- E-postDonald.Gullberg@uib.no
- Telefon+47 55 58 63 32+47 928 04 941
- BesøksadresseJonas Lies vei 915009 Bergen
- PostadressePostboks 78045020 Bergen
Molekylære mekanismer av celleadehsion
Gullberg laboratoriet har undersøkt integrin α11β1, som uttrykkes på delsett av normale fibroblaster og på karcinom-assosierte fibroblaster. Celler som mangler α11β1, viser forstyrret cellekollagen-interaksjoner, endret metalloproteinasesyntese og redusert celleproliferasjon. Store prosjekter innenfor gruppen tar sikte på å forstå hvilken rolle denne kollagenreseptoren og andre fibroblastinteginer har i løpet av helsen og sykdommen.
- (2023). Matrix Stiffness-dependent Regulation of Integrin α11β1 Expression.
- (2022). Upregulated integrin α11 in the stroma of cutaneous squamous cell carcinoma promotes skin carcinogenesis. Frontiers in Oncology. 17 sider.
- (2022). Integrin α11β1 in tumor fibrosis: more than just another cancer-associated fibroblast biomarker? Journal of cell communication and signaling. 649-660.
- (2022). Integrin α11β1 and syndecan-4 dual receptor ablation attenuates cardiac hypertrophy in the pressure overloaded heart. American Journal of Physiology. Heart and Circulatory Physiology. H1057-H1071.
- (2021). Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin. Toxicology and Applied Pharmacology.
- (2021). Role of evolutionary conserved residues in integrin α11 cytoplasmic tail.
- (2021). Collagen assembly at the cell surface: dogmas revisited. Cells. 1-22.
- (2020). Integrin α11β1 is a receptor for collagen XIII. Cell and Tissue Research.
1990 Phd Medical Chemistry, Uppsala University
1990-1992 Post Doc, Molecular Biology Institute, University of California Los Angeles
1993-2003 Researcher, Uppsala University
2004- today Professor, Department of Biomedicine, UoB