Daniela Elena Costea
Professor, tumour pathology
- E-postDaniela.Costea@uib.no
- Telefon+47 55 97 25 65+47 483 52 677
- BesøksadresseHaukeland University HospitalBergenRom5104, 1st floor, Pathology
- PostadressePostboks 78045020 Bergen
My main research interests are in the field of tumour biology, particularly of oral carcinogenesis, focusing on the role of normal neighbouring cells on the invasive and self renewal properties of oral cancer cells. I am however, fascinated by the cell-to-cell interactions, such that I am currently involved in research projects looking at cell-to-cell interactions in normal human oral tissues as well, and between human cells and periodontal bacterial cells.
Oral pathology and tumour biology
Vitenskapelig artikkel
- 2020. Tumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology report. PLOS ONE. 1-13.
- 2020. Trends and clinicopathological characteristics of oral squamous cell carcinomas reported at a tertiary cancer hospital in Nepal during 1999 to 2009. Clinical and Experimental Dental Research. 356-362.
- 2020. Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells. Pharmaceutics. 1-17.
- 2020. Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma. Head and Neck. 1-11.
- 2020. Helicobacter pylori was not detected in oral squamous cell carcinomas from cohorts of Norwegian and Nepalese patients. Scientific Reports. 8 sider.
- 2020. Grading of oral squamous cell carcinomas – Intra and interrater agreeability: Simpler is better? Journal of Oral Pathology & Medicine. 630-635.
- 2020. Establishment of a novel cancer cell line derived from vulvar carcinoma associated with lichen sclerosus exhibiting a fibroblast-dependent tumorigenic potential. Experimental Cell Research. 1-9.
- 2020. Cancer cell line-specific protein profiles in extracellular vesicles identified by proteomics. PLOS ONE. 1-20.
- 2020. A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer. Virchows Archiv. 865-872.
- 2019. α11β1 integrin is induced in a subset of cancer- associated fibroblasts in desmoplastic tumor stroma and mediates in vitro cell migration. Cancers.
- 2019. Use of nanomaterials in dentistry: covariates of risk and benefit perceptions among dentists and hygienists in Norway. Acta Odontologica Scandinavica. 152-160.
- 2019. Metabolic reprogramming of normal oral fibroblasts correlated with increased glycolytic metabolism of oral squamous cell carcinoma and precedes their activation into carcinoma associated fibroblasts. Cellular and Molecular Life Sciences (CMLS). 1-19.
- 2019. Knowledge about nanotechnology and intention to use nanomaterials: a comparative study among dental students in Norway and Romania. European journal of dental education. 79-87.
- 2019. Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells. Scientific Reports. 1-18.
- 2019. Fibroblasts rescue oral squamous cancer cell from metformin-induced apoptosis via alleviating metabolic disbalance and inhibiting AMPK pathway. Cell Cycle. 949-962.
- 2018. Oral tongue malignancies in Autoimmune polyendocrine syndrome type 1. Frontiers in Endocrinology. 1-9.
- 2018. Isolation and characterization of cells derived from human epithelial rests of Malassez. Odontology : official journal of The Society of the Nippon Dental University. 1-10.
- 2018. Efficient extracellular vesicle isolation by combining cell media modifications, ultrafiltration, and size-exclusion chromatography. PLOS ONE. 1-17.
- 2018. Effect of glycerol on reconstructed human oral mucosa. European Journal of Oral Sciences. 1-8.
- 2018. Aberrant expression of vimentin predisposes oral premalignant lesion derived cells towards transformation. Experimental and molecular pathology (Print). 243-251.
- 2017. Nano-TiO2 penetration of oral mucosa: in vitro analysis using 3D organotypic human buccal mucosa models. Journal of Oral Pathology & Medicine. 214-222.
- 2017. Cleavage of the urokinase receptor (uPAR) on oral cancer cells: Regulation by transforming growth factor - beta1 (TGF-beta1) and potential effects on migration and invasion. BMC Cancer.
- 2017. CHITOSAN MODIFIED POLY(LACTIC-CO-GLYCOLIC) ACID NANOPARTICLES INTERACTION WITH NORMAL, PRECANCEROUS KERATINOCYTES AND DENTAL PULP CELLS. Stomatology Edu Journal. 16-26.
- 2016. Vimentin-mediated regulation of cell motility through modulation of beta4 integrin protein levels in oral tumor derived cells. International Journal of Biochemistry and Cell Biology. 161-172.
- 2016. Phenotypic plasticity determines cancer stem cell therapeutic resistance in oral squamous cell carcinoma. EBioMedicine. 138-145.
- 2016. Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes. Biomaterials. 11-21.
- 2016. Nano-TiO2 penetration of oral mucosa: in vitro analysis using 3D organotypic human buccal mucosa models. Journal of Oral Pathology & Medicine. 214-222.
- 2016. Integrin α11 is overexpressed by tumour stroma of head and neck squamous cell carcinoma and correlates positively with alpha smooth muscle actin expression. Journal of Oral Pathology & Medicine. 267-275.
- 2016. In vivo host response and degradation of copolymer scaffolds functionalized with nanodiamonds and bone morphogenetic protein 2. Advanced Healthcare Materials. 730-742.
- 2016. Establishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds. Head and Neck. E1177-E1187.
- 2016. Establishment of 3D co-culture models from different stages of human tongue tumorigenesis: Utility in understanding neoplastic progression. PLOS ONE.
- 2015. The low-affinity nerve growth factor receptor p75NTR identifies a transient stem cell-like state in oral squamous cell carcinoma cells. Journal of Oral Pathology & Medicine. 410-419.
- 2015. S100A16 promotes differentiation and contributes to a less aggressive tumor phenotype in oral squamous cell carcinoma. BMC Cancer. 14 sider.
- 2014. Rapid adherence to collagen IV enriches for tumour initiating cells in oral cancer. European Journal of Cancer. 3262-3270.
- 2014. Human oral cancer cells with increasing tumorigenic abilities exhibit higher effective membrane capacitance. Integrative Biology. 545-554.
- 2014. A co-culture model with brain tumor-specific bioluminescence demonstrates astrocytes-induced drug resistance in glioblastoma. Journal of Translational Medicine.
- 2013. The effects of CD44 down-regulation on stem cell properties of head and neck cancer cell lines. Journal of Oral Pathology & Medicine. 682-690.
- 2013. Successful triple immuno enzymatic method employing primary antibodies from same species and same immunoglobulin subclass. European journal of histochemistry. 143-150.
- 2013. S100A14 interacts with S100A16 and regulates its expression in human cancer cells. PLOS ONE. 10 sider.
- 2013. In vitro reconstruction of human junctional and sulcular epithelium. Journal of Oral Pathology & Medicine. 396-404.
- 2013. Identification of two distinct carcinoma-associated fibroblast subtypes with differential tumor-promoting abilities in oral squamous cell carcinoma. Cancer Research. 3888-3901.
- 2013. Identification of FOXM1-induced epigenetic markers for head and neck squamous cell carcinomas. Cancer. 4249-4258.
- 2013. Human bone marrow mesenchymal stem cells induce collagen production and tongue cancer invasion. PLOS ONE. 15 sider.
- 2013. Exploiting FOXM1-orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis. International Journal of Cancer. 2095-2106.
- 2012. Time-dependent biological differences in molecular markers of high-grade urothelial cancer over 7 decades (ras proteins, pTEN, uPAR, PAI-1 and MMP-9). Virchows Archiv. 541-551.
- 2012. S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest. Oral Oncology. 219-225.
- 2012. Molecular crosstalk between cancer cells and tumor microenvironment components suggests potential targets for new therapeutic approaches in mobile tongue cancer. Cancer Medicine. 128-140.
- 2012. Limited in-depth invasion of Fusobacterium nucleatum into in vitro reconstructed human gingiva. Archives of Oral Biology. 344-351.
- 2011. S100A14 regulates the invasive potential of oral squamous cell carcinoma derived cell-lines in vitro by modulating expression of matrix metalloproteinases, MMP1 and MMP9. European Journal of Cancer. 600-610.
- 2011. MicroRNA Alterations and Associated Aberrant DNA Methylation Patterns across Multiple Sample Types in Oral Squamous Cell Carcinoma. PLOS ONE. 11 sider.
- 2011. Coexpression and nuclear colocalization of metastasis-promoting protein S100A4 and p53 without mutual regulation in colorectal carcinoma. Amino Acids. 875-884.
- 2011. Cancer, pre-cancer and normal oral cells distinguished by dielectrophoresis. Analytical and Bioanalytical Chemistry. 2455-2463.
- 2011. Cancer Stem Cells in Squamous Cell Carcinoma Switch between Two Distinct Phenotypes That Are Preferentially Migratory or Proliferative. Cancer Research. 5317-5326.
- 2010. Normal and malignant epithelial cells with stem-like properties have an extended G2 cell cycle phase that is associated with apoptotic resistance. BMC Cancer. 16 sider.
- 2010. Khat alters the phenotype of in vitro-reconstructed human oral mucosa. Journal of Dental Research. 270-275.
- 2010. Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1. Cancer Research. 9515-9526.
- 2010. Adverse effects of Sudanese toombak vs. Swedish snuff on human oral cells. Journal of Oral Pathology & Medicine. 128-140.
- 2009. Khat Alters the Phenotype of in vitro-reconstructed Human Oral Mucosa. Journal of Dental Research.
- 2009. Fusobacterium nucleatum Enters Normal Human Oral Fibroblasts In Vitro. Journal of Periodontology. 1174-1183.
- 2009. Early loss of mitochondrial inner transmembrane potential in khat-induced cell death of primary normal human oral cells. Toxicology. 108-116.
- 2009. Cancer progression is associated with increased expression of basement membrane proteins in three-dimensional in vitro models of human oral cancer. Archives of Oral Biology. 924-931.
- 2009. Adverse effects of Sudanese toombak vs Swedish snuff on human oral cells. Journal of Oral Pathology & Medicine.
- 2008. Tissue engineering of oral dysplasia. Journal of Pathology. 280-289.
- 2008. Khat induces G1-phase arrest and increased expression of stress-sensitive p53 and p16 proteins in normal human oral keratinocytes and fibroblasts. European Journal of Oral Sciences. 23-30.
- 2008. Khat (Catha edulis) induces reactive oxygen species and apoptosis in normal human oral keratinocytes and fibroblasts. Toxicological Sciences. 311-324.
- 2007. Dual effects of sodium lauryl sulphate on human oral epithelial structure. Experimental Dermatology. 574-579.
- 2006. Species-specific fibroblasts required for triggering invasiveness of partially transformed oral keratinocytes. American Journal of Pathology. 1889-1897.
- 2005. The phenotype of in vitro reconstituted normal human oral epithelium is essentially determined by culture medium. Journal of Oral Pathology & Medicine. 247-252.
- 2005. Fibroblast control on epithelial differentiation is gradually lost during <EM>in vitro</EM> tumor progression. Differentiation. 134-141.
- 2004. Khat (Catha edulis)-induced apoptosis is inhibited by antagonists of caspase-1 and -8 in human leukaemia cells. British Journal of Cancer. 1726-1726.
- 2003. Crucial effects of fibroblasts and keratinocyte growth factor on morphogenesis of reconstructed human oral epithelium. Journal of Investigative Dermatology. 1479-1486.
Faglig foredrag
- 2016. The role of fibroblasts on tumor progression.
- 2015. Identification of Phenotypically Distinct Cancer Stem Cell Subpopulations in Oral Squamous Cell Carcinoma.
- 2013. The role of tumor microenvironment on oral cancer invasion.
- 2013. The role of tumor microenvironment on oral cancer invasion.
- 2013. The role of tumor microenvironment on oral cancer invasion.
- 2013. The role of tumor microenvironment on oral cancer invasion.
- 2013. Carcinoma-associated fibroblasts promote a cancer stem cell-like phenotype through TGFβ1 secretion.
Populærvitenskapelig foredrag
- 2019. Helicobacter pylori is not present in oral squamous cell carcinomas from cohorts of Norwegian and Nepalese patients .
- 2013. Possibilitites to study at University of Bergen through Quota Programme.
- 2013. Possibilitites to study at University of Bergen through Quota Programme.
- 2013. Possibilitites to study at University of Bergen through Quota Programme.
- 2013. Possibilitites to study at University of Bergen through Quota Programme.
- 2013. Possibilitites to study at University of Bergen through Quota Programme.
- 2005. Kunstige slimhinners uante muligheter.
- 2004. Artificial human oral mucosa - new tools in dental research.
Vitenskapelig foredrag
- 2016. Nano-TiO2 Penetrates Human Oral Mucosa.
- 2015. Transforming growth factor beta 1 (TGFβ1) induces stem cell-like properties preferentially in cancer stem cell like–depleted cell subpopulations in human oral squamous cell carcinoma.
- 2015. Oral premalignant lesions overexpress the collagen-elastin crosslinking enzyme LOXL4.
- 2015. In vitro reconstruction of tumor microenvironment by use of organotypic 3D models .
- 2015. Expression of integrin α-11 by carcinoma associated fibroblasts modulates oral squamous cell carcinoma behaviour.
- 2015. Expression of integrin α-11 by carcinoma associated fibroblasts modulates oral squa- mous cell carcinoma behaviour .
- 2015. Different subsets of carcinoma-associated fibroblasts promote oral carcinoma cell invasion by distinct mechanisms.
- 2015. Development of a novel scaffold stimulating stem cells growth, differentiation and bone regeneration.
- 2014. Role of S100A16 in Differentiation of Oral Squamous Cell Carcinoma.
- 2014. Nanoparticle penetration in 3D oral mucosa models.
- 2014. Carcinoma-associated fibroblasts promote a cancer stem cell-like phenotype.
- 2013. Cancer associated fibroblasts increase stem cell -like properties of oral cancer cells.
- 2013. Cancer associated fibroblast stimulate self-renewal and invasion of oral cancer cells through TGFb secretion.
- 2008. Stromal fibroblasts enhance clonogenic growth of transformed oral keratinocytes.
- 2008. Phenotypic and functional differences between oral carcinoma-associated fibroblasts and normal oral.
- 2008. Oral squamous cell carcinoma cells inhibit the growth and induce apoptosis of normal oral keratin.
- 2008. Migratory cancer stem cells exist in oral cancers.
- 2008. Interactions between stromal fibroblasts, normal oral keratinocytes and oral cancer-derived kerat.
- 2008. Fusobacterium nucleatum Enters Oral Fibroblasts.
- 2008. FOXM1 is Upregulated in Oral Cancer and Induces Genomic Instability.
- 2008. Epithelial mesenchymal interactions in oral squamous cell carcinomas - in vitro studies on three.
- 2008. Cell cycle particularities and selective resistance of cancer stem cells to drug induced apoptosi.
- 2008. CD44 down-regulation reduces self-renewal of oral carcinoma stem cells.
- 2007. Tumour initiating cells spend an extended time in the g2 phase of the cell cycle.
- 2007. Tumour fibroblasts enhance the self renewal properties of malignant epithelial cells.
- 2007. The cd44+ fraction of carcinoma cells shows apoptotic resistance and spends an extended time in the g2 phase of the cell cycle.
- 2007. Reactive Oxygen Species Mediate Khat Induced Cytotoxicity in Oral Cells.
- 2006. Spontaneous sorting of fibroblasts and keratinocytes in organotypic oral mucosa.
- 2006. Normal Oral Keratinocytes and Fibroblasts Stimulate Clonal Expansion of Oral Squamous Cell Carcinoma – Derived Cells.
- 2006. Characterisation of Khat Induced Cell Death in Oral Fibroblasts.
- 2005. Stromal fibroblasts modulate tumuor invasion and expression of Basement membarne(BM) proteins in in vitro models of normal and neoplastic oral mucosa.
- 2005. Stromal fibroblasts modulate tumuor invasion and expression of Basement membarne(BM) proteins in in vitro models of normal and neoplastic oral mucosa.
- 2005. Mechanisms of apoptosis induction by khat alkaloids in leukaemia cells.
- 2004. Significance of epithelial-mesenchymal interactions for morphogenesis of in vitro reconstituted dysplastic human oral epithelium.
- 2004. Significance of epithelial-mesenchymal interactions for morphogenesis of in vitro reconstituted dysplastic human oral epithelium.
- 2004. Local invasiveness of oral epithelial dysplastic cells is triggered by human but not mouse fibroblasts: study on in vitro models of normal, dysplastic and neoplastic human oral mucosa.
- 2004. Local invasiveness of oral epithelial dysplastic cells is triggered by human but not mouse fibroblasts: study on in vitro models of normal, dysplastic and neoplastic human oral mucosa.
- 2004. Invasion of early neoplastic oral keratinocytes is triggered by species specific diffusible factors.
- 2004. Invasion of early neoplastic oral keratinocytes is triggered by species specific diffusible factors.
- 2004. Fibroblasts modulate the pattern of epithelial cell death in vitro reconstituted human oral mucosa through a mechanism independent of keratinocyte growth factor synthesis.
- 2004. Fibroblasts modulate the pattern of epithelial cell death in in vitro reconstituted human oral mucosa through a mechanism independent of keratinocyte growth factor synthesis.
- 2004. Diffusible factors derived from species-specific oral fibroblasts trigger invasiveness of early neoplastic oral keratinocytes.
- 2004. Diffusible factors derived from species-specific oral fibroblasts trigger invasiveness of early neoplastic oral keratinocytes.
- 2002. Serum free organotypic cultures of normal human oral mucosa.
- 2002. Proliferation, differentiation and cell death in organotypic serum free cultures of normal human oral mucosa.
- 2002. Cytotoxic effects of Catha edulis on leukemia cell lines and primary human oral cells.
- 2002. Cytotoxic effects of Catha edulis on human oral cells in vitro.
Mastergradsoppgave
- 2015. FREMSKRITT INNENFOR NANOTEKNOLOGI VED DIAGNOSTIKK OG BEHANDLING AV KREFT.
Doktorgradsavhandling
- 2020. Biomarkers and preclinical models for more precise diagnosis and personalized treatment of oral and vulva carcinomas - Study on human samples and experimental models.
- 2020. Biomarker identification in oral squamous cell carcinoma : study on cohorts of patients from Sudan.
- 2020. Biomarker Identification in Oral Squamous Cell Carcinoma Study on Cohorts of Patients from Sudan.
- 2018. Identification of prognostic biomarkers for oral squamous cell carcinoma. Study on human samples and experimental models.
- 2016. Role of integrin α11 in oral carcinogenesis. In vitro and in vivo studies.
- 2015. Time relations of biological markers in urothelial carcinomas.
- 2015. Bioactive copolymer scaffolds for bone tissue engineering. Efficacy and host response.
- 2012. Interactions between Fusobacterium nucleatum and Primary Oral cells, In Vitro Studies in Monolayer and Organotypic Culture Models.
- 2012. Cancer stem cells in oral squamous cell carcinomas - identification and characterization.
- 2009. Toxicity of khat on normal human oral cells. In vitro studies using primary human oral keratinocytes and fibroblasts in monolayer and organotyic cultures.
- 2005. Epithelial-Mesenchymal Interactions in Normal and Neoplastic Human Oral Mucosa - A Study on in Vitro Organotypic Models.
Intervju
- 2014. Daniela Costea, cercetătoarea care aparţine Europei, marţi la “Lumea şi noi”.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
- 2002. Proliferation and differentiation in organotypic serum free cultures of normal oral mucosa. 6 sider.
Sammendrag/abstract
- 2010. Rapid adherence to collagen IV enriches for tumour initiating cells. European Journal of Cancer. 124-124.
- 2009. Phenotypic and functional differences between oral carcinoma-associated fibroblasts and normal oral fibroblasts. Oral Oncology. 221-221.
- 2009. Enhanced self-renewal properties of transformed oral epithelial cells after interactions with stromal fibroblasts. Oral Oncology. 92-93.
- 2009. Coexpression and nuclear colocalization of metastasis-promoting protein S100A4 and p53 without mutual regulation in colorectal carcinoma. Amino Acids. 79-79.
- 2008. Generation of skin and oral mucosa from mouse embryonic stem cells under the influence of regional specific components. Journal of Investigative Dermatology. S145-S145.
- 2007. Recapitulating the features of mild, moderate and severe dysplasia using keratinocytes derived from clinical lesions and artificial connective tissue supports. Oral Oncology. 180-181.
- 2007. Oral squamous cell carcinoma cells inhibit the growth of normal oral keratinocytes: a putative mechanism for intraepithelial tumour expansion. Oral Oncology. 73-73.
- 2007. Khat inhibits proliferation of normal oral keratinocytes in monolayers and organotypic cultures. Oral Oncology. 198-198.
- 2006. Effects of khat (Catha edulis) on normal human oral cells. Journal of Oral Pathology & Medicine. 443-443.
- 2006. Differentiation of oral epithelium is regulated by GM-CSF and KGF at early but not terminal stages. Journal of Oral Pathology & Medicine. 417-417.
- 2005. The role of Bcl-2 in apoptosis induced by khat (Catha edulis) in acute myeloid leukemia cell lines. Blood. 195b-195b.
- 2005. Keratinocyte sensitivity to fibroblast-derived differentiation signals is gradually lost during in vitro tumour progression. Oral Oncology. 150-150.
- 2005. Basement membrane proteins in step-wise in vitro culture models of oral cancer progression. Oral Oncology. 150-150.
Poster
- 2020. Low involucrin expression correlates to poor prognosis in oral squamous cell carcinoma of mobile tongue .
- 2019. Oral squamous cell carcinomas expressing higher levels of S100A14 correlate with prognosis.
- 2019. Dental Health Care Workers’ Intention to Use Nanomaterials.
- 2018. Perception of risks and benefits related to nanomaterials.
- 2016. Nano-TiO2 penetrates human oral mucosa.
- 2014. Uptake of TiO2 nanoparticles in a human oral mucosa model.
- 2014. Deeper penetration of TiO2 nanoparticles in neoplastic vs. Normal human oral mucosa models.
- 2014. Comparison of uptake of TiO2 nanoparticles in normal and cancer human oral mucosa models.
- 2014. Assessment of knowledge about nanotechnology in dentistry among dental students.
- 2013. A novel model: Microenvironmentally-induced carcinogenesis for screening bone regeneration scaffolds.
- 2012. Expression of cancer stem cell markers in oral squamous cell carcinoma.
- 2008. The colony forming ability of HNSCC lines in-vitro.
- 2008. Stromal fibroblasts enhance self renewal properties of transformed oral keratinocytes.
- 2008. In vitro reconstruction of human sulcular epithelium.
- 2008. Generation of skin and oral mucosa from mouse embryonic stem cells under the influence of regional specific cells.
- 2008. Fusobacterium nucleatum Enters the in Vitro Engineered Human Oral Mucosa.
- 2008. CD44+ carcinoma cells show apoptotic resistance and cell cycle differences.
- 2007. Targeting cancer treatment at oral cancer stem cells.
- 2007. Targeting cancer treatment at breast cancer stem cells.
- 2007. Similar hierarchical stem cell patterns in vivo and in vitro in oral malignancies.
- 2007. Mechanisms of selective resistance of malignant stem cells to the induction of apoptotic cell death.
- 2007. Fusobacterium nucleatum Invades Primary Normal Human Gingival Fibroblasts.
- 2007. Fusobacterium nucleatum Invades Primary Normal Human Gingival Fibroblasts.
- 2007. Differential apoptotic cell responses within malignant cell lines.
- 2007. 0ral malignancies show similar hierarchical stem cell patterns in vivo and in vitro.
- 2006. Normal Keratinocytes and Fibroblasts Control Oral Cancer Cell Expansion.
- 2005. Species-Specific Fibroblasts Trigger Invasiveness of Early Neoplastic Oral Keratinocytes.
- 2005. Keratinocyte Sensitivity To Fibroblast-Derived Differentiation Signals Is Gradually Lost During In Vitro Tumour Progression.
- 2005. Basement membrane proteins during in vitro tumour progression.
- 2004. Invasion of early neoplastic oral keratinocytes is triggered by species specific diffusable factors.
- 2004. Invasion of early neoplastic oral keratinocytes is triggered by species specific diffusable factors.
- 2002. Establishment of organotypic cultures of normal human oral mucosa.
- 2002. Cytotoxic effects of Catha edulis on human oral cells in vitro.
Vitenskapelig oversiktsartikkel/review
- 2019. Expression profile and functional role of S100A14 in human cancer. OncoTarget. 2996-3012.
- 2016. Gene expression and proteome analysis as sources of biomarkers in basal cell carcinoma. Disease Markers. 9 sider.
- 2015. MicroRNAs as important players and biomarkers in oral carcinogenesis. BioMed Research International. 10 sider.
- 2012. The use of salivary cytokines as a screening tool for oral squamous cell carcinoma: A review of the literature. Journal of Oral and Maxillofacial Pathology. 256-261.
- 2008. Epithelial stem cells and malignancy. Journal of Anatomy. 45-51.
- 2007. The changing face of p53 in head and neck cancer. International Journal of Oral & Maxillofacial Surgery. 1123-1138.
- 2006. Cancer Stem Cells – New and Potentially Important Targets for the Therapy of Oral Squamous Cell Carcinoma. Oral Diseases. 443-454.
Se fullstendig oversikt over publikasjoner i CRIStin.
Dr.Odont Thesis:
“Epithelial-Mesenchymal Interactions in Normal and Neoplastic Human Oral Mucosa - Studies on in Vitro Organotypic Models” ISBN 82-8006-022-70, UoB, Norway, 2005
Publications in peer reviewed international journals:
1. Costea DE, Loro LL, Dimba EA, Vintermyr OK, Johannessen AC (2003): Crucial effects of fibroblasts and keratinocyte growth factor on morphogenesis of reconstituted human oral epithelium. J Invest Dermatol. 121(6):1479-86.
2. Dimba EA, Gjertsen BT, Bredholt T, Fossan KO, Costea DE, Francis GW, Johannessen AC,Vintermyr OK (2004): Khat (Catha edulis)-induced apoptosis is inhibited by antagonists of
caspase-1 and -8 in human leukaemia cells. Br J Cancer. 91(9):1726-34.
3. Costea DE, Dimba AO, Loro LL, Vintermyr OK, Johannessen AC (2005): The phenotype of in vitro reconstituted normal human oral epithelium is essentially determined by culture medium. J
Oral Pathol Med. 34(4):247-52.
4. Costea DE, Johannessen AC, Vintermyr OK (2005): Fibroblast control on epithelial differentiation is gradually lost during in vitro tumor progression. Differentiation. 73(4):134-41.
5. Costea DE, Kulasekara K, Neppelberg E, Johannessen AC, Vintermyr OK (2006): Species-specific fibroblasts required for triggering invasiveness of partially transformed oral keratinocytes. Am J Pathol. 168(6):1889-97.
6. Costea DE, Tsinkalovsky O, Vintermyr OK, Johannessen AC, Mackenzie IC (2006): Cancer stem cells - new and potentially important targets for the therapy of oral squamous cell carcinoma. Oral Dis. 12(5):443-54. Review.
7. Neppelberg E, Costea DE, Vintermyr OK, Johannessen AC (2007): Dual effects of sodium lauryl sulphate on human oral epithelial structure. Exp Dermatol. 16(7):574-9.
8. Partridge M, Costea DE, Huang X (2007): The changing face of p53 in head and neck cancer. Int J Oral Maxillofac Surg. 36(12):1123-38. Review.
9. Costea DE (2007): Meeting students’ and supervisors’ expectations - findings from a pilot study done at Centre for International Health, University of Bergen; Bergen Open Research Archive (BORA).
10. Lukandu OM, Costea DE, Dimba EA, Neppelberg E, Bredholt T, Gjertsen BT, Vintermyr OK, Johannessen AC (2008): Khat induces G1-phase arrest and increased expression of stress-sensitive
p53 and p16 proteins in normal human oral keratinocytes and fibroblasts. Eur J Oral Sci. 116(1):23-30.
11. Lukandu OM, Costea DE, Neppelberg E, Johannessen AC, Vintermyr OK (2008): Khat (Catha edulis) induces reactive oxygen species and apoptosis in normal human oral keratinocytes and
fibroblasts. Toxicol Sci. 103(2):311-24.
12. Costea DE, Gammon L, Kitajima K, Harper L and Mackenzie IC (2008): Epithelial stem cells and malignancy. J Anat. 213(1):45-51.Review.
13. Gaballah K, Costea DE, Hills A, Gollin SM, Harrison P, Partridge M (2008): Tissue engineering of oral dysplasia, J Pathol, 215(3):280-9.
14. Dabija-Wolter G, Cimpan MR, Costea DE, Johannessen AC, Sornes S, Neppelberg E, Al-Haroni M, Skaug N, Bakken V (2009): Fusobacterium nucleatum enters normal human oral fibroblasts in vitro, J Periodontol., 80(7):1174-83.
15. Lukandu OM, Bredholdt T, Neppelberg E, Gjertsen BT, Johannessen AC , Vintermyr OK , Costea DE (2009):Early Loss of Mitochondrial Membrane Potential in Khat-Induced Cell Death of
Primary Normal Human Oral Cells, Toxicology, 263(2-3):108-16.
16. Kulasekara KK, Lukandu OM, Neppelberg E, Vintermyr OK , Johannessen AC, Costea DE (2009) Increased basement membrane protein expression during cancer progression and under stromal
influence in experimental three-dimensional models of human oral mucosa, Arch Oral Biol. e-pub ahead of print.
17. Lukandu OM, Neppelberg E, Vintermyr OK , Johannessen AC , Costea DE (2009): Khat alters the phenotype of in vitro reconstructed human oral mucosa, accepted to J Dent Res.
18. Costea DE, Lukandu OM, Bui L, Ibrahim MJ, Lygre R, Neppelberg E, Ibrahim SO, Vintermyr OK, Johannessen AC (2009): Adverse effects of Sudanese Toombak versus Swedish snuff on primary human oral cells, accepted to J Oral Pathol Med.
Main research project
· The role of normal neighbouring cells on invasive and self renewal properties of oral cancer cells
Collaborative research projects - directly related to the main project
· Characterization of normal, dysplastic and tumour associated fibroblasts and their interactions with early transformed keratinocytes (with prof. M Partridge, Oncology, King’s College, UK, and prof. T Salo and postdoc P Nyberg, University of Oulu, Finland)
· Sensitivity of oral and breast cancer stem cells to apoptotic cell death induced by therapeutic agents (with prof. IC Mackenzie, Stem Cell Initiative, QMUL,UK, and assoc.prof. K Kitajima, Niigata Dental School, Japan)
· Identification and isolation of cancer stem cells in oral and colon cancers (collaboration with assoc. prof. F Labeed, University of Surrey, UK, postdoc O Tsinkalovsky and prof. OD Lærum , The Gade Institute, assoc. prof. PØ Enger, Institute of Biomedicine, University of Bergen, Norway)
Collaborative research projects – affiliated to the main project
· Interactions between oral cells and periodontal pathogens (collaboration with prof. V Bakken at Department of Microbiology, University of Bergen, Norway)
· Cytotoxic effects of Catha Edulis on oral cells (collaboration with prof. BT Gjertsen, Department of Internal Medicine, University of Bergen, Norway)