Hjem
Hans-René Bjørsviks bilde

Hans-René Bjørsvik

Professor
  • E-postHans.Bjorsvik@uib.no
  • Telefon+47 55 58 34 52
  • Besøksadresse
    Realfagbygget, Allégt. 41
    Rom 
    3016
  • Postadresse
    Postboks 7803
    5020 BERGEN

Organic synthesis and organometallic catalysed reactions in organic synthesis are one of the main research areas of Bjørsvik research group. The research activities comprise design and development of new and better catalytic processes, focusing both on improvement of synthetic processes and methods as well as the design of new ligands with the goal to improved selectivity and activity of the final catalyst. For this work, multivariate statistics and mathematical methods are frequently used. Total synthesis of some natural products have also been included in our project portfolio.

N-heterocyclic compounds where molecular scaffolds of particular interests includes benzo[c]cinnolines, carbazoles, beta-carbolines, phenothiazines, and imidazoles. Functionalization of the imidazole scaffold are of particular interest as such compounds can be used as precursors for NHC ligands used in organometallics for various catalysts, for example for olefin metathesis, cross-coupling reactions, and as oxidation catalysts. Recent years, NHC-Ag complexes have also turnet out to be an interesting target molecules as such compound have shown potent anti-cancer activity.

Medicinal chemistry – drug development is conducted in collaboration with three various biomedicine groups at the Department of Biomedisin at UoB, we are currently working with three distinct drug development projects. In two of the projects we are working with the development of inhibitors for the xCT antiport and for the autophagy process. These two project are targeted treatment of glioblastoma (brain cancer). The thirds project is related to the development of NHC-Ag complexes that has shown potent anti-leukaemia activity.

Flow Chemistry and other instrumental assisted methods in synthesis. Development and investigation of continuous flow organic synthesis reactor systems is an important long standing project in the group. We have successfully developed a novel approach for flow chemistry that is realized as a milli-reactor system that we have named multi-jet oscillation disk (MJOD) milli reactor system.

Regular courses

  • KARM236 Medicinal Chemistry
  • KJEM232 Experimental organic synthesis
  • KJEM131 Organic Synthesis and Analysis (past)
  • KJEM233 Organic mass spectrometry (past)
  • KJEM335 Physical Organic Chemistry (past)

Special Topics

  • Organometallic reactions in organic synthesis
  • Experimental organic synthesis and spectroscopy (laboratory project course)
  • N-heterocyclic carbenes in synthesis
  • Heterocyclic chemistry
  • Free Radical Reactions in Synthetic Organic Chemistry
  • Instrumental methods in organic synthesis (flow sythesis and microwave reactors)
  • Experimental Design and Modelling in Organic Synthesis
  • Retrosynthetic analysis
Vitenskapelig artikkel
  • 2020. Synthesis of N-aryl- and N-alkyl-substituted imidazolium silver complexes: Cytotoxic screening by using human cell lines modelling acute myeloid leukaemia. ChemMedChem. 1-7.
  • 2020. Functionalization of the Imidazole Backbone by Means of a Tailored and Optimized Oxidative Heck Cross-Coupling. Advanced Synthesis and Catalysis. 5079-5092.
  • 2019. A two-step telescoped continuous flow switchable process leading to nitriles, diaziridine or hydrazine derivatives. Reaction Chemistry & Engineering. 41-51.
  • 2018. Synthesis of Boscalid via a three-step telescoped continuous flow process implemented on a MJOD reactor platform. Reaction Chemistry & Engineering. 550-558.
  • 2018. Synthesis of Amides from Alcohols and Amines Through a Domino Oxidative Amidation and Telescoped Transamidation Process. European Journal of Organic Chemistry. 4436-4445.
  • 2018. Carbazomycin G: Method Development and Total Synthesis. European Journal of Organic Chemistry. 1984-1992.
  • 2018. Amino-TEMPO Grafted on Magnetic Multi-Walled Nanotubes: An Efficient and Recyclable Heterogeneous Oxidation Catalyst. European Journal of Organic Chemistry. 1405-1412.
  • 2018. A Co2B Mediated NaBH4 Reduction Protocol Applicable to a Selection of Functional Groups in Organic Synthesis. European Journal of Organic Chemistry. 3416-3425.
  • 2017. A concise synthesis to Benzo[c]cinnolines via 2,2’-dinitro-1,1’-biphenyls attained from a novel tailored Suzuki cross-coupling. ChemistrySelect. 9387-9390.
  • 2016. Synthesis of the carbazole scaffold directly from 2-aminobiphenyl by means of tandem C–H activation and C–N bond formation. European Journal of Organic Chemistry. 5474-5479.
  • 2016. Indium powder as the reducing agent in the synthesis of 2-amino-1,1′-biphenyls. Tetrahedron Letters. 1224-1226.
  • 2016. Continuous flow synthesis of the iodination agent 1,3-diiodo-5,5-dimethyl-imidazolidine-2,4-dione telescoped with semi-continuous product isolation. Reaction Chemistry & Engineering. 379-386.
  • 2016. Continuous flow synthesis concatenated with continuous flow liquid–liquid extraction for work- up and purification: selective mono- and di- iodination of the imidazole backbone. Reaction Chemistry & Engineering. 436-444.
  • 2016. A highly efficient Pd(PPh3)4-catalyzed Suzuki cross-coupling method for the preparation of 2-nitrobi­phenyls from 1-chloro-2-nitrobenz­enes and phenylboronic acids. European Journal of Organic Chemistry. 1344-1354.
  • 2015. The Baeyer-Villiger oxidation versus aromatic ring hydroxylation: Competing organic peracid oxidation mechanisms explored by multivariate modelling of designed multi-response experiments. Journal of Physical Organic Chemistry. 619-628.
  • 2015. Stille cross-coupling for the functionalization of the imidazole backbone: Revisit, improvement, and applications of the method. European Journal of Organic Chemistry. 3506-3512.
  • 2015. Scope and mechanistic limitations of a sonogashira coupling reaction on an imidazole backbone. European Journal of Organic Chemistry. 4658-4666.
  • 2015. Controlling the course of a two-way switchable Pd-catalyzed process by means of empirical multivariate models. ChemCatChem. 2196-2205.
  • 2015. 4-alkylated silver-N-heterocyclic carbene (NHC) complexes with cytotoxic effects in leukemia cells. ChemMedChem. 1522-1527.
  • 2014. Multivariate optimization of a cyclopropanation, the key step in the synthesis of 3,3,4,4-tetraethoxybut-1-yne. Organic Process Research & Development. 891-896.
  • 2014. Continuous flow olefin metathesis using a multijet oscillating disk reactor as the reaction platform. Organic Process Research & Development. 1509-1515.
  • 2013. Fast halogenation of some N-heterocycles by means of N,N-dihalo-5,5-dimethylhydantoin. Advanced Synthesis and Catalysis. 499-507.
  • 2013. A Three-Way Switchable Process for Suzuki Cross-Coupling, Hydrodehalogenation, or an Assisted Tandem Hydrodehalogenation and Suzuki Cross-Coupling Sequence. Advanced Synthesis and Catalysis. 3231-3243.
  • 2012. Synthesis of phenylboronic acids in continuous flow by means of a multijet oscillating disc reactor system operating at cryogenic temperatures. Organic Process Research & Development. 1121-1130.
  • 2012. Separation of reaction product and palladium catalyst after a heck coupling reaction by means of organic solvent nanofiltration. ChemSusChem. 188-193.
  • 2012. Organocatalyzed epoxidation of alkenes in continuous flow using a multi-jet oscillating disk reactor. ChemSusChem. 261-265.
  • 2012. Extraction, isolation, and purification of analytes from samples of marine origin - A multivariate task. Journal of chromatography. B. 46-53.
  • 2011. Synthetic Route Discovery and Introductory Optimization of a Novel Process to Idebenone. Organic Process Research & Development. 673-680.
  • 2011. Multijet Oscillating Disc Millireactor: A Novel Approach for Continuous Flow Organic Synthesis. Organic Process Research & Development. 997-1009.
  • 2010. An optimized process to 10-bromo-1-decanol. Organic Process Research & Development. 1215-1220.
  • 2010. A switchable oxidation process leading to two various versatile pharmaceutical intermediates. Organic Process Research & Development. 1379-1384.
  • 2009. Synthesis of a new bidentate NHC–Ag(I) complex and its unanticipated reaction with the Hoveyda–Grubbs first generation catalyst. Tetrahedron. 7186-7194.
  • 2009. A novel simple and efficient bromination protocol for activated arenes. Tetrahedron Letters. 831-833.
  • 2007. The first imidazolium-substituted metal alkylidene. Organometallics. 4383-4385.
  • 2007. Green and efficient synthesis of bidentate Schiff base Ru catalysts for olefin metathesis. Journal of Organic Chemistry. 3561-3564.
  • 2006. Efficient and green telescoped process to 2-methoxy-3-methyl-[1,4]benzoquinone. Journal of Organic Chemistry. 1703-1706.
  • 2005. Synthesis of methoxy-substituted phenols by peracid oxidation of the aromatic ring. Journal of Organic Chemistry. 7290-7296.
  • 2005. Synthesis of 2-Nitro and 2,2’-Dinitro Biphenyls by means of the Suzuki Cross-Coupling reaction. Journal of Organic Chemistry. 9591-9594.
  • 2005. A novel efficient deoxygenation process for N-heteroarene N-oxides. Journal of Organic Chemistry. 3218-3224.
  • 2004. Online Spectroscopy and Multivariate Data Analysis as a Combined Tool for Process Monitoring and Reaction Optimization. Organic Process Research & Development. 495-503.
  • 2004. Nitroarene Catalyzed Oxidation with Sodium percarbonate or Sodium perborate as the Terminal Oxidant. Tetrahedron Letters. 8615-8620.
  • 2004. Investigations of a novel process to the framework of benzo[c]cinnoline. Journal of Organic Chemistry. 7720-7727.
  • 2002. Organic Processes to Pharmaceutical Chemicals Based on Fine Chemicals from Lignosulfonates. Organic Process Research & Development. 279-290.
  • 2002. N-Acylation Reactions Performed in Aqueous Reaction Medium. Synthesis of Iodixanol. Organic Process Research & Development. 113-119.
  • 2002. Highly Selective and Efficient Conversion of Alkyl Aryl and Alkyl Cyclopropyl Ketones to Aromatic and Cyclopropane Carboxylic Acids by Aerobic Catalytic Oxidation: A Free-Radical Redox Chain Mechanism. Synlett. 610-612.
  • 2002. Carboxylic acids from methyl aryl ketones by means of a new composite aerobic oxidation process. Tetrahedron Letters. 4985-4987.
  • 2002. A New Modified “Montanari Oxidation Process” by Means of Chlorine Dissolved in the reaction Solvent as Oxidant and TEMPO as Catalyst: Oxidation of 3-S-Quinuclidinol to 3-Quinuclidinone. Organic Process Research & Development. 197-200.
  • 2002. A Highly Selective Aerobic Oxidation Process Catalysed by Electron Deficient Nitroarenes via Single Electron Transfer Processes. Journal of Organic Chemistry. 7493-7500.
  • 2001. Process for the production of iodinated organic x-ray contrast agents. US Patent.
  • 2001. New Selective Oxidation Reactions by Nitroarenes in Basic Medium Involving Electron Transfer Processes. Organic Process Research & Development. 136-140.
  • 2001. A Selective Process for N-Alkylation in Competition with O-Alkylation. Boric acid as a Cheap and Effective Protecting Group Applicable for Industrial Scale Synthetic Processes. Organic Process Research & Development. 472-478.
  • 2001. A Bromine Catalysed Free-Radical Oxidation of Acetamides From Primary and Secondary Alkylamines by H_2O_2. Chemical Communications. 523-524.
  • 2000. Organic Process Research and Development by Means of Statistical Experimental Design, Multivariate Modelling, and Mechanistic Interpretation. La Chimica e l'Industria. 8 sider.
  • 2000. High Selectivity in the Oxidation of Mandelic acid derivatives and in O-methylation of protocatechualdehyde. New Processes for Synthesis of Vanillin, iso-Vanillin and Heliotropin. Organic Process Research & Development. 9 sider.
  • 1999. Stability of Iodixanol=3,3',5,5'-tetrakis(2,3-dihydroxypropylcarbamoyl)2,2',4,4',6,6'-hexaiodo-N,N'-(2-hydroxypropane-1,3-diyl)diacetanilide towards acid, base, oxygen, heat and light. Journal of Clinical Pharmacy and Therapeutics. 227-235.
  • 1999. Polar Effects in Free-Radical Reactions. the Paradox of Reductions of alkyl Iodides and Reductive alkylation of Alkenes by Strong Oxidants (t-BuOOH,Pb(OAc)4. Journal of the American Chemical Society. 7760-7765.
  • 1999. Fine Chemicals from Lignosulfonates. 1. Synthesis of Vanillin by Oxidation of Lignosulfonate. Organic Process Research & Development. 330-340.
  • 1999. Fine Chemicals from Lignosulfonates 2. Synthesis of Veratric acid from Acetoveratrone. Organic Process Research & Development. 341-346.
  • 1999. Electrophilic Aromatic Alkylation by Hydroperoxides, Dompetition Between Ionic and Radical Mechanism. Journal of Organic Chemistry. 8812-8815.
Rapport
  • 2006. Organic Free Radicals. Program and abstract collection from the EUCHEM conference on organic free radicals, Scandinavian collaboration for the 2006 conference. .
Faglig foredrag
  • 2018. «Medisinsk teknologi - Nytt studie ved UiB».
  • 2018. Synthesis of targeting molecules as tracers for PET and anticancer pro-drugs: investigation of tumor drug distribution.
  • 2018. Synthesis of targeting molecules as tracers for PET and anticancer pro-drugs: investigation of tumor drug distribution.
  • 2018. Novel probes for hypoxia and NTR-reporter gene imaging .
  • 2018. Grønnkjemi og organisk syntese.
  • 2018. Developing Novel Probes for Hypoxia. PET3D Consortium meeting.
  • 2018. About Department of Chemistry UoB and HUS Centre for Nuclear Medicine and PET – “the home for ESR 9 and ESR10 and short about the research activities”.
  • 2013. New Methods for the Synthesis of Marine Imidazole Alkaloids.
  • 2013. Development and Scale-up of a Synthesis leading to N-tosyl-4-iodoimidazole.
Populærvitenskapelig foredrag
  • 2018. Hvordan lage medisiner.
  • 2010. Krysskoblinger i organisk sytese – Nobelprisen i kjemi 2010.
  • 2009. Erfaringer og resultater fra et forskningsprosjekt som resulterte i etablering av teknologiselskapet Fluens Synthesis.
Vitenskapelig foredrag
  • 2019. Synthesis of targeting molecules : PET and therapeutics.
  • 2018. «Cystine-glutamate antiporter (xCT) inhibitors to overcome radioresistance in brain cancer» .
  • 2018. xCT inhibitors to overcome radioresistance in brain cancer - Some Chemistry. .
  • 2018. Transition metal catalyzed sodium borohydride reduction: applications in organic synthesis .
  • 2018. Synthesis of targeting molecules as tracers for PET and anticancer pro-drugs: investigation of tumor drug distribution.
  • 2018. Synthesis of targeting molecules as tracers for PET and anticancer pro-drugs: investigation of tumor drug distribution .
  • 2018. Novel probes for hypoxia and NTR-reporter gene imaging.
  • 2018. Multi-gram Synthetic Processes Involving Continuous Flow Reactors Telescoped with Semi-Continuous Work-Up and Purification Steps.
  • 2018. A new synthetic method for the preparation of amides.
  • 2017. Synthesis of the Carbazole Scaffold by Means of Tandem C–H Activation and C–N Bond Formation .
  • 2017. Structural modifications of a NHC(-Ag) skeleton with the purpose to optimize the cytotoxic properties .
  • 2016. Synthesis of backbone iodinated imidazole: Continious flow reaction concatenated with continuous work-up steps.
  • 2016. Synthesis of 11C-labelled sulfasalazine as a PET tracer .
  • 2016. Synthesis of 11C labeled sulfasalazine for PET imaging of drug delivery across the blood brain barrier and uptake in tumor tissue.
  • 2016. Synthesis of 11C labeled sulfasalazine for PET imaging of drug delivery across the blood brain barrier and uptake in tumor tissue.
  • 2016. Oral presentation: Flow synthesis concatenated with continuous and semi-continious work-up steps.
  • 2016. Continuous Flow Reactions Concatenated with Continuous Work-up Steps.
  • 2015. Batch and flow processes leading to the iodinating agent 1,3-diiodo-5,5-dimethylimidazolidine-2,4-dione.
  • 2012. Continuous flow synthesis of phenylboronic acids using a multijet oscillating disc (MJOD) telescoped flow reactor system.
  • 2012. Continuous flow synthesis of arylboronic acids.
  • 2012. Continuous flow synthesis at cryogenic temperatures: Synthesis of arylboronic acids in a telescoped flow reactor system.
  • 2010. Towards a novel synthesis of idebenol.
  • 2010. Synthesis in Continuous Flow by means of the Multi-Jet Oscillating Disk milli-Reactor Technology.
  • 2010. Organic Phase Nano-Filtration for Isolation of Palladium Catalyst after Heck Coupling Reaction.
  • 2010. Multi-Jet Oscillating Disk (MJOD) Reactor Technology for Challenging Reactions in Continuous Flow Organic Synthesis: Heterogeneous Reaction Mixtures, Two-Phase Reactions and Catalytic Reactions.
  • 2010. Continuous Flow Olefin Metathesis using the Novel Multi-Jet Oscillating Disk Reactor System as Reaction Platform.
  • 2009. Olefin Metathesis in Continuous Flow using the Novel MJOD milli-reactor Technology.
  • 2008. Organic Synthesis in Continuous Flow by means of the Novel MJOD Reactor System.
  • 2008. Organic Synthesis in Continuous Flow by means of MJOD milli-Reactor System.
  • 2008. Organic Synthesis in Continuous Flow by means of MJOD Reactor System.
  • 2007. Organic Synthesis in Continuous Flow by means of MJOD Reactor System.
  • 2007. Organic Synthesis in Continuous Flow.
  • 2007. Multi-Jet Oscillating Disc Linear Reactor: Towards a Continuous Flow milli-Reactor System for Organic Synthesis.
  • 2006. Multi-Jet Oscillating Disc Reactor: Towards Continuous Flow Milli-Reactor for Organic Synthesis.
  • 2005. Theory-based design of catalysts for olefin metathesis.
  • 2004. Pre-Experimental Design.
  • 2004. Multivariate Data Analysis and On-Line Spectroscopy in Process Research and Optimising.
  • 2004. Building, Analysis and Use of Descriptor Matrices in Multivariate Experimental Design.
  • 2003. Development of Organic Syntheses, Processes, and Reactions by Means of Multivariate Methodology.
  • 2003. DFT investigation of the Pd-catalyzed Suzuki-coupling of nitro-bromo-benzenes and nitrophenyl boronic acids.
  • 2002. Process Evolution by means of Experimental Design and Modelling.
  • 2002. Oxidation Processes Catalyzed by Electron Deficient Nitroarenes via Single Electron Transfer Processes.
  • 2002. Organisk syntese og grønn kjemi (Organic synthesis and green chemistry).
  • 2001. Synthesis of Benzo[c]cinnolines.
  • 2001. Single electron transfer processes in Organic Synthesis.
  • 2001. Organic Processes Optimisation by Means of Experimental Design and Multivariate Modelling, and Response Surface Methodology.
  • 2001. Optimisation of Organic Processes by Means of Multivariate Methods (a serie of four lectures).
  • 2001. New Oxidation Methods Involving Electron Transfer Processes. 1,3-Dinitrobenzene as Stoichiometric Oxidant or as Catalyst with Molecular Oxygen as Terminal Oxidant.
  • 2000. Selective Oxidations by Nitroarenes in Basic Medium Involving Electron Transfer Processes.
  • 2000. Hydroperoxides as Alkylating Reagents.
  • 1999. Oxidation of Ketones into Carboxylic acids with Molecular Oxygen.
  • 1999. Free Radicals in Oxidation Processes. From Academic Research to Industrial Process and Vise Versa.
Kompendium
  • 2010. IUPAC ICOS-18 Proceedings.
  • 2009. Introduction to design and modelling of organic reactions and processes. Lecture notes from course for PhD students and researchers of the research training network InSolEx.
  • 2002. Introduction to design and modelling of organic reactions and processes.
Doktorgradsavhandling
  • 2018. Novel Synthetic Methodology and Total Syntheses of Highly Functionalized Carbazoles and Benzo[c]cinnolines .
  • 2018. Continuous flow processing an enabling technology. Amidation, oxidation, reduction, and other essential synthetic reactions.
Intervju
  • 2009. TEMA: NATURVITENSKAPEN OG FREMTIDEN Grønt fra grunnen.
  • 2006. Fluens Synthesis AS - kjemiprofessor ved UiB starter nytt teknologifirma.
  • 2005. Kjemisk oppfinnelse til Europa.
  • 2003. FINE CHEMICALS Process design and improvement tools help chemists and engineers quickly deliver cleaner, safer, and more cost-effective methods.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
  • 2007. Data Analysis: Calibration of NIR Instruments by PLS Regression. 18 sider.
  • 2001. Chapter 8: Data Analysis:PLS Calibration of NIR instruments by PLS regression. 23 sider.
Poster
  • 2019. Synthesis and optimization of 10H-phenothiazine analogues for the inhibition of autophagy.
  • 2019. Synthesis and investigation of Ag-NHC complexes with cytotoxic properties towards cell lines modelling acute myeloid leukemia .
  • 2019. Response surface modelling of microwave assisted bischler-napieralski reaction: synthesis of eudostomin H.
  • 2019. Drug repurposing: sulfasalazine as a new anticancer treatment. Study of tumour drug distribution through pet and MRI imaging.
  • 2019. Developing novel PET tracers for hypoxia .
  • 2018. Synthesis and investigation of NHC-Ag complexes with cytotoxic properties.
  • 2017. Synthesis and investigation of NHC-Ag complexes with cytotoxic properties.
  • 2017. Carbazole synthesis from 2-aminobiphenyl via intramolecular C-H activation and C-N bond formation .
  • 2015. Expedite synthesis of 2-Nitrobiphenyls from Chloroarenes using the Suzuki cross-coupling reaction.
  • 2013. Synthesis of Isodecaprene and other Intermediates for a New Total Synthesis of CoQ10.
  • 2013. Multivariate Optimization of Microwave Assisted Bischler-Napieralski Reaction.
  • 2013. Development of a New Process Leading to N,N’-Diiodo-5,5-Dimethylhydantoin.
  • 2012. A simple synthetic route to 4-(5)-substituted imidazoles.
  • 2010. Synthesis of Bulky1,2-Diamines as Precursors for Sterically Hindered NHC Ligands.
  • 2010. Selective Epoxidation of Alkenes in Continuous Flow usingthe Multi-Jet Oscillating Disk milli-Reactor System.
  • 2010. Reaction mixture purification by means of organic phase nano-filtration: Removal of palladium catalyst after Heck coupling and hydrogenation reactions.
  • 2010. Continuous Flow Synthesis of 2-bromo-3,4,5-trimethoxytoluene by means of a Multi-Jet Oscillating Disk milli-Reactor System as the Reaction Platform. Pumping a Slurry of KBr as the only Bromine Source.
  • 2010. A Green and Efficient Bromination Process.
  • 2009. Multi-Jet Oscillating Disk milli-Reactor a Novel Approach for Conducting Organic Synthesis in Continuous Flow.
  • 2009. A Green and Efficient Bromination Process.
  • 2008. The first imidazolium-substituted metal alkylidene.
  • 2008. Olefin Metathesis in Continuous Flow by means of the Novel Fluens Synthesis Multi-Jet Oscillating Disk (MJOD) milli-Reactor System.
  • 2008. Investigation and Optimization of Cross-Coupling Metathesis by means of Statistical Experimental Design and Multivariate Regression.
  • 2008. A Three Step Efficient Synthesis to Dissymmetric Substituted Carbazole Derivatives.
  • 2007. Olefin Metathesis in Continuous Flow by means of the Novel Fluens Synthesis Multi-Jet Oscillating Disk milli-Reactor System.
  • 2007. Fluens Synthesis Continuous Flow milli-Reactor System.
  • 2007. Fluens Synthesis Continuous Flow milli-Reactor System.
  • 2006. Quantitative Structure Quantitative Structure−Activity Relationship Activity Relationships of Ruthenium catalysts for Olefin Metathesis.
  • 2006. Fluens Synthesis Continuous Flow milli-Reactor System.
  • 2006. Fluens Synthesis Continuous Flow milli-Reactor System.
  • 2006. Design of Catalysts for Olefin Metathesis: Development and Application of a Novel QSAR/DFT-Strategy.
  • 2006. A Novel Efficient Deoxygenation Process for N-Heteroarene N-Oxides.
  • 2005. DFT-driven multivariate prediction of activity for olefin metathesis catalysts.
  • 2005. DFT-Based Approach for QSAR-Prediction of Olefin Metathesis Catalysts.
  • 2005. A New Benign Metal Free Deoxygenation Process for N-Heteroarene N-Oxides.
  • 2004. A Novel Synthetic Process to Benzo[c]cinnoline Derivatives.
  • 2002. Aromatic carboxylic acids from a New Green Oxidation Process.
  • 2002. A Short Synthetic Pathway to N,N'-Diphenyldiazenes and N-Oxide diphenyldiazene.
  • 2002. A Selective Non-Metal Catalysed Aerobic Oxidation Process for the Preparation of Aromatic Carboxylic Acids from Aromatics with Oxygen Functionalised Benzylic Carbon.
  • 2001. Oxidation of Acetamides Ivolving a Bromine Catalyse Free-radical Reaction with Hydrogen peroxide as the Terminal Oxidant.
  • 2001. A Selective Process for N-alkylation in Competition with O-alkylation.
  • 2001. A Selective Process for N-alkylation in Competition with O-alkylation.
  • 2001. A Selective Process for N-alkylation in Competition with O-alkylation.
  • 2000. Vanillin Synthesis and Analytical standards.
  • 2000. Selective Oxidations by Means of a New Alkaline Nitroarene Oxidation Procedure.
  • 1999. Peroxides as New Electrophilic Agents of Aromatic Alkylations.
Vitenskapelig oversiktsartikkel/review
  • 2014. Synthesis of imidazole alkaloids originated in marine sponges. 33-57.
  • 2007. Ruthenium alkylidene complexes of Chelating amine Ligands. 5803-5814.
  • 2006. Quantitative structure-activity relationships of ruthenium catalysts for olefin metathesis. 6952-6964.

Se fullstendig oversikt over publikasjoner i CRIStin.

Recent publications

  • Vijayaragavan Elumalai and Hans-René Bjørsvik.* Indium powder as a reducing agent in the synthesis of 2-amino-1,1'-biphenyls. Tetrahedron Letters 201657, 1224–1226. 
  • Vijayaragavan Elumalai, Alexander H. Sandtorv, and Hans-René Bjørsvik.* A Highly Efficient Pd(PPh3)4-Catalyzed Suzuki Cross-Coupling Method for the Preparation of 2-Nitrobiphenyls from 1-Chloro-2-Nitrobenzenes and Phenylboronic acids. European Journal of Organic Chemistry 2016, 1344-1354. 
  • Marta Ferreri, Audun Drageset, Cristian Gambarotti, and Hans-René Bjørsvik.* Continuous flow synthesis of the iodination agent 1,3-diiodo-5,5-dimethyl-imidazolidine-2,4-dione telescoped with semi-continuous product isolation. Reaction Chemistry & Engineering 20161, 379-386. 
  • Audun Drageset and Hans-René Bjørsvik.* Continuous flow synthesis cocatenated with continious flow liquid-liquid extraction for work-up and purification: selective mono- and di-iodination of the imidazole backbone. Reaction Chemistry & Engineering 20161, 436-444. 
  • Hans-René Bjørsvik* and Vijayaragavan Elumalai. Synthesis of the Carbazole Scaffold Direcly form 2-amino-biphenyl by means of tandem C-H activation and C-N bond formation. European Journal of Organic Chemistry 2016, 5474-5479. 
  • Vijayaragavan Elumalai and Hans-René Bjørsvik.* A Concise Synthesis to Benzo[c]cinnolines via 2,2´-Dinitro-1,1´-Biphenyls Attained from a Novel Tailored Suzuki Cross-Coupling. ChemistrySelect 20172, 9387-9390
  • Vijayaragavan Elumalai, Cristian Gambarotti, and Hans-René Bjørsvik.*  Carbazomycin G: Method Development and Total SynthesisEur. J. Org. Chem. 2018, 1984–1992. 
  • Frida Johanne Lundevall, Vijayaragavan Elumalai, Audun Drageset,  Christian Totland, Hans-René Bjørsvik.* A Co2B mediated NaBH4 reduction protocol applicable for a selection of functional groups in organic synthesisEur. J. Org. Chem. 2018, 3416-3425.
  • Audun Drageset,  Hans-René Bjørsvik.* Synthesis of amides from alcohols and amines thru a domino oxidative amidation and telescoped transamidation processEur. J. Org. Chem. 2018, 4436-4445.
  • Audun Drageset,  Vijayaragavan Elumalai, Hans-René Bjørsvik.* Synthesis of Boscalid via a Three-step Telescoped Continuous Flow Process Implemented on a MJOD Reactor Platform. Reaction Chemistry & Engineering 20183, 550-558.
  • Audun Drageset, Nils Åge Frøystein, Karl Wilhelm Törnroos, Hans-René Bjørsvik.* A two-step telescoped continious flow switchable process leading to nitriles, diaziridinee or hydrazine derivatives. Reaction Chemistry & Engineering 2019, 4, 41-51.
  • Cristian Gambarotti, Hans-René Bjørsvik.* Amino-TEMPO grafted on magnetic multi walled nanotubes: An efficient and recyclable heterogenious oxidation catalyst. European Journal of Organic Chemistry 2019, 1405-1412.
  • Hans-René Bjørsvik,* Bjørn Tore Gjertsen, Vijayaragavan Elumalai. Hit to Leads with Cytotoxic Effect in Leukemic Cells: Total Synthesis Intermediates as a Molecule Treasure Chest. ChemMedChem 2020, 15, 862–870.
  • Eirin Alme, Karl Wilhelm Törnroos, Bjørn Tore Gjertsen, and Hans-René Bjørsvik.* Synthesis of N-Aryl- and N-alkyl-Substituted Imidazolium Silver Complexes: Cytotoxic Screening by Using Human Cell Lines Modelling Acute Myeloid Leukaemia. ChemMedChem 202015, 1509-1514.
  • Davide Cirillo, Francesco Angelucci, Hans-René Bjørsvik.* Functionalization of the imidazole backbone by means of a tailored and optimized oxidative Heck cross‐coupling. Advanced Catalysis and Synthesis 2020, https://doi.org/10.1002/adsc.202000909
  • Organic Chemistry
  • Organic synthesis method development
  • Organic total synthesis
  • Heterocyclic chemistry, in particular N-heterocycles
  • NHC ligands and transition metals for catalysis
  • Flow chemistry technologies and flow synthesis
  • Microwave in organic synthesis
  • Optimization and investigation of organic syntheses and processes by means of statistical experimental design and multivariate regressionOxidation and antioxidants
  • Medicinal chemistry
  • Free radical chemistry
  • Fiber optical spectroscopy for reaction monitoring

 

 

A thesis project in organic synthesis will deal with the development of one or more steps of a synthesis leading either to a key intermediate or to a target molecule of a total synthesis. Moreover, other investigations may be required in order to support a proposal for a reaction mechanisms.

The synthetic task can be: (1) investigation of an one step reaction, (2) design and development of a multi-step synthesis of either academic or commercial industrial interest, or (3) a study that involves investigation of a synthetic transformation where the goal is to maximize the profit of an industrial synthesis, improve the yield and / or the selectivity. Target molecule or intermediate can be an important intermediate products or preferably a biologically active compound that can be used as a pharmaceutical chemical. Usually, the target molecule, or model molecule is a N-heterocyclic natural compound. 

A project in advanced spectroscopy and organic synthesis will start out with searching the chemical literature and studies of previous research work. This is followed by introductory experiments in the laboratory, where techniques for synthesis laboratory will be used (performing reaction under different conditions, filtration, drying, extraction, crystallization, distillation, flash chromatography, thin layer chromatography, etc.). Of instrumental analytical methods, different chromatographic methods such as GC, GC-MS and HPLC can be necessary  for quantification.

Various spectroscopy and spectrometry are of paramount importance in this project, and will involve the utilization of mass spectrometry (MS), infrared spectroscopy (ATR FT-IR) and nuclear magnetic resonance (1H NMR and 13C NMR and other nucleuses if necessary) will be used for identification and structure elucidation of target products and eventually side- and by-products that have been produced.

Keywords: Synthesis, N-heterocyclic compounds, natural products, metal organic reactions, 1H NMR, 13C NMR, MS, FT-IR, fiber optical raman, fiber optical Near-IR, reaction monitoring