Hjem
Frits Alan Thorsens bilde

Frits Alan Thorsen

Professor, Plattformleder Molecular Imaging Center
  • E-postFrits.Thorsen@uib.no
  • Telefon+47 55 58 62 72+47 957 49 681
  • Besøksadresse
    Jonas Lies vei 91
  • Postadresse
    Postboks 7804
    5020 Bergen

Background

Brain metastasis is a complication occurring in one third of all cancer patients. Metastases to the brain occur 10 times more often than primary malignant brain tumors. The most common sources of metastatic brain lesions involve the lung (50-60%), breast (15-20%), skin (5-10%) and gastrointestinal tract (4-6%).

Patients with metastatic spread to the central nervous system (CNS) have a poor prognosis. Treatment strategies available today are ineffective, with low response rates, as current chemotherapeutic agents are ineffective. Clearly there is a need for suitable animal models in which spontaneous CNS metastases develop when cancer cells metastasize from the primary lesion in a manner that reflects the patient setting. We have developed such models, which will enable us to study the biology and the treatment of brain metastases.

Development of new metastatic animal models

We have recently developed novel model systems where tumor cells from human melanoma brain metastases are injected systemically in immunodeficient mice and metastasize to the mouse brain. This animal model recapitulates most steps of the metastatic cascade, and a better understanding of the molecular mechanisms behind tumor metastasis may thus be obtained.

Ongoing research activities

Our work focuses on 3 main avenues:

We have performed genetic studies on our model systems, and performed bioinformatics analysis to determine a brain metastasis-specific gene signature. This work has resulted in determination of several novel drugs originally used for other conditions than cancer, which shows inhibitory effects on brain metastases in vivo.  

We are also studying the blood-brain barrier (BBB), which prevents therapeutic drugs from entering the brain. We are currently collaborating with partners from Germany, UK, China and the US, to modulate the BBB for prevention and treatment of brain metastases.

Currently, we are studying the effect of exosomes on the tumor microenvironment, and have encouraging data showing that miRNAs delivered to the brain by exosomes are important in preparing the pre-metastatic niche. This is an ongoing collaboration with our partner at Shandong University, China.

 

POPULÆRVITENSKAPELIGE ARTIKLER

1.   Nøtter kan redusere kreft med spredning til hjernen. Kreftforeningen.no, July 1, 2015 (In Norwegian). (https://kreftforeningen.no/forskning/forskningsprosjekter-vi-stotter/notter-kan-redusere-kreft-med-spredning-til-hjernen/?utm_source=apsis-anp-3&utm_medium=email&utm_content=unspecified&utm_campaign=01.%20juli).

2.  Nøtter kan redusere kreft med spredning til hjernen.University of Bergen web site, July 1, 2015 (In Norwegian). (http://www.uib.no/aktuelt/89958/n%C3%B8tter-kan-redusere-kreft-med-spredning-til-hjernen).

3.  Forsker: Jeg trodde det var for godt til å være sant. Bergens Tidende, July 2, 2015 (In Norwegian). (http://www.bt.no/nyheter/lokalt/--Jeg-har-ikke-sett-lignende-i-mine-20-ar-som-forsker-3393563.html).

4.     Nøttestoff reduserte kreft i musehjerner. Forskning.no, July 25, 2015 (In Norwegian). https://forskning.no/2015/07/nottestoff-reduserte-kreft-i-musehjerner

5.    Frits Thorsen in Bergens Tidende: Exciting findings in preventing metastatic spreading. http://www.uib.no/en/rg/mic/90150/frits-thorsen-bergens-tidende-exciting-findings-preventing-metastatic-spreading   

6.   207 millioner til kreftforskning. Kreftforeningen (blog), Oct 27, 2015 (In Norwegian). (http://www.kreftforeningens-blogg.no/2015/10/207-millioner-til-kreftforskning/)

7.   30 millioner til kreftforskning. University of Bergen web site, Nov 1, 2016 (In Norwegian). http://www.uib.no/mofa/102056/30-millioner-til-kreftforskning

8.   Slik jobber 100 forskere i Bergen hver dag for å løse kreftgåten. Bergens Tidende, July 22, 2017 (In Norwegian). https://www.bt.no/btmagasinet/i/voqmV/Bruker-designermus-for-a-lose-kreftgaten?utm_campaign=Echobox&utm_medium=Social&utm_source=Facebook#link_time=1500704688

9.   Fikk kinesisk æresprofessorat. På Høyden, October 31, 2018 (In Norwegian). http://pahoyden.no/2018/10/fikk-kinesisk-aeresprofessorat

1989-2002 Underviser for medisinsk personell om strålehygiene, Haukeland Universitetssykehus, Bergen.

1991-1994 Timelærer i Apparatlære, ved Radiografhøgskolen i Bergen.

1993-2006 Opplæring av sykehuspersonell i bruk av Strålekniven (Elekta Instrument AB, Stockholm, Sverige).

2004-2017 Foreleser i histologi og anatomi, Institutt for biomedisin, UiB.

2008-2019 Invitert foredragsholder ved 18 kreftkonferanser (Prague, Turku, Oulu, Kranjska Gora, Travemünde, Davis CA, Frankfurt, Turin, Chicago, Marseille, Copenhagen, Mannheim, Qingdao, Boston, Jinan, Bergen).

 

Tidsskriftartikler
  • Baghirov, Habib; Snipstad, Sofie; Sulheim, Einar; Berg, Sigrid; Hansen, Rune; Thorsen, Frits; Mørch, Ýrr Asbjørg; Davies, Catharina de Lange; Åslund, Andreas. 2018. Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model. PLoS ONE. 13. 18 sider. doi: 10.1371/journal.pone.0191102
  • Wang, Jiwei; Qi, Qichao; Zhou, Wenjing; Feng, Zichao; Huang, Bin; Chen, Anjing; Zhang, Di; Li, Wenjie; Zhang, Qing; Jiang, Zheng; Bjerkvig, Rolf; Prestegarden, Lars; Thorsen, Frits; Wang, Xinyu; Li, Xingang; Wang, Jian. 2018. Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. Autophagy. 14: 2007-2022. doi: 10.1080/15548627.2018.1501133
  • Zeiner, PS; Zinke, Jens; Kowalewski, DJ; Bernatz, S; Tichy, J; Ronellenfitsch, MW; Thorsen, Frits; Berger, A.; Forster, Marie Thérèse; Muller, A; Steinbach, Joachim P.; Beschorner, Rudi; Wischhusen, J; Kvasnicka, HM; Plate, KH; Stefanovic, Sasha; Weide, Benjamin; Mittelbronn, Michel; Harter, Patrick N. 2018. CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival. Acta neuropathologica communications. 6: 18. doi: 10.1186/s40478-018-0521-5
  • Talasila, Krishna Mukharji; Røsland, Gro Vatne; Hagland, Hanne Røland; Eskilsson, Eskil; Flønes, Irene Hana; Fritah, Sabrina; Azuaje, Francisco; Atai, Nadia A; Harter, Patrick N.; Mittelbronn, Michel; Andersen, Michael Borenste; Vareecal Joseph, Justin; Hossain, Jubayer; Vallar, Laurent; van Noorden, Cornelis J.F.; Niclou, Simone Pierrette; Thorsen, Frits; Tronstad, Karl Johan; Tzoulis, Charalampos; Bjerkvig, Rolf; Miletic, Hrvoje. 2017. The angiogenic switch leads to a metabolic shift in human glioblastoma. Neuro-Oncology. 19: 383-393. doi: 10.1093/neuonc/now175
  • Zhang, Xin; Xu, Ran; Zhang, Chao; Xu, Yangyang; Han, Mingzhi; Huang, Bin; Chen, Anjing; Qiu, Chen; Thorsen, Frits; Prestegarden, Lars; Bjerkvig, Rolf; Wang, Jian; Li, Xingang. 2017. Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination. Journal of Experimental & Clinical Cancer Research. 36:118: 1-13. doi: 10.1186/s13046-017-0588-z
  • Ilhan-Mutlu, Aysegül; Osswald, Matthias; Liao, Yunxiang; Gömmel, Miriam; Reck, Martin; Miles, David; Mariani, Paola; Gianni, Luca; Lutiger, Beatrix; Nendel, Viktor; Srock, Stefanie; Perez-Moreno, Pablo; Thorsen, Frits; Von Baumgarten, Louisa; Preusser, Matthias; Wick, Wolfgang; Winkler, Frank. 2016. Bevacizumab prevents brain metastases formation in lung adenocarcinoma. Molecular Cancer Therapeutics. 15: 702-710. doi: 10.1158/1535-7163.MCT-15-0582
  • Aasen, Synnøve Nymark; Pospíšilová, Aneta; Eichler, Tilo Wolf; Pánek, Jiří; Hrubý, Martin; Štěpánek, Petr; Spriet, Endy; Jirák, Daniel; Skaftnesmo, Kai Ove; Thorsen, Frits. 2015. A novel nanoprobe for multimodal imaging is effectively incorporated into human melanoma metastatic cell lines. International Journal of Molecular Sciences. 16: 21658-21680. doi: 10.3390/ijms160921658
  • Sundstrøm, Terje; Espedal, Heidi; Harter, Patrick N.; Fasmer, Kristine Eldevik; Skaftnesmo, Kai Ove; Horn, Sindre August; Hodneland, Erlend; Mittelbronn, Michel; Weide, Benjamin; Beschorner, Rudi; Bender, Benjamin; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Bjerkvig, Rolf; Thorsen, Frits. 2015. Melanoma brain metastasis is independent of lactate dehydrogenase A expression. Neuro-Oncology. 17: 1374-1385. doi: 10.1093/neuonc/nov040
  • Brekke, Cecilie; Wang, Jian; Thuen, Marte; Gras Navarro, Andrea; Huuse-Røneid, Else Marie; Thorsen, Frits Alan; Poli, Aurélie; Zimmer, Jacques; Haraldseth, Olav; Lie, Stein Atle; Enger, Per Øyvind; Chekenya, Martha. 2014. Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma. PLoS ONE. 9. doi: 10.1371/journal.pone.0108414
  • Daphu, Inderjit Kaur; Horn, Sindre August; Stieber, Daniel; Varughese, Jobin K.; Spriet, Endy; Dale, Hege Avsnes; Skaftnesmo, Kai Ove; Bjerkvig, Rolf; Thorsen, Frits Alan. 2014. In vitro treatment of melanoma brain metastasis by simultaneously targeting the MAPK and PI3K signaling pathways. International Journal of Molecular Sciences. 15: 8773-8794. doi: 10.3390/ijms15058773
  • Keunen, Olivier; Taxt, Torfinn; Grüner, Ragna Elisabeth; Lund-Johansen, Morten; Tonn, J.-C.; Pavlin, Tina; Bjerkvig, Rolf; Niclou, Simone; Thorsen, Frits Alan. 2014. Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies. Advanced Drug Delivery Reviews. 76: 98-115. doi: 10.1016/j.addr.2014.07.010
  • Rygh, Cecilie Brekke; Wang, Jian; Thuen, Marte; Navarro, Andrea Gras; Huuse, Else Marie; Thorsen, Frits; Poli, Aurélie; Zimmer, J.; Haraldseth, Olav; Lie, Stein Atle; Enger, Per Øyvind; Chekenya, Martha. 2014. Dynamic Contrast Enhanced MRI Detects Early Response to Adoptive NK Cellular Immunotherapy Targeting the NG2 Proteoglycan in a Rat Model of Glioblastoma. PLoS ONE. 9. 12 sider. Publisert 2014-09-30. doi: 10.1371
  • Daphu, Inderjit Kaur; Sundstrøm, Terje; Horn, Sindre August; Huszthy, Peter Csaba; Niclou, Simone P; Sakariassen, Per Øystein; Immervoll, Heike; Miletic, Hrvoje; Bjerkvig, Rolf; Thorsen, Frits Alan. 2013. In vivo animal models for studying brain metastasis: value and limitations. Clinical and Experimental Metastasis. 30: 695-710. Publisert 2013-01-16. doi: 10.1007/s10585-013-9566-9
  • Lillefosse, Haldis Haukås; Tastesen, Hanne Sørup; Du, Zhen-yu; Ditlev, Ditte B.; Thorsen, Frits Alan; Madsen, Lise; Kristiansen, Karsten; Liaset, Bjørn. 2013. Hydrolyzed casein reduces diet-induced obesity in male C57BL/6J mice. Journal of Nutrition. 143: 1367-1375. doi: 10.3945/jn.112.170415
  • Poli, Aurélie; Wang, Jian; Domingues, Olivia; Planaguma, Jesus; Yan, Tao; Brekke, Cecilie; Skaftnesmo, Kai Ove; Thorsen, Frits Alan; McCormack, Emmet; Hentges, François; Pedersen, Paal-Henning; Zimmer, Jacques; Enger, Per Øyvind; Chekenya, Martha. 2013. Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival. OncoTarget. 4: 1527-1546.
  • Qin, SP; Fite, BZ; Gagnon, KG; Seo, JW; Curry, F; Thorsen, Frits Alan; Ferrara, KW. 2013. A physiological perspective on the use of imaging to assess the in vivo delivery of therapeutics. Annals of Biomedical Engineering. doi: 10.1007/s10439-013-0895-2
  • Sundstrøm, Terje; Daphu, Inderjit Kaur; Wendelbo, Ingvild Haukaas; Hodneland, Erlend; Lundervold, Arvid; Immervoll, Heike; Skaftnesmo, Kai Ove; Babic, Michal; Jendelova, Pavla; Sykova, Eva; Lund-Johansen, Morten; Bjerkvig, Rolf; Thorsen, Frits Alan. 2013. Automated tracking of nanoparticle-labeled melanoma cells improves the predictive power of a brain metastasis model. Cancer Research. 73: 2445-2456. Publisert 2013-04-15. doi: 10.1158/0008-5472.CAN-12-3514
  • Sundstrøm, Terje; Varughese, Jobin K.; Harter, Patrick; Prestegarden, Lars; Petersen, Kjell; Azuaje, Fransisco; Tepper, Clifford; Ingham, Elizabeth; Even, Lisa; Johnson, Sarah; Skaftnesmo, Kai Ove; Lund-Johansen, Morten; Bjerkvig, Rolf; Ferrara, Katherine W.; Thorsen, Frits Alan. 2013. BRAIN-SPECIFIC GENE SIGNATURE OF MELANOMA METASTASIS. Neuro-Oncology. 15: 27-27.
  • Thorsen, Frits Alan; Fite, B; Mahakian, Lisa M.; Seo, Jai W.; Qin, Shengping; Harrison, Victoria; Sundstrøm, Terje; Harter, P; Johnson, Sarah; Ingham, Elizabeth; Caskey, Charles; Meade, Thomas J.; Skaftnesmo, Kai Ove; Ferrara, Katherine W. 2013. EARLY TUMOR DETECTION AND CHARACTERIZATION OF CHANGES IN TUMOR PERMEABILITY OF BRAINMETASTASES USING MULTIMODAL IMAGING. Neuro-Oncology. 15: 241-241.
  • Thorsen, Frits Alan; Fite, Brett; Mahakian, Lisa M.; Seo, Jai W.; Qin, Shengping; Victoria, Harrison; Johnson, Sarah; Ingham, Elizabeth; Caskey, Charles; Sundstrøm, Terje; Meade, Thomas J.; Harter, Patrick; Skaftnesmo, Kai Ove; Ferrara, Katherine W. 2013. Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases. Journal of Controlled Release. 172: 812-822. Publisert 2013-10-28. doi: 10.1016/j.jconrel.2013.10.019
  • Brekke, Cecilie; Thuen, Marte; Poli, Aurélie; Wang, Jian; Lokka, Guro; Huuse, Else Marie; Thorsen, Frits Alan; Enger, Per Øyvind; Chekenya, Martha. 2012. Early MRI findings of targeting the NG2 proteoglycan in GBM. The FASEB Journal. 26. 1 sider.
  • Huszthy, Peter Csaba; Daphu, Inderjit Kaur; Niclou, Simone P; Stieber, Daniel; Nigro, Janice Marie; Sakariassen, Per Øystein; Miletic, Hrvoje; Thorsen, Frits Alan; Bjerkvig, Rolf. 2012. In vivo models of primary brain tumors: pitfalls and perspectives. Neuro-Oncology. 14: 979-993. doi: 10.1093/neuonc/nos135
  • Skeie, Bente; Enger, Per Øyvind; Brøgger, Jan C; Ganz, Jeremy Christopher; Thorsen, Frits Alan; Heggdal, Jan Ingemann; Pedersen, Paal-Henning. 2012. Gamma knife surgery versus reoperation for recurrent glioblastoma multiforme. World Neurosurgery. 78: 658-669. doi: 10.1016/j.wneu.2012.03.024
  • Viel, Thomas; Talasila, Krishna Mukharji; Monfared, Parisa; Wang, Jian; Jikeli, Jan F.; Waerzeggers, Yannic; Neumaier, Bernd; Backes, Heiko; Brekkå, Narve; Thorsen, Frits Alan; Stieber, Daniel; Niclou, Simone P; Winkeler, Alexandra; Tavitian, Bertrand; Hoehn, Mathias; Bjerkvig, Rolf; Miletic, Hrvoje; Jacobs, Andreas Hans. 2012. Analysis of the growth dynamics of angiogenesis-dependent and -independent experimental glioblastomas by multimodal small-animal PET and MRI. Journal of Nuclear Medicine. 53: 1135-1145. doi: 10.2967/jnumed.111.101659
  • Daphu, Inderjit Kaur; Immervoll, Heike; Bjerkvig, Rolf; Thorsen, Frits Alan. 2011. A novel and clinically relevant mouse model reflecting the disease progression in melanoma brain metastasis in patients. Clinical and Experimental Metastasis. 28: 238-238.
  • Daphu, Inderjit Kaur; Immervoll, Heike; Wendelbo, Ingvild Haukaas; Bjerkvig, Rolf; Thorsen, Frits Alan. 2011. Molecular imaging and genetic studies reveal selective homing of human brain metastatic cells to various organs in NOD/SCID mice. Clinical and Experimental Metastasis. 28: 194-194.
  • Jacobsen, Hege; Dicko, Aly; Wang, Jian; Storli, Kristian Eeg; Leh, Sabine; Thorsen, Frits Alan; Pavlin, Tina; Sondenaa, Karl; Gullberg, Donald; Bjerkvig, Rolf; Enger, Per Øyvind. 2011. Separate analysis of the cancer and stroma cell populations from orthotopically implanted tumor biopsies in eGFP scid mice. Clinical and Experimental Metastasis. 28: 203-203.
  • Ke, Xisong; Li, Wencheng; Hovland, Randi; Qu, Yi; Liu, Run-hui; McCormack, Emmet Martin; Thorsen, Frits Alan; Olsen, Jan Roger; Molven, Anders; Kogan-Sakin, Ira; Rotter, Varda; Akslen, Lars A.; Øyan, Anne Margrete; Kalland, Karl-Henning. 2011. Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model. Experimental Cell Research. 317: 234-247. doi: 10.1016/j.yexcr.2010.10.009
  • Keunen, Olivier; Johansson, Mikael; Oudin, Anaîs; Sanzey, Morgane; Rahim, Siti A. Abdul; Fack, Fred; Thorsen, Frits Alan; Taxt, Torfinn; Bartos, Michael; Jirík, Radovan; Miletic, Hrvoje; Wang, Jian; Stieber, Daniel; Stuhr, Linda Elin Birkhaug; Moen, Ingrid; Brekke, Cecilie; Bjerkvig, Rolf; Niclou, Simone P. 2011. Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proceedings of the National Academy of Sciences of the United States of America. 108: 3749-3754. doi: 10.1073/pnas.1014480108
  • Szczepanski, C; Bjerkvig, Rolf; Tenstad, Olav; Thorsen, Frits Alan; Wendelbo, Ingvild Haukaas; Martinez, Aurora; Baumann, Anne; Prestegarden, Lars. 2011. Treatment of Solid Cancers Using a New Cationic Cytolytic Peptide. European Journal of Cancer. 47: S148-S148.
  • Thorsen, Frits Alan. 2011. MRI of experimental gliomas. Methods in Molecular Biology. 711: 451-471. doi: 10.1007/978-1-61737-992-5_23
  • Wang, Jian; Daphu, Inderjit Kaur; Pedersen, Paal-Henning; Miletic, Hrvoje; Hovland, Randi; Mørk, Sverre; Bjerkvig, Rolf; Tiron, Crina Elena; McCormack, Emmet Martin; Micklem, David Robert; Lorens, James; Immervoll, Heike; Thorsen, Frits Alan. 2011. A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients. Neuropathology and Applied Neurobiology. 37: 189-205. doi: 10.1111/j.1365-2990.2010.01119.x
  • Chekenya, Martha; Wang, Jian; Poli, A; Thuen, Marte; Brekke, Cecilie; Thorsen, Frits Alan; Zimmer, J; Enger, Per Øyvind. 2010. THERAPEUTIC TARGETING OF THE NG2 PROTEOGLYCAN WITH MAB 9.2.27 AND ADOPTIVELY TRANSFERRED NK CELLS LYSES HUMAN GLIOBLASTOMA MULTIFORME IN VIVO. Neuro-Oncology. 12: 9-9.
  • Curry, Fitz-Roy E.; Brekke, Cecilie; Karlsen, Tine Veronica; Wiig, Helge; Adamson, RH; Clark, Joyce F.; Lin, Yueh-Chen; Gassner, Birgit; Thorsen, Frits Alan; Moen, Ingrid; Tenstad, Olav; Kuhn, Michaela; Reed, Rolf K. 2010. Atrial natriuretic peptide modulation of albumin clearance and contrast agent permeability in mouse skeletal muscle and skin: role in regulation of plasma volume. Journal of Physiology. 588: 325-339. doi: 10.1113/jphysiol.2009.180463
  • Daphu, Inderjit Kaur; Immervoll, Heike; Bjerkvig, Rolf; Thorsen, Frits Alan. 2010. A NOVEL PATIENT MELANOMA BRAIN METASTASIS MODEL DEVELOPED IN NOD-SCID MICE REFLECTS THE CLINICAL METASTATIC DISEASE PROGRESSION IN PATIENTS. Neuro-Oncology. 12: 135-136.
  • Enger, Per Øyvind; Skeie, Geir Olve; Thorsen, Frits Alan; Pedersen, Paal-Henning; Skeie, Bente. 2010. Gamma knife surgery of meningiomas involving the cavernous sinus: long-term follow-up of 100 patients. Neurosurgery. 66: 661-669. doi: 10.1227/01.NEU.0000366112.04015.E2
  • Niclou, SP; Johansson, Mikael; Keunen, O; Wang, Jian; Thorsen, Frits Alan; Bjerkvig, Rolf. 2009. PHENOTYPIC AND PHYSIOLOGIC EFFECTS OF BEVACIZUMAB IN A HIGHLY INFILTRATIVE AND ANGIOGENIC HUMAN GLIOBLASTOMA MODEL. Neuro-Oncology. 11: 906-906.
  • Torkildsen, Øivind Fredvik; Brunborg, Linn Anne; Thorsen, Frits Alan; Mørk, Sverre; Stangel, Martin; Myhr, Kjell-Morten; Bø, Lars. 2009. Effects of dietary intervention on MRI activity, de- and remyelination in the cuprizone model for demyelination. Experimental Neurology. 215: 160-166. doi: 10.1016/j.expneurol.2008.09.026
  • Vik-Mo, Einar Osland; Øksnes, Marianne; Pedersen, Paal-Henning; Wentzel-Larsen, Tore; Rødahl, Eyvind; Thorsen, Frits Alan; Schreiner, Thomas; Aanderud, Sylvi; Lund-Johansen, Morten. 2009. Gamma knife stereotactic radiosurgery of Nelson syndrome. European Journal of Endocrinology. 160: 143-148. doi: 10.1530/EJE-08-0687
  • Huszthy, Peter Csaba; Goplen, Dorota; Thorsen, Frits Alan; Immervoll, Heike; Wang, Jian; Gutermann, Anja; Miletic, Hrvoje; Bjerkvig, Rolf. 2008. Oncolytic herpes simplex virus type-1 therapy in a highly infiltrative animal model of human glioblastoma. Clinical Cancer Research. 14: 1571-1580. doi: 10.1158/1078-0432.CCR-07-2000
  • Thorsen, Frits Alan; Daphu, Inderjit Kaur; Pedersen, Paal-Henning; Wang, Jian; Miletic, Hrvoje; Bjerkvig, Rolf. 2008. DEVELOPMENT OF A NEW BRAIN METASTASES MODEL IN IMMUNODEFICIENT ANIMALS. Neuro-Oncology. 10: 854-854.
  • Thorsen, Frits Alan; Jirak, Daniel; Wang, Jian; Sykova, Eva; Bjerkvig, Rolf; Enger, Per Øyvind; van der Kogel, Albert; Hajek, Milan. 2008. Two distinct tumor phenotypes isolated from glioblastomas show different MRS characteristics. NMR in Biomedicine. 21: 830-838. Publisert 2008-10-21. doi: 10.1002/nbm.1263
  • Wang, Jian; Sakariassen, Per Øystein; Tsinkalovsky, Oleg; Immervoll, Heike; Bøe, Stig Ove; Svendsen, Agnete; Prestegarden, Lars; Røsland, Gro Vatne; Thorsen, Frits Alan; Stuhr, Linda Elin Birkhaug; Molven, Anders; Bjerkvig, Rolf; Enger, Per Øyvind. 2008. CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. International Journal of Cancer. 122: 761-768. doi: 10.1002/ijc.23130
  • Brekke, Cecilie; Williams, SC; Price, J; Thorsen, Frits Alan; Modo, M. 2007. Cellular multiparametric MRI of neural stem cell therapy in a rat glioma model. NeuroImage. 37: 769-782. doi: 10.1016/j.neuroimage.2007.06.006
  • Eikefjord, Eli N.; Thorsen, Frits Alan; Rørvik, Jarle. 2007. Comparison of effective radiation doses in patients undergoing unenhanced MDCT and excretory urography for acute flank pain. American Journal of Roentgenology. 188: 934-939. doi: 10.2214/AJR.06.0676
  • Thorsen, Frits Alan; Enger, Per Øyvind; Wang, Jian; Bjerkvig, Rolf; Pedersen, PH. 2007. Human glioblastoma biopsy spheroids xenografted into the nude rat brain show growth inhibition after stereotactic radiosurgery. Journal of Neuro-Oncology. 82: 1-10. doi: 10.1007/s11060-006-9240-z
  • Vik-Mo, Einar O; Øksnes, Marianne; Pedersen, Paal-Henning; Wentzel-Larsen, Tore; Rødahl, Eyvind; Thorsen, Frits Alan; Schreiner, Thomas; Aanderud, Sylvi; Lund-Johansen, Morten. 2007. Gamma knife stereotactic radiosurgery for acromegaly. European Journal of Endocrinology. 157: 255-263. doi: 10.1530/EJE-07-0189
  • Huszthy, Peter Csaba; Brekken, Christian; Pedersen, Tina Bugge; Thorsen, Frits Alan; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Haraldseth, Olav; Lønning, Per Eystein; Lonning, PE; Bjerkvig, Rolf; Enger, Per Øyvind. 2006. Antitumor efficacy improved by local delivery of species-specific endostatin. Journal of Neurosurgery. 104: 118-128.
  • Thorsen, Frits Alan; Afione, Sandra; Huszthy, Peter Csaba; Tysnes, Berit Bølge; Svendsen, Agnete; Bjerkvig, Rolf; Kotin, Robert M.; Lønning, Per Eystein; Hoover, Frank. 2006. Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma. Journal of Gene Medicine. 8: 1131-1140. doi: 10.1002/jgm.939
Rapporter/avhandlinger
  • Horn, Sindre August; Thorsen, Frits. 2014. In Vitro Treatment of Melanoma Brain Metastasis by Simultaneously Targeting the MAPK and PI3K Signaling Pathways. Open Access Journals Platform, International Journal of Molecular Sciences. 22 sider.

Se fullstendig oversikt over publikasjoner i CRIStin.

Publikasjoner 2013-2019

1.    Sundstrøm T, Prestegarden L, Azuaje F, Røsland GV, Varughese JK, Aasen SN, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Inghem ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Bjerkvig R, Thorsen F. Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Comm 7:55, Apr 10, 2019. 

2.    Bjerkvig R, Thorsen F. Glioblastoma: a prognostic value of AMT-PET? Neuro-Oncol 21(2):146-147, 2019. 

3.    Wang J, Qi Q, Zhou W, Feng Z, Huang B, Chen A, Zhang D, Li W, Zhang Q, Bjerkvig R, Prestegarden L, Thorsen F, Li X, Wang J. Inhibition of glioma growth by flavokawain B is mediated through endoplasmatic reticulum stress induced autophagy. Autophagy 2018 Jul 19. doi: 10.1080/15548627.2018.1501133. 

4.   Zeiner PS, Zinke J, Kowalewski DJ, Bernatz S, Tichy J, Ronellenfitsch MW, Thorsen F, Berger A, Forster MT, Muller A, Steinbach JP, Beschorner R, Wischhusen J, Kvasnicka HM, Plate KH, Stefanovic S, Weide B, Mittelbronn M, Harter PN. CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival. Acta Neuropathol Comm 6:18, https://doi.org/10.1186/s40478-018-0521-5, 2018. 

5.    Baghirov H, Snipstad S, Sulheim E, Berg S, Hansen R, Thorsen F, Mørch Y, de Lange Davies C, Åslund ÅKO. Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model. PLoS ONE, 13(1):e0191102, 2018. 

6.    Zhang X, Xu R, Zhang C, Xu Y, Han M, Huang B, Chen A, Qiu C, Thorsen F, Prestegarden L, Bjerkvig R, Wang J, Li XG. Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination. J Exp Clin Cancer Res 36(1):118.doi:10.1186/s13046-017-0588-z, 2017. 

7.    Talasila KM, Røsland G, Hagland H, Eskilsson E, Tran GT, Fritah S, Azuaje F, Atai N, Harter P, Mittelbronn M, Anderson M, van Noorden R, Niclou SP, Thorsen F, Tronstad KJ, Tzoulis C, Bjerkvig R, Miletic H. The angiogenic switch leads to a metabolic switch in human glioblastoma. Neuro-Oncol Sep 19(3):383-393, 2017. 

8.    Ilhan-Mutlu A, Osswald M, Liao Y, Gömmel M, Reck M, Miles D, Mariani P, Gianni L, Lutiger B, Nendel V, Srock S, Perez-Moreno P, Thorsen F, von Baumgarten L, Preusser M, Wick W, Winkler F. Bevacizumab prevents brain metastases formation in lung adenocarcinoma. Mol Cancer Ther Jan 25, 15(4):702-710, 2016. 

9.    Aasen SN, Pospisilova A, Eichler T, Panek J, Hruby M, Stepanek P, Spriet E, Jirak D, Skaftnesmo KO, Thorsen F. A novel nanoprobe for visualisation of melanoma metastatic cells by fluorescence and MRI. Int J Mol Sci 16:21658-21680, 2015. 

10.  Sundstrøm T, Espedal H, Harter P, Fasmer KE, Skaftnesmo KO, Horn S, Hodneland E, Mittelbronn M, Weide B, Beschorner R, Bendner B, Rygh CB, Lund-Johansen M, Bjerkvig R, Thorsen F. Melanoma brain metastasis is independent on LDHA expression. Neuro-Oncol 17:1374-1385, 2015. 

11.  Keunen O, Taxt T, Tonn JC, Grüner R, Lund-Johansen M, Pavlin T, Bjerkvig R, Niclou S, Thorsen F. Multimodal imaging of gliomas in the context of cellular and molecular therapies. Adv Drug Deliv Rev 76:98-115, 2014.

12.  Rygh, CB, Wang J, Thuen M, Gras-Navarro A, Huuse EM, Thorsen F, Poli A, Zimmer J, Haraldseth O, Lie SA, Enger PØ, Chekenya M. Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma. PLoS ONE 2014 9(9):e108414. 

13.  Daphu I, Horn S, Stieber D, Varughese J, Skaftnesmo KO, Bjerkvig R, Thorsen F. In vitro treatment of melanoma brain metastasis by simultaneously targeting the MAPK and PI3K signaling pathways. Int J Mol Sci 15:8773-8794, 2014. 

14.  Qin SP, Fite BZ, Gagnon KG, Seo JW, Curry F, Thorsen F, Ferrara KW. A physiological perspective on the use of imaging to assess the in vivo delivery of therapeutics. Ann Biomed Eng 42(2):280-298, 2014. 

15.  Thorsen F, Fite B, Mahakian L, Seo JW, Qin SP, Harrison V, Johnson S, Ingham E, Meade T, Caskey C, Sundstrøm T, Meade T, Harter PN, Skaftnesmo KO, Ferrara KW. Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases. J Control Release 172:812-822, 2013. 

16.  Poli A, Wang J, Domingues O, Planagumá J, Yan T, Rygh CB, Skaftnesmo KO, Thorsen F, McCormack E, Hentges F, Pedersen PH, Zimmer J, Enger PO, Chekenya M. Targeting glioblastoma with NK-cells and mAb against NG2/CSPG4 prolongs animal survival. Oncotarget 4(9):1527-1546, 2013. 

17.  Lillefosse HH, Tastesen HS, Du ZY, Ditlev DB, Thorsen F, Madsen L, Kristiansen K, Liaset B. Hydrolyzed casein reduces diet-induced obesity in male C57BL/6J mice. J Nutr 143(9):1367-1375, 2013.

18.  Sundstrøm T,  Daphu I, Wendelbo I, Hodneland E, Lundervoll A, Immervoll H, Skaftnesmo KO, Babic M, Jendelova P, Sykova E, Lund-Johansen M, Bjerkvig R, Thorsen F. Quantitative tracking of nanoparticle labeled melanoma cells improves the predictive power of an experimental brain metastasis model. Cancer Res 73(8):2445-2456, 2013.

19.  Daphu I, Sundstrøm T, Huszthy PC, Niclou SP, Sakariassen P, Immervoll H, Miletic H, Bjerkvig R, Thorsen F. In vivo animal models for studying brain metastasis: value and limitations. Clin Exp Metastasis 30:695-710, 2013. 

Forskningsveiledning:

2000-2019 Hovedveileder 3 Post Docs, 10 PhD studenter (5 - hovedveileder, 5 - biveileder), Hovedveileder 11 Master studenter, Institutt for Biomedisin, UiB

2014-2015 Biveileder 1 Master student, Universitetet i Algarve, Portugal

2004          Hovedveileder 1 Sivilingeniør, NTNU, Trondheim

2003-2005 Biveileder 1 Master student, Høgskolen på Vestlandet, Bergen

2014-2019 Hovedveileder 6 Forskerlinjestudenter, Det Medisinske Fakultet, UiB

1997          Hovedveileder 2 radiografistudenter,  Høgskolen på Vestlandet, Bergen

1996-1999 Biveileder 1 Master student, Universitetet i Trondheim

Arbeidserfaring:

1989-1995 Haukeland Sykehus. Medisinsk Fysiker, Overingeniør.

1991-1994 Timelærer i Apparatlære, Radiografhøgskolen i Bergen.

1993-2006 Elekta Instrument AB. Medisinsk konsulent.

1995- 1998 Universitetet i Bergen. Stipendiat.

1998-2004 Haukeland Universitetssykehus. Medisinsk Fysiker, Sjefingeniør.    

2000-2002 Institutt for Anatomi og Cellebiologi. Forsker (Post. doc.).                    

2004-2008 UNIFOB AS. Vitenskapelig Prosjektleder. 

2008-2010 Institutt for Biomedisin, UiB. Førsteamanuensis.

2010-2019 Institutt for Biomedisin, UiB. Professor.

2019-2021 Shandong University, Jinan, Kina. Professor.                             

Utdannelse:

1989 Cand Mag i fysikk, matematikk og data, Universitetet i Trondheim.

1989 Cand Scient i biofysikk, Universitetet i Trondheim.

1998 Dr Scient, Institutt for Anatomi og Cellebiologi, Universitetet i Bergen.

Kurs:

1990 Bedriftspedagogisk senter. Presentasjonsteknikk og kommunikasjon.  

1994 Elektrisitetstilsynet. Godkjenning for å reparere elektromedisinsk utstyr.

1998 Hewlett Packard, Oslo. Sluttbrukerkurs i Unix operativsystem.

1998 Universitetet i Bergen. Påbyggingsseminarer i forsøksdyrlære.

1999 Haukeland Sykehus. Prosjektledelse.

2000 Advanced Visualization System. Introduksjon i AVS programmering.

2004 Hyperion Ltd (Ressurssenteret,Bergen). How to negotiate, manage, administer and finish an EU Contract.

2006 Psykologisk Fakultet, UiB. Basismodul i universitetespedagogikk.

2007 Psykologisk Fakultet, UiB. Forskningsveiledning.

2007-09 UNIFOB AS, Bergen. Utviklingsprogram for Forskningsledere.

2018 UiB PhD-veileder kurs bestått 31.07.2018.

2018  Begynnerkurs i Kinesisk-Mandarin (Mandarin nivå A1, del 1 og 2).