Hjem
Francisco Gomez Reals bilde

Francisco Gomez Real

Professor, , Leder, Forskningsenhet for helseundersøkelser (FHU), overlege, Kvinneklinikken HUS
  • E-postFrancisco.Real@uib.no
  • Besøksadresse
    Overlege Danielssens hus, Årstadveien 21
  • Postadresse
    Postboks 7804
    5020 BERGEN

Medisinsk spesialist og konsulent

Prof Francisco Gómez Real, MD PhD, deler sin tid mellom vitenskapelig og klinisk arbeid. Han er professor ved Institutt for Klinisk medisin (K2), Det Medisinske Fakultet (MOF) ved Universitetet i Bergen, Norge. Han er spesialist i gynekologi og fødselshjelp, jobber som konsulent ved Kvinneklinikken, Haukeland Universitetssykehus, og er ansvarlig for oppfølgingen av gravide kvinner med fedme. Han har erfaring fra allmennmedisin og lungemedisin.

Forskning

Real er banebryter og internasjonal ekspert innen forskning om kjønnshormoner, reproduktive- og metabolske faktorer, og tidlige livsfaktorer for lungehelse. Han er banebrytende for dette feltet gjennom sin egen doktorgrad, postdoktorarbeid, doktorgradsstudenter og postdoktor.

Han leder Forskningsenhet for helseundersøkelser (FHU), en kjernefasilitet ved Universitetet i Bergen som gjennomfører kliniske forskningsprosjekter som ikke krever sykehusinfrastruktur. FHU er et samarbeid mellom Det Medisinske Fakultet og Haukeland universitetssykehus (HUS), administrativt underlagt Institutt for klinisk medisin, og finansiert av Trond Mohn Foundation/Trond Mohn Stiftelse (TMS).

Omfattende dekning av forskningsaktiviteter gjennom nasjonale og internasjonale medier (inkl. Reuters) - aviser (inkl. New York Times, Washington Post, Der Standard, El Pais, Aftenposten), magasiner (inkl. Dagens Medisin, Allergi i Praksis, Tidskriftet for den Norske Legeforeningen), kvinneblader (inkl. Women's Weekly magazine, SELF magazine), radio (inkl. BBC-nyheter, ABC-nyheter, norske radiostasjoner) og elektroniske medier (inkl. Times News, Medical News Today, American Academy of Allergy Asthma & Immunology, RT online, Web MD, Women's Day, På Høyden).

Han har mottatt Best Paper Awards, Norsk forning for lungemedisin, 2007 som første forfatter, og 2011, 2016 og 2017 som siste forfatter.

Han foreleser for 5. års medisinstudenter i gynekologi og fødselslære, i det engelske semsesteret, ved Universitetet i Bergen.

Han var ansvarlig for å organisere og starte klinisk praksis for 5. års medisinstudenter i det engelse semestert for gynekologi og fødselslære, Universitetet i Bergen.

Han har bygget en utmerket karriere innen reproduksjon og lungehelse hos kvinner, og over generasjoner. Han har 69 fagfellevurderte publikasjoner, inkludert 53 de siste 5 årene. Hans vitenskapelige produksjon er stigende, med 14 publikasjoner det siste året, 25 publikasjoner i topprangerte tidsskrifter (IF 8 eller høyere), og han er første/andre/ seniorforfatter på 25. Han er en erfaren veileder for forskere.

Vitenskapelig artikkel
  • Vis forfatter(e) (2021). Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS). Maturitas. 49-55.
  • Vis forfatter(e) (2021). Exposures during the prepuberty period and future offspring's health: evidence from human cohort studies. Biology of Reproduction. 667-680.
  • Vis forfatter(e) (2021). Childhood lung function as a determinant of menopause-dependent lung function decline. Maturitas. 41-47.
  • Vis forfatter(e) (2021). CT-defined emphysema in COPD patients and risk for change in desaturation status in 6-min walk test. Respiratory Medicine. 8 sider.
  • Vis forfatter(e) (2020). Sleep time and sleep-related symptoms across two generations – results of the community-based RHINE and RHINESSA studies. Sleep Medicine. 8-13.
  • Vis forfatter(e) (2020). Regular Physical Activity Levels and Incidence of Restrictive Spirometry Pattern: A Longitudinal Analysis of 2 Population-Based Cohorts. American Journal of Epidemiology. 1521-1528.
  • Vis forfatter(e) (2020). Parents’ smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation study. PLOS ONE. 1-20.
  • Vis forfatter(e) (2020). One Year Change in 6-Minute Walk Test Outcomes is Associated with COPD Prognosis. COPD: Journal of Chronic Obstructive Pulmonary Disease. 662-671.
  • Vis forfatter(e) (2020). Early Age at Natural Menopause Is Related to Lower Post-Bronchodilator Lung Function. A Longitudinal Population-based Study. Annals of the American Thoracic Society.
  • Vis forfatter(e) (2020). Describing the status of reproductive ageing simply and precisely: A reproductive ageing score based on three questions and validated with hormone levels. PLOS ONE.
  • Vis forfatter(e) (2020). Association of adult lung function with accelerated biological aging. Aging. 518-542.
  • Vis forfatter(e) (2019). Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial. The Lancet Diabetes and Endocrinology. 256-266.
  • Vis forfatter(e) (2019). Snoring and nocturnal reflux: association with lung function decline and respiratory symptoms. European Respiratory Journal Open Research (ERJ Open Research).
  • Vis forfatter(e) (2019). Restrictive spirometry pattern is associated with low physical activity levels. A population based international study. Respiratory Medicine. 116-123.
  • Vis forfatter(e) (2019). Residential surrounding greenspace and age at menopause: A 20-year European study (ECRHS). Environment International. 1-7.
  • Vis forfatter(e) (2019). Polycystic ovary syndrome and lung function: a Mendelian randomization study. European Respiratory Journal.
  • Vis forfatter(e) (2019). Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS). Maturitas. 29-34.
  • Vis forfatter(e) (2019). Epigenome-wide association of father's smoking with offspring DNA methylation: a hypothesis-generating study. Environmental Epigenetics. 10 sider.
  • Vis forfatter(e) (2019). Early menarche is associated with lower adult lung function: A longitudinal cohort study from the first to sixth decade of life. Respirology (Carlton South. Print). 1-9.
  • Vis forfatter(e) (2019). Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation? Journal of Allergy and Clinical Immunology. 1-13.
  • Vis forfatter(e) (2019). Age at menopause and lung function: a Mendelian randomisation study. European Respiratory Journal. 1-10.
  • Vis forfatter(e) (2018). Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway. Clinical and Experimental Allergy. 66-77.
  • Vis forfatter(e) (2018). Polycystic ovary syndrome, body mass index and hypertensive disorders in pregnancy. Pregnancy Hypertension. 32-37.
  • Vis forfatter(e) (2018). Periodontal Health status and lung function in two Norwegian cohorts. PLOS ONE. 1-15.
  • Vis forfatter(e) (2018). Leisure-time vigorous physical activity is associated with better lung function: The prospective ECRHS study. Thorax. 376-384.
  • Vis forfatter(e) (2018). Critical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokers. Environmental Research. 241-247.
  • Vis forfatter(e) (2018). Body silhouettes as a tool to reflect obesity in the past. PLOS ONE. 1-13.
  • Vis forfatter(e) (2018). Agreement in reporting of asthma by parents or offspring - the RHINESSA generation study. BMC Pulmonary Medicine. 1-10.
  • Vis forfatter(e) (2018). A three-generation study on the association of tobacco smoking with asthma. International Journal of Epidemiology. 1106-1117.
  • Vis forfatter(e) (2017). Women with symptoms of sleep-disordered breathing are less likely to be diagnosed and treated for sleep apnea than men. Sleep Medicine. 17-22.
  • Vis forfatter(e) (2017). Validation of maternal reported pregnancy and birth characteristics against the Medical Birth Registry of Norway. PLOS ONE. 1-12.
  • Vis forfatter(e) (2017). The effects of growing up on a farm on adult lung function and allergic phenotypes: An international population-based study. Thorax. 236-244.
  • Vis forfatter(e) (2017). Physical activity and asthma: A longitudinal and multi-country study. Journal of Asthma. 938-945.
  • Vis forfatter(e) (2017). Menopause is associated with accelerated lung function decline. American Journal of Respiratory and Critical Care Medicine. 1058-1065.
  • Vis forfatter(e) (2017). Early menarche and new onset of asthma: Results from the SAPALDIA cohort study. Maturitas. 57-63.
  • Vis forfatter(e) (2017). Cohort Profile: Melbourne Atopy Cohort study (MACS). International Journal of Epidemiology. 25-26g.
  • Vis forfatter(e) (2017). Asthma in reproductive-aged women with polycystic ovary syndrome and association with obesity. European Respiratory Journal. 1-8.
  • Vis forfatter(e) (2017). Age at menarche and lung function: a Mendelian randomization study. European Journal of Epidemiology (EJE). 701-710.
  • Vis forfatter(e) (2016). Validation of self-reported figural drawing scales against anthropometric measurements in adults. Public Health Nutrition. 1944-1951.
  • Vis forfatter(e) (2016). The Association of gum bleeding With respiratory Health in a population based study from Northern Europe. PLOS ONE.
  • Vis forfatter(e) (2016). Self-reported exposure to traffic pollution in relation to daytime sleepiness and habitual snoring: a questionnaire study in seven North-European cities. Sleep Medicine. 93-99.
  • Vis forfatter(e) (2016). Oxygen desaturation in 6-min walk test is a risk factor for adverse outcomes in COPD patients. European Respiratory Journal. 82-91.
  • Vis forfatter(e) (2016). Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study. Journal of Allergy and Clinical Immunology. 50-57.e6.
  • Vis forfatter(e) (2016). Lower lung function associates with cessation of menstruation: UK Biobank data. European Respiratory Journal. 1288-1297.
  • Vis forfatter(e) (2016). Father’s environment before conception and asthma risk in his children: a multi-generation analysis of the Respiratory Health In Northern Europe study. International Journal of Epidemiology. 235-245.
  • Vis forfatter(e) (2016). Early life origins of lung ageing: Early life exposures and lung function decline in adulthood in two European cohorts aged 28-73 years. PLOS ONE.
  • Vis forfatter(e) (2015). Respiratory health in cleaners in Northern Europe: Is susceptibility established in early life? PLOS ONE. 13 sider.
  • Vis forfatter(e) (2015). Hormonal contraception increases risk of asthma among obese but decreases it among nonobese subjects: A prospective, population-based cohort study. European Respiratory Journal Open Research (ERJ Open Research). 1-8.
  • Vis forfatter(e) (2014). Longterm follow-up in European respiratory health studies - patterns and implications. BMC Pulmonary Medicine.
  • Vis forfatter(e) (2012). Gender differences in prevalence, diagnosis and incidence of allergic and non-allergic asthma: a population-based cohort. Thorax. 625-631.
  • Vis forfatter(e) (2011). Early age at menarche, lung function, and adult asthma. American Journal of Respiratory and Critical Care Medicine. 8-14.
  • Vis forfatter(e) (2010). Perimenstrual increase in bronchial hyperreactivity in premenopausal women: Results from the population-based SAPALDIA 2 cohort. Journal of Allergy and Clinical Immunology. 823-829.
  • Vis forfatter(e) (2009). Oral contraception, body mass index, and asthma: A cross-sectional Nordic-Baltic population survey. Journal of Allergy and Clinical Immunology. 391-397.
  • Vis forfatter(e) (2009). Is age at menopause increasing across Europe? Results on age at menopause and determinants from two population-based studies. Menopause. 385-394.
  • Vis forfatter(e) (2008). Lung function, respiratory symptoms, and the menopausal transition. Journal of Allergy and Clinical Immunology.
  • Vis forfatter(e) (2008). Hormonal factors and respiratory health in women - a review. Clinical Respiratory Journal. 111-119.
  • Vis forfatter(e) (2007). Menstrual irregularity and asthma and lung function. Journal of Allergy and Clinical Immunology. 557-564.
  • Vis forfatter(e) (2006). Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey. Thorax. 34-40.
  • Vis forfatter(e) (2005). Association of asthma and hay fever with irregular menstruation. Thorax. 793-794.
Vitenskapelig foredrag
  • Vis forfatter(e) (2017). Repeated desaturation in 6 minute walk test increases risk for mortality in COPD patients.
Doktorgradsavhandling
  • Vis forfatter(e) (2017). Respiratory health in aging women. The influence of menopause on asthma incidence and lung function decline.
  • Vis forfatter(e) (2008). Hormonal status in women and asthma, allergy and lung function. Results from population-based studies concerning menstrual irregularity, menopausal transition, hormonal replacement therapy and body mass index.
Poster
  • Vis forfatter(e) (2018). Associations of fathers and their offsprings weight gain With non-allergic asthma.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) (2018). Maternal age at delivery, lung function and asthma in offspring: A population-based survey. European Respiratory Journal. 1-11.
  • Vis forfatter(e) (2018). Environmental Impact on Health across Generations: Policy Meets Biology. A Review of Animal and Human Models. Challenges.
  • Vis forfatter(e) (2017). Risk factors for premenstrual asthma: a systematic review and meta-analysis. Expert Review of Respiratory Medicine. 57-72.
  • Vis forfatter(e) (2012). Respiratory health in women: from menarche to menopause. Expert Review of Respiratory Medicine. 187-202.

Se fullstendig oversikt over publikasjoner i CRIStin.

Prosjektleder og samarbeidspartner

Han samarbeider i sin forskning med Respiratory Health in Northern Europe (RHINE), European Community Respiratory Health Survey (ECRHS), Tasmanian Health Survey (TAHS), den sveitsiske kohortstudien om luftforurensning og lungesykdommer hos voksne (SAPALDIA), UK BioBank, PregMet-studien, og den transgenerasjonelle Respiratory Health in Northern Europe, Spain and Australia (RHINESSA). Han var PI i den banebrytende studien om Overgangsalder og respiratorisk helse, som Norges forskningsråd (NFR) finansierte, hvor ECRHS, RHINE og TAHS samarbeidet. Han tilbrakte seks måneder som postdoktor ved prof Shyamali Dharmage´s Allergy and Lung Health Unit, University of Melbourne. Han leder Reproductive Respiratory Health arbeidsgruppen for RHINE og RHINESSA studier, er med-leder i ECRHS Gender Working Group med AI Leynaert, og PI for ECRHS i Bergen.

Hans styrker som forsker er original- og innovativ tenkning, god nettverksbyggingskapasitet og erfaring med forskningsadministrasjon. Dette vises i artikler som har bidratt til ny tenkning i feltet.

Han samarbeider om å utvikle CASCADE (Centre of Multigeneration Science on Health and Disease), et senter ledet av professor Cecilie Svanes som tar sikte på å gjennomføre multigenerasjonell menneskelig forskning.

Hans doktorgradsstudent og postdoktorforsker, KaI Triebner, publiserte nylig artikler som viser overgangsalderen er relatert til nyoppstått astma og akselerert lungefunksjonsfall (publisert i ledende luftveis- og allergitidsskrifter).

 

2018-2023        Partner, “Preconception exposures and related epigenetic mechanisms in Asthma and allergies”. TOPFORSK Norwegian Research Council (NRC) grant, 25,000,000 NOK

2018-2021        Veileder, «Life course with good Health» program, West Health Council (Helse Vest) grant, PhD research fellowship, PhD candidate Marianne Lønnebotn

2017-2021        Leder, Forskningsenhet for helseundersøkelser, Trond Mohn stiftelse (TMS) stipend 11,000,000 NOK

2017-2020        Veileder, “Post-menopausal deterioration of respiratory health:  Lifestyle strategies to preserve healthy lungs in aging women”, Universitet i Bergen stipend , postdoctoral research fellowship, PhD Kai Triebner