- E-posthakon.gjessing@uib.no
- Telefon+47 21 07 82 41
- BesøksadresseAlrek helseklynge, blokk D, Årstadveien 175009 Bergen
- PostadressePostboks 78045020 Bergen
Vitenskapelig artikkel
- (2023). The X-factor in ART: does the use of assisted reproductive technologies influence DNA methylation on the X chromosome? Human Genomics.
- (2022). Effectiveness of mRNA booster vaccination against mild, moderate, and severe COVID-19 caused by the Omicron variant in a large, population-based, Norwegian cohort. Journal of Infectious Diseases. 1924-1933.
- (2022). DNA methylation in newborns conceived by assisted reproductive technology. Nature Communications. 1-12.
- (2022). Association of SARS-CoV-2 Vaccination during Pregnancy with Pregnancy Outcomes. Journal of the American Medical Association (JAMA). 1469-1477.
- (2021). Wavelet Screening: a novel approach to analyzing GWAS data. BMC Bioinformatics. 20 sider.
- (2021). Wavelet Screening identifies regions highly enriched for differentially methylated loci for orofacial clefts. NAR Genomics and Bioinformatics. 1-16.
- (2021). Psychosocial work factors and sick leave risk after a terrorist bomb attack: a survey and registry-based longitudinal study of governmental employees in Norway. BMJ Open. 9 sider.
- (2021). Pregnancy and risk of COVID-19: a Norwegian registry-linkage study. BJOG: An International Journal of Obstetrics and Gynaecology. 101-109.
- (2021). Growth in children conceived by ART. Human Reproduction. 1074-1082.
- (2021). An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies. Clinical Epigenetics. 13 sider.
- (2021). A fast wavelet-based functional association analysis replicates several susceptibility loci for birth weight in a Norwegian population. BMC Genomics. 9 sider.
- (2020). Seasonal and pandemic influenza during pregnancy and risk of fetal death: A Norwegian registry‑based cohort study. European Journal of Epidemiology (EJE). 371-379.
- (2020). PHLDA2 gene polymorphisms and risk of HELLP syndrome and severe preeclampsia. Pregnancy Hypertension. 190-194.
- (2020). Heritability curves: A local measure of heritability in family models. Statistics in Medicine. 1357-1382.
- (2020). Gene-methylation interactions: Discovering region-wise DNA methylation levels that modify SNP-associated disease risk. Clinical Epigenetics. 18 sider.
- (2020). Design efficiency in genetic association studies. Statistics in Medicine. 1292-1310.
- (2020). Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array. BMC Genomics. 13 sider.
- (2019). Placental epigenetic clocks: estimating gestational age using placental DNA methylation levels. Aging. 4238-4253.
- (2019). Intake of sucrose‑sweetened soft beverages during pregnancy and risk of congenital heart defects (CHD) in offspring: A Norwegian pregnancy cohort study. European Journal of Epidemiology (EJE). 383-396.
- (2019). Haplin power analysis: a software module for power and sample size calculations in genetic association analyses of family triads and unrelated controls. BMC Bioinformatics. 11 sider.
- (2019). Association of Household Income with Life Expectancy and Cause-Specific Mortality in Norway, 2005-2015. Journal of the American Medical Association (JAMA). 1916-1925.
- (2019). A genome-wide scan of cleft lip triads identifies parent-of-origin interaction effects between ANK3 and maternal smoking, and between ARHGEF10 and alcohol consumption. F1000 Research. 28 sider.
- (2018). Analysis of parent-of-origin effects on the X chromosome in asian and european orofacial cleft triads identifies associations with DMD, FGF13, EGFL6, and additional loci at Xp22.2. Frontiers in Genetics. 17 sider.
- (2018). A genome-wide search for gene-environment effects in isolated cleft lip with or without cleft palate triads points to an interaction between maternal periconceptional vitamin use and variants in ESRRG. Frontiers in Genetics. 16 sider.
- (2017). Variants in the fetal genome near FLT1 are associated with risk of preeclampsia. Nature Genetics. 1255-1260.
- (2017). Symfyse-fundus-mål – prediktiv verdi av ny referansekurve. Tidsskrift for Den norske legeforening. 717-720.
- (2017). Svangerskapsdatering. Norsk Epidemiologi. 13-18.
- (2017). Parent-of-origin-environment interactions in case-parent triads with or without independent controls. Annals of Human Genetics. 60-73.
- (2017). Human birth weight and reproductive immunology: testing for interactions between maternal and offspring KIR and HLA-C genes. Human Heredity. 181-193.
- (2017). Genome-wide analysis of parent-of-origin interaction effects with environmental exposure (PoOxE): An application to European and Asian cleft palate trios. PLOS ONE. 19 sider.
- (2017). A new approach to chromosome-wide analysis of X-linked markers identifies new associations in Asian and European case-parent triads of orofacial clefts. PLOS ONE. 23 sider.
- (2017). A Population-Based Study of Effects of Genetic Loci on Orofacial Clefts. Journal of Dental Research. 1322-1329.
- (2016). Seed viability and germination success of Acacia tortilis along land-use and aridity gradients in the Eastern Sahara. Ecology and Evolution. 256-266.
- (2016). Prediction of small-for-gestational-age status by symphysis–fundus height: a registry-based population cohort study. BJOG: An International Journal of Obstetrics and Gynaecology. 1167-1173.
- (2016). Prediction of gestational age based on genome-wide differentially methylated regions. Genome Biology. 9 sider.
- (2016). Fetal size monitoring and birth-weight prediction: a new population-based approach. Ultrasound in Obstetrics and Gynecology. 500-507.
- (2016). Estimation of fetal weight in pregnancies past term. Acta Obstetricia et Gynecologica Scandinavica. 183-189.
- (2015). Genetic determinants of enterovirus infections: Polymorphisms in type 1 diabetes and innate immune genes in the MIDIA study. Viral immunology. 556-563.
- (2014). Maternal KIR in combination with paternal HLA-C2 regulate human birth weight. Journal of Immunology. 5069-5073.
- (2014). KIR and HLA-C: Immunogenetic regulation of human birth weight. Norsk Epidemiologi. 107-110.
- (2013). X-chromosomal maternal and fetal SNPs and the risk of spontaneous preterm delivery in a Danish/Norwegian genome-wide association study. PLOS ONE. 11 sider.
- (2013). Risk of Fetal Death after Pandemic Influenza Virus Infection or Vaccination. New England Journal of Medicine. 333-340.
- (2013). GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment. Science. 1467-1471.
- (2013). Body mass index, smoking, and risk of death between 40 and 70 years of age in a Norwegian cohort of 32,727 women and 33,475 men. European Journal of Epidemiology (EJE). 35-43.
- (2013). A new population-based reference curve for symphysis-fundus height. Acta Obstetricia et Gynecologica Scandinavica. 925-933.
- (2012). X-Linked Genes and Risk of Orofacial Clefts: Evidence from Two Population-Based Studies in Scandinavia. PLOS ONE.
- (2012). Using offspring-parent triads to study complex traits : a tutorial based on orofacial clefts. Norsk Epidemiologi. 251-267.
- (2012). Risk factors for extended duration of acute diarrhea in young children. PLOS ONE.
- (2012). Relative importance of risk factors for coronary heart disease - The Hordaland Homocysteine Study. Scandinavian Cardiovascular Journal. 316-323.
- (2012). Maternal tryptophan and kynurenine pathway metabolites and risk of preeclampsia. Obstetrics and Gynecology. 1243-1250.
- (2012). Case/Control studies with follow-up: constructing the source population to estimate effects of risk factors on development, disease, and survival. Clinical Infectious Diseases. s262-s270.
- (2012). Assessing the impact of nicotine dependence genes on the risk of facial clefts: An example of the use of national registry and biobank data. Norsk Epidemiologi. 241-250.
- (2012). Application of a Novel Hybrid Study Design to Explore Gene-Environment Interactions in Orofacial Clefts. Annals of Human Genetics. 221-236.
- (2012). Advantages of the population-based approach to pregnancy dating: results from 23 020 ultrasound examinations. Ultrasound in Obstetrics and Gynecology. 563-568.
- (2011). Narrowed beam width in newer ultrasound machines shortens measurements in the lateral direction: fetal measurement charts may be obsolete. Ultrasound in Obstetrics and Gynecology. 82-87.
- (2011). Intake of probiotic food and risk of spontaneous preterm delivery. American Journal of Clinical Nutrition. 151-157.
- (2011). Fetal genetic risk of isolated cleft lip only versus isolated cleft lip and palate: a subphenotype analysis using two population-based studies of orofacial clefts in Scandinavia. Birth Defects Research Part A: Clinical and Molecular Teratology. 85-92.
- (2011). Extensive variation and low heritability of DNA methylation identified in a twin study. Genome Research. 1813-1821.
- (2011). Candidate gene analysis of spontaneous preterm delivery: New insights from re-analysis of a case-control study using case-parent triads and control-mother dyads. BMC Medical Genetics.
- (2011). A new population-based term prediction model vs. two traditional sample-based models: validation on 9046 ultrasound examinations. Ultrasound in Obstetrics and Gynecology. 207-213.
- (2011). A hierarchical frailty model applied to two-generation melanoma data. Lifetime Data Analysis. 445-460.
- (2010). Recurrent events and the exploding Cox model. Lifetime Data Analysis. 525-546.
- (2010). Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. PLOS ONE.
- (2010). Maternal angiotensinogen (AGT) haplotypes, fetal renin (REN) haplotypes and risk of preeclampsia; estimation of gene-gene interaction from family-triad data. BMC Medical Genetics. 7 sider.
- (2010). Biases of traditional term prediction models: results from different sample-based models evaluated on 41 343 ultrasound examinations. Ultrasound in Obstetrics and Gynecology. 728-734.
- (2009). Vaccination as teenagers against meningococcal disease and the risk of the chronic fatigue syndrome. Vaccine. 23-27.
- (2009). Self-selection and bias in a large prospective pregnancy cohort in Norway. Paediatric and Perinatal Epidemiology. 597-608.
- (2009). Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study. Genetic Epidemiology. 247-255.
- (2009). Genetic determinants of facial clefting: analysis of 357 candidate genes using two national cleft studies from Scandinavia. PLOS ONE.
- (2008). Maternal smoking and oral clefts - The role of detoxification pathway genes. Epidemiology. 606-615.
- (2008). Genetic variants in IRF6 and the risk of facial clefts: Single-marker and haplotype-based analyses in a population-based case-control study of facial clefts in Norway. Genetic Epidemiology. 413-424.
- (2008). Biometrical modelling in genetics: are complex traits too complex? Statistical Methods in Medical Research. 75-96.
- (2008). Biometrical modeling of twin and family data using standard mixed model software. Biometrics. 280-288.
- (2007). The association of gastric cancer risk with plasma folate, cobalamin, and Methylenetetrahydrofolate reductase polymorphisms in the European prospective investigation into cancer and nutrition. Cancer Epidemiology, Biomarkers and Prevention. 2416-2424.
- (2007). Marriages and psychological distress among adult offspring of divorce: A Norwegian study. Scandinavian Journal of Psychology. 467-476.
- (2007). Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy. Human Genetics. 529-538.
- (2007). Genetic and environmental influences on birth weight, birth length, head circumference and gestational age using population based parent-offspring data. American Journal of Epidemiology. 734-741.
- (2007). Folate, but not vitamin B-12 status, predicts respiratory morbidity in north Indian children. American Journal of Clinical Nutrition. 139-144.
- (2007). A direct method for ultrasound prediction of day of delivery: a new, population-based approach. Ultrasound in Obstetrics and Gynecology. 19-27.
- (2006). Smoking and deaths between 40 and 70 years of age in women and men. Annals of Internal Medicine. 381-389.
- (2006). Plasma total homocysteine level and bone mineral density - The Hordaland homocysteine study. Archives of Internal Medicine. 88-94.
- (2006). Patterns and predictors of folic acid supplement use among pregnant women: the Norwegian Mother and Child Cohort Study. American Journal of Clinical Nutrition. 1134-1141.
- (2006). Likelihood ratio tests in behavioral genetics: Problems and solutions. Behavior Genetics. 331-340.
- (2006). Genetic polymorphisms in arginase I and II and childhood asthma and atopy. Journal of Allergy and Clinical Immunology. 119-126.
- (2006). Case-parent triads: Estimating single- and double-dose effects of fetal and maternal disease gene haplotypes. Annals of Human Genetics. 382-396.
- (2005). Folate supplementation and twin pregnancies. Epidemiology. 201-205.
- (2005). Case-parent triads: Estimating single- and double-dose effects of fetal and maternal disease gene haplotypes. Annals of Human Genetics. 1-15.
- (2004). Survival models based on the Ornstein-Uhlenbeck process. Lifetime Data Analysis. 407-423.
- (2004). Protection from natural infections with enterotoxigenic Escherichia coli: longitudinal study. Ugeskrift for Læger. 4051-4053.
- (2004). Dependency issues in survival analyses of 55 782 primary hip replacements from 47 355 patients. Statistics in Medicine. 3227-3240.
- (2004). Analysis of testicular cancer data using a frailty model with familial dependence. Statistics in Medicine. 617-632.
- (2003). Protection from natural infections with enterotoxigenic Escherichia coli: longitudinal study. The Lancet. 286-291.
- (2003). Protection from natural infections with enterotoxigenic Escherichia coli: longitudinal study. The Lancet. 286-291.
- (2003). Frailty models based on L{\'e}vy processes. Advances in Applied Probability. 532-550.
- (2001). Understanding the shape of the hazard rate: a process point of view. Statistical Science. 1-22.
- (2001). Understanding the shape of the hazard rate: A process point of view - Comments and rejoinder. Statistical Science. 14-22.
- (2001). Pneumococcal pulmonary infection, septicaemia and survival in young zinc-depleted mice. British Journal of Nutrition. 301-306.
- (2001). Paternal contribution to birth weight. Journal of Epidemiology and Community Health. 873-877.
- (2000). Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine Study. American Journal of Clinical Nutrition. 962-968.
- (2000). Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine Study. American Journal of Clinical Nutrition. 962-968.
- (2000). New standards for birth weight by gestational age using family data. American Journal of Obstetrics and Gynecology. 689-696.
- (2000). New standards for birth weight by gestational age using family data. American Journal of Obstetrics and Gynecology. 689-696.
- (2000). Mortality after total hip replacement: 0-10-year follow-up of 39,543 patients in the Norwegian Arthroplasty Register. Acta Orthopaedica Scandinavica. 19-27.
- (2000). Mortality after total hip replacement - 0-10-year follow-up of 39,543 patients in the Norwegian Arthroplasty Register. Acta Orthopaedica Scandinavica. 19-27.
- (2000). Measurement of specific IgA in faecal extracts and intestinal lavage fluid for monitoring of mucosal immune responses. JIM - Journal of Immunological Methods. 53-62.
- (2000). Measurement of specific IgA in faecal extracts and intestinal lavage fluid for monitoring of mucosal immune responses. JIM - Journal of Immunological Methods. 53-62.
- (2000). Measurement of specific IgA in faecal extracts and intestinal lavage fluid for monitoring of mucosal immune responses. JIM - Journal of Immunological Methods. 53-62.
- (2000). Infants' length at birth: an independent effect on perinatal mortality. Acta Obstetricia et Gynecologica Scandinavica. 459-464.
- (2000). Infant's length at birth: an independent effect on perinatal mortality. Acta Obstetricia et Gynecologica Scandinavica. 459-464.
- (2000). Birthweight by gestational age in Norway. Acta Obstetricia et Gynecologica Scandinavica. 440-449.
- (2000). Birthweight by gestational age in Norway. Acta Obstetricia et Gynecologica Scandinavica. 440-449.
- (2000). A nonlinear parabolic equation with noise. A reduction method. Potential Analysis. 385-401.
- (2000). A nonlinear parabolic equation with noise - A reduction method. Potential Analysis. 385-401.
- (1999). Recurrence of gestational age in sibships: Implications for perinatal mortality. American Journal of Epidemiology. 756-762.
- (1999). Recurrence of gestational age in sibships: Implications for perinatal mortality. American Journal of Epidemiology. 756-762.
- (1999). Community-based randomized controlled trial of reduced osmolarity oral rehydration solution in acute childhood diarrhea. Pediatr Infect Dis J. 789-795.
- (1998). Fetal and maternal contributions to risk of pre-eclampsia: population based study. BMJ. British Medical Journal. 1343-1347.
- (1997). Ruin theory with stochastic return on investments. Advances in Applied Probability. 965-985.
- (1997). Ruin theory with stochastic return on investments. Advances in Applied Probability. 965-985.
- (1997). Present value distributions with applications to ruin theory and stochastic equations. Stochastic Processes and their Applications. 123-144.
- (1997). Present value distributions with applications to ruin theory and stochastic equations. Stochastic Processes and their Applications. 123-144.
- (1997). Optimal choice of dividend barriers for a risk process with stochastic return on investments. Insurance, Mathematics & Economics. 215-223.
- (1997). Optimal choice of dividend barriers for a risk process with stochastic return on investments. Insurance, Mathematics & Economics. 215-223.
- (1997). Fetal and maternal contributions to risk of pre-eclampsia: population based study. BMJ. British Medical Journal. 1343-47.
- (1994). A stochastic model for the presence/absence of readings in Nidrstigningar Saga. World archaeology.
Rapport
- (2006). Hvor dødelig er røyking? Rapport om dødsfall og tapte leveår som skyldes røyking. .
- (2006). Hvor dødelig er røyking? Rapport om dødsfall og tapte leveår som skyldes røyking. 2006:4. 2006:4. .
- (1994). Integral conditions for Skorod stochastical differential equations. 24. 24. .
- (1993). A note on the Wick product. Report No.23 March 1993. .
Populærvitenskapelig foredrag
- (1997). Blødninger tidlig i svangerskapet; farligere enn tidligere antatt?
Vitenskapelig foredrag
- (2016). Prenatal detection of macrosomia in pregnancies past term.
- (2016). Prenatal detection of low birthweight in pregnancies past term.
- (2016). Estimation of fetal weight in pregnancies past term.
- (2005). Folate, but not cobalamin status predicts respiratory morbidity in north Indian children.
- (2001). Frailty as a stochastic process.
- (1999). Patient mortality after total hip replacement - follow-up of 35938 patients in the Norwegian Arthroplasty Register.
- (1999). Mortality after total hip replacement. 10 years follow-up of 39453 patients in the Norwegian Arthroplasty Register.
- (1998). Perinatal mortality and infants' length at birth.
- (1998). Distinguishing maternal and fetal contributions to birth weight using half-sib data.
- (1997). Svangerskapsvarigheter og fødselsvekter, noe for en statistiker?
- (1997). Svangerskapsvarigheter og fødselsvekter, noe for en statistiker?
- (1997). Svangerskapsvarigheter og fødselsvekter, noe for en statistiker?
- (1997). New standards for birth weight by gestational age using family data.
- (1997). Føtalt og maternelt bidrag til risiko for preeklampsi.
- (1997). Føtalt og maternelt bidrag til risiko for preeklampsi.
- (1997). Føtalt og maternelt bidrag til risiko for preeklampsi.
- (1997). Errors in gestational age. A somewhat different analysis of errors in computed length of gestation, using birth weight as reference.
- (1997). Errors in gestational age. A somewhat different analysis of errors in computed length of gestation, using birth weight as reference.
- (1997). Errors in gestational age. A somewhat different analysis of errors in computed length of gestation, using birth weight as reference.
- (1996). A variation of parameters solution of a quasi-linear Skorohod stochastic differential equations using the Wick product.
Leder
- (2019). Special issue dedicated to Odd O. Aalen. Lifetime Data Analysis. 587-592.
- (2019). Editorial. Scandinavian Journal of Statistics. 1-1.
- (2013). Risk of Fetal Death After Pandemic Influenza Virus Infection or Vaccination EDITORIAL COMMENT. Obstetrical and Gynecological Survey. 348-349.
Leserinnlegg
- (2010). Comment and reply on: Prediction of the date of delivery based on first trimester ultrasound measurements: an independent method from estimated date of conception. Journal of Maternal-Fetal & Neonatal Medicine. 944-946.
- (2007). Accuracy of second trimester fetal head circumference and biparietal diameter for predicting the time of spontaneous birth. Journal of Perinatal Medicine. 350-351.
- (2006). Regarding "Term prediction with ultrasound: evaluation of a new dating curve for biparietal diameter". Acta Obstetricia et Gynecologica Scandinavica. 1276-1278.
Vitenskapelig monografi
- (2008). Survival and event history analysis: a process point of view. 2008.
- (2008). Survival and Event History Analysis: A Process Point of View.
- (2008). Event history analysis: A process point of view.
Hovedfagsoppgave
- (1990). Some convergence results for ITO diffusions and optimal stopping.
Populærvitenskapelig artikkel
- (2006). Redusert analytisk tilgjengelighet for PCB i humusfarget vann. Vann. 118-126.
Brev til redaktøren
- (2021). Covid-19 vaccination during pregnancy and first-trimester miscarriage. New England Journal of Medicine. 2008-2010.
- (2009). Comment and reply on: Prediction of the date of delivery based on first trimester ultrasound measurements: an independent method from estimated date of conception. Journal of Maternal-Fetal & Neonatal Medicine.
- (2008). Re: A direct method for ultrasound prediction of day of delivery: a new, population-based approach. Problems of accounting for a retrospective selection - Reply. Ultrasound in Obstetrics and Gynecology. 225-227.
- (2006). Regarding "Term prediction with ultrasound: evaluation of a new dating curve for biparietal diameter". Acta Obstetricia et Gynecologica Scandinavica. 1276-1279.
Doktorgradsavhandling
- (1995). Anticipating calculus and wick products.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
- (2003). A look behind survival data: Underlying processes and quasi-stationarity. 14 sider.
Sammendrag/abstract
- (2016). Prenatal detection of macrosomia in pregnancies past term. Ultrasound in Obstetrics and Gynecology.
- (2016). Prenatal detection of low birthweight in pregnancies past term. Ultrasound in Obstetrics and Gynecology.
- (2016). Estimation of fetal weight in pregnancies past term. Ultrasound in Obstetrics and Gynecology.
- (2012). The 2009 Influenza Pandemic, Vaccination during Pregnancy and Fetal Death: A National Registry-Based Study in Norway. Pharmacoepidemiology and Drug Safety. 382-382.
- (2012). OP32.01: The importance of standardizing pregnancy dating models. Ultrasound in Obstetrics and Gynecology. 151-152.
- (2012). Intake of food with antimicrobial diet components and risk of spontaneous preterm delivery. American Journal of Obstetrics and Gynecology. S213-S213.
- (2012). Genetic variants in gene-environment interaction analysis of probiotic intake in spontaneous preterm delivery. American Journal of Obstetrics and Gynecology. S212-S212.
- (2012). Advantages of the population-based approch to pregnancy dating demonstrated with results from 73,400 second-trimester ultrasound examinations. Acta Obstetricia et Gynecologica Scandinavica. 116-117.
- (2012). A population-based reference chart for fundal height measures. Acta Obstetricia et Gynecologica Scandinavica. 117-118.
- (2007). Predicting remaining time of pregnancy - a new population-based approach for the prediction of day of delivery based on Femur length. Ultrasound in Obstetrics and Gynecology. 478-478.
- (2007). Haplotype relative risk estimation in epidemiological studies; New methodology applied to a study of smoking, relevant detoxification genes and oral clefts in Norway. American Journal of Epidemiology. S142.
- (2007). Haplotype relative risk estimation in epidemiological studies; New methodology applied to a study of smoking, relevant detoxification genes and oral clefts in Norway. American Journal of Epidemiology. S142-S142.
- (2007). A new population-based term prediction method-evaluation of the FL-based predictions. Ultrasound in Obstetrics and Gynecology. 367.
- (2007). A new population-based term prediction method-evaluation of the BPD-based predictions. Ultrasound in Obstetrics and Gynecology. 478-479.
Poster
- (2022). Parent-of-origin effects in childhood aggression.
- (2015). Haplin — a powerful tool for studying gene-environment interactions.
- (2010). Relative importance of risk factors for cardiovascular disease incidence and mortality: a prospective cohort study.