My research projects are focused on understanding cellular signaling (phosphorylation) and can be divided in four topics.
- Basal research understanding signaling node cascade.
- Aberrant signaling pattern in chronic and acute myeloid leukemia.
- Phospho-signaling and hematologic pattern to immunologic response.
- Mass Cytometry – a new instrument analyzing over 40 parameters in a single cell manner.
I have shown that analyzing in vivo patient whole blood, the change in the signaling pattern shortly after start a new treatment regime reflects the drug that is given. Using this methodology I’m involved in several cancer sub-studies - local and international.
Monitoring signaling patterns in patients starting a new treatment is likely to be of important for patient progress, early drug evaluation, as well as increased understanding of complex diseases.