Hjem
Harleen Grewals bilde

Harleen Grewal

Professor
  • E-postHarleen.Grewal@uib.no
  • Telefon+47 55 97 46 31+47 994 50 554
  • Besøksadresse
    Haukeland universitetssykehus, Laboratoriebygget
  • Postadresse
    Postboks 7804
    5020 Bergen
Vitenskapelig artikkel
  • 2018. Incidence of tuberculosis and the influence of surveillance strategy on tuberculosis case-finding and all-cause mortality: A cluster randomised trial in Indian neonates vaccinated with BCG. BMJ Open Respiratory Research. 1-9.
  • 2017. Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children. Scientific Reports. 1-9.
  • 2016. The effect of deworming on tests of tuberculosis infection in children with recent tuberculosis exposure a randomized controlled trial. The Pediatric Infectious Disease Journal. 622-627.
  • 2016. Incidence of tuberculosis among school-going adolescents in South India. BMC Public Health. 11 sider.
  • 2016. High prevalence of primary drug resistance in children with intrathoracic tuberculosis in India. Paediatrics and International Child Health. 214-218.
  • 2016. BLR1 and FCGR1A transcripts in peripheral blood associate with the extent of intrathoracic tuberculosis in children and predict treatment outcome. Scientific Reports. 1-11.
  • 2016. Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum. Scientific Reports.
  • 2016. Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis - Specific Immunity in Young Children. The Pediatric Infectious Disease Journal.
  • 2015. Xpert MTB/RIF assay can be used on archived gastric aspirate and induced sputum samples for sensitive diagnosis of paediatric tuberculosis. BMC Microbiology.
  • 2015. Optimizing the detection of recent tuberculosis infection in children in a high tuberculosis-HIV burden setting. American Journal of Respiratory and Critical Care Medicine. 820-830.
  • 2014. Vitamin D levels in Indian children with intrathoracic tuberculosis. Indian Journal of Medical Research (IJMR). 531-537.
  • 2014. The tuberculin skin test in school going adolescents in South India: associations of socio-demographic and clinical characteristics with TST positivity and non-response. BMC Infectious Diseases.
  • 2014. The frequencies of IFNγ+IL2+TNFα+ PPD-specific CD4+CD45RO+ T-cells correlate with the magnitude of the QuantiFERON® gold in-tube response in a prospective study of healthy Indian adolescents. PLOS ONE.
  • 2014. TB Trials Study Group: Concordant or discordant results by the tuberculin skin test and the quantiFERON-TB test in children reflect immune biomarker profiles. Genes and Immunity. 265-274.
  • 2014. Influence of age and nutritional status on the performance of the tuberculin skin test and QuantiFERON®-TB Gold In-Tube in young children evaluated for tuberculosis in southern India. The Pediatric Infectious Disease Journal. e260-e269.
  • 2014. Increased level of acute phase reactants in patients infected with modern mycobacterium tuberculosis genotypes in mwanza, tanzania. BMC Infectious Diseases.
  • 2014. Effect of non-tuberculous mycobacteria on host biomarkers potentially relevant for tuberculosis management. PLoS Neglected Tropical Diseases.
  • 2014. Effect of micronutrient supplementation on treatment outcomes in children with intrathoracic tuberculosis: a randomized controlled trial. American Journal of Clinical Nutrition. 1287-1297.
  • 2014. Effect of micronutrient deficiency on QuantiFERON-TB Gold In-Tube test and tuberculin skin test in diagnosis of childhood intrathoracic tuberculosis. European Journal of Clinical Nutrition. 38-42.
  • 2014. Concordant or discordant results by the tuberculin skin test and the quantiFERON-TB test in children reflect immune biomarker profiles. Genes and Immunity. 265-274.
  • 2013. Two-step tuberculin skin testing in school-going adolescents with initial 0-4 millimeter responses in a high tuberculosis prevalence setting in South India. PLOS ONE. 10 sider.
  • 2013. TB Trials Study Group; Two-step tuberculin skin testing in school-going adolescents with initial 0-4 millimeter responses in a high tuberculosis prevalence setting in South India. PLOS ONE. e71470.
  • 2013. Role of the QuantiFERON (R)-TB Gold In-Tube test in the diagnosis of intrathoracic childhood tuberculosis. The International Journal of Tuberculosis and Lung Disease. 1383-1388.
  • 2013. Identification of biomarkers for Mycobacterium tuberculosis infection and disease in BCG-vaccinated young children in Southern India. Genes and Immunity. 356-364.
  • 2013. Does Neutralization of Gastric Aspirates from Children with Suspected Intrathoracic Tuberculosis Affect Mycobacterial Yields on MGIT Culture? Journal of Clinical Microbiology. 1753-1756.
  • 2013. Diabetes is a strong predictor of mortality during tuberculosis treatment: a prospective cohort study among tuberculosis patients from Mwanza, Tanzania. Tropical medicine & international health. 822-829.
  • 2013. Ambulatory gastric lavages provide better yields of mycobacterium tuberculosis than induced sputum in children with intrathoracic tuberculosis. The Pediatric Infectious Disease Journal. 1313-1317.
  • 2012. Well-quantified tuberculosis exposure is a reliable surrogate measure of tuberculosis infection. The International Journal of Tuberculosis and Lung Disease. 1033-1039.
  • 2012. The effect of energy-protein supplementation on weight, body composition and handgrip strength among pulmonary tuberculosis HIV-co-infected patients: randomised controlled trial in Mwanza, Tanzania. British Journal of Nutrition. 263-271.
  • 2012. Mycobacterium tuberculosis Mcel protein complex initiates rapid induction of transcription of genes involved in substrate trafficking. Genes and Immunity. 496-502.
  • 2012. Effect of Ascaris Lumbricoides specific IgE on tuberculin skin test responses in children in a high-burden setting: a cross-sectional community-based study. BMC Infectious Diseases. 8 sider.
  • 2012. CD4 lymphocyte dynamics in Tanzanian pulmonary tuberculosis patients with and without HIV co-infection. BMC Infectious Diseases. 7 sider.
  • 2012. Baseline Predictors of Sputum Culture Conversion in Pulmonary Tuberculosis: Importance of Cavities, Smoking, Time to Detection and W-Beijing Genotype. PLOS ONE. 7 sider.
  • 2011. Weight, body composition and handgrip strength among pulmonary tuberculosis patients: a matched cross-sectional study in Mwanza, Tanzania. Transactions of the Royal Society of Tropical Medicine and Hygiene. 140-147.
  • 2011. The effect of vitamin A and zinc supplementation on treatment outcomes in pulmonary tuberculosis: a randomized controlled trial. American Journal of Clinical Nutrition. 93-100.
  • 2011. Modulation of transcriptional and inflammatory responses in murine macrophages by the mycobacterium tuberculosis mammalian cell entry (Mce) 1 complex. PLOS ONE. 11 sider.
  • 2011. How participatory is parental consent in low literacy rural settings in low income countries? Lessons learned from a community based study of infants in South India. BMC Medical Ethics. 9 sider.
  • 2011. Environmental tobacco smoke exposure increases Mycobacterium tuberculosis infection risk in children. The International Journal of Tuberculosis and Lung Disease. 1490-1496.
  • 2011. Daily multi-micronutrient supplementation during tuberculosis treatment increases weight and grip strength among HIV-uninfected but not HIV-Infected patients in Mwanza, Tanzania. Journal of Nutrition. 685-691.
  • 2010. Determination of the susceptibility of Mycobacterium tuberculosis to pyrazinamide in liquid and solid media assessed by a colorimetric nitrate reductase assay. Journal of Antimicrobial Chemotherapy. 704-712.
  • 2010. BCG vaccination status may predict sputum conversion in patients with pulmonary tuberculosis: a new consideration for an old vaccine? Thorax. 1072-1076.
  • 2009. Short-Term Reproducibility of a Commercial Interferon Gamma Release Assay. Clinical and Vaccine Immunology. 1170-1175.
  • 2009. Predominance of mycobacterium tuberculosis EAI and Beijing lineages in Yangon, Myanmar. Journal of Clinical Microbiology. 335-344.
  • 2009. Isoniazid and rifampicin resistance-asTisociated mutations in Mycobacterium tuberculosis isolates from Yangon, Myanmar: implications for rapid molecular testing. Journal of Antimicrobial Chemotherapy. 694-701.
  • 2009. In-depth molecular characterization of Mycobacterium tuberculosis from New Delhi--predominance of drug resistant isolates of the 'modern' (TbD1) type. PLOS ONE.
  • 2009. High diversity of Mycobacterium tuberculosis genotypes in South Africa and preponderance of mixed infections among ST53 isolates. Journal of Clinical Microbiology. 1848-1856.
  • 2009. Direct detection of mycobacterial species in pulmonary specimens by two rapid amplification tests, the gen-probe amplified mycobacterium tuberculosis direct test and the genotype mycobacteria direct test. Journal of Clinical Microbiology. 3635-3639.
  • 2008. Pyrazinamide resistance among South African multidrug-resistant Mycobacterium tuberculosis isolates. Journal of Clinical Microbiology. 3459-3464.
  • 2008. Genomic Diversity among Beijing and non-Beijing Mycobacterium tuberculosis Isolates from Myanmar. PLOS ONE. e1973.
  • 2008. Effect of high dose oral zinc in mice with severe infection with Streptococcus pneumoniae. Scandinavian Journal of Infectious Diseases. 363-367.
  • 2006. Evaluation of the nitrate-based colorimetric method for testing the susceptibility of Mycobacterium tuberculosis to streptomycin and ethambutol in liquid cultures. Journal of Antimicrobial Chemotherapy. 987-991.
  • 2005. Tuberculosis in contacts need not indicate disease transmission. Thorax. 136-137.
  • 2005. Drug-resistant tuberculosis in Yangon, Myanmar. Scandinavian Journal of Infectious Diseases. 846-851.
  • 2004. Identification and molecular characterization of the gene encoding coli surface antigen 20 of enterotoxigenic Escherichia coli. FEMS Microbiology Letters. 131-138.
  • 1998. Mucosal antibodies can be measured in air-dried samples of saliva and feces. JIM - Journal of Immunological Methods. 163-172.
  • 1998. Mucosal antibodies can be measured in air-dried samples of saliva and feces. JIM - Journal of Immunological Methods. 163-172.
  • 1997. Expression of colonization factor antigen I fimbriae by enterotoxigenic Escherichia coli; influence by growth conditions and a recombinant positive regulatory gene. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 247-254.
  • 1997. Expression of colonization factor antigen I by enterotoxigenic <I>Escherichia coli</I>; influence of growth conditions and a recombinant positive regulatory gene. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 247-254.
  • 1997. Detection and characterization of the coli surface antigen 6 of enterotoxigenic <I>Escherichia coli</I> by using monoclonal antibodies. Journal of Clinical Microbiology. 867-872.
  • 1997. Detection and characterisation of the coli surface antigen 6 of enterotoxigenic Escherichia coli by using monoclonal antibodies. Journal of Clinical Microbiology. 867-872.
  • 1997. A new putative colonization factor, CS19, of human enterotoxigenic Escherichia coli. Infection and Immunity. 507-513.
  • 1997. A new fimbrial putative colonization factor, CS19 in human enterotoxigenic <I>Escherichia coli</I>. Infection and Immunity. 507-13.
  • 1994. Genotypic and phenotypic identification of coli surface antigen 6-positive enterotoxigenic Escherichia coli. Journal of Clinical Microbiology. 1295-1301.
  • 1993. Induction of Colonization Factor Antigen I and Coli Surface Antigen 4 of enterotoxigenic Escherichia coli. Vaccine. 221-226.
  • 1992. Use of nonradioactive DNA Hybridization for the identification of enterotoxigenic Escherichia coli harboring genes for colonization factor antigen/1, coli surface antigen 4 and putative colonization factor 0166. Journal of Clinical Microbiology. 1823-1828.
  • 1992. Genetic relationship of putative colonization factor 0166 to colonization factor antigen I and coli surface antigen 4 of enterotoxigenic Escherichia coli. Infection and Immunity. 3799-3806.
  • 1992. Colonization factor antigen I, coli surface antigen 4 and putative colonization factor 0166 of enterotoxigenic Escherichia coli are genetically related. Vaccine. 289-289.
  • 1991. Presence of cfaD-homologous sequences and expression of coli surface antigen 4 on enterotoxigenic Escherichia coli; relevance for diagnostic procedures. Microbial Pathogenesis. 297-304.
Faglig foredrag
  • 2018. ADVANCES IN THE DIAGNOSIS AND TREATMENT OF TUBERCULOSIS IN  CHILDREN- a decade of collaboration.
  • 2016. Vaccines for TB.
  • 2016. The future for diagnostics for TB with a focus on children.
  • 2016. MPT64 Antigen test.
  • 2015. Biomarkers of TB disease and treatment response in children with intrathoracic TB in India.
Populærvitenskapelig foredrag
  • 1998. Molecular microbiological and immunological studies of childhood diarrhea in India and Guinea-Bissau - relevance for vaccine development.
Vitenskapelig foredrag
  • 2018. Biomarkers of TB disease and treatment response in children.
  • 2015. Biomarkers of TB disease and treatment response in Indian children,.
  • 2014. TB Vaccines; Presented at the AIIMS Conferenceon Childhood Tuberculosis, New Delhi, India 16th November 2014.
  • 2014. TB Trials:Development of a TB clinical trial site in Southern India; presented at the TBVI conference on: A new horizon for preventive vaccines against TB. Spain, 7-8 May 2014 .
  • 2014. Immune responses to TB in children;presented at theAll India Institute of Medical Science Conference on Childhood Tuberculosis, NewDelhi, India 15th November 2014.
  • 2010. Nutritional intervention and novel diagnostics to improve community-based control of tuberculosis.
  • 2010. Interferon gamma release assays for TB.
  • 2010. Frequency and clinical outcome of patients with mixed Mycobacterium tuberculosis infections.
  • 2010. DIAGNOSTIC UTILITY OF THE QUANTIFERON GOLD IN-TUBE ASSAY IN PAEDIATRIC INTRATHORACIC TB PATIENTS.
  • 2010. A comparison of the QuantiFERON Gold In-Tube assay with the tuberculin skin test in infants.
  • 2008. Childhood Tuberculosis and HIV: epidemiology and research priorities.
  • 2007. • Role of intestinal pathogens in necrotizing enterocolitis, International conference on Necrotizing enterocolitis, EUPSA (European Pediatric Surgeons Association).
  • 2007. Preparing for tuberculosis vaccine efficacy trials.
  • 2005. The Host-pathogen interaction in TB with a special focus on the infecting strain.
  • 2004. Levels of antibodies against enterotoxigenic Escherichia coli and Vibrio cholerae in young childrenin Bhanktapur, Nepal.
  • 2001. Applications of microarrays. Department of epidemiology and International health, University of Barcelona, Spain.
  • 2001. Applications of microarrays in microbiology. Norwegian Annual society of microbiology meeting, Ullevål hospital, Oslo, 10th October 2001.
  • 1998. Measurement of specific IgA in fecal extracts and in intestinal lavage fluid for monitoring of mucosal immune responses after rectal and gastric immunization.
  • 1998. Measurement of specific IgA in fecal extracts and in intestinal lavage fluid for monitoring of mucosal immune responses after rectal and gastric immunization.
  • 1997. The colonization factor antigen I like group of fimbrial proteins of human enterotoxigenic Escherichia coli.
  • 1997. The colonization factor antigen I like group of fimbrial proteins of human enterotoxigenic <I>Escherichia coli</I>.
  • 1997. Air-dried saliva and feces can be used for analyses of mucosal antibodies.
  • 1997. Air-dried saliva and feces can be used for analyses of mucosal antibodies.
Leder
  • 2008. Opportunistic pathogens in AIDS: trends, diagnosis and priorities. Expert Review of Anti-Infective Therapy. 163-166.
Leserinnlegg
  • 2013. BCG protects against tuberculosis irrespective of HIV status: a matched case-control study in Mwanza, Tanzania. Thorax. 288-289.
  • 2011. Isoniazid and rifampicin resistance-associated mutations in Mycobacterium tuberculosis isolates from Yangon, Myanmar: implications for rapid molecular testing-authors' response. Journal of Antimicrobial Chemotherapy. 687-687.
Fagbok
  • 2006. The Role of Nutrition in Tuberculosis. In: Practical Approach to Tuberculosis Management. Jaypee Brothers Medical Publishers,(P) Ltd., New Delhi, India .
Mastergradsoppgave
  • 2012. Diagnostic utility of the tuberculin skin test and QuantiFERON-TB Gold In-Tube assay in children with probable intra-thoracic tuberculosis in India.
  • 2012. Assessment of the utility of repeat tuberculin testing: a prospective study of adolescents in a high tuberculosis prevalence setting in South India.
  • 2011. Feasibility, utility and acceptability of gastric aspiration and induced sputum sampling in young children for the diagnosis of mycobacterial infections; study conducted as part of the development of a TB vaccine site in South India.
  • 2011. Comparison of Tuberculin Skin Test and QuantiFERON TB Gold In-tube Assay for the diagnosis of tuberculosis infection and disease in young children; study conducted as part of the development of a TB vaccine site in Southern India.
  • 2009. Predictors of sputum conversion among pulmonary tuberculosis patients in Mwanza, Tanzania.
  • 2005. Pyrazinamide resistance among multi-drug resistant M. tuberculosis isolates from South African pulmonary tuberculosis patients.
  • 2004. Drug resistant tuberculosis in Yangon, Myanmar.
  • 2004. Drug resistant tuberculosis in Yangon, Myanmar.
Populærvitenskapelig artikkel
  • 2016. Recent progress in host transcriptome profiling paves the way for a future point-of-care test for pediatric TB. Clinical Laboratory International.
Brev til redaktøren
  • 2017. Re: "It may be too early to try to prove the effect of deworming on tuberculin reactivity". The Pediatric Infectious Disease Journal. 241-242.
  • 2015. Authors' responses. Indian Journal of Medical Research (IJMR).
Doktorgradsavhandling
  • 2015. Biomarkers Mycobacterium tuberculosis infection and disease in children in Southern India.
  • 2010. Antibiotic drug susceptibility testing of Mycobacterium tuberculosis.
  • 2009. Genotypic charactrisation of Mycobacterium tuberculosis isolates from high TB-burden countries.
  • 2004. Colonisation Factors of Enterotoxigenic Escherichia coli; detection and characterisation.
  • 1995. Colonization factors of enterotoxigenic Escerichia coli: detection and expression (dr. med.). -.
Intervju
  • 2005. De-fusing the TB time-bomb.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
  • 2011. Immunology of Tubercolosis: Basic Aspects and Relevance for Immunodiagnostic Tests. 24 sider.
Sammendrag/abstract
  • 2012. Effect of Ascaris Lumbricoides specific IgE on tuberculin skin test responses in children. BMC Infectious Diseases.
Poster
  • 2015. Point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum.
  • 2015. Do Non-tuberculous Mycobacteria affect Host Biomarkers Potentially Relevant for Tuberculosis Management?
  • 2015. Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum.
  • 2010. Vitamin A and zinc supplementation and treatment outcome in pulmonary TB: a controlled trial.
  • 2010. Clinical, Microbiological and Micronutrient profiles of pediatric intrathoracic TB patients in Delhi, India,.
  • 2010. A comparison of two different size standards for the determination of MIRU‐VNTR copy numbers.
  • 2007. Testing pyrazinamide resistance among South African multidrug-resistant Mycobacterium tuberculosis isolates.
  • 2006. Identification of deletions in clinical Mycobacterium tuberculosis isolates using comparative genomic hybridisation.
  • 2006. Dynamics of global macrophage expression responses to in vitro infection with wild-type and a hypervirulent mce1-mutant of M. tuberculosis.
  • 2004. Reactivation and reinfection of Mycobacterium tuberculosis contribute to disease among immigrants.
  • 2004. Detection of common agents of bacterial meningitis with a low density DNA array.
  • 2002. Genotypic and phenotypic characterisation of Mycobacterium tuberculosis isolates from Yangon, Myanmar.
Errata
  • 2009. Predominance of Mycobacterium tuberculosis EAI and Beijing Lineages in Yangon, Myanmar. Journal of Clinical Microbiology. 1283-1283.
Briefs
  • 2014. Childhood TB:evidence generated at All India Institute of Medical Sciences, New Delhi, India over the last 5 years.

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