Hjem
Hans-René Bjørsviks bilde

Hans-René Bjørsvik

Professor
  • E-postHans.Bjorsvik@uib.no
  • Telefon+47 55 58 34 52
  • Besøksadresse
    Realfagbygget, Allégt. 41
    Rom 
    3016
  • Postadresse
    Postboks 7803
    5020 BERGEN

Organic synthesis and organometallic catalysed reactions in organic synthesis are one of the main research areas of Bjørsvik research group. The research activities comprise design and development of new and better catalytic processes, focusing both on improvement of synthetic processes and methods as well as the design of new ligands with the goal to improved selectivity and activity of the final catalyst. For this work, multivariate statistics and mathematical methods are frequently used. Total synthesis of some natural products have also been included in our project portfolio.

N-heterocyclic compounds where molecular scaffolds of particular interests includes benzo[c]cinnolines, carbazoles, beta-carbolines, phenothiazines, and imidazoles. Functionalization of the imidazole scaffold are of particular interest as such compounds can be used as precursors for NHC ligands used in organometallics for various catalysts, for example for olefin metathesis, cross-coupling reactions, and as oxidation catalysts. Recent years, NHC-Ag complexes have also turnet out to be an interesting target molecules as such compound have shown potent anti-cancer activity.

Medicinal chemistry – drug development is conducted in collaboration with three various biomedicine groups at the Department of Biomedisin at UoB, we are currently working with three distinct drug development projects. In two of the projects we are working with the development of inhibitors for the xCT antiport and for the autophagy process. These two project are targeted treatment of glioblastoma (brain cancer). The thirds project is related to the development of NHC-Ag complexes that has shown potent anti-leukaemia activity.

Flow Chemistry and other instrumental assisted methods in synthesis. Development and investigation of continuous flow organic synthesis reactor systems is an important long standing project in the group. We have successfully developed a novel approach for flow chemistry that is realized as a milli-reactor system that we have named multi-jet oscillation disk (MJOD) milli reactor system.

Regular courses

  • KARM236 Medicinal Chemistry
  • KJEM232 Experimental organic synthesis
  • KJEM131 Organic Synthesis and Analysis (past)
  • KJEM233 Organic mass spectrometry (past)
  • KJEM335 Physical Organic Chemistry (past)

Special Topics

  • Organometallic reactions in organic synthesis
  • Experimental organic synthesis and spectroscopy (laboratory project course)
  • N-heterocyclic carbenes in synthesis
  • Heterocyclic chemistry
  • Free Radical Reactions in Synthetic Organic Chemistry
  • Instrumental methods in organic synthesis (flow sythesis and microwave reactors)
  • Experimental Design and Modelling in Organic Synthesis
  • Retrosynthetic analysis
Vitenskapelig artikkel
  • Vis forfatter(e) 2021. Structure–Activity Relationships AidedDesign and Synthesis of xCTAntiporter Inhibitors. ChemMedChem.
  • Vis forfatter(e) 2021. Structure–Activity Relationships Aided Design and Synthesis of xCT Antiporter Inhibitors. ChemMedChem.
  • Vis forfatter(e) 2020. Synthesis of N-aryl- and N-alkyl-substituted imidazolium silver complexes: Cytotoxic screening by using human cell lines modelling acute myeloid leukaemia. ChemMedChem. 1509-1514.
  • Vis forfatter(e) 2020. Hit to leads with cytotoxic effect in leukemic cells: Total synthesis intermediates as a molecule treasure chest. ChemMedChem. 862-870.
  • Vis forfatter(e) 2020. Functionalization of the Imidazole Backbone by Means of a Tailored and Optimized Oxidative Heck Cross-Coupling. Advanced Synthesis and Catalysis. 5079-5092.
  • Vis forfatter(e) 2019. A two-step telescoped continuous flow switchable process leading to nitriles, diaziridine or hydrazine derivatives. Reaction Chemistry & Engineering. 41-51.
  • Vis forfatter(e) 2018. Synthesis of Boscalid via a three-step telescoped continuous flow process implemented on a MJOD reactor platform. Reaction Chemistry & Engineering. 550-558.
  • Vis forfatter(e) 2018. Synthesis of Amides from Alcohols and Amines Through a Domino Oxidative Amidation and Telescoped Transamidation Process. European Journal of Organic Chemistry. 4436-4445.
  • Vis forfatter(e) 2018. Carbazomycin G: Method Development and Total Synthesis. European Journal of Organic Chemistry. 1984-1992.
  • Vis forfatter(e) 2018. Amino-TEMPO Grafted on Magnetic Multi-Walled Nanotubes: An Efficient and Recyclable Heterogeneous Oxidation Catalyst. European Journal of Organic Chemistry. 1405-1412.
  • Vis forfatter(e) 2018. A Co2B Mediated NaBH4 Reduction Protocol Applicable to a Selection of Functional Groups in Organic Synthesis. European Journal of Organic Chemistry. 3416-3425.
  • Vis forfatter(e) 2017. A concise synthesis to Benzo[c]cinnolines via 2,2’-dinitro-1,1’-biphenyls attained from a novel tailored Suzuki cross-coupling. ChemistrySelect. 9387-9390.
  • Vis forfatter(e) 2016. Synthesis of the carbazole scaffold directly from 2-aminobiphenyl by means of tandem C–H activation and C–N bond formation. European Journal of Organic Chemistry. 5474-5479.
  • Vis forfatter(e) 2016. Indium powder as the reducing agent in the synthesis of 2-amino-1,1′-biphenyls. Tetrahedron Letters. 1224-1226.
  • Vis forfatter(e) 2016. Continuous flow synthesis of the iodination agent 1,3-diiodo-5,5-dimethyl-imidazolidine-2,4-dione telescoped with semi-continuous product isolation. Reaction Chemistry & Engineering. 379-386.
  • Vis forfatter(e) 2016. Continuous flow synthesis concatenated with continuous flow liquid–liquid extraction for work- up and purification: selective mono- and di- iodination of the imidazole backbone. Reaction Chemistry & Engineering. 436-444.
  • Vis forfatter(e) 2016. A highly efficient Pd(PPh3)4-catalyzed Suzuki cross-coupling method for the preparation of 2-nitrobi­phenyls from 1-chloro-2-nitrobenz­enes and phenylboronic acids. European Journal of Organic Chemistry. 1344-1354.
  • Vis forfatter(e) 2015. The Baeyer-Villiger oxidation versus aromatic ring hydroxylation: Competing organic peracid oxidation mechanisms explored by multivariate modelling of designed multi-response experiments. Journal of Physical Organic Chemistry. 619-628.
  • Vis forfatter(e) 2015. Stille cross-coupling for the functionalization of the imidazole backbone: Revisit, improvement, and applications of the method. European Journal of Organic Chemistry. 3506-3512.
  • Vis forfatter(e) 2015. Scope and mechanistic limitations of a sonogashira coupling reaction on an imidazole backbone. European Journal of Organic Chemistry. 4658-4666.
  • Vis forfatter(e) 2015. Controlling the course of a two-way switchable Pd-catalyzed process by means of empirical multivariate models. ChemCatChem. 2196-2205.
  • Vis forfatter(e) 2015. 4-alkylated silver-N-heterocyclic carbene (NHC) complexes with cytotoxic effects in leukemia cells. ChemMedChem. 1522-1527.
  • Vis forfatter(e) 2014. Multivariate optimization of a cyclopropanation, the key step in the synthesis of 3,3,4,4-tetraethoxybut-1-yne. Organic Process Research & Development. 891-896.
  • Vis forfatter(e) 2014. Continuous flow olefin metathesis using a multijet oscillating disk reactor as the reaction platform. Organic Process Research & Development. 1509-1515.
  • Vis forfatter(e) 2013. Fast halogenation of some N-heterocycles by means of N,N-dihalo-5,5-dimethylhydantoin. Advanced Synthesis and Catalysis. 499-507.
  • Vis forfatter(e) 2013. A Three-Way Switchable Process for Suzuki Cross-Coupling, Hydrodehalogenation, or an Assisted Tandem Hydrodehalogenation and Suzuki Cross-Coupling Sequence. Advanced Synthesis and Catalysis. 3231-3243.
  • Vis forfatter(e) 2012. Synthesis of phenylboronic acids in continuous flow by means of a multijet oscillating disc reactor system operating at cryogenic temperatures. Organic Process Research & Development. 1121-1130.
  • Vis forfatter(e) 2012. Separation of reaction product and palladium catalyst after a heck coupling reaction by means of organic solvent nanofiltration. ChemSusChem. 188-193.
  • Vis forfatter(e) 2012. Organocatalyzed epoxidation of alkenes in continuous flow using a multi-jet oscillating disk reactor. ChemSusChem. 261-265.
  • Vis forfatter(e) 2012. Extraction, isolation, and purification of analytes from samples of marine origin - A multivariate task. Journal of chromatography. B. 46-53.
  • Vis forfatter(e) 2011. Synthetic Route Discovery and Introductory Optimization of a Novel Process to Idebenone. Organic Process Research & Development. 673-680.
  • Vis forfatter(e) 2011. Multijet Oscillating Disc Millireactor: A Novel Approach for Continuous Flow Organic Synthesis. Organic Process Research & Development. 997-1009.
  • Vis forfatter(e) 2010. An optimized process to 10-bromo-1-decanol. Organic Process Research & Development. 1215-1220.
  • Vis forfatter(e) 2010. A switchable oxidation process leading to two various versatile pharmaceutical intermediates. Organic Process Research & Development. 1379-1384.
  • Vis forfatter(e) 2009. Synthesis of a new bidentate NHC–Ag(I) complex and its unanticipated reaction with the Hoveyda–Grubbs first generation catalyst. Tetrahedron. 7186-7194.
  • Vis forfatter(e) 2009. A novel simple and efficient bromination protocol for activated arenes. Tetrahedron Letters. 831-833.
  • Vis forfatter(e) 2007. The first imidazolium-substituted metal alkylidene. Organometallics. 4383-4385.
  • Vis forfatter(e) 2007. Green and efficient synthesis of bidentate Schiff base Ru catalysts for olefin metathesis. Journal of Organic Chemistry. 3561-3564.
  • Vis forfatter(e) 2006. Efficient and green telescoped process to 2-methoxy-3-methyl-[1,4]benzoquinone. Journal of Organic Chemistry. 1703-1706.
  • Vis forfatter(e) 2005. Synthesis of methoxy-substituted phenols by peracid oxidation of the aromatic ring. Journal of Organic Chemistry. 7290-7296.
  • Vis forfatter(e) 2005. Synthesis of 2-Nitro and 2,2’-Dinitro Biphenyls by means of the Suzuki Cross-Coupling reaction. Journal of Organic Chemistry. 9591-9594.
  • Vis forfatter(e) 2005. A novel efficient deoxygenation process for N-heteroarene N-oxides. Journal of Organic Chemistry. 3218-3224.
  • Vis forfatter(e) 2004. Online Spectroscopy and Multivariate Data Analysis as a Combined Tool for Process Monitoring and Reaction Optimization. Organic Process Research & Development. 495-503.
  • Vis forfatter(e) 2004. Nitroarene Catalyzed Oxidation with Sodium percarbonate or Sodium perborate as the Terminal Oxidant. Tetrahedron Letters. 8615-8620.
  • Vis forfatter(e) 2004. Investigations of a novel process to the framework of benzo[c]cinnoline. Journal of Organic Chemistry. 7720-7727.
  • Vis forfatter(e) 2002. Organic Processes to Pharmaceutical Chemicals Based on Fine Chemicals from Lignosulfonates. Organic Process Research & Development. 279-290.
  • Vis forfatter(e) 2002. N-Acylation Reactions Performed in Aqueous Reaction Medium. Synthesis of Iodixanol. Organic Process Research & Development. 113-119.
  • Vis forfatter(e) 2002. Highly Selective and Efficient Conversion of Alkyl Aryl and Alkyl Cyclopropyl Ketones to Aromatic and Cyclopropane Carboxylic Acids by Aerobic Catalytic Oxidation: A Free-Radical Redox Chain Mechanism. Synlett. 610-612.
  • Vis forfatter(e) 2002. Carboxylic acids from methyl aryl ketones by means of a new composite aerobic oxidation process. Tetrahedron Letters. 4985-4987.
  • Vis forfatter(e) 2002. A New Modified “Montanari Oxidation Process” by Means of Chlorine Dissolved in the reaction Solvent as Oxidant and TEMPO as Catalyst: Oxidation of 3-S-Quinuclidinol to 3-Quinuclidinone. Organic Process Research & Development. 197-200.
  • Vis forfatter(e) 2002. A Highly Selective Aerobic Oxidation Process Catalysed by Electron Deficient Nitroarenes via Single Electron Transfer Processes. Journal of Organic Chemistry. 7493-7500.
  • Vis forfatter(e) 2001. Process for the production of iodinated organic x-ray contrast agents. US Patent.
  • Vis forfatter(e) 2001. New Selective Oxidation Reactions by Nitroarenes in Basic Medium Involving Electron Transfer Processes. Organic Process Research & Development. 136-140.
  • Vis forfatter(e) 2001. A Selective Process for N-Alkylation in Competition with O-Alkylation. Boric acid as a Cheap and Effective Protecting Group Applicable for Industrial Scale Synthetic Processes. Organic Process Research & Development. 472-478.
  • Vis forfatter(e) 2001. A Bromine Catalysed Free-Radical Oxidation of Acetamides From Primary and Secondary Alkylamines by H_2O_2. Chemical Communications. 523-524.
  • Vis forfatter(e) 2000. Organic Process Research and Development by Means of Statistical Experimental Design, Multivariate Modelling, and Mechanistic Interpretation. La Chimica e l'Industria. 8 sider.
  • Vis forfatter(e) 2000. High Selectivity in the Oxidation of Mandelic acid derivatives and in O-methylation of protocatechualdehyde. New Processes for Synthesis of Vanillin, iso-Vanillin and Heliotropin. Organic Process Research & Development. 9 sider.
  • Vis forfatter(e) 1999. Stability of Iodixanol=3,3',5,5'-tetrakis(2,3-dihydroxypropylcarbamoyl)2,2',4,4',6,6'-hexaiodo-N,N'-(2-hydroxypropane-1,3-diyl)diacetanilide towards acid, base, oxygen, heat and light. Journal of Clinical Pharmacy and Therapeutics. 227-235.
  • Vis forfatter(e) 1999. Polar Effects in Free-Radical Reactions. the Paradox of Reductions of alkyl Iodides and Reductive alkylation of Alkenes by Strong Oxidants (t-BuOOH,Pb(OAc)4. Journal of the American Chemical Society. 7760-7765.
  • Vis forfatter(e) 1999. Fine Chemicals from Lignosulfonates. 1. Synthesis of Vanillin by Oxidation of Lignosulfonate. Organic Process Research & Development. 330-340.
  • Vis forfatter(e) 1999. Fine Chemicals from Lignosulfonates 2. Synthesis of Veratric acid from Acetoveratrone. Organic Process Research & Development. 341-346.
  • Vis forfatter(e) 1999. Electrophilic Aromatic Alkylation by Hydroperoxides, Dompetition Between Ionic and Radical Mechanism. Journal of Organic Chemistry. 8812-8815.
Rapport
  • Vis forfatter(e) 2006. Organic Free Radicals. Program and abstract collection from the EUCHEM conference on organic free radicals, Scandinavian collaboration for the 2006 conference. .
Faglig foredrag
  • Vis forfatter(e) 2018. «Medisinsk teknologi - Nytt studie ved UiB».
  • Vis forfatter(e) 2018. Synthesis of targeting molecules as tracers for PET and anticancer pro-drugs: investigation of tumor drug distribution.
  • Vis forfatter(e) 2018. Synthesis of targeting molecules as tracers for PET and anticancer pro-drugs: investigation of tumor drug distribution.
  • Vis forfatter(e) 2018. Novel probes for hypoxia and NTR-reporter gene imaging .
  • Vis forfatter(e) 2018. Grønnkjemi og organisk syntese.
  • Vis forfatter(e) 2018. Developing Novel Probes for Hypoxia. PET3D Consortium meeting.
  • Vis forfatter(e) 2018. About Department of Chemistry UoB and HUS Centre for Nuclear Medicine and PET – “the home for ESR 9 and ESR10 and short about the research activities”.
  • Vis forfatter(e) 2013. New Methods for the Synthesis of Marine Imidazole Alkaloids.
  • Vis forfatter(e) 2013. Development and Scale-up of a Synthesis leading to N-tosyl-4-iodoimidazole.
Populærvitenskapelig foredrag
  • Vis forfatter(e) 2018. Hvordan lage medisiner.
  • Vis forfatter(e) 2010. Krysskoblinger i organisk sytese – Nobelprisen i kjemi 2010.
  • Vis forfatter(e) 2009. Erfaringer og resultater fra et forskningsprosjekt som resulterte i etablering av teknologiselskapet Fluens Synthesis.
Vitenskapelig foredrag
  • Vis forfatter(e) 2019. Synthesis of targeting molecules : PET and therapeutics.
  • Vis forfatter(e) 2018. «Cystine-glutamate antiporter (xCT) inhibitors to overcome radioresistance in brain cancer» .
  • Vis forfatter(e) 2018. xCT inhibitors to overcome radioresistance in brain cancer - Some Chemistry. .
  • Vis forfatter(e) 2018. Transition metal catalyzed sodium borohydride reduction: applications in organic synthesis .
  • Vis forfatter(e) 2018. Synthesis of targeting molecules as tracers for PET and anticancer pro-drugs: investigation of tumor drug distribution.
  • Vis forfatter(e) 2018. Synthesis of targeting molecules as tracers for PET and anticancer pro-drugs: investigation of tumor drug distribution .
  • Vis forfatter(e) 2018. Novel probes for hypoxia and NTR-reporter gene imaging.
  • Vis forfatter(e) 2018. Multi-gram Synthetic Processes Involving Continuous Flow Reactors Telescoped with Semi-Continuous Work-Up and Purification Steps.
  • Vis forfatter(e) 2018. A new synthetic method for the preparation of amides.
  • Vis forfatter(e) 2017. Synthesis of the Carbazole Scaffold by Means of Tandem C–H Activation and C–N Bond Formation .
  • Vis forfatter(e) 2017. Structural modifications of a NHC(-Ag) skeleton with the purpose to optimize the cytotoxic properties .
  • Vis forfatter(e) 2016. Synthesis of backbone iodinated imidazole: Continious flow reaction concatenated with continuous work-up steps.
  • Vis forfatter(e) 2016. Synthesis of 11C-labelled sulfasalazine as a PET tracer .
  • Vis forfatter(e) 2016. Synthesis of 11C labeled sulfasalazine for PET imaging of drug delivery across the blood brain barrier and uptake in tumor tissue.
  • Vis forfatter(e) 2016. Synthesis of 11C labeled sulfasalazine for PET imaging of drug delivery across the blood brain barrier and uptake in tumor tissue.
  • Vis forfatter(e) 2016. Oral presentation: Flow synthesis concatenated with continuous and semi-continious work-up steps.
  • Vis forfatter(e) 2016. Continuous Flow Reactions Concatenated with Continuous Work-up Steps.
  • Vis forfatter(e) 2015. Batch and flow processes leading to the iodinating agent 1,3-diiodo-5,5-dimethylimidazolidine-2,4-dione.
  • Vis forfatter(e) 2012. Continuous flow synthesis of phenylboronic acids using a multijet oscillating disc (MJOD) telescoped flow reactor system.
  • Vis forfatter(e) 2012. Continuous flow synthesis of arylboronic acids.
  • Vis forfatter(e) 2012. Continuous flow synthesis at cryogenic temperatures: Synthesis of arylboronic acids in a telescoped flow reactor system.
  • Vis forfatter(e) 2010. Towards a novel synthesis of idebenol.
  • Vis forfatter(e) 2010. Synthesis in Continuous Flow by means of the Multi-Jet Oscillating Disk milli-Reactor Technology.
  • Vis forfatter(e) 2010. Organic Phase Nano-Filtration for Isolation of Palladium Catalyst after Heck Coupling Reaction.
  • Vis forfatter(e) 2010. Multi-Jet Oscillating Disk (MJOD) Reactor Technology for Challenging Reactions in Continuous Flow Organic Synthesis: Heterogeneous Reaction Mixtures, Two-Phase Reactions and Catalytic Reactions.
  • Vis forfatter(e) 2010. Continuous Flow Olefin Metathesis using the Novel Multi-Jet Oscillating Disk Reactor System as Reaction Platform.
  • Vis forfatter(e) 2009. Olefin Metathesis in Continuous Flow using the Novel MJOD milli-reactor Technology.
  • Vis forfatter(e) 2008. Organic Synthesis in Continuous Flow by means of the Novel MJOD Reactor System.
  • Vis forfatter(e) 2008. Organic Synthesis in Continuous Flow by means of MJOD milli-Reactor System.
  • Vis forfatter(e) 2008. Organic Synthesis in Continuous Flow by means of MJOD Reactor System.
  • Vis forfatter(e) 2007. Organic Synthesis in Continuous Flow by means of MJOD Reactor System.
  • Vis forfatter(e) 2007. Organic Synthesis in Continuous Flow.
  • Vis forfatter(e) 2007. Multi-Jet Oscillating Disc Linear Reactor: Towards a Continuous Flow milli-Reactor System for Organic Synthesis.
  • Vis forfatter(e) 2006. Multi-Jet Oscillating Disc Reactor: Towards Continuous Flow Milli-Reactor for Organic Synthesis.
  • Vis forfatter(e) 2005. Theory-based design of catalysts for olefin metathesis.
  • Vis forfatter(e) 2004. Pre-Experimental Design.
  • Vis forfatter(e) 2004. Multivariate Data Analysis and On-Line Spectroscopy in Process Research and Optimising.
  • Vis forfatter(e) 2004. Building, Analysis and Use of Descriptor Matrices in Multivariate Experimental Design.
  • Vis forfatter(e) 2003. Development of Organic Syntheses, Processes, and Reactions by Means of Multivariate Methodology.
  • Vis forfatter(e) 2003. DFT investigation of the Pd-catalyzed Suzuki-coupling of nitro-bromo-benzenes and nitrophenyl boronic acids.
  • Vis forfatter(e) 2002. Process Evolution by means of Experimental Design and Modelling.
  • Vis forfatter(e) 2002. Oxidation Processes Catalyzed by Electron Deficient Nitroarenes via Single Electron Transfer Processes.
  • Vis forfatter(e) 2002. Organisk syntese og grønn kjemi (Organic synthesis and green chemistry).
  • Vis forfatter(e) 2001. Synthesis of Benzo[c]cinnolines.
  • Vis forfatter(e) 2001. Single electron transfer processes in Organic Synthesis.
  • Vis forfatter(e) 2001. Organic Processes Optimisation by Means of Experimental Design and Multivariate Modelling, and Response Surface Methodology.
  • Vis forfatter(e) 2001. Optimisation of Organic Processes by Means of Multivariate Methods (a serie of four lectures).
  • Vis forfatter(e) 2001. New Oxidation Methods Involving Electron Transfer Processes. 1,3-Dinitrobenzene as Stoichiometric Oxidant or as Catalyst with Molecular Oxygen as Terminal Oxidant.
  • Vis forfatter(e) 2000. Selective Oxidations by Nitroarenes in Basic Medium Involving Electron Transfer Processes.
  • Vis forfatter(e) 2000. Hydroperoxides as Alkylating Reagents.
  • Vis forfatter(e) 1999. Oxidation of Ketones into Carboxylic acids with Molecular Oxygen.
  • Vis forfatter(e) 1999. Free Radicals in Oxidation Processes. From Academic Research to Industrial Process and Vise Versa.
Kompendium
  • Vis forfatter(e) 2010. IUPAC ICOS-18 Proceedings.
  • Vis forfatter(e) 2009. Introduction to design and modelling of organic reactions and processes. Lecture notes from course for PhD students and researchers of the research training network InSolEx.
  • Vis forfatter(e) 2002. Introduction to design and modelling of organic reactions and processes.
Doktorgradsavhandling
  • Vis forfatter(e) 2018. Novel Synthetic Methodology and Total Syntheses of Highly Functionalized Carbazoles and Benzo[c]cinnolines .
  • Vis forfatter(e) 2018. Continuous flow processing an enabling technology. Amidation, oxidation, reduction, and other essential synthetic reactions.
Intervju
  • Vis forfatter(e) 2009. TEMA: NATURVITENSKAPEN OG FREMTIDEN Grønt fra grunnen.
  • Vis forfatter(e) 2006. Fluens Synthesis AS - kjemiprofessor ved UiB starter nytt teknologifirma.
  • Vis forfatter(e) 2005. Kjemisk oppfinnelse til Europa.
  • Vis forfatter(e) 2003. FINE CHEMICALS Process design and improvement tools help chemists and engineers quickly deliver cleaner, safer, and more cost-effective methods.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
  • Vis forfatter(e) 2007. Data Analysis: Calibration of NIR Instruments by PLS Regression. 18 sider.
  • Vis forfatter(e) 2001. Chapter 8: Data Analysis:PLS Calibration of NIR instruments by PLS regression. 23 sider.
Poster
  • Vis forfatter(e) 2019. Synthesis and optimization of 10H-phenothiazine analogues for the inhibition of autophagy.
  • Vis forfatter(e) 2019. Synthesis and investigation of Ag-NHC complexes with cytotoxic properties towards cell lines modelling acute myeloid leukemia .
  • Vis forfatter(e) 2019. Response surface modelling of microwave assisted bischler-napieralski reaction: synthesis of eudostomin H.
  • Vis forfatter(e) 2019. Drug repurposing: sulfasalazine as a new anticancer treatment. Study of tumour drug distribution through pet and MRI imaging.
  • Vis forfatter(e) 2019. Developing novel PET tracers for hypoxia .
  • Vis forfatter(e) 2018. Synthesis and investigation of NHC-Ag complexes with cytotoxic properties.
  • Vis forfatter(e) 2017. Synthesis and investigation of NHC-Ag complexes with cytotoxic properties.
  • Vis forfatter(e) 2017. Carbazole synthesis from 2-aminobiphenyl via intramolecular C-H activation and C-N bond formation .
  • Vis forfatter(e) 2015. Expedite synthesis of 2-Nitrobiphenyls from Chloroarenes using the Suzuki cross-coupling reaction.
  • Vis forfatter(e) 2013. Synthesis of Isodecaprene and other Intermediates for a New Total Synthesis of CoQ10.
  • Vis forfatter(e) 2013. Multivariate Optimization of Microwave Assisted Bischler-Napieralski Reaction.
  • Vis forfatter(e) 2013. Development of a New Process Leading to N,N’-Diiodo-5,5-Dimethylhydantoin.
  • Vis forfatter(e) 2012. A simple synthetic route to 4-(5)-substituted imidazoles.
  • Vis forfatter(e) 2010. Synthesis of Bulky1,2-Diamines as Precursors for Sterically Hindered NHC Ligands.
  • Vis forfatter(e) 2010. Selective Epoxidation of Alkenes in Continuous Flow usingthe Multi-Jet Oscillating Disk milli-Reactor System.
  • Vis forfatter(e) 2010. Reaction mixture purification by means of organic phase nano-filtration: Removal of palladium catalyst after Heck coupling and hydrogenation reactions.
  • Vis forfatter(e) 2010. Continuous Flow Synthesis of 2-bromo-3,4,5-trimethoxytoluene by means of a Multi-Jet Oscillating Disk milli-Reactor System as the Reaction Platform. Pumping a Slurry of KBr as the only Bromine Source.
  • Vis forfatter(e) 2010. A Green and Efficient Bromination Process.
  • Vis forfatter(e) 2009. Multi-Jet Oscillating Disk milli-Reactor a Novel Approach for Conducting Organic Synthesis in Continuous Flow.
  • Vis forfatter(e) 2009. A Green and Efficient Bromination Process.
  • Vis forfatter(e) 2008. The first imidazolium-substituted metal alkylidene.
  • Vis forfatter(e) 2008. Olefin Metathesis in Continuous Flow by means of the Novel Fluens Synthesis Multi-Jet Oscillating Disk (MJOD) milli-Reactor System.
  • Vis forfatter(e) 2008. Investigation and Optimization of Cross-Coupling Metathesis by means of Statistical Experimental Design and Multivariate Regression.
  • Vis forfatter(e) 2008. A Three Step Efficient Synthesis to Dissymmetric Substituted Carbazole Derivatives.
  • Vis forfatter(e) 2007. Olefin Metathesis in Continuous Flow by means of the Novel Fluens Synthesis Multi-Jet Oscillating Disk milli-Reactor System.
  • Vis forfatter(e) 2007. Fluens Synthesis Continuous Flow milli-Reactor System.
  • Vis forfatter(e) 2007. Fluens Synthesis Continuous Flow milli-Reactor System.
  • Vis forfatter(e) 2006. Quantitative Structure Quantitative Structure−Activity Relationship Activity Relationships of Ruthenium catalysts for Olefin Metathesis.
  • Vis forfatter(e) 2006. Fluens Synthesis Continuous Flow milli-Reactor System.
  • Vis forfatter(e) 2006. Fluens Synthesis Continuous Flow milli-Reactor System.
  • Vis forfatter(e) 2006. Design of Catalysts for Olefin Metathesis: Development and Application of a Novel QSAR/DFT-Strategy.
  • Vis forfatter(e) 2006. A Novel Efficient Deoxygenation Process for N-Heteroarene N-Oxides.
  • Vis forfatter(e) 2005. DFT-driven multivariate prediction of activity for olefin metathesis catalysts.
  • Vis forfatter(e) 2005. DFT-Based Approach for QSAR-Prediction of Olefin Metathesis Catalysts.
  • Vis forfatter(e) 2005. A New Benign Metal Free Deoxygenation Process for N-Heteroarene N-Oxides.
  • Vis forfatter(e) 2004. A Novel Synthetic Process to Benzo[c]cinnoline Derivatives.
  • Vis forfatter(e) 2002. Aromatic carboxylic acids from a New Green Oxidation Process.
  • Vis forfatter(e) 2002. A Short Synthetic Pathway to N,N'-Diphenyldiazenes and N-Oxide diphenyldiazene.
  • Vis forfatter(e) 2002. A Selective Non-Metal Catalysed Aerobic Oxidation Process for the Preparation of Aromatic Carboxylic Acids from Aromatics with Oxygen Functionalised Benzylic Carbon.
  • Vis forfatter(e) 2001. Oxidation of Acetamides Ivolving a Bromine Catalyse Free-radical Reaction with Hydrogen peroxide as the Terminal Oxidant.
  • Vis forfatter(e) 2001. A Selective Process for N-alkylation in Competition with O-alkylation.
  • Vis forfatter(e) 2001. A Selective Process for N-alkylation in Competition with O-alkylation.
  • Vis forfatter(e) 2001. A Selective Process for N-alkylation in Competition with O-alkylation.
  • Vis forfatter(e) 2000. Vanillin Synthesis and Analytical standards.
  • Vis forfatter(e) 2000. Selective Oxidations by Means of a New Alkaline Nitroarene Oxidation Procedure.
  • Vis forfatter(e) 1999. Peroxides as New Electrophilic Agents of Aromatic Alkylations.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) 2014. Synthesis of imidazole alkaloids originated in marine sponges. Studies in Natural Products Chemistry. 33-57.
  • Vis forfatter(e) 2007. Ruthenium alkylidene complexes of Chelating amine Ligands. Organometallics. 5803-5814.
  • Vis forfatter(e) 2006. Quantitative structure-activity relationships of ruthenium catalysts for olefin metathesis. Journal of the American Chemical Society. 6952-6964.

Se fullstendig oversikt over publikasjoner i CRIStin.

Recent publications

  • Vijayaragavan Elumalai and Hans-René Bjørsvik.* Indium powder as a reducing agent in the synthesis of 2-amino-1,1'-biphenyls. Tetrahedron Letters 201657, 1224–1226. 
  • Vijayaragavan Elumalai, Alexander H. Sandtorv, and Hans-René Bjørsvik.* A Highly Efficient Pd(PPh3)4-Catalyzed Suzuki Cross-Coupling Method for the Preparation of 2-Nitrobiphenyls from 1-Chloro-2-Nitrobenzenes and Phenylboronic acids. European Journal of Organic Chemistry 2016, 1344-1354. 
  • Marta Ferreri, Audun Drageset, Cristian Gambarotti, and Hans-René Bjørsvik.* Continuous flow synthesis of the iodination agent 1,3-diiodo-5,5-dimethyl-imidazolidine-2,4-dione telescoped with semi-continuous product isolation. Reaction Chemistry & Engineering 20161, 379-386. 
  • Audun Drageset and Hans-René Bjørsvik.* Continuous flow synthesis cocatenated with continious flow liquid-liquid extraction for work-up and purification: selective mono- and di-iodination of the imidazole backbone. Reaction Chemistry & Engineering 20161, 436-444. 
  • Hans-René Bjørsvik* and Vijayaragavan Elumalai. Synthesis of the Carbazole Scaffold Direcly form 2-amino-biphenyl by means of tandem C-H activation and C-N bond formation. European Journal of Organic Chemistry 2016, 5474-5479. 
  • Vijayaragavan Elumalai and Hans-René Bjørsvik.* A Concise Synthesis to Benzo[c]cinnolines via 2,2´-Dinitro-1,1´-Biphenyls Attained from a Novel Tailored Suzuki Cross-Coupling. ChemistrySelect 20172, 9387-9390
  • Vijayaragavan Elumalai, Cristian Gambarotti, and Hans-René Bjørsvik.*  Carbazomycin G: Method Development and Total SynthesisEur. J. Org. Chem. 2018, 1984–1992. 
  • Frida Johanne Lundevall, Vijayaragavan Elumalai, Audun Drageset,  Christian Totland, Hans-René Bjørsvik.* A Co2B mediated NaBH4 reduction protocol applicable for a selection of functional groups in organic synthesisEur. J. Org. Chem. 2018, 3416-3425.
  • Audun Drageset,  Hans-René Bjørsvik.* Synthesis of amides from alcohols and amines thru a domino oxidative amidation and telescoped transamidation processEur. J. Org. Chem. 2018, 4436-4445.
  • Audun Drageset,  Vijayaragavan Elumalai, Hans-René Bjørsvik.* Synthesis of Boscalid via a Three-step Telescoped Continuous Flow Process Implemented on a MJOD Reactor Platform. Reaction Chemistry & Engineering 20183, 550-558.
  • Audun Drageset, Nils Åge Frøystein, Karl Wilhelm Törnroos, Hans-René Bjørsvik.* A two-step telescoped continious flow switchable process leading to nitriles, diaziridinee or hydrazine derivatives. Reaction Chemistry & Engineering 2019, 4, 41-51.
  • Cristian Gambarotti, Hans-René Bjørsvik.* Amino-TEMPO grafted on magnetic multi walled nanotubes: An efficient and recyclable heterogenious oxidation catalyst. European Journal of Organic Chemistry 2019, 1405-1412.
  • Hans-René Bjørsvik,* Bjørn Tore Gjertsen, Vijayaragavan Elumalai. Hit to Leads with Cytotoxic Effect in Leukemic Cells: Total Synthesis Intermediates as a Molecule Treasure Chest. ChemMedChem 2020, 15, 862–870.
  • Eirin Alme, Karl Wilhelm Törnroos, Bjørn Tore Gjertsen, and Hans-René Bjørsvik.* Synthesis of N-Aryl- and N-alkyl-Substituted Imidazolium Silver Complexes: Cytotoxic Screening by Using Human Cell Lines Modelling Acute Myeloid Leukaemia. ChemMedChem 202015, 1509-1514.
  • Davide Cirillo, Francesco Angelucci, Hans-René Bjørsvik.* Functionalization of the imidazole backbone by means of a tailored and optimized oxidative Heck cross‐coupling. Advanced Catalysis and Synthesis 2020, https://doi.org/10.1002/adsc.202000909

A thesis project in organic synthesis will deal with the development of one or more steps of a synthesis leading either to a key intermediate or to a target molecule of a total synthesis. Moreover, other investigations may be required in order to support a proposal for a reaction mechanisms.

The synthetic task can be: (1) investigation of an one step reaction, (2) design and development of a multi-step synthesis of either academic or commercial industrial interest, or (3) a study that involves investigation of a synthetic transformation where the goal is to maximize the profit of an industrial synthesis, improve the yield and / or the selectivity. Target molecule or intermediate can be an important intermediate products or preferably a biologically active compound that can be used as a pharmaceutical chemical. Usually, the target molecule, or model molecule is a N-heterocyclic natural compound. 

A project in advanced spectroscopy and organic synthesis will start out with searching the chemical literature and studies of previous research work. This is followed by introductory experiments in the laboratory, where techniques for synthesis laboratory will be used (performing reaction under different conditions, filtration, drying, extraction, crystallization, distillation, flash chromatography, thin layer chromatography, etc.). Of instrumental analytical methods, different chromatographic methods such as GC, GC-MS and HPLC can be necessary  for quantification.

Various spectroscopy and spectrometry are of paramount importance in this project, and will involve the utilization of mass spectrometry (MS), infrared spectroscopy (ATR FT-IR) and nuclear magnetic resonance (1H NMR and 13C NMR and other nucleuses if necessary) will be used for identification and structure elucidation of target products and eventually side- and by-products that have been produced.

Keywords: Synthesis, N-heterocyclic compounds, natural products, metal organic reactions, 1H NMR, 13C NMR, MS, FT-IR, fiber optical raman, fiber optical Near-IR, reaction monitoring

  • Organic Chemistry
  • Organic synthesis method development
  • Organic total synthesis
  • Heterocyclic chemistry, in particular N-heterocycles
  • NHC ligands and transition metals for catalysis
  • Flow chemistry technologies and flow synthesis
  • Microwave in organic synthesis
  • Optimization and investigation of organic syntheses and processes by means of statistical experimental design and multivariate regressionOxidation and antioxidants
  • Medicinal chemistry
  • Free radical chemistry
  • Fiber optical spectroscopy for reaction monitoring