Hjem
Frits Alan Thorsens bilde

Frits Alan Thorsen

Professor, Plattformleder Molecular Imaging Center
  • E-postFrits.Thorsen@uib.no
  • Telefon+47 55 58 62 72+47 957 49 681
  • Besøksadresse
    Jonas Lies vei 91
  • Postadresse
    Postboks 7804
    5020 Bergen

Bakgrunn

Omtrent 1/3 av alle kreftpasienter får spredning av kreften til hjernen (hjernemetastaser), og metastaser til hjernen er 10 ganger mer vanlig enn kreft som oppstår i hjernen. De mest vanlige krefttypene som sprer seg til hjernen, er lungekreft (50-60%), brystkreft (15-20%), hudkreft (5-10%), og kreft i mage/tarm (4-6%).

Kreftpasienter med hjernemetastaser har en dårlig prognose, og dagens kreftbehandling øker ikke pasientoverlevelsen nevneverdig. Det er derfor nødvendig med forskning for å kunne finne nye behandlingsmetoder, og i denne sammenheng er det behov for gode modeller for å kunne forstå metastaseringsprosessen bedre. Vår gruppe har i mange år utviklet nye dyremodeller, som gjør oss i stand til å forstå biologien bak kreftspredningen, og utvikle nye behandlingsmetoder.

Utvikling av nye dyremodeller for å studere kreftspredning til hjernen

Vi injiserer kreftceller fra humane hjernemetastaser direkte inn i blodstrømmen på immundefekte mus. Vi ser da at cellene sprer seg til dyrehjernen, på samme måte som man observerer i pasienten. Disse modellene rekapitulerer de ulike stegene i kreftspredningsprosessen, og gjør oss i stand til å effektivt kunne teste ut nye behandlingsalternativer.

Pågående forskningsaktiviteter

Vår forskning fokuserer på 3 ulike angrepsmåter:

Vi har utført genetiske studier av kreftspredningen i våre dyremodeller, og bestemt en gensignatur for hjernemetastaser fra hudkreft. På bakgrunn av disse dataene har vi funnet flere ulike medikamenter, idag i bruk på andre sykdommer enn kreft, som viser seg å hemme veksten av hudkreft i hjernen.

Vi studerer blod-hjerne barrieren (BBB), som blokkerer medikamenter fra å trenge inn i hjernen, og dermed hindrer effektiv behandling. I et forskningsprosjekt har vi vært istand til å åpne BBB på forsøksdyr, og dermed oppnå god effekt av behandlingen.

For tiden studerer vi betydningen av såkalte exosomer i spredningen av hjernekreft. Vi har lovende data som viser at mikro-RNA levert til hjernen av exosomene, øker kreftspredningen. Vi har greidd å hemme denne spredningen ved å genetisk blokkere enkelte mikro-RNA til hjernen.

POPULÆRVITENSKAPELIGE ARTIKLER

1.   Mottok kinesiske forskningsmidler. Medical Faculty web site, University of Bergen, October 2, 2020 (In Norwegian). https://www.uib.no/med/139047/mottok-kinesiske-forskningsmidler

2.   Fikk kinesisk æresprofessorat. På Høyden, October 31, 2018 (In Norwegian). http://pahoyden.no/2018/10/fikk-kinesisk-aeresprofessorat

3.   Slik jobber 100 forskere i Bergen hver dag for å løse kreftgåten. Bergens Tidende, July 22, 2017 (In Norwegian). https://www.bt.no/btmagasinet/i/voqmV/Bruker-designermus-for-a-lose-kreftgaten?utm_campaign=Echobox&utm_medium=Social&utm_source=Facebook#link_time=1500704688

4.   30 millioner til kreftforskning. University of Bergen web site, Nov 1, 2016 (In Norwegian). http://www.uib.no/mofa/102056/30-millioner-til-kreftforskning

5.   207 millioner til kreftforskning. Kreftforeningen (blog), Oct 27, 2015 (In Norwegian). (http://www.kreftforeningens-blogg.no/2015/10/207-millioner-til-kreftforskning/ )

6.     Nøttestoff reduserte kreft i musehjerner. Forskning.no, July 25, 2015 (In Norwegian). https://forskning.no/2015/07/nottestoff-reduserte-kreft-i-musehjerner

7.   Forsker: Jeg trodde det var for godt til å være sant. Bergens Tidende, July 2, 2015 (In Norwegian). (http://www.bt.no/nyheter/lokalt/--Jeg-har-ikke-sett-lignende-i-mine-20-ar-som-forsker-3393563.html ).

8.   Nøtter kan redusere kreft med spredning til hjernen. Kreftforeningen.no, July 1, 2015 (In Norwegian). (https://kreftforeningen.no/forskning/forskningsprosjekter-vi-stotter/notter-kan-redusere-kreft-med-spredning-til-hjernen/?utm_source=apsis-anp-3&utm_medium=email&utm_content=unspecified&utm_campaign=01.%20juli ).

9.   Nøtter kan redusere kreft med spredning til hjernen. University of Bergen web site, July 1, 2015 (In Norwegian). (http://www.uib.no/aktuelt/89958/n%C3%B8tter-kan-redusere-kreft-med-spredning-til-hjernen ).

10.   Frits Thorsen in Bergens Tidende: Exciting findings in preventing metastatic spreading. http://www.uib.no/en/rg/mic/90150/frits-thorsen-bergens-tidende-exciting-findings-preventing-metastatic-spreading   

1989-2002 Underviser i strålingsfysikk, Haukeland Universitetssykehus, Bergen.

1991-1994 Timelærer i Apparatlære, ved Radiografhøgskolen i Bergen.

1993-2006 Klinisk konsulent, Elekta Instrument AB, Stockholm, Sverige.

2004-2021 Foreleser i histologi og anatomi, Institutt for biomedisin, UiB.

2008-2021 Invitert foredragsholder ved 18 internasjonale kreftkonferanser.

 

Vitenskapelig artikkel
  • Vis forfatter(e) (2021). Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines. Oncogene. 1425-1439.
  • Vis forfatter(e) (2021). Fluspirilene exerts an anti-glioblastoma effect through suppression of the FOXM1-KIF20A/BIRC5 axis. . Journal of Cellular and Molecular Medicine.
  • Vis forfatter(e) (2021). Cabozantinib is effective in melanoma brain metastasis cell lines and affects key signaling pathways. International Journal of Molecular Sciences. 1-15.
  • Vis forfatter(e) (2020). Trifluoperazine prolongs the survival of experimental brain metastases by STAT3-dependent lysosome membrane permeabilization. . American Journal of Cancer Research. 545-563.
  • Vis forfatter(e) (2020). TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα. . Cell Death and Differentiation. 367-381.
  • Vis forfatter(e) (2020). Identification of immune-related genes contributing to the development of glioblastoma using weighted gene co-expression network analysis. . Frontiers in Immunology.
  • Vis forfatter(e) (2020). Glioblastoma Therapy Using Codelivery of Cisplatin and Glutathione Peroxidase Targeting siRNA from Iron Oxide Nanoparticles. ACS Applied Materials & Interfaces.
  • Vis forfatter(e) (2019). Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma. EMBO Molecular Medicine.
  • Vis forfatter(e) (2019). Reduced expression of proteolipid protein 2 increases ER stress-induced apoptosis and autophagy in glioblastoma. Journal of Cellular and Molecular Medicine.
  • Vis forfatter(e) (2019). PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1. Oncogene. 1-15.
  • Vis forfatter(e) (2019). Long Noncoding RNA SChLAP1 Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-kappa B Signaling. Clinical Cancer Research. 6868-6881.
  • Vis forfatter(e) (2019). Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signalling. Brain. 512-530.
  • Vis forfatter(e) (2019). Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta neuropathologica communications. 1-19.
  • Vis forfatter(e) (2019). Improved drug delivery to brain metastases by peptide-mediated permeabilization of the blood-brain barrier. Molecular Cancer Therapeutics. 2171-2181.
  • Vis forfatter(e) (2019). Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases. Journal of Experimental & Clinical Cancer Research.
  • Vis forfatter(e) (2019). Effective treatment of metastatic melanoma by combining mapk and pi3k signaling pathway inhibitors. International Journal of Molecular Sciences. 1-19.
  • Vis forfatter(e) (2018). Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model. PLOS ONE. 18 sider.
  • Vis forfatter(e) (2018). Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. Autophagy. 2007-2022.
  • Vis forfatter(e) (2018). CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival. Acta neuropathologica communications. 18.
  • Vis forfatter(e) (2017). Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination. Journal of Experimental & Clinical Cancer Research. 1-13.
  • Vis forfatter(e) (2017). The angiogenic switch leads to a metabolic shift in human glioblastoma. Neuro-Oncology. 383-393.
  • Vis forfatter(e) (2016). Bevacizumab prevents brain metastases formation in lung adenocarcinoma. Molecular Cancer Therapeutics. 702-710.
  • Vis forfatter(e) (2015). Melanoma brain metastasis is independent of lactate dehydrogenase A expression. Neuro-Oncology. 1374-1385.
  • Vis forfatter(e) (2015). A novel nanoprobe for multimodal imaging is effectively incorporated into human melanoma metastatic cell lines. International Journal of Molecular Sciences. 21658-21680.
  • Vis forfatter(e) (2014). Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies. Advanced Drug Delivery Reviews. 98-115.
  • Vis forfatter(e) (2014). In vitro treatment of melanoma brain metastasis by simultaneously targeting the MAPK and PI3K signaling pathways. International Journal of Molecular Sciences. 8773-8794.
  • Vis forfatter(e) (2014). Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma. PLOS ONE.
  • Vis forfatter(e) (2014). Dynamic Contrast Enhanced MRI Detects Early Response to Adoptive NK Cellular Immunotherapy Targeting the NG2 Proteoglycan in a Rat Model of Glioblastoma. PLOS ONE. 12 sider.
  • Vis forfatter(e) (2013). Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival. OncoTarget. 1527-1546.
  • Vis forfatter(e) (2013). Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases. Journal of Controlled Release. 812-822.
  • Vis forfatter(e) (2013). Hydrolyzed casein reduces diet-induced obesity in male C57BL/6J mice. Journal of Nutrition. 1367-1375.
  • Vis forfatter(e) (2013). Automated tracking of nanoparticle-labeled melanoma cells improves the predictive power of a brain metastasis model. Cancer Research. 2445-2456.
  • Vis forfatter(e) (2012). Gamma knife surgery versus reoperation for recurrent glioblastoma multiforme. World Neurosurgery. 658-669.
  • Vis forfatter(e) (2012). Analysis of the growth dynamics of angiogenesis-dependent and -independent experimental glioblastomas by multimodal small-animal PET and MRI. Journal of Nuclear Medicine. 1135-1145.
  • Vis forfatter(e) (2011). Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model. Experimental Cell Research. 234-247.
  • Vis forfatter(e) (2011). MRI of experimental gliomas. Methods in molecular biology. 451-471.
  • Vis forfatter(e) (2011). Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proceedings of the National Academy of Sciences of the United States of America. 3749-3754.
  • Vis forfatter(e) (2011). A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients. Neuropathology and Applied Neurobiology. 189-205.
  • Vis forfatter(e) (2010). Gamma knife surgery of meningiomas involving the cavernous sinus: long-term follow-up of 100 patients. Neurosurgery. 661-669.
  • Vis forfatter(e) (2010). Atrial natriuretic peptide modulation of albumin clearance and contrast agent permeability in mouse skeletal muscle and skin: role in regulation of plasma volume. Journal of Physiology. 325-339.
  • Vis forfatter(e) (2009). Gamma knife stereotactic radiosurgery of Nelson syndrome. European Journal of Endocrinology (EJE). 143-148.
  • Vis forfatter(e) (2009). Effects of dietary intervention on MRI activity, de- and remyelination in the cuprizone model for demyelination. Experimental Neurology. 160-166.
  • Vis forfatter(e) (2008). Two distinct tumor phenotypes isolated from glioblastomas show different MRS characteristics. NMR in Biomedicine. 830-838.
  • Vis forfatter(e) (2008). Oncolytic herpes simplex virus type-1 therapy in a highly infiltrative animal model of human glioblastoma. Clinical Cancer Research. 1571-1580.
  • Vis forfatter(e) (2008). CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. International Journal of Cancer. 761-768.
  • Vis forfatter(e) (2007). Human glioblastoma biopsy spheroids xenografted into the nude rat brain show growth inhibition after stereotactic radiosurgery. Journal of Neuro-Oncology. 1-10.
  • Vis forfatter(e) (2007). Gamma knife stereotactic radiosurgery for acromegaly. European Journal of Endocrinology (EJE). 255-263.
  • Vis forfatter(e) (2007). Comparison of effective radiation doses in patients undergoing unenhanced MDCT and excretory urography for acute flank pain. American Journal of Roentgenology. 934-939.
  • Vis forfatter(e) (2007). Cellular multiparametric MRI of neural stem cell therapy in a rat glioma model. NeuroImage. 769-782.
  • Vis forfatter(e) (2006). Antitumor efficacy improved by local delivery of species-specific endostatin. Journal of Neurosurgery. 118-128.
  • Vis forfatter(e) (2006). Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma. Journal of Gene Medicine. 1131-1140.
Faglig foredrag
  • Vis forfatter(e) (2016). Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma and melanoma metastases.
Vitenskapelig foredrag
  • Vis forfatter(e) (2016). Focused ultrasound-mediated transport of poly(alkyl) cyanoacrylate nanoparticles across the blood-brain barrier in a melanoma brain metastasis model.
  • Vis forfatter(e) (2016). Focused ultrasound-mediated transport of poly(alkyl) cyanoacrylate nanoparticles across the blood-brain barrier in a melanoma brain metastasis model.
  • Vis forfatter(e) (2009). EMT Promotes Malignant Transformation of Prostate Epithelial Cells in Culture.
Mastergradsoppgave
  • Vis forfatter(e) (2021). Development of 3D in vitro Interaction Models for the Evaluation and Treatment of Brain Metastases.
  • Vis forfatter(e) (2020). In vitro study of a selective PI3K inhibitor on brain metastases.
  • Vis forfatter(e) (2019). Characterization of Melanoma Brain Metastasis Cell Lines.
  • Vis forfatter(e) (2017). In vitro study of the effect of cabozantinib (XL184) on canine oral melanoma cell lines.
  • Vis forfatter(e) (2017). An In vitro Drug Study of Cabozantinib on Glioblastoma Cell Lines.
  • Vis forfatter(e) (2016). In vitro and in vivo studies of a novel blood brain barrier permeabilizing peptide K16ApoE. And novel in vivo treatment of melanoma brain metastases.
  • Vis forfatter(e) (2015). In vitro effects of BEZ-235 on human melanoma metastatic cell lines.
  • Vis forfatter(e) (2014). Visualization of metastatic melanoma cells by fluorescence microscopy and MRI using a novel glycogen nanoprobe.
  • Vis forfatter(e) (2010). IN VITRO EFFECTS OF NANOPARTICLE CONTRAST AGENTS ON CELLULAR FUNCTIONS AND RELAXOMETRY.
Doktorgradsavhandling
  • Vis forfatter(e) (2019). Treatment strategies for experimental melanoma brain metastases.
Sammendrag/abstract
  • Vis forfatter(e) (2013). EARLY TUMOR DETECTION AND CHARACTERIZATION OF CHANGES IN TUMOR PERMEABILITY OF BRAINMETASTASES USING MULTIMODAL IMAGING. Neuro-Oncology. 241-241.
  • Vis forfatter(e) (2013). BRAIN-SPECIFIC GENE SIGNATURE OF MELANOMA METASTASIS. Neuro-Oncology. 27-27.
  • Vis forfatter(e) (2012). Early MRI findings of targeting the NG2 proteoglycan in GBM. The FASEB Journal. 1 sider.
  • Vis forfatter(e) (2011). Treatment of Solid Cancers Using a New Cationic Cytolytic Peptide. European Journal of Cancer. S148-S148.
  • Vis forfatter(e) (2011). Separate analysis of the cancer and stroma cell populations from orthotopically implanted tumor biopsies in eGFP scid mice. Clinical and Experimental Metastasis. 203-203.
  • Vis forfatter(e) (2011). Molecular imaging and genetic studies reveal selective homing of human brain metastatic cells to various organs in NOD/SCID mice. Clinical and Experimental Metastasis. 194-194.
  • Vis forfatter(e) (2011). A novel and clinically relevant mouse model reflecting the disease progression in melanoma brain metastasis in patients. Clinical and Experimental Metastasis. 238-238.
  • Vis forfatter(e) (2010). THERAPEUTIC TARGETING OF THE NG2 PROTEOGLYCAN WITH MAB 9.2.27 AND ADOPTIVELY TRANSFERRED NK CELLS LYSES HUMAN GLIOBLASTOMA MULTIFORME IN VIVO. Neuro-Oncology. 9-9.
  • Vis forfatter(e) (2010). A NOVEL PATIENT MELANOMA BRAIN METASTASIS MODEL DEVELOPED IN NOD-SCID MICE REFLECTS THE CLINICAL METASTATIC DISEASE PROGRESSION IN PATIENTS. Neuro-Oncology. 135-136.
  • Vis forfatter(e) (2009). PHENOTYPIC AND PHYSIOLOGIC EFFECTS OF BEVACIZUMAB IN A HIGHLY INFILTRATIVE AND ANGIOGENIC HUMAN GLIOBLASTOMA MODEL. Neuro-Oncology. 906-906.
  • Vis forfatter(e) (2008). DEVELOPMENT OF A NEW BRAIN METASTASES MODEL IN IMMUNODEFICIENT ANIMALS. Neuro-Oncology. 854-854.
Poster
  • Vis forfatter(e) (2019). Effective Treatment Of Metastatic Melanomas Using Combined MAPK And PI3K Pathways Inhibitors.
  • Vis forfatter(e) (2017). Multiparametric MRI for optimal prostate cancer detection in TRAMP mice.
  • Vis forfatter(e) (2016). Focused ultrasound-mediated transport of poly(alkyl) cyanoacrylate nanoparticles across the blood-brain barrier in a melanoma brain metastasis model.
  • Vis forfatter(e) (2011). Therapeutic Targeting of NG2 Proteoglycan with MAb & Pre-Armed NK Cells in Human GMB Evaluated with Dynamic Enhanced & Diffusion Weighted MRI in Rats.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) (2020). Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines. . Cancer Research. 4314-4323.
  • Vis forfatter(e) (2014). A physiological perspective on the use of imaging to assess the in vivo delivery of therapeutics. Annals of Biomedical Engineering. 280-298.
  • Vis forfatter(e) (2013). In vivo animal models for studying brain metastasis: value and limitations. Clinical and Experimental Metastasis. 695-710.
  • Vis forfatter(e) (2012). In vivo models of primary brain tumors: pitfalls and perspectives. Neuro-Oncology. 979-993.
Forskerlinjeoppgave
  • Vis forfatter(e) (2014). In Vitro Treatment of Melanoma Brain Metastasis by Simultaneously Targeting the MAPK and PI3K Signaling Pathways.

Se fullstendig oversikt over publikasjoner i CRIStin.

Publikasjonsliste 2013-2021

* = delt siste forfatterskap

1.     Zhang Y, Kong Y, Ma Y, Ni S, Wikerholmen T, Wang J, Xi K, Bin H, Chen A, Yao Z, Han M, Zhou W, Feng Z, Hu Y, Chen A, Thorsen F*, Wang J*, Li X*. NCOA4-mediated autophagy alters intracellular homeostasis and increases ferroptosis by loss of COPZ1 in human glioblastoma. Oncogene 2020 (In Press). [IF 7.971]

2.     Kong Y, Li X, Huang B, Feng Z, Zhang Y, Han M, Chen A, Xiang G, Zhao Z, Zhang Y, Zhang Q, Zhang D, Thorsen F, Wang J, Yang N. Fluspirilene exerts an anti-glioblastoma effect through suppression of the FOXM1-KIF20A/BIRC5 axis. J Cell Mol Med 2020 (In Press). [IF 4.486]

3.     Zhang Y, Fu X, Jia J, Wikerholmen T, Xi K, Kong Y, Wang J, Chen H, Ma Y, Li Z, Wang C, Qi Q, Thorsen F, Wang J, Cui J, Li X, Ni S. Glioblastoma therapy using codelivery of cisplatin and gluthathione peroxidase targeting siRNA from iron oxide particles. ACS Appl Mater Interfaces 2020 Sep 4. [IF 8.758]

4.     Ji J, Ding K, Luo T, Zhang X, Chen A, Zhang D, Li G, Thorsen F, Huang B, Li X, Wang J. TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα. Cell Death & Diff 2020 Aug 19, 18:6938-15. [IF 10.717]

5.     Kong Y, Feng Z, Zhang Y, Liu X, Yuan M, Zhao Z, Huang B, Chen A, Zhang D, Thorsen F, Wang J, Yang N, Li X. Identification of immune-related genes contributing to the development of glioblastoma using weighted gene co-expression network analysis. Front Immunol 2020 July 16, 11:1281. [IF 5.085]

  1. Valiente M, Van Swearingen AED, Anders C, Bairoch A, Boire A, Bos P, Cittelly D, Erez N, Ferraro G, Fukumura D, Gril BM, Herlyn M, Holmen SL, Jain RK, Joyce JA, Lorger M, Massagué J, Neman J, Sibson N, Steeg P, Thorsen F, Young L, Vareslija D, Vultur A, Weis-García F, Winkler F. Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines. Cancer Res 2020 July 8. [IF 9.727]

7.     Feng Z, Zhou W, Wang J, Qi Q, Han M, Kong Y, Zhang Y, Chen A, Huang B, Chen A, Zhang D, Li W, Zhang Q, Bjerkvig R, Wang J*, Thorsen F*, Li X*. Reduced expression of proteolipid 2 increases ER-stress-induced apoptosis and autophagy in glioblastoma. J Cell Mol Med 2020 Mar 17, 24(5):2847-2856. [IF 4.486]

  1. Zhang X, Ding K, Ji J, Parajuli H, Aasen SN, Espedal H, Huang B, Chen A, Wang J*, Li X*, Thorsen F*. Trifluoperazine prolongs the survival of experimental brain metastases by STAT3-dependent lysosome membrane permeabilization. Am J Cancer Res 2020 Feb 1, 10(2):545-563. [IF 5.177]

9.     Han M, Wang S, Fritah S, Zhou W, Yang N, Huang B, Chen A, Li G, Miletic H, Thorsen F, Bjerkvig R, Li X, Wang J. Interfering with long non-coding RNA MIR22HG processing inhibits glioma progression through suppression of Wnt/b-catenin signalling. Brain 2020 Feb 1, 143(2):512-530.  [IF 11.337

10.   Ji J, Ding K, LuoT, Xu R, Zhang X, Huang B, Chen A, Zhang D, Miletic H, Bjerkvig R*, Thorsen F*, Wang J*, Li X*. PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1. Oncogene 2020 Jan 11, 39(5):1125-1139. [IF 7.791]

  1. Han M, Wang S, Zhao W, Kong Y, Huang B, Chen A, Saed HS, Li G, Miletic H, Thorsen F, Bjerkvig R, Li X, Wang J. Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma. EMBO Mol Med, 2020 Jan 9;12(1):e10924. [IF 10.293]

12.   Bernatz S, Ilina E, Devraj K, Harter PN, Mueller K, Kleber S, Braun Y, Penski C, Renner C, Halder R, Jennewein L, Solbach C, Thorsen F, Pestalozzi BC, Mischo A, Mittelbronn M. Impact of docetaxel on blood-brain barrier function and formation of breast cancer brain metastases. J Exp & Clin Cancer Res 2019 Oct 29;38(1):434. [IF 5.646]

13.   Ji J, Xu R, Ding K, Bao G, Zhang X, Huang B, Wang X, Martinez A, Wang X, Li G, Miletic H, Thorsen F, Bjerkvig R, Xiang L, Han B, Chen A, Li X, Wang J. Long noncoding RNA SChLAP1 forms a growth promoting complex with HNRNPL in human glioblastoma through stabilization and activation of NF-kB signalling. Clin Cancer Res 2019 Sep. 6. [IF 10.107]

14.   Aasen SN, Espedal H, Holte CF, Keunen O, Karlsen TV, Tenstad O, Maherally Z, Miletic H, Hoang T, Eikeland AV, Baghirov H, Olberg DE, Pilkington GJ, Sarkar G, Jenkins R, Sundstrøm T, Bjerkvig R, Thorsen F. Improved drug delivery to experimental melanoma brain metastasis by peptide-mediated permeabilization of the blood-brain barrier. Mol Cancer Ther 2019 Aug 29. [IF 5.615]

15.   Aasen SN, Parajuli H, Roy K, Hoang T, Stokke K, Wang J, Feng Z, Bjerkvig R, Thorsen F. Effective treatment of metastatic melanoma by combining MAPK and PI3K signaling pathway inhibitors. Int J Mol Sci 20(17):4235, Aug 29, 2019. [IF 4.556].

16.   Sundstrøm T, Prestegarden L, Azuaje F, Røsland GV, Varughese JK, Aasen SN, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Inghem ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Bjerkvig R*, Thorsen F*. Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Comm 7:55, Apr 10, 2019. doi: 10.1186/s40478-019-0712-8. [IF 6.270]

17.   Bjerkvig R, Thorsen F. Glioblastoma: a prognostic value of AMT-PET? Neuro-Oncol 21(2):146-147, Feb 14, 2019. [IF 10.091]

18.   Wang J, Qi Q, Zhou W, Feng Z, Huang B, Chen A, Zhang D, Li W, Zhang Q, Bjerkvig R, Prestegarden L, Thorsen F, Li X, Wang J. Inhibition of glioma growth by flavokawain B is mediated through endoplasmatic reticulum stress induced autophagy. Autophagy 2018 Jul 19. [IF 9.770]

  1. Zeiner PS, Zinke J, Kowalewski DJ, Bernatz S, Tichy J, Ronellenfitsch MW, Thorsen F, Berger A, Forster MT, Muller A, Steinbach JP, Beschorner R, Wischhusen J, Kvasnicka HM, Plate KH, Stefanovic S, Weide B, Mittelbronn M, Harter PN. CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival. Acta Neuropathol Comm 6:18, 2018. [IF 6.270]

20.   Baghirov H, Snipstad S, Sulheim E, Berg S, Hansen R, Thorsen F, Mørch Y, de Lange Davies C, Åslund ÅKO. Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model. PLoS ONE, 13(1):e0191102, 2018. [IF 2.740]

21.   Zhang X, Xu R, Zhang C, Xu Y, Han M, Huang B, Chen A, Qiu C, Thorsen F, Prestegarden L, Bjerkvig R, Wang J, Li XG. Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination. J Exp Clin Cancer Res 36(1):118, 2017. doi:10.1186/s13046-017-0588-z. [IF 5.646]

22.   Talasila KM, Røsland G, Hagland H, Eskilsson E, Tran GT, Fritah S, Azuaje F, Atai N, Harter P, Mittelbronn M, Anderson M, van Noorden R, Niclou SP, Thorsen F, Tronstad KJ, Tzoulis C, Bjerkvig R, Miletic H. The angiogenic switch leads to a metabolic switch in human glioblastoma. Neuro-Oncol Sep 19(3):383-393, 2017. [IF 10.091]

23.   Ilhan-Mutlu A, Osswald M, Liao Y, Gömmel M, Reck M, Miles D, Mariani P, Gianni L, Lutiger B, Nendel V, Srock S, Perez-Moreno P, Thorsen F, von Baumgarten L, Preusser M, Wick W, Winkler F. Bevacizumab prevents brain metastases formation in lung adenocarcinoma. Mol Cancer Ther Jan 25, 15(4):702-710, 2016. [IF 5.615]

24.   Aasen SN, Pospisilova A, Eichler T, Panek J, Hruby M, Stepanek P, Spriet E, Jirak D, Skaftnesmo KO, Thorsen F. A novel nanoprobe for visualisation of melanoma metastatic cells by fluorescence and MRI. Int J Mol Sci 16:21658-21680, 2015. [IF 4.556]

25.   Sundstrøm T, Espedal H, Harter P, Fasmer KE, Skaftnesmo KO, Horn S, Hodneland E, Mittelbronn M, Weide B, Beschorner R, Bendner B, Rygh CB, Lund-Johansen M, Bjerkvig R, Thorsen F. Melanoma brain metastasis is independent on LDHA expression. Neuro-Oncol 17:1374-1385, 2015. [IF 10.091]

26.   Keunen O, Taxt T, Tonn JC, Grüner R, Lund-Johansen M, Pavlin T, Bjerkvig R, Niclou S, Thorsen F. Multimodal imaging of gliomas in the context of cellular and molecular therapies. Adv Drug Deliv Rev 76:98-115, 2014. [IF 13.300]

27.   Rygh, CB, Wang J, Thuen M, Gras-Navarro A, Huuse EM, Thorsen F, Poli A, Zimmer J, Haraldseth O, Lie SA, Enger PØ, Chekenya M. Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma. PLoS ONE 2014 9(9):e108414. [IF 2.740]

28.   Daphu I, Horn S, Stieber D, Varughese J, Skaftnesmo KO, Bjerkvig R, Thorsen F. In vitro treatment of melanoma brain metastasis by simultaneously targeting the MAPK and PI3K signaling pathways. Int J Mol Sci 15:8773-8794, 2014. [IF 4.556]

29.   Qin SP, Fite BZ, Gagnon KG, Seo JW, Curry F, Thorsen F, Ferrara KW. A physiological perspective on the use of imaging to assess the in vivo delivery of therapeutics. Ann Biomed Eng 42(2):280-298, 2014. [IF 3.324]

30.   Thorsen F, Fite B, Mahakian L, Seo JW, Qin SP, Harrison V, Johnson S, Ingham E, Meade T, Caskey C, Sundstrøm T, Meade T, Harter PN, Skaftnesmo KO, Ferrara KW. Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases. J Control Rel 172:812-822, 2013. [IF 7.877] 

31.   Poli A, Wang J, Domingues O, Planagumá J, Yan T, Rygh CB, Skaftnesmo KO, Thorsen F, McCormack E, Hentges F, Pedersen PH, Zimmer J, Enger PO, Chekenya M. Targeting glioblastoma with NK-cells and mAb against NG2/CSPG4 prolongs animal survival. Oncotarget 4(9):1527-1546, 2013. [IF 3.710]

32.   Lillefosse HH, Tastesen HS, Du ZY, Ditlev DB, Thorsen F, Madsen L, Kristiansen K, Liaset B. Hydrolyzed casein reduces diet-induced obesity in male C57BL/6J mice. J Nutr 143(9):1367-1375, 2013 [IF 4.281]

33.   Sundstrøm T,  Daphu I, Wendelbo I, Hodneland E, Lundervoll A, Immervoll H, Skaftnesmo KO, Babic M, Jendelova P, Sykova E, Lund-Johansen M, Bjerkvig R, Thorsen F. Quantitative tracking of nanoparticle labeled melanoma cells improves the predictive power of an experimental brain metastasis model. Cancer Res 73(8):2445-2456, 2013. [IF 9.727]

34.   Daphu I, Sundstrøm T, Huszthy PC, Niclou SP, Sakariassen P, Immervoll H, Miletic H, Bjerkvig R, Thorsen F. In vivo animal models for studying brain metastasis: value and limitations. Clin Exp Metastasis 30:695-710, 2013. [IF 3.027]

Forskningsveiledning:

2016-2021 Hovedveileder for 3 Post Docs.

2014-2021 Hovedveileder for 9 studenter i Forskerlinjeprogrammet, UiB.

2005-2021 Veileder for 11 PhD studenter (6 som biveileder).

1996-2021 Veileder for 16 Master studenter (3 som biveileder).

Arbeidserfaring:

1989-1995 Haukeland Sykehus. Medisinsk Fysiker, Overingeniør.

1991-1994 Timelærer i Apparatlære, Radiografhøgskolen i Bergen.

1993-2006 Elekta Instrument AB. Medisinsk konsulent.

1995- 1998 Universitetet i Bergen. Stipendiat.

1998-2004 Haukeland Universitetssykehus. Medisinsk Fysiker, Sjefingeniør.    

2000-2002 Institutt for Anatomi og Cellebiologi. Forsker (Post. doc.).                    

2004-2008 UNIFOB AS. Vitenskapelig Prosjektleder. 

2008-2010 Institutt for Biomedisin, UiB. Førsteamanuensis.

2010-2021 Institutt for Biomedisin, UiB. Professor.

2019-2021 Shandong University, Jinan, Kina. Professor.                             

Utdannelse:

1989 Cand Mag i fysikk, matematikk og data, Universitetet i Trondheim.

1989 Cand Scient i biofysikk, Universitetet i Trondheim.

1998 Dr Scient, Institutt for Anatomi og Cellebiologi, Universitetet i Bergen.

Kurs:

1990 Bedriftspedagogisk senter. Presentasjonsteknikk og kommunikasjon.  

1994 Elektrisitetstilsynet. Godkjenning for å reparere elektromedisinsk utstyr.

1998 Hewlett Packard, Oslo. Sluttbrukerkurs i Unix operativsystem.

1998 Universitetet i Bergen. Påbyggingsseminarer i forsøksdyrlære.

1999 Haukeland Sykehus. Prosjektledelse.

2000 Advanced Visualization System. Introduksjon i AVS programmering.

2004 Hyperion Ltd (Ressurssenteret,Bergen). How to negotiate, manage, administer and finish an EU Contract.

2006 Psykologisk Fakultet, UiB. Basismodul i universitetespedagogikk.

2007 Psykologisk Fakultet, UiB. Forskningsveiledning.

2007-09 UNIFOB AS, Bergen. Utviklingsprogram for Forskningsledere.

2018 UiB PhD-veileder kurs bestått 31.07.2018.

2018  Begynnerkurs i Kinesisk-Mandarin (Mandarin nivå A1, del 1 og 2).