Hjem
Universitetet i Bergen
Jaakko Sarastes bilde

Jaakko Saraste

Emeritus
Institutt for biomedisin
  • E-postJaakko.Saraste@uib.no
  • Telefon+47 55 58 63 29
  • Besøksadresse
    Jonas Lies vei 91
    5009 Bergen
  • Postadresse
    Postboks 7804
    5020 Bergen

Jaakko received his PhD at the University of Helsinki, Finland. He did his postdoctoral work at Yale University School of Medicine, USA. From 1987-1992 he worked as a group leader at Ludwig Institute for Cancer Research, Karolinska Institute, Stockholm. From 1993-1998 he worked as a Research Fellow at the Department of Biochemistry and Molecular Biology. In 1998 he took up a position as a Professor at the Department of Anatomy and Cell Biology.
His group is working on the functional organisation of the intermediate compartment, a membrane system operating between the endoplasmic reticulum and the Golgi complex.

Vitenskapelig artikkel
  • Vis forfatter(e) (2023). Subcellular Distribution of BALF2 and the Role of Rab1 in the Formation of Epstein-Barr Virus Cytoplasmic Assembly Compartment and Virion Release. Microbiology spectrum.
  • Vis forfatter(e) (2022). Evidence for the role of Rab11-positive recycling endosomes as intermediates in coronavirus egress from epithelial cells. Histochemistry and Cell Biology. 241-251.
  • Vis forfatter(e) (2020). N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus. Experimental Cell Research. 1-9.
  • Vis forfatter(e) (2019). A New Look at the Functional Organization of the Golgi Ribbon. Frontiers in Cell and Developmental Biology. 1-21.
  • Vis forfatter(e) (2017). Post-translational modifications of Annexin A2 are linked to its association with perinuclear nonpolysomal mRNP complexes. FEBS Open Bio. 160-173.
  • Vis forfatter(e) (2017). Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules. Journal of Biological Chemistry. 14092-14107.
  • Vis forfatter(e) (2017). PKU mutation p.G46S prevents the stereospecific binding of l-phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain. FEBS Open Bio. 195-203.
  • Vis forfatter(e) (2016). Spatial and functional aspects of ER-Golgi Rabs and Tethers. Frontiers in Cell and Developmental Biology.
  • Vis forfatter(e) (2016). Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2. Journal of Cell Science. 314-328.
  • Vis forfatter(e) (2015). Development of congenital stromal corneal dystrophy is dependent on export and extracellular deposition of truncated decorin. Investigative Ophthalmology and Visual Science. 2909-2915.
  • Vis forfatter(e) (2014). Endocytosis of secreted carboxyl ester lipase in a syndrome of diabetes and pancreatic exocrine dysfunction. Journal of Biological Chemistry. 29097-29111.
  • Vis forfatter(e) (2014). Effect of serine phosphorylation and ser25 phospho-mimicking mutations on nuclear localisation and ligand interactions of annexin A2. Journal of Molecular Biology (JMB). 2486-2499.
  • Vis forfatter(e) (2012). Division of the intermediate compartment at the onset of mitosis provides a mechanism for Golgi inheritance. Journal of Cell Science. 5403-5416.
  • Vis forfatter(e) (2011). Phenylketonuria as a protein misfolding disease: The mutation pG46S in phenylalanine hydroxylase promotes self-association and fibril formation. Biochimica et Biophysica Acta - Molecular Basis of Disease. 106-120.
  • Vis forfatter(e) (2011). Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. Journal of Biological Chemistry. 34593-34605.
  • Vis forfatter(e) (2009). The Function of the Intermediate Compartment in Pre-Golgi Trafficking Involves its Stable Connection with the Centrosome. Molecular Biology of the Cell. 4458-4470.
  • Vis forfatter(e) (2007). Functional symmetry of endomembranes. Molecular Biology of the Cell. 1430-1436.
  • Vis forfatter(e) (2006). Rab1 defines a novel pathway connecting the pre-Golgi intermediate compartment with the cell periphery. Molecular Biology of the Cell. 1514-1526.
  • Vis forfatter(e) (1998). Retrograde transport from the pre-Golgi intermediate compartment and the Golgi complex is affected by the vacuolar H -ATPase inhibitor bafilomycin. Molecular Biology of the Cell. 3561-3578.
  • Vis forfatter(e) (1998). Ongoing controversy: How are proteins transported through the Golgi complex? NBS-nytt. 10-11..
  • Vis forfatter(e) (1997). Protein segregation in peripheral 15ºC intermediates in response to caffeine treatment. European Journal of Cell Biology. 150-164.
  • Vis forfatter(e) (1997). Endoplasmic reticulum to Golgi trafficking in multi-nucleated skeletal muscle fibers. Experimental Cell Research. 452-464.
  • Vis forfatter(e) (1996). Selective movement of pre-golgi and cis-golgi membranes to developing neurites and growth cones in ngf-treated pc12 cells. Molecular Biology of the Cell. 1679.
  • Vis forfatter(e) (1996). Molecular cloning and expression of a 58-kDa cis-Golgi and intermediate compartment protein. Journal of Biological Chemistry. 4031-4037.
  • Vis forfatter(e) (1996). Localization of the small gtp-binding protein rab1p to early compartments of the secretory pathway. Journal of Cell Science. 1541-1552.
  • Vis forfatter(e) (1996). Differential-effects of vincristine and phenytoin on the proliferation, migration and invasion of human glioma cell-lines. Journal of Neurosurgery. 1035-1043.
  • Vis forfatter(e) (1996). Differential redistribution of marker proteins of the er-golgi interface in response to the caffeine-induces transport block. Molecular Biology of the Cell. 1680.
  • Vis forfatter(e) (1996). Differential effects of vincristine and phenytoin on the proliferation, migration, and invasion of human glioma cell lines. Journal of Neurosurgery. 1035-1043.
  • Vis forfatter(e) (1996). Communication of post-golgi elements with early Endocytic pathwayregulation of endoproteolytic cleavage of semliki forest virus-p62 precursor. Journal of Cell Science. 2465-2475.
Vitenskapelig foredrag
  • Vis forfatter(e) (1998). The pre-Golgi intermediate compartment and protein recycling at the ER-Golgi boundary: Studies of p58-binding ligands and the effect of transport inhibitors.
  • Vis forfatter(e) (1997). Retrograde transport from the intermediate compartment and Golgi complex is affected by the vacuolar H%+-ATPase inhibitor bafilomysin A1.
  • Vis forfatter(e) (1997). Protein transport between the rough endoplasmic reticulum and the Golgi apparatus: role of the intermediate compartment.
  • Vis forfatter(e) (1997). Identification of protein ligands that bind to p58 in the early secretory pathway.
  • Vis forfatter(e) (1995). Selective movement of pre-golgi and cis-golgi membranes to developing neurites and growth cones in ngf-treated pc12 cells.
  • Vis forfatter(e) (1995). Differential redistribution of marker proteins of the ER-GOLGI interface in response to the caffeine-induces transport block.
Mastergradsoppgave
  • Vis forfatter(e) (2021). TOWARDS DEFINING THE ENDOMEMBRANE COMPARTMENTS OPERATING IN CELLULAR EXIT OF CORONVIRUSES.
  • Vis forfatter(e) (2011). The role of the intermediate compartment in membrane traffic during different stages of the cell cycle.
  • Vis forfatter(e) (2009). The effect of ER stress on protein traffic in the early secretory pathway.
  • Vis forfatter(e) (2006). Distribution of markers of early secretory compartments in pancreatic exocrine cells.
Kronikk
  • Vis forfatter(e) (2020). A life in pictures-Marilyn Gist Farquhar. Journal of Cell Biology. 1-2.
Doktorgradsavhandling
  • Vis forfatter(e) (2015). Phosphorylation of Annexin A2. Regulation of subcellular localisation and function.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
  • Vis forfatter(e) (2008). Use of polarized PC12 cells to monitor protein localization in the early biosynthetic pathway. 13 sider.
Sammendrag/abstract
  • Vis forfatter(e) (2013). Cellular re-uptake of secreted carboxyl-ester lipase protein in CEL-MODY, a syndrome of diabetes and pancreatic exocrine dysfunction. Diabetologia. S152-S152.
  • Vis forfatter(e) (2012). Self-association of the regulatory domain of human phenylalanine hydroxylase: contribution to the protein instability. The FEBS Journal. 465-465.
  • Vis forfatter(e) (2008). Pancreatic exocrine dysfunction in diabetes: functional characterisation of the carboxyl-ester lipase gene. Diabetologia. S123-S124.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) (2022). The life cycle and enigmatic egress of coronaviruses. Molecular Microbiology. 1308-1316.
  • Vis forfatter(e) (2021). Assembly and cellular exit of coronaviruses: Hijacking an unconventional secretory pathway from the pre-Golgi Intermediate compartment via the Golgi ribbon to the extracellular space. Cells. 1-20.
  • Vis forfatter(e) (2020). Editorial: Golgi Dynamics in Physiological and Pathological Conditions. Frontiers in Cell and Developmental Biology. 1-4.
  • Vis forfatter(e) (2018). Intermediate compartment (IC): from pre-Golgi vacuoles to a semi-autonomous membrane system. Histochemistry and Cell Biology. 407-430.
  • Vis forfatter(e) (2017). Protein phosphorylation and its role in the regulation of Annexin A2 function. Biochimica et Biophysica Acta - General Subjects. 2515-2529.
  • Vis forfatter(e) (2013). Arrivals and departures at the plasma membrane: direct and indirect transport routes. Cell and Tissue Research. 5-20.
  • Vis forfatter(e) (2011). The G46S-hPAH mutant protein: A model to study the rescue of aggregation-prone PKU mutations by chaperones. Molecular Genetics and Metabolism. S40-S44.
  • Vis forfatter(e) (2009). Emerging new roles of the pre-Golgi intermediate compartment in biosynthetic-secretory trafficking. FEBS Letters. 3804-3810.
  • Vis forfatter(e) (2008). Take the 'A' train: on fast tracks to the cell surface. Cellular and Molecular Life Sciences (CMLS). 2859-2874.

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