Jørn Skavlands bilde

Jørn Skavland

  • E-postJorn.Skavland@uib.no
  • Telefon+47 55 58 53 36
  • Besøksadresse
    Haukeland universitetssykehus, Laboratoriebygget
  • Postadresse
    Postboks 7804
    5020 Bergen

My research projects are focused on understanding cellular signaling (phosphorylation) and can be divided in four topics.

-          Basal research understanding signaling node cascade.

-          Aberrant signaling pattern in chronic and acute myeloid leukemia.

-          Phospho-signaling and hematologic pattern to immunologic response.

-          Mass Cytometry – a new instrument analyzing over 40 parameters in a single cell manner.                      

I have shown that analyzing in vivo patient whole blood, the change in the signaling pattern shortly after start a new treatment regime reflects the drug that is given. Using this methodology I’m involved in several cancer sub-studies - local and international.


Monitoring signaling patterns in patients starting a new treatment is likely to be of important for patient progress, early drug evaluation, as well as increased understanding of complex diseases. 

Vitenskapelig artikkel
  • Sakkestad, Sunniva Todnem; Skavland, Jørn; Hanevik, Kurt. 2019. Whole blood preservation methods alter chemokine receptor detection in mass cytometry experiments. JIM - Journal of Immunological Methods.
  • Gullaksen, Stein-Erik; Bader, Lucius; Hellesøy, Monica; Sulen, Andre; Fagerholt, Oda Helen Eck; Engen, Caroline Benedicte Nitter; Skavland, Jørn; Gjertsen, Bjørn Tore; Gavasso, Sonia. 2019. Titrating complex mass cytometry panels. Cytometry Part A. 1-6.
  • Nepstad, Ina; Hatfield, Kimberley Joanne; Aasebø, Elise; Hernandez-Valladares, Maria; Brenner, Annette; Bartaula-Brevik, Sushma; Berven, Frode; Selheim, Frode; Skavland, Jørn; Gjertsen, Bjørn Tore; Reikvam, Håkon; Bruserud, Øystein. 2018. Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic and transcriptomic comparison. Expert opinion on therapeutic targets. 639-653.
  • Reikvam, Håkon; Skavland, Jørn; Gullaksen, Stein-Erik; Hovland, Randi; Gedde-Dahl, Tobias; Bruserud, Øystein; Gjertsen, Bjørn Tore. 2018. Chronic Myeloid Leukemia Relapsing 25 Years after Allogenic Stem Cell Transplantation. Case reports in hematology.
  • Gullaksen, Stein-Erik; Skavland, Jørn; Gavasso, Sonia; Tosevski, Vinko; Warzocha, Krzysztof; Dumrese, Claudia; Ferrant, Augustin; Gedde-Dahl, Thobias; Hellmann, Andrzej; Janssen, Jeroen; Labar, Boris; Lang, Alois; Majeed, Mohammed Waleed; Mihaylov, Georgi; Stentoft, Jesper; Stenke, Leif; Thaler, Josef; Thielen, Noortje; Verhoef, Gregor; Voglova, Jaroslava; Ossenkoppele, Gert; Hochhaus, Andreas; Hjorth-Hansen, Henrik; Mustjoki, Satu; Sopper, Sieghart; Giles, Francis; Porkka, Kimmo; Wolf, Dominik; Gjertsen, Bjørn Tore. 2017. Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib. Haematologica. 1361-1367.
  • Sulen, Andre; Gullaksen, Stein-Erik; Bader, Lucius; McClymont, David; Skavland, Jørn; Gavasso, Sonia; Gjertsen, Bjørn Tore. 2016. Signaling effects of sodium hydrosulfide in healthy donor peripheral blood mononuclear cells. Pharmacological Research. 216-227.
  • Bruserud, Øystein; Reikvam, Håkon; Fredly, Hanne Kristin; Skavland, Jørn; Hagen, Karen Marie; Hoang, Tuyen; Brenner, Annette; Kadi, Amir; Astori, Audrey; Gjertsen, Bjørn Tore; Pendino, Frederic. 2015. Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation. OncoTarget. 2794-2811.
  • Gausdal, Gro; Wergeland, Anita; Skavland, Jørn; Nguyen, Eric; Pendino, Frederic; ROUHEE, NAZANIN; McCormack, Emmet ; Herfindal, Lars; Kleppe, Rune; Havemann, Ursula; Schwede, Frank; Bruserud, Øystein; Gjertsen, Bjørn Tore; Lanotte, Michel; Ségal-Bendirdjian, Evelyne; Doskeland, Stein Ove. 2013. Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. Cell Death & Disease.
  • Skavland, Jørn; Shewry, Peter R.; Marsh, John; Geisner, Benedikte Larsen; Marcusson, Jan Anders. 2012. In vitro screening for putative psoriasis-specific antigens among wheat proteins and peptides. British Journal of Dermatology. 67-73.
  • Reikvam, Håkon; Hatfield, Kimberley Joanne; Ersvær, Elisabeth; Hovland, Randi; Skavland, Jørn; Gjertsen, Bjørn Tore; Petersen, Kjell; Bruserud, Øystein. 2012. Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status - consequences and potentials for pharmacological intervention. British Journal of Haematology. 468-480.
  • Skavland, Jørn; Jørgensen, Katarina Mariann; Hadziavdic, Kenan; Hovland, Randi; Jonassen, Inge; Bruserud, Øystein; Gjertsen, Bjørn Tore. 2011. Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia. Blood Cancer Journal.
  • McCormack, Emmet Martin; Skavland, Jørn; Mujic, Maja; Bruserud, Øystein; Gjertsen, Bjørn Tore. 2010. Lentinan: hematopoietic, immunological, and efficacy studies in a syngeneic model of acute myeloid leukemia. Nutrition and Cancer. 574-583.
  • Ersvær, Elisabeth; Liseth, Knut; Skavland, Jørn; Gjertsen, Bjørn Tore; Bruserud, Øystein. 2010. Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells. BMC Immunology.
  • Semaeva, Elvira; Tenstad, Olav; Skavland, Jørn; Enger, Marianne; Iversen, Per Ole; Gjertsen, Bjørn Tore; Wiig, Helge. 2010. Access to the spleen microenvironment through lymph shows local cytokine production, increased cell flux, and altered signaling of immune cells during lipopolysaccharide-induced acute inflammation. Journal of Immunology. 4547-4556.
  • Bredholt, Therese; Dimba, Elisabeth Anne Okumu; Hagland, Hanne; Wergeland, Line; Skavland, Jørn; Fossan, Kjell O.; Tronstad, Karl Johan; Johannessen, Anne Chr.; Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore. 2009. Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. Molecular Cancer.
  • Irish, Jonathan C.; Ånensen, Nina; Hovland, Randi; Skavland, Jørn; Børresen-Dale, Anne-Lise; Bruserud, Øystein; Nolan, Gary P; Gjertsen, Bjørn Tore. 2007. Flt3 Y591 duplication and Bc1-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53. Blood. 2589-2596.
  • Ersvær, Elisabeth; Skavland, Jørn; Ulvestad, Elling; Gjertsen, Bjørn Tore; Bruserud, Øystein. 2007. Effects of interferon gamma on native human acute myelogenous leukaemia cells. Cancer Immunology and Immunotherapy. 13-24.
Vitenskapelig foredrag
  • Rim, Sehee; Sakkestad, Sunniva Todnem; Zhou, Fan; Skavland, Jørn; Steinsland, Hans; Hanevik, Kurt. 2019. Comprehensive characterization and kinetics of circulating lymphocytes in human volunteers experimentally infected with enterotoxigenic Escherichia coli.
  • Skavland, Jørn. 2013. Risk stratification and therapy response monitoring by phosphoprotein profiles in acute myeloid leukaemia.
  • Skavland, Jørn; Hadziavdic, Kenan; Jonassen, Inge; Bruserud, Øystein; Gjertsen, Bjørn Tore. 2010. Combined epigenetic and signal transduction therapy modulate specific signal transduction patterns in acute myeloid leukemia. Haematologica. 510-510.
  • Gavasso, Sonia; Skavland, Jørn; Gjertsen, Bjørn Tore; Myhr, Kjell-Morten; Vedeler, Christian A. 2008. Interferon-beta signal transduction, multiple sclerosis and auto-antibodies. Journal of Neuroimmunology. 134-135.
  • Rim, Sehee; Sakkestad, Sunniva Todnem; Skavland, Jørn; Zhou, Fan; Steinsland, Hans; Hanevik, Kurt. 2018. Comprehensive characterization of circulating T follicular helper cells and plasmablasts in human volunteers experimentally infected with enterotoxigenic Escherichia coli.
Vitenskapelig oversiktsartikkel/review
  • Gavasso, Sonia; Gullaksen, Stein-Erik; Skavland, Jørn; Gjertsen, Bjørn Tore. 2016. Single-cell proteomics: Potential implications for cancer diagnostics. 579-589.
  • Jørgensen, Katarina Mariann; Hjelle, Sigrun Margrethe; Øye, Ola Kristoffer; Puntervoll, Pål; Reikvam, Håkon; Skavland, Jørn; Anderssen, Endre; Bruserud, Øystein; Gjertsen, Bjørn Tore. 2011. Untangling the intracellular signalling network in cancer - a strategy for data integration in acute myeloid leukemia. 269-281.

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