Hjem
Universitetet i Bergen
Gunnar Mellgrens bilde

Gunnar Mellgren

Professor
Klinisk institutt 2
Hjemmeside
  • E-postGunnar.Mellgren@uib.no
  • Telefon+47 55 97 43 66
  • Besøksadresse
    Haukeland Universitetssykehus
    Laboratoriebygget, 7. etg.
    5020 Haukeland Universitetssykehus
  • Postadresse
    Postboks 7804
    5020 Bergen

Diabetes, fedme og ernæring

Hormoner, diagnostikk og brystkreft

 

Hormonlaboratoriets forskningsgruppe http://www.uib.no/en/rg/hormonelaboratory

Mohn Nutrition Research Laboratory www.uib.no/mohn-elab

Hormonsykdommer og medisinsk biokjemi

Vitenskapelig artikkel
  • Vis forfatter(e) (2023). Sex-specific responses in glucose-insulin homeostasis and lipoprotein-lipid components after high-dose supplementation with marine n-3 PUFAs in abdominal obesity: a randomized double-blind crossover study. Frontiers in Nutrition.
  • Vis forfatter(e) (2023). Serum concentrations of amino acids and tryptophan metabolites are affected by consumption of a light breakfast: a clinical intervention study in adults with overweight or obesity. BMC Nutrition.
  • Vis forfatter(e) (2023). Relationship between Ketones, Ghrelin, and, Appetite on Isocaloric Diets with Varying Carbohydrate Quality and Amount: Results from a Randomized Controlled Trial in People with Obesity (CARBFUNC). Journal of Nutrition. 459-469.
  • Vis forfatter(e) (2023). Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: A prospective 2-cohort study. Journal of Internal Medicine. 508-519.
  • Vis forfatter(e) (2023). Phenotypic diversity of human adipose tissue-resident NK cells in obesity. Frontiers in Immunology.
  • Vis forfatter(e) (2023). Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue. International Journal of Molecular Sciences.
  • Vis forfatter(e) (2023). Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease. EBioMedicine. 18 sider.
  • Vis forfatter(e) (2023). Importance of endocrine treatment adherence and persistence in breast cancer survivorship: a systematic review. BMC Cancer.
  • Vis forfatter(e) (2023). Efficacy of Alternative Dose Regimens of Exemestane in Postmenopausal Women With Stage 0 to II Estrogen Receptor-Positive Breast Cancer: A Randomized Clinical Trial. JAMA Oncology. 664-672.
  • Vis forfatter(e) (2023). Dietary fish intake increased the concentration of soluble ACE2 in rats. Can fish consumption reduce the risk of COVID-19 infection through interception of SARS-CoV-2 by soluble ACE2? British Journal of Nutrition. 1-8.
  • Vis forfatter(e) (2022). Subtype-specific surface proteins on adipose tissue macrophages and their association to obesity-induced insulin resistance. Frontiers in Endocrinology. 1-13.
  • Vis forfatter(e) (2022). Seven-year trajectories of body weight, quality of life and comorbidities following Roux-en-Y gastric bypass and sleeve gastrectomy. International Journal of Obesity. 739-749.
  • Vis forfatter(e) (2022). Reference Curves for Pediatric Endocrinology: Leveraging Biomarker Z-Scores for Clinical Classifications. Journal of Clinical Endocrinology and Metabolism (JCEM). 2004-2015.
  • Vis forfatter(e) (2022). Physical activity and risk of all-cause mortality in patients with stable angina pectoris: Effect modification by β-blocker treatment. International Journal of Cardiology: Cardiovascular Risk and Prevention (IJCCRP). 6 sider.
  • Vis forfatter(e) (2022). MRI adipose tissue segmentation and quantification in R (RAdipoSeg). Diabetology and Metabolic Syndrome. 1-8.
  • Vis forfatter(e) (2022). Distinct T cell subsets in adipose tissue are associated with obesity. European Journal of Immunology.
  • Vis forfatter(e) (2022). Diets differing in carbohydrate cellularity and amount similarly reduced visceral fat in people with obesity - a randomized controlled trial (CARBFUNC). Clinical Nutrition. 2345-2355.
  • Vis forfatter(e) (2022). Consumption of a light meal affects serum concentrations of one-carbon metabolites and B-vitamins. A clinical intervention study. British Journal of Nutrition. 10 sider.
  • Vis forfatter(e) (2021). Simultaneous Quantification of Aromatase Inhibitors and Estrogens in Postmenopausal Breast Cancer Patients. Journal of Clinical Endocrinology and Metabolism (JCEM). 1368-1374.
  • Vis forfatter(e) (2021). Serglycin Is Involved in Adipose Tissue Inflammation in Obesity. Journal of Immunology. 121-132.
  • Vis forfatter(e) (2021). Role of the Neutral Amino Acid Transporter Slc7a10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance. Diabetes. 680-695.
  • Vis forfatter(e) (2021). Meal patterns associated with energy intake in people with obesity. British Journal of Nutrition.
  • Vis forfatter(e) (2021). Maternal PCOS status and metformin in pregnancy: Steroid hormones in 5–10 years old children from the PregMet randomized controlled study. PLOS ONE. 1-14.
  • Vis forfatter(e) (2021). Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice. Arteriosclerosis, Thrombosis and Vascular Biology. 2563-2574.
  • Vis forfatter(e) (2021). Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial. European Journal of Nutrition. 3237-3248.
  • Vis forfatter(e) (2021). Effect of genetic variability in 20 pharmacogenes on concentrations of tamoxifen and its metabolites. Journal of Personalized Medicine. 11 sider.
  • Vis forfatter(e) (2021). Changes in lipoprotein particle subclasses, standard lipids, and apolipoproteins after supplementation with n-3 or n-6 PUFAs in abdominal obesity: A randomized double-blind crossover study. Clinical Nutrition. 2556-2575.
  • Vis forfatter(e) (2021). Bedtime Salivary Cortisol as a Screening Test for Cushing Syndrome in Children. Journal of the Endocrine Society (JES). 1-8.
  • Vis forfatter(e) (2021). Baked cod consumption delayed the development of kidney and liver dysfunction and affected plasma amino acid concentrations, but did not affect blood pressure, blood glucose or liver triacylglycerol concentrations in obese fa/fa Zucker rats. Nutrition Research. 72-83.
  • Vis forfatter(e) (2021). Association of CYP2D6 genotype and tamoxifen metabolites with breast cancer recurrence in a low-dose trial. NPJ breast cancer. 1-34.
  • Vis forfatter(e) (2021). A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density. Cell Metabolism. 615-628.
  • Vis forfatter(e) (2020). Testicular Ultrasound to Stratify Hormone References in a Cross-Sectional Norwegian Study of Male Puberty . Journal of Clinical Endocrinology and Metabolism (JCEM). 1888-1898.
  • Vis forfatter(e) (2020). Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen. Molecular Oncology. 11 sider.
  • Vis forfatter(e) (2020). Hormone references for ultrasound breast staging and endocrine profiling to detect female onset of puberty. Journal of Clinical Endocrinology and Metabolism (JCEM). e4886-e4895.
  • Vis forfatter(e) (2020). Five salmon dinners per week were not sufficient to prevent the reduction in serum vitamin D in autumn at 60° north latitude: A randomised trial. British Journal of Nutrition. 419-427.
  • Vis forfatter(e) (2020). First-in-human pharmacokinetics of tamoxifen and its metabolites in the milk of a lactating mother: A case study. ESMO Open. 1-5.
  • Vis forfatter(e) (2020). Effects of high intake of cod or salmon on gut microbiota profile, faecal output and serum concentrations of lipids and bile acids in overweight adults: a randomised clinical trial. European Journal of Nutrition. 1-18.
  • Vis forfatter(e) (2020). COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1. Scientific Reports. 1-11.
  • Vis forfatter(e) (2020). A MicroRNA Linking Human Positive Selection and Metabolic Disorders. Cell. 684-701.
  • Vis forfatter(e) (2020). 3-hydroxyisobutyrate, a strong marker of insulin resistance in type 2 diabetes and obesity that modulates white and brown adipocyte metabolism. Diabetes. 1903-1916.
  • Vis forfatter(e) (2019). Urine and plasma concentrations of amino acids and plasma vitamin status differ, and are differently affected by salmon intake, in obese Zucker fa/fa rats with impaired kidney function and in Long-Evans rats with healthy kidneys. British Journal of Nutrition. 262-273.
  • Vis forfatter(e) (2019). The homeobox factor Irx3 maintains adipogenic identity. Metabolism: Clinical and Experimental.
  • Vis forfatter(e) (2019). The Rho GTPase RND3 regulates adipocyte lipolysis. Metabolism: Clinical and Experimental. 1-12.
  • Vis forfatter(e) (2019). Testicular ultrasound to stratify hormone references in a cross-sectional Norwegian study of male puberty. Journal of Clinical Endocrinology and Metabolism (JCEM). 27 sider.
  • Vis forfatter(e) (2019). TMAO, creatine and 1-methylhistidine in serum and urine are potential biomarkers of cod and salmon intake: a randomised clinical trial in adults with overweight or obesity. European Journal of Nutrition. 1-11.
  • Vis forfatter(e) (2019). Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis. Scientific Reports. 1-7.
  • Vis forfatter(e) (2019). Retained NK cell phenotype and functionality in non-alcoholic fatty liver disease. Frontiers in Immunology. 1-13.
  • Vis forfatter(e) (2019). Prognostic impact of genetic variants of CYP19A1 and UGT2B17 in a randomized trial for endocrine-responsive postmenopausal breast cancer. The Pharmacogenomics Journal. 1-8.
  • Vis forfatter(e) (2019). Effects of low doses of fish and milk proteins on glucose regulation and markers of insulin sensitivity in overweight adults: a randomised, double blind study. European Journal of Nutrition. 1-17.
  • Vis forfatter(e) (2019). Drug monitoring of tamoxifen metabolites predicts vaginal dryness and verifies a low discontinuation rate from the Norwegian Prescription Database. Breast Cancer Research and Treatment. 185-195.
  • Vis forfatter(e) (2019). Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice. Scientific Reports.
  • Vis forfatter(e) (2018). The short cosyntropin test revisited: new normal reference range using LC-MS/MS. Journal of Clinical Endocrinology and Metabolism (JCEM). 1696-1703.
  • Vis forfatter(e) (2018). The effect of lean-seafood and non-seafood diets on fecal metabolites and gut microbiome: results from a randomized crossover intervention study. Molecular Nutrition & Food Research. 1-8.
  • Vis forfatter(e) (2018). The effect of lean-seafood and non-seafood diets on fasting and postprandial serum metabolites and lipid species: Results from a randomized crossover intervention study in healthy adults. Nutrients. 1-12.
  • Vis forfatter(e) (2018). Salmon fillet intake led to higher serum triacylglycerol in obese zucker Fa/Fa rats but not in normolipidemic Long-Evans rats. Nutrients. 1-13.
  • Vis forfatter(e) (2018). LC-MS/MS based profiling and dynamic modelling of the steroidogenesis pathway in adrenocarcinoma H295R cells. Toxicology in Vitro. 332-341.
  • Vis forfatter(e) (2018). Intake of baked cod fillet resulted in lower serum cholesterol and higher long chain n-3 PUFA concentrations in serum and tissues in hypercholesterolemic obese Zucker fa/fa rats. Nutrients. 1-15.
  • Vis forfatter(e) (2018). Inflammatory markers, the tryptophan-kynurenine pathway, and Vitamin B status after bariatric surgery. PLOS ONE. 1-14.
  • Vis forfatter(e) (2018). IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. International Journal of Obesity.
  • Vis forfatter(e) (2018). Diets containing salmon fillet delay development of high blood pressure and hyperfusion damage in kidneys in obese Zucker fa/fa rats. Journal of the American Society of Hypertension : JASH. 294-302.
  • Vis forfatter(e) (2018). Daily intake of protein from cod residual material lowers serum concentrations of nonesterified fatty acids in overweight healthy adults: A randomized double-blind pilot study. Marine Drugs. 1-15.
  • Vis forfatter(e) (2018). A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells. Journal of Steroid Biochemistry and Molecular Biology. 57-70.
  • Vis forfatter(e) (2017). Visceral adiposity and metabolic syndrome after very high-fat and low-fat isocaloric diets: A randomized controlled trial. American Journal of Clinical Nutrition. 85-99.
  • Vis forfatter(e) (2017). The kynurenine:tryptophan ratio as a predictor of incident type 2 diabetes mellitus in individuals with coronary artery disease. Diabetologia. 1712-1721.
  • Vis forfatter(e) (2017). Simultaneous assay of cortisol and dexamethasone improved diagnostic accuracy of the dexamethasone suppression test. European Journal of Endocrinology (EJE). 705-713.
  • Vis forfatter(e) (2017). Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients. Breast Cancer Research.
  • Vis forfatter(e) (2017). Serum acylcarnitines and risk of cardiovascular death and acute myocardial infarction in patients with stable angina pectoris. Journal of the American Heart Association (JAHA). 1-28.
  • Vis forfatter(e) (2017). Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation. Molecular and Cellular Endocrinology. 146-157.
  • Vis forfatter(e) (2017). Lack of ovarian secretions reverts the anabolic action of olanzapine in female rats. International Journal of Neuropsychopharmacology. 1005-1012.
  • Vis forfatter(e) (2017). High visceral fat percentage is associated with poor outcome in endometrial cancer. OncoTarget. 105184-105195.
  • Vis forfatter(e) (2017). High intake of fatty fish, but not of lean fish, improved postprandial glucose regulation and increased the n-3 PUFA content in the leucocyte membrane in healthy overweight adults: A randomised trial. British Journal of Nutrition. 1368-1378.
  • Vis forfatter(e) (2017). Effects of baked and raw salmon fillet on lipids and n-3 PUFAs in serum and tissues in Zucker fa/fa rats. Food & Nutrition Research (FNR). 1-12.
  • Vis forfatter(e) (2017). Clinical Characteristics and Long-Term Outcome of Primary Aldosteronism in a Norwegian Population. Hormone and Metabolic Research. 838-846.
  • Vis forfatter(e) (2017). Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery. Translational Research: The Journal of Laboratory and Clinical Medicine. 35-44.e4.
  • Vis forfatter(e) (2016). Treatment with aromatase inhibitors stimulates the expression of epidermal growth factor receptor-1 and neuregulin 1 in ER positive/HER-2/neu non-amplified primary breast cancers. Journal of Steroid Biochemistry and Molecular Biology. 228-235.
  • Vis forfatter(e) (2016). The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORα and SRC-2 coactivator transcriptional activity. Molecular and Cellular Endocrinology. 92-101.
  • Vis forfatter(e) (2016). Prospective associations of systemic and urinary choline metabolites with incident type 2 diabetes. Clinical Chemistry. 755-765.
  • Vis forfatter(e) (2016). Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism . OncoTarget. 1878-1894.
  • Vis forfatter(e) (2016). Lean-seafood intake decreases urinary markers of mitochondrial lipid and energy metabolism in healthy subjects: Metabolomics results from a randomized crossover intervention study. Molecular Nutrition & Food Research. 1661-1672.
  • Vis forfatter(e) (2016). Lean seafood intake reduces postprandial c-peptid and lactate concentrations in healthy adults in a randomized controlled trial with a crossover design. Journal of Nutrition. 1027-1034.
  • Vis forfatter(e) (2016). High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: A randomised trial. British Journal of Nutrition. 648-657.
  • Vis forfatter(e) (2016). DNA Topoisomerase IIα contributes to the early steps of adipogenesis in 3T3-L1 cells. Cellular Signalling. 1593-1603.
  • Vis forfatter(e) (2016). A pooled analysis of CYP2D6 genotype in breast cancer prevention trials of low-dose tamoxifen. Breast Cancer Research and Treatment. 97-108.
  • Vis forfatter(e) (2015). The active tamoxifen metabolite endoxifen (4OHNDtam) strongly down-regulates cytokeratin 6 (CK6) in MCF-7 breast cancer cells. PLOS ONE. 19 sider.
  • Vis forfatter(e) (2015). Novel inflammatory biomarkers in primary hyperparathyroidism. European Journal of Endocrinology (EJE). 9-17.
  • Vis forfatter(e) (2015). Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2). Scientific Reports.
  • Vis forfatter(e) (2015). Lean-seafood intake reduces cardiovascular lipid risk factors in healthy subjects: results from a randomized controlled trial with a crossover design. American Journal of Clinical Nutrition. 582-592.
  • Vis forfatter(e) (2015). FTO obesity variant circuitry and adipocyte browning in humans. New England Journal of Medicine. 895-907.
  • Vis forfatter(e) (2015). Estrogens correlate with PELP1 expression in ER positive breast cancer. PLOS ONE. 12 sider.
  • Vis forfatter(e) (2015). Elevated plasma dimethylglycine is a risk marker of mortality in patients with coronary heart disease. European Journal of Preventive Cardiology (EJPC). 743-752.
  • Vis forfatter(e) (2015). Efficacy of fish intake on Vitamin D status: A meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition. 837-847.
  • Vis forfatter(e) (2015). Determination of 21-hydroxylase autoantibodies: Inter-laboratory concordance in the Euradrenal International Serum Exchange Program. Clinical Chemistry and Laboratory Medicine. 1761-1770.
  • Vis forfatter(e) (2015). Cyclin C interacts with steroid receptor coactivator 2 and upregulates cell cycle genes in MCF-7 cells. BBA - Molecular Cell Research. 2383-2391.
  • Vis forfatter(e) (2015). COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity. Endocrinology. 134-146.
  • Vis forfatter(e) (2015). Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris. Arteriosclerosis, Thrombosis and Vascular Biology. 455-462.
  • Vis forfatter(e) (2014). Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice. American Journal of Physiology. Endocrinology and Metabolism. E210-E224.
  • Vis forfatter(e) (2014). Leveraging cross- species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms. Cell. 343-358.
  • Vis forfatter(e) (2014). Estradiol determines the effects of PTH on ERα-dependent transcription in MC3T3-E1 cells. Biochemical and Biophysical Research Communications - BBRC. 360-365.
  • Vis forfatter(e) (2014). Effects of duodenal switch alone or in combination with sleeve gastrectomy on body weight and lipid metabolism in rats. Nutrition and Diabetes. 6 sider.
  • Vis forfatter(e) (2014). Changes in obesity-related diseases and biochemical variables after laparoscopic sleeve gastrectomy: A two-year follow-up study. BMC Surgery.
  • Vis forfatter(e) (2014). COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size. Obesity. 1807-1813.
  • Vis forfatter(e) (2014). ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science Translational Medicine.
  • Vis forfatter(e) (2013). cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1. Endocrinology. 1513-1527.
  • Vis forfatter(e) (2013). Serum concentrations of tamoxifen and its metabolites increase with age during steady-state treatment. Breast Cancer Research and Treatment. 243-248.
  • Vis forfatter(e) (2013). Predictors for remission of major components of the metabolic syndrome after biliopancreatic diversion with duodenal switch (BPDDS). Obesity Surgery. 80-86.
  • Vis forfatter(e) (2013). Inverse regulation of EGFR/HER1 and HER2-4 in normal and malignant human breast tissue. PLOS ONE. 12 sider.
  • Vis forfatter(e) (2013). Energy intake, nutritional status and weight reduction in patients one year after laparoscopic sleeve gastrectomy. SpringerPlus. 1-7.
  • Vis forfatter(e) (2013). Efficacy of adrenal venous sampling is increased by point of care cortisol analysis. Endocrine Connections. 236-242.
  • Vis forfatter(e) (2013). Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of MCF-7 breast cancer cells. PLOS ONE. 10 sider.
  • Vis forfatter(e) (2013). Changes in adipose glucocorticoid metabolism before and after bariatric surgery assessed by direct hormone measurements. Obesity. 2495-2503.
  • Vis forfatter(e) (2013). 1,25-dihydroxyvitamin D and the vitamin D receptor gene polymorphism apa1 influence bone mineral density in primary hyperparathyroidism. PLOS ONE. 8 sider.
  • Vis forfatter(e) (2012). Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism. Journal of Internal Medicine. 583-591.
  • Vis forfatter(e) (2012). Tissue distribution of 4-hydroxy-N-desmethyltamoxifen and tamoxifen-N-oxide. Breast Cancer Research and Treatment. 693-700.
  • Vis forfatter(e) (2012). The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss. International Journal of Obesity. 1195-1202.
  • Vis forfatter(e) (2012). Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer. BMC Cancer. 12 sider.
  • Vis forfatter(e) (2011). Primary hyperparathyroidism influences the expression of inflammatory and metabolic genes in adipose tissue. PLOS ONE. 10 sider.
  • Vis forfatter(e) (2011). Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome. Journal of Biological Chemistry. 28382-28395.
  • Vis forfatter(e) (2011). Efficacy of tamoxifen based on cytochrome P450 2D6, CYP2C19 and SULT1A1 genotype in the Italian Tamoxifen Prevention Trial. The Pharmacogenomics Journal. 100-107.
  • Vis forfatter(e) (2010). cAMP-mediated regulation of HNF-4 alpha depends on the level of coactivator PGC-1 alpha. BBA - Molecular Cell Research. 1013-1019.
  • Vis forfatter(e) (2010). Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLOS ONE. 12 sider.
  • Vis forfatter(e) (2010). Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells. Endocrinology. 2151-2161.
  • Vis forfatter(e) (2010). Effect of low-dose tamoxifen on steroid receptor coactivator 3/amplified in breast cancer 1 in normal and malignant human breast tissue. Clinical Cancer Research. 2176-2186.
  • Vis forfatter(e) (2010). Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer. BMC Cancer. 13 sider.
  • Vis forfatter(e) (2009). The purification and application of biologically active recombinant steroid cytochrome P450 21-hydroxylase: The major autoantigen in autoimmune Addison's disease. Journal of Autoimmunity. 58-67.
  • Vis forfatter(e) (2009). Nuclear receptor co-activators and HER-2/neu are upregulated in breast cancer patients during neo-adjuvant treatment with aromatase inhibitors. British Journal of Cancer. 1253-1260.
  • Vis forfatter(e) (2009). Fish protein hydrolysate elevates plasma bile acids and reduces visceral adipose tissue mass in rats. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 254-262.
  • Vis forfatter(e) (2009). A pan-PPAR ligand induces hepatic fatty acid oxidation in PPAR alpha-/- mice possibly through PGC-1 mediated PPAR delta coactivation. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1076-1083.
  • Vis forfatter(e) (2008). Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. Endocrinology. 4336-4345.
  • Vis forfatter(e) (2008). Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. Annals of Oncology. 56-61.
  • Vis forfatter(e) (2007). A study of association between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferae 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady sate tamoxifen treatment. Breast Cancer Research and Treatment. S144-S144.
  • Vis forfatter(e) (2005). Induction of hepatic drug-metabolising enzymes and tamoxifen metabolite profile in relation to administration route during low-dose treatment in nude rats. Journal of Steroid Biochemistry and Molecular Biology. 489-498.
  • Vis forfatter(e) (2005). Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry. Journal of Chromatography A. 6-14.
  • Vis forfatter(e) (2005). Excretion of hydroxylated metabolites of tamoxifen in human bile and urine. Anticancer Research. 4487-4492.
  • Vis forfatter(e) (2004). cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1. Journal of Biological Chemistry. 49120-49130.
  • Vis forfatter(e) (2004). Autoantibodies against 21-hydroxylase and side-chain cleavage enzyme in autoimmune Addison's disease are mainly immunoglobulin G1. European Journal of Endocrinology (EJE). 49-56.
  • Vis forfatter(e) (2002). Activation of cAMP-dependent protein kinase increases the protein level of steroidogenic factor-1. Endocrinology.
  • Vis forfatter(e) (1998). Biochemical and functional analysis of nuclear receptors as targets in cAMP-dependent control of bovine CYP17. Endocrine Research. 497-504.
  • Vis forfatter(e) (1998). Biochemical and functional analysis of nuclear receptors as targets in cAMP-dependent control of bovine CYP17. Endocrine Research.
  • Vis forfatter(e) (1997). Transcriptional regulation of the bovine CYP17 gene by cAMP. Steroids. 43-45.
  • Vis forfatter(e) (1997). Synergistic antiproliferative actions of cyclic adenosine 3',5'-monophosphate, interleukin-1beta, and activators of Ca%2%+/calmodulin-dependent protein kinase in primary hepatocytes. Endocrinology. 4373-4383.
  • Vis forfatter(e) (1997). Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. Hepatology. 847-855.
  • Vis forfatter(e) (1997). Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. Hepatology. 847-855.
  • Vis forfatter(e) (1995). Sensitive and rapid detection of _b-galactosidase expression in intact cells by microinjection of fluorescent substrate. Experimental Cell Research. 372-378.
  • Vis forfatter(e) (1995). Okadaic acid, cAMP, and selected nutrients inhibit hepatocyte proliferation at different stages in G%b: Modulation of the cAMP effect by phosphatase inhibitors and nutrients. Journal of Cellular Physiology. 232-240.
  • Vis forfatter(e) (1995). Novel Rp-cAMPS analogs as tools for inhibition of type I cAMP-dependent protein kinase in cell culture. Basal cAMP-kinase activity modulates hepatocyte DNA replication and interleukin-1_b action. Journal of Biological Chemistry. 22599-20607.
  • Vis forfatter(e) (1995). Fine mapping of 28S rRNA sites specifically cleaved in cells undergoing apoptosis. Molecular and Cellular Biology. 2051-2062.
  • Vis forfatter(e) (1994). Cleaved intracellular plasminogen activator inhibitor-2 is a marker of apoptosis present in human myeloid leukemia cells. British Journal of Cancer. 834-840.
  • Vis forfatter(e) (1993). Hepatocyte DNA replication is abolished by inhibitors selecting protein phosphatase 2A rather than phosphatase 1. Exp Cell Res. 293-301.
Vitenskapelig foredrag
  • Vis forfatter(e) (2023). Long-term impact of gastropexy on use of acid-reducing medication, second operations for gastroesophageal reflux and subjective reflux symptoms after sleeve gastrectomy .
  • Vis forfatter(e) (2021). Epigenetic control of adipogenesis by Irx3.
  • Vis forfatter(e) (2021). Altered hepatic HIBCH expression is associated with hepatic lipid accumulation and fatty liver.
  • Vis forfatter(e) (2019). Circulating 3-hydroxyisobutyrate (3-HIB) as a clinical marker of prediabetes and T2D in patients with obesity.
  • Vis forfatter(e) (2018). Amino acid metabolism in adipocytes.
  • Vis forfatter(e) (2015). Lean seafood intake reduces cardiovascular risk factors in healthy subjects.
  • Vis forfatter(e) (2012). Weight cycling affects adipose tissue genes involved in circadian rhythm and lipid metabolism.
  • Vis forfatter(e) (2012). Novel transcription factors in obesity.
  • Vis forfatter(e) (2012). Integrative genomics links homeobox transcription factors to intra-abdominal obesity.
  • Vis forfatter(e) (2012). Homeobox transcription factors IRX3 and 5 in obesity.
  • Vis forfatter(e) (2012). Effects of a high fish intake on lipid and bile acid levels in serum and feces from overweight and obese adults.
  • Vis forfatter(e) (2012). Effects of a high fish intake on leukocyte membrane fatty acid composition and leukocyte function ex vivo in overweight and obese adults.
  • Vis forfatter(e) (2012). Effect of a high fish intake on glucose tolerance and GLP-1 levels in overweight and obese adults.
  • Vis forfatter(e) (2010). Presentasjon av strategisk satsing innen ernæring og overvekt.
  • Vis forfatter(e) (2010). Oppregulering av østrogen-receptor koaktivatorer og HER-2/neu under endokrin behandling av brystkreft.
  • Vis forfatter(e) (2009). Hva kan vi lære av sykelig fedme? Fedme og genekspresjon.
  • Vis forfatter(e) (2009). Bariatric surgery dramatically alters global gene expression in adipose tissue.
  • Vis forfatter(e) (2009). Adipogen – en studie av fettvev til pasienter som har gjennomgått overvektskirurgi.
  • Vis forfatter(e) (2008). Nuclear Receptor Coactivators.
  • Vis forfatter(e) (2008). Marine macronutrients, metabolic homeostasis and obesity.
  • Vis forfatter(e) (2007). Role of cAMP in Regulation of the Nuclear Receptor Coactivator GRIP1.
  • Vis forfatter(e) (2006). NUCLEAR RECEPTORS IN ENDOCRINE FUNCTION AND DISEASE.
  • Vis forfatter(e) (2005). Regulering av steroidhormonreseptorer ved protein-protein interaksjon.
  • Vis forfatter(e) (2005). Endocrine regulation of a nuclear receptor coactivator.
  • Vis forfatter(e) (2005). Cellular immunity to 21-hydroxylase in patients with autoimmune Addison's disease.
  • Vis forfatter(e) (2005). A pan-PPAR ligand induces differential coactivation of PPARs by SRCs and PGC-1.
  • Vis forfatter(e) (2004). cAMP-depentent protein kinase regulates ubiquitin-proteasome mediated degradation of the nuclear receptor coactivator GRIP1.
  • Vis forfatter(e) (2004). Tetradecylthioacetic acid induces ligand dependent coactivation of PPARs by PGC-1 and SRC coactivators.
  • Vis forfatter(e) (2004). Prisforedrag - Novo Nordisk pris for fremragende forskning i endokrinologi.
  • Vis forfatter(e) (2004). Nuclear Receptor Interacting Proteins as Molecular Targets in Breast Carcinoma.
  • Vis forfatter(e) (2004). Intracellulære hormonreseptorer - betydning av nye koregulator proteiner.
  • Vis forfatter(e) (2004). Hormonal regulation of the Glucocorticoid receptor interacting protein 1 (GRIP1).
  • Vis forfatter(e) (2004). Hormonal regulation of nuclear receptor coactivator GRIP1.
  • Vis forfatter(e) (1998). Ultrarapid apoptosis induction in a variety of cell types injected with phosphatase inhibitors is mediated through Ca2 /calmodulin dependent protei kinase activity.
Populærvitenskapelig artikkel
  • Vis forfatter(e) (2013). Steroid reseptor koaktivatorer, HER-2 og hormonbehandling ved brystkreft. Bestpractice : dialog mellom leger. 8-13.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
  • Vis forfatter(e) (2012). Tamoxifen metabolism and biological activity. 22 sider.
  • Vis forfatter(e) (2011). Steroid Receptor Coactivators and Their Expression, Regulation and Functional Role in Endocrine Responsive and Resistant Breast Cancer. 18 sider.
  • Vis forfatter(e) (2011). Steroid Receptor Coactivators and Endocrine Treatment in Breast Cancer. 32 sider.
  • Vis forfatter(e) (1996). Sensitive and rapid detection of B-galactosidase expression in intact cells by microinjection of fluorecent substrate.
Sammendrag/abstract
  • Vis forfatter(e) (2020). Relationship between CYP2D6 genotype, tamoxifen metabolites, and adverse events, tumor biomarkers and breast cancer recurrence in a low-dose phase III trial in noninvasive disease. Journal of Clinical Oncology.
  • Vis forfatter(e) (2010). Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss. Endocrine reviews. 1 sider.
  • Vis forfatter(e) (2010). From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery. Endocrine journal. S429-S429.
  • Vis forfatter(e) (2010). Effects of CYP2C19 genotype on tamoxifen and estrogen metabolism. European Journal of Cancer. 60-60.
  • Vis forfatter(e) (2007). Effect of CYP2D6 and SULT1A1 genotypes on the serum concentration of 4-hydroxytamoxifen and 4-hydroxy-N-demethyltamoxifen during steady state treatment of breast cancer patients. Breast. S15-S15.
  • Vis forfatter(e) (2007). A study of associations between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferase 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady state tamoxifen treatment. Breast Cancer Research and Treatment.
  • Vis forfatter(e) (2005). Relationship between CYP2D6 and SULT1A1 genotypes and serum concentrations of tamoxifen and its metabolites during steady state treatment in breast cancer patients. Breast Cancer Research and Treatment. S236-S237.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) (2022). Metabolic and Epigenetic Regulation by Estrogen in Adipocytes. Frontiers in Endocrinology.
  • Vis forfatter(e) (2021). Generating a precision endoxifen prediction algorithm to advance personalized tamoxifen treatment in patients with breast cancer. Journal of Personalized Medicine. 1-23.
  • Vis forfatter(e) (2019). Natural killer cells as sensors of adipose tissue stress. Trends in endocrinology and metabolism. 1-10.
  • Vis forfatter(e) (2011). Tissue-specific effects of bariatric surgery including mitochondrial function. International Journal of Obesity. 435245.
  • Vis forfatter(e) (2002). Differential regulation of SF-1-cofactor interactions. Endocrine Research.
Fagartikkel
  • Vis forfatter(e) (2022). Liquid biopsies and patient-reported outcome measures for integrative monitoring of patients with early-stage breast cancer: a study protocol for the longitudinal observational Prospective Breast Cancer Biobanking (PBCB) study. BMJ Open.

Se fullstendig oversikt over publikasjoner i CRIStin.

Selekterte publikasjoner:

Mellgren, G., Gjertsen, B.T, Otten, A., Maronde, E., Genieser, H-G., Jasdorff, B., Vintermyr, O.K., McKnight, G.S., and Døskeland, S.O. (1995) Novel Rp-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1b action. J. Biol. Chem., 270:20599-20607.

Fladmark, K.E, Brustugun, O.T, Mellgren, G, Krakstad, C, Bøe, R., Vintermyr, O.K., Schulman, H., and Døskeland, S.O. (2002) Ca2+/calmodulin dependent protein kinase II is required for microcystin-induced apoptosis. J. Biol. Chem., 277:2804-2811.

Børud, B., Hoang, T., Bakke, M, Jacob, A., Lund, J, and Mellgren, G (2002). The nuclear coactivators p/CIP and TIF2 differentially regulate PKA-dependent transcriptional activity of Steroidogenic factor-1. Mol. Endocrinol., 16:757-773.

Børud, B., Mellgren, G., Lund, J. and Bakke, M. (2003) Cloning and Characterization of a Novel Zinc-finger Protein that Modulates the Transcriptional Activity of Nuclear Receptors. Mol. Endocrinol., 17:2303-2319 

Hoang, T., Fenne, I., Cook, C., Børud, B., Bakke, M., Lien, E.A and Mellgren, G (2004) cAMP-dependent Protein Kinase Regulates Ubiquitin-proteasome mediated Degradation and Subcellular Localization of the Nuclear Receptor Coactivator GRIP1. J. Biol. Chem., 279:49120-49130.

Gjerde, J., Hauglid, M., Breilid, H., Lundgren, S., Varhaug, J.E., Kisanga, E.R., Mellgren, G., Steen, V.M., and Lien, E.A. (2007). Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. Ann Oncol., 19:56-61.

Fenne, I.S., Hoang, T., Hauglid, M, Sagen, JV, Lien, E.A., and Mellgren, G. (2008). Recruitment of coactivator GRIP1 to an estrogen receptor transcription complex is regulated by cAMP-dependent protein kinase. Endocrinology, 149:4336-45.

Moi, L.H.L., Hauglid, M., Gandini, S, Aliana, G.G., Bonanni, B., Lazzeroni, M., Gjerde, J, Lien, E.A., Decensi, A, and Mellgren G. (2010) Effects of low dose tamoxifen on Steroid Receptor Coactivator 1/Amplified in Breast Cancer 1 in normal an malignant breast tissue. Clin. Cancer Res., 16:2176-86

Dankel SE, Fadnes D, Stavrum AK, Stansberg C, Holdhus R, Hoang T, Veum V, Christensen B, Vaage V, Sagen JV, Steen VM, Mellgren G (2010) Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLoS ONE, 9;5(6):e11033

Monika H.E. Christensen, Eva K.R. Pedersen, Yngve Nordbø, Jan Erik Varhaug, Øyvind Midttun, Per M. Ueland, Ottar K. Nygaard, Gunnar Mellgren, Ernst A. Lien (2012) Vitamin B6 Status and Interferon-γ Mediated Immune Activation in Primary Hyperparathyroidism. J Intern Medicine. Jul 3. doi: 10.1111/j.1365-2796.2012.02570.x

Hoang, T. Fenne, I,  Johannessen, M, Lien, E.A., Moens, U and Mellgren, G. (2013) cAMP Response Element Binding Protein (CREB) Interacts with the nuclear receptor coactivator GRIP1 and mediates its degradation. Endocrinology,Apr;154(4):1513-27. doi: 10.1210/en.2012-2049. Epub 2013 Mar 5.

Claussnitzer M, Dankel SN, Klocke B, Grallert H, Glunk V, Berulava T, Lee H, Oskolkov N, Fadista J, Ehlers K, Wahl S, Hoffmann C, Qian K, Rönn T, Riess H, Müller-Nurasyid M, Bretschneider N, Schroeder T, Skurk T, Horsthemke B; DIAGRAM+Consortium, Spieler D, Klingenspor M, Seifert M, Kern MJ, Mejhert N, Dahlman I, Hansson O, Hauck SM, Blüher M, Arner P, Groop L, Illig T, Suhre K, Hsu YH, Mellgren G, Hauner H, Laumen H. Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms. Cell. 2014 Jan 16;156(1-2):343-58

Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science Translational Medicine, 2014, 6(247);247ra103. 

Aadland EK, Lavigne C, Graff IE, Eng Ø, Paquette M, Holthe A, Mellgren G, Jacques H, Liaset B. Lean-seafood intake reduces cardiovascular lipid risk factors in healthy subjects: results from a randomized controlled trial with a crossover design. Am J Clin Nutr. 2015 Sep;102(3):582-92. 

Melina Claussnitzer, Simon Nitter Dankel, Gerald Quon, Kyoung-Han Kim, Wouter Meuleman, Christine Haugen, Viktoria Glunk, Isabel Sousa, Jacqueline L. Beaudry, Vijitha Puviindran, Nezar A. Abdennur, Jannel Liu, Per-Arne Svensson, Yi-Hsiang Hsu, Daniel J. Drucker, Gunnar Mellgren, Chi-Chung Hui, Hans Hauner, Manolis Kellis. FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. New Engl. J. Medicine, 2015 Sep 3;373(10):895-907

Vivian L. Veum, Johnny Laupsa-Borge, Øyvin Eng, Espen Rostrup, Terje H. Larsen, Jan Erik Nordrehaug, Ottar Nygård, Jørn V. Sagen, Oddrun A. Gudbrandsen, Simon N. Dankel, Gunnar Mellgren. Visceral adiposity and metabolic syndrome after very-high-fat and low-fat isocaloric diets: a randomized controlled trial (FATFUNC). Am J Clin Nutr. 2017 Jan;105(1):85-99

Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients. Helland T, Henne N, Bifulco E, Naume B, Borgen E, Kristensen VN, Kvaløy JT, Lash TL, Alnæs GIG, van Schaik RH, Janssen EAM, Hustad S, Lien EA, ‡Mellgren G, ‡Søiland H. Breast Cancer Res. 2017 Nov 28;19(1):125. doi: 10.1186/s13058-017-0916-4. 

IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. Bjune JI, Haugen C, Gudbrandsen O, Nordbø OP, Nielsen HJ, Våge V, Njølstad PR, Sagen JV, Dankel SN, Mellgren G. Int J Obes (Lond). 2019 Nov;43(11):2151-2162

The homeobox factor Irx3 maintains adipogenic identity. Bjune JI, Dyer L, Røsland GV, Tronstad KJ, Njølstad PR, Sagen JV, Dankel SN, Mellgren G. Metabolism. 2019 Nov 18;103:154014. doi: 10.1016/j.metabol.2019.154014.

Testicular ultrasound to stratify hormone references in a cross-sectional Norwegian study of male puberty. Madsen A, Oehme NB, Roelants M, Bruserud IS, Eide GE, Viste K, Bjerknes R, Almås B, Rosendahl K, Sagen JV, Mellgren G, Juliusson PB. J Clin Endocrinol Metab. 2019 Oct 26. pii: dgz094. doi: 10.1210/clinem/dgz094.

3-Hydroxyisobutyrate, A Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte Metabolism. Nilsen MS, Jersin RÅ, Ulvik A, Madsen A, McCann A, Svensson P-A, Svensson M-E, Nedrebø B-G, Gudbrandsen OA, Tell GS, Kahn CR,Ueland PM, Mellgren G, and Dankel SN. Diabetes 2020; 69:1–14 https://doi.org/10.2337/db19-1174.

https://www.uib.no/en/rg/hormonelaboratory

Mohn Nutrition Research Laboratory funded by Trond Mohn stiftelse www.uib.no/mohn-elab

https://www.uib.no/diabetes

Spesialist i indremedisin, hormonsykdommer og medisinsk biokjemi

Kompetansefelt 
Adipose Tissue
Diabetes
Genomics
Hormones and breast cancer
Obesity