordring', Dagsavisen, 17.08. 2009.

'Protonterapi - men hva så?' Dagsavisen, 03.02.2008.

'Fusk og forskningskultur', Morgenbladet 06.06, 2006 

'Angrep på vitenskapelig utprøvd medisin skyter over målet', Aftenposten 02.09.2004.

 

EDUCATION:

  • MSc of Biophysics and biomedical technology, Norwegian Institute of Technology, Trondheim, 1986.
  • PhD of Medical physics, University of Oslo, Oslo, 1999.
  • Management program, Norwegian School of Economics and Business Administration, Bergen, 2006.

PREVIOUS POSITIONS:

  • Medical physicist, The Norwegian Radium Hospital, Oslo, 1986-2004.         
  • Assistant and later associate professor, Oslo University College, Oslo, 1996-2000.
  • Professor of Medical Physics, University of Oslo, Oslo, 2000-2010.
  • Head of department, Institute of Cancer Research, Oslo University Hospital, Oslo, 2004-2010.

 CURRENT POSITION:

Dean, Faculty of Mathematics and Natural Sciences, University of Bergen, 2010-date

INTERNATIONAL RESEARCH AWARDS:

Klaas Breur Gold Medal 2008

PROFESSIONAL ACTIVITIES (previous and current):

  • Editorial board member of Acta Oncologica and Radiotherapy and Oncology, and Physics in Medicine and Biology.
  •  Referee for several international journals: Radiotherapy and Oncology, Acta Oncological, Medical Physics, Physics in Medicine and Biology, International Journal of Radiation Oncology, Biology and Physics, International Journal of Radiation Biology, Lancet Oncology.
  •  Reviewer of research programs for Cancer Research Campaign, UK, Medical Research Council, UK, The Danish Medical Research Council and EURATOM, EC.
  •  Member of evaluation committees for professorship/associated professorship at Karolinska Institute, University of Stockholm, University of Århus, University of Umeå, University of Bergen, Oslo University College, Gjøvik University College, University of  Oslo, Trinity College Dublin, University of Madison, Wisconsin, University of Vienna and University of Lund.
  •  External evaluator and opponent of PhD thesis at Norwegian University for Technology and Science, University of Bergen, University of Lund, University of Århus, University of Oslo, University of Lindköping.
  •  External examiner at Trinity College, University of Dublin, Norwegian University for Technology and Science and Oslo University College.
  •  Member of committee for evaluation of higher education, the Swedish National Agency for Higher Education.
  •  Chairman and member of working groups on heath technology assessment at the Norwegian Knowledge Centre for the Health Services.
  • Member of Council for Translational Research, The Norwegian Radium Hospital and member of the management group of Institute of Cancer Research.
  • Member of the committee on science and education, and chairman of the education subcommittee in the merger process between The Norwegian Radium Hospital and Rikshospitalet, University of Oslo.
  • Member of working group on research strategy for South-Eastern Norway Regional Health Authority
  • Delegate to the WHO Global Initiative on Radiation Safety in Health Care Settings  and to the IAEA Interregional Technical Cooperation Project in medical physics.
  • Member of the international advisory board for the National Radiation Oncology Plan, Ireland
  • Member of review committee of clinical research, University of Gothenburg.

Professional society memberships: 

  • European Society of Radiotherapy and Oncology, acting past chair of physics committee and member of the education and training committee.
  • European Institute of Radiotherapy, past board member
  • Norwegian Association of Medical Physics, board member and chair.
  • board member European Society of Radiotherapy and Oncology