Hjem
James B. Lorenss bilde

James B. Lorens

Professor
  • E-postJim.Lorens@uib.no
  • Telefon+47 55 58 67 76+47 975 57 112
  • Besøksadresse
    Jonas Lies vei 91
  • Postadresse
    Postboks 7804
    5020 Bergen
Vitenskapelig artikkel
  • Røsland, Gro Vatne; Dyrstad, Sissel Elisabeth; Tusubira, Deusdedit; Helwa, Reham; Tan, Tuan Zea; Lotsberg, Maria Lie; Pettersen, Ina Katrine Nitschke; Berg, Anna; Kindt, Charlotte; Hoel, Fredrik; Jacobsen, Kristine; Arason, Ari Jon; Engelsen, Agnete; Ditzel, Henrik J.; Lønning, Per Eystein; Krakstad, Camilla; Thiery, Jean Paul; Lorens, James; Knappskog, Stian; Tronstad, Karl Johan. 2019. Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC. Cancer & Metabolism.
  • Sharma, Sunita; Xue, Ying; Xing, Zhe; Yassin, Mohammed Ahmed; Sun, Yang; Lorens, James; Finne-Wistrand, Anna; Sapkota, Dipak; Mustafa, Kamal Babikeir Eln. 2019. Adenoviral mediated mono delivery of BMP2 is superior to the combined delivery of BMP2 and VEGFA in bone regeneration in a critical-sized rat calvarial bone defect. Bone Reports.
  • Landolt, Lea Zoe; Furriol, Jessica; Babickova, Janka; Ahmed, Lavina; Eikrem, Øystein Solberg; Skogstrand, Trude; Scherer, Andreas; Suliman, Salwa; Leh, Sabine Maria; Lorens, James; Gausdal, Gro; Marti, Hans-Peter; Osman, Tarig Al-Hadi. 2019. AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction. Physiological Reports. 1-20.
  • Terry, Stéphane; Abdou, Abderemane; Svendsen, Agnete; Buart, Stéphanie; Dessen, Philippe; Corgnac, Stéphanie; Collares, Davi; Meurice, Guillaume; Gausdal, Gro; Baud, Véronique; Saintigny, Pierre; Lorens, James; Thiery, Jean Paul; Mami-Chouaib, Fathia; Chouaib, Salem. 2019. AXL targeting overcomes human lung cancer cell resistance to NK- And CTL-mediated cytotoxicity. Cancer immunology research. 1789-1802.
  • Tutusaus, Anna; de Gregorio, Estefanía; Cucarull, Blanca; Cristóbal, Helena; Aresté, Cristina; Graupera, Isabel; Coll, Mar; Colell, Anna; Gausdal, Gro; Lorens, James; García de Frutos, Pablo; Morales, Albert; Marí, Montserrat. 2019. A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target. Cellular and Molecular Gastroenterology and Hepatology (CMGH).
  • Jokela, Tiina; Svendsen, Agnete; Rybicka, Agata; Pelissier, Fanny; Garbe, James C.; Miyano, Masaru; Tiron, Crina Elena; Ferariu, Dan; Akslen, Lars A.; Stampfer, Martha R.; Lorens, James; LaBarge, Mark A. 2018. Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance. Frontiers in Cell and Developmental Biology.
  • Poirier, Marion; Awale, Mahendra; Roelli, Matthias A.; Giuffredi, Guy T.; Ruddigkeit, Lars; Evensen, Lasse; Stoos, Amandine; Calarco, Serafina; Lorens, James; Charles, Roch-Philippe; Reymond, Jean-Louis. 2018. Identifying Lysophosphatidic Acid Acyltransferase β (LPAAT‐β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2. ChemMedChem. 224-236.
  • Pelissier, Fanny; Schapiro, Dennis; Chang, Hang; Borowsky, Alexander D.; Lee, Jonathan K.; Parvin, Bahram; Stampfer, Martha R.; LaBarge, Mark A.; Bodenmiller, Bernd; Lorens, James. 2018. High-Dimensional Phenotyping Identifies Age-Emergent Cells in Human Mammary Epithelia. Cell reports. 1205-1219.
  • Bozickovic, Olivera; Skartveit, Linn; Svendsen, Agnete; Helland, Thomas; Jonsdottir, Kristin; Flågeng, Marianne Hauglid; Fenne, Ingvild Sveinsgjerd; Janssen, Emiel; Lorens, James; Bjørkhaug, Lise; Sagen, Jørn V.; Mellgren, Gunnar. 2018. A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells. Journal of Steroid Biochemistry and Molecular Biology. 57-70.
  • Ludwig, Kathleen F.; Du, Wenting; Sorelle, Noah B.; Wnuk-Lipinska, Katarzyna; Topalovski, Mary; Toombs, Jason E.; Cruz, Victoria H.; Yabuuchi, Shinichi; Rajeshkumar, N. V.; Maitra, Anirban; Lorens, James; Brekken, Rolf A. 2017. Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer. Cancer Research. 246-255.
  • Ertsås, Henriette Christie; Nolan, Garry P.; LaBarge, Mark A.; Lorens, James. 2017. Microsphere cytometry to interrogate microenvironment-dependent cell signaling. Integrative Biology. 123-134.
  • Landolt, Lea Zoe; Eikrem, Øystein Solberg; Strauss, Philipp; Scherer, Andreas; Lovett, David H.; Beisland, Christian; Finne, Kenneth; Osman, Tarig Al-Hadi; Ibrahim, Mohammad Madani; Gausdal, Gro; Ahmed, Lavina; Lorens, James; Thiery, Jean Paul; Tan, Tuan Zea; Sekulic, Miroslav; Marti, Hans-Peter. 2017. Clear cell renal cell carcinoma is linked to epithelial-to-mesenchymal transition and to fibrosis. Physiological Reports. 1-18.
  • Haaland, Gry Sandvik; Falk, Ragnhild Sørum; Straume, Oddbjørn; Lorens, James. 2017. Association of Warfarin Use With Lower Overall Cancer Incidence Among Patients Older Than 50 Years. JAMA Internal Medicine. 1774-1780.
  • Terry, Stéphane; Buart, Stéphanie; Tan, Tuan Zea; Gros, Gwendoline; Noman, Muhammad Zaeem; Lorens, James; Mami-Chouaib, Fathia; Thiery, Jean Paul; Chouaib, Salem. 2017. Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity. Oncoimmunology. 1-11.
  • Kirane, Amanda; Ludwig, Kathleen F.; Sorrelle, Noah; Haaland, Gry Sandvik; Sandal, Tone; Ranaweera, Renate; Toombs, Jason E.; Wang, Miao; Dineen, Sean P.; Micklem, David Robert; Dellinger, Michael T.; Lorens, James; Brekken, Rolf A. 2015. Warfarin blocks Gas6-mediated Axl activation required for pancreatic cancer epithelial plasticity and metastasis. Cancer Research. 3699-3705.
  • Virtakoivu, Reetta; Mai, Anja; Mattila, Elina; de Franceschi, Nicola; Imanishi, Susumu Y.; Corthals, Garry; Kaukonen, Riina; Saari, Markku; Cheng, Fang; Torvaldson, Elin; Kosma, Veli-Matti; Mannermaa, Arto; Muharram, Ghaffar; Gilles, Christine; Eriksson, John; Soini, Ylermi; Lorens, James; Ivaska, Johanna. 2015. Vimentin-ERK signaling uncouples slug gene regulatory function. Cancer Research. 2349-2362.
  • Lorens, James. 2015. The immortality two-step. Cell Cycle. 798 sider.
  • Hellesøy, Monica; Lorens, James. 2015. Cellular context-mediated Akt dynamics regulates MAP kinase signaling thresholds during angiogenesis. Molecular Biology of the Cell. 2698-2711.
  • Ocal, Ozhan; Pashkov, Victor; Kollipara, Rahul K.; Zolghadri, Yalda; Cruz, Victoria H.; Hale, Michael A.; Heath, Blake R.; Artyukhin, Alex B.; Christie, Alana L.; Tsoulfas, Pantelis; Lorens, James; Swift, Galvin H.; Brekken, Rolf A.; Wilkie, Thomas M. 2015. A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics. Disease Models and Mechanisms. 1201-1211.
  • Hodneland, Linn I.; Pettersen, Ina Katrine Nitschke; Nikolaisen, Julie; Micklem, David Robert; Dale, Hege Avsnes; Røsland, Gro Vatne; Lorens, James; Tronstad, Karl Johan. 2015. A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology. Scientific Reports.
  • Pedersen, Torbjørn Østvik; Blois, Anna; Xue, Ying; Xing, Zhe; Sun, Yang; Finne-Wistrand, Anna; Lorens, James; Fristad, Inge; Leknes, Knut N.; Mustafa, Kamal Babikeir Eln. 2014. Mesenchymal stem cells induce endothelial cell quiescence and promote capillary formation. Stem Cell Research & Therapy.
  • Kvestad, Hilde; Evensen, Lasse; Lorens, James; Bruserud, Øystein; Hatfield, Kimberley Joanne. 2014. In Vitro Characterization of Valproic Acid, ATRA, and Cytarabine Used for Disease-Stabilization in Human Acute Myeloid Leukemia: Antiproliferative Effects of Drugs on Endothelial and Osteoblastic Cells and Altered Release of Angioregulatory Mediators by Endothelial Cells. Leukemia Research and Treatment.
  • Micklem, David Robert; Blø, Magnus; Bergström, Petra; Hodneland, Erlend; Tiron, Crina Elena; Høiby, Torill; Gjerdrum, Christine; Hammarsten, Ola; Lorens, James. 2014. Flow cytometry-based functional selection of RNA interference triggers for efficient epi-allelic analysis of therapeutic targets. BMC Biotechnology.
  • Ellensen, Vegard Skalstad; Abrahamsen, Iren; Lorens, James; Jonung, Torbjörn. 2014. Effects of enoxaparin and dalteparin on proliferation and migration of patient-derived vascular smooth muscle cells . VASA. 124-131.
  • Nikolaisen, Julie; Hodneland, Linn I.; Pettersen, Ina Katrine Nitschke; Willems, Peter H.G.M.; Lorens, James; Koopman, Werner J.H.; Tronstad, Karl Johan. 2014. Automated quantification and integrative analysis of 2D and 3D mitochondrial shape and network properties. PLOS ONE.
  • Ellensen, Vegard Skalstad; Abrahamsen, Iren; Lorens, James; Jonung, Torbjörn. 2014. Auswirkungen von enoxaparin und dalteparin auf die proliferation und migration humaner vaskulärer glatter muskelzellen aus einem patientenkollektiv. VASA. 124-131.
  • Hellesøy, Monica; Blois, Anna; Tiron, Crina Elena; Mannelqvist, Monica; Akslen, Lars A.; Lorens, James. 2014. Akt1 activity regulates vessel maturation in a tissue engineering model of angiogenesis. Tissue Engineering. Part A. 2590-2603.
  • Pelissier, Fanny; Garbe, James C.; Ananthanarayanan, Badriprasad; Miyano, Masaru; Lin, ChunHan; Jokela, Tiina; Kumar, Sanjay; Stampfer, Martha R.; Lorens, James; LaBarge, Mark A. 2014. Age-Related Dysfunction in Mechanotransduction Impairs Differentiation of Human Mammary Epithelial Progenitors. Cell reports. 1926-1939.
  • Olsen, Jan Roger; Øyan, Anne Margrete; Rostad, Kari; Hellem, Margrete Reime; Liu, Jie; Li, Lisha; Micklem, David Robert; Haugen, Hallvard; Lorens, James; Rotter, Varda; Ke, Xisong; Lin, Biaoyang; Kalland, Karl-Henning. 2013. p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLOS ONE. 12 sider.
  • McCormack, Emmet ; Silden, Elisabeth; West, Richard M.; Pavlin, Tina; Micklem, David Robert; Lorens, James; Haug, Bengt Erik; Cooper, Michael E.; Gjertsen, Bjørn Tore. 2013. Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer. Cancer Research. 1276-1286.
  • Abrahamsen, Iren; Lorens, James. 2013. Evaluating extracellular matrix influence on adherent cell signaling by cold trypsin phosphorylation-specific flow cytometry. BMC Cell Biology. 7 sider.
  • Pedersen, Torbjørn Østvik; Blois, Anna; Xing, Zhe; Xue, Ying; Sun, Yang; Finne-Wistrand, Anna; Akslen, Lars A.; Lorens, James; Leknes, Knut N.; Fristad, Inge; Mustafa, Kamal Babikeir Eln. 2013. Endothelial microvascular networks affect gene-expression profiles and osteogenic potential of tissue-engineered constructs. Stem Cell Research & Therapy. 10 sider.
  • Raddum, Aase Merethe; Evensen, Lasse; Hollås, Hanne; Grindheim, Ann Kari; Lorens, James; Vedeler, Anni. 2013. Domains I and IV of annexin A2 affect the formation and integrity of in vitro capillary-like networks. PLOS ONE. 12 sider.
  • Evensen, Lasse; Odlo, Kristin; Micklem, David Robert; Littlewood-Evans, Amanda; Wood, Jeanette; Kuzniewski, Christian; Altmann, Karl-Heinz; Hansen, Trond Vidar; Lorens, James. 2013. Contextual compound screening for improved therapeutic discovery. ChemBioChem. 2512-2518.
  • Ben-Batalla, Isabel; Schultze, Alexander; Wroblewski, Mark; Erdmann, Robert; Heuser, Michael; Waizenegger, Jonas S.; Riecken, Kristoffer; Binder, Mascha; Schewe, Denis; Sawall, Stefanie; Witzke, Victoria; Cubas-Cordova, Miguel; Janning, Melanie; Wellbrock, Jasmin; Fehse, Boris; Hagel, Christian; Krauter, Jürgen; Ganser, Arnold; Lorens, James; Fiedler, Walter; Carmeliet, Peter; Pantel, Klaus; Bokemeyer, Carsten; Loges, Sonja. 2013. Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma. Blood. 2443-2452.
  • McCormack, Emmet Martin; Haaland, Ingvild; Venås, Gurid; Forthun, Rakel Brendsdal; Huseby, Sjur; Gausdal, Gro; Knappskog, Stian; Micklem, David Robert; Lorens, James; Bruserud, Øystein; Gjertsen, Bjørn Tore. 2012. Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia. Leukemia. 910-917.
  • Hatfield, Kimberley Joanne; Evensen, Lasse; Reikvam, Håkon; Lorens, James; Bruserud, Øystein. 2012. Soluble mediators released by acute myeloid leukemia cells increase capillary-like networks. European Journal of Haematology. 478-490.
  • Sapkota, Dipak; Costea, Daniela Elena; Blø, Magnus; Bruland, Ove; Lorens, James B.; Vasstrand, Endre N.; Ibrahim, Salah Osman. 2012. S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest. Oral Oncology. 219-225.
  • Pedersen, Torbjørn; Blois, Anna; Xue, Ying; Xing, Zhe; Cottler-Fox, Michele; Fristad, Inge; Leknes, Knut N.; Lorens, James; Mustafa, Kamal Babikeir Eln. 2012. Osteogenic stimulatory conditions enhance growth and maturation of endothelial cell microvascular networks in culture with mesenchymal stem cells. Journal of Tissue Engineering.
  • Oveland, Eystein; Wergeland, Line; Hovland, Randi; Lorens, James; Gjertsen, Bjørn Tore; Fladmark, Kari Espolin. 2012. Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines. Cell Biology and Toxicology. 201-212.
  • Christodoulou, Michael S; Zunino, Franco; Zuco, Valentina; Borrelli, Stella; Comi, Daniella; Fontana, Gabriele; Martinelli, Marisa; Lorens, James; Evensen, Lasse; Sironi, Maurizio; Pieraccini, Stefano; Dalla Via, Lisa; Gia, Ornella Maria; Passarella, Daniele. 2012. Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation. ChemMedChem. 2134-2143.
  • Radi, Marco; Evensen, Lasse; Dreassi, Elena; Zamperini, Claudio; Caporicci, Marialessandra; Falchi, Federico; Musumeci, Francesca; Schenone, Silvia; Lorens, James; Botta, Maurizio. 2012. A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation. Bioorganic & Medicinal Chemistry Letters. 5579-5583.
  • Vuoriluoto, Karoliina; Haugen, Hallvard; Kiviluoto, Santeri; Mpindi, John-Patrick; Nevo, Jonna; Gjerdrum, Christine; Tiron, Crina Elena; Lorens, James; Ivaska, Johanna. 2011. Vimentin regulates EMT induction by Slug and oncogenic H-ras and migration by governing Axl expression in breast cancer. Oncogene. 1436-1448.
  • Napolitano, Carmela; Natoni, Alessandro; Santocanale, Corrado; Evensen, Lasse; Lorens, James; Murphy, Paul V. 2011. Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation. Bioorganic & Medicinal Chemistry Letters. 1167-1170.
  • Hegen, Anja; Blois, Anna; Tiron, Crina Elena; Hellesøy, Monica; Micklem, David Robert; Nör, Jacques E; Akslen, Lars A.; Lorens, James. 2011. Efficient in vivo vascularization of tissue-engineering scaffolds. Journal of Tissue Engineering and Regenerative Medicine. E52-E62.
  • Wang, Jian; Daphu, Inderjit Kaur; Pedersen, Paal-Henning; Miletic, Hrvoje; Hovland, Randi; Mørk, Sverre; Bjerkvig, Rolf; Tiron, Crina Elena; McCormack, Emmet Martin; Micklem, David Robert; Lorens, James; Immervoll, Heike ; Thorsen, Frits Alan. 2011. A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients. Neuropathology and Applied Neurobiology. 189-205.
  • Riva, Elena; Comi, Daniella; Borrelli, Stella; Colombo, Francesco; Danieli, Bruno; Borlak, Jurgen; Evensen, Lasse; Lorens, James; Fontana, Gabriele; Gia, Ornella Maria; Via, Lisa Dalla; Passarella, Daniele. 2010. Synthesis and biological evaluation of new camptothecin derivatives obtained by modification of position 20. Bioorganic & Medicinal Chemistry. 8660-8668.
  • Napolitano, Carmela; Natoni, Alessandro; Santocanale, Corrado; Evensen, Lasse; Lorens, James; Murphy, Paul V. 2010. Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcyclic acid lactone series and biological evaluation. Bioorganic & Medicinal Chemistry Letters. 1167-1170.
  • Gjerdrum, Christine; Tiron, Crina Elena; Høiby, Torill; Stefansson, Ingunn Marie; Haugen, Hallvard; Sandal, Tone; Collett, Karin; Li, Shan; McCormack, Emmet Martin; Gjertsen, Bjørn Tore; Micklem, David Robert; Akslen, Lars A.; Glackin, Carlotta A.; Lorens, James. 2010. Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. Proceedings of the National Academy of Sciences of the United States of America. 1124-1129.
  • Evensen, Lasse; Micklem, David Robert; Link, Wolfgang; Lorens, James. 2010. A novel imaging-based high-throughput screening approach to anti-angiogenic drug discovery. Cytometry. 41-51.
  • Evensen, Lasse; Micklem, David Robert; Blois, Anna; Berge, Sissel Vik; Aarsaether, Niels; Littlewood-Evans, A; Wood, J.; Lorens, James. 2009. Mural cell associated VEGF is required for organotypic vessel formation. PLOS ONE.
  • Parlati, Francesco; Lee, Susan J.; Aujay, Monette; Suzuki, Erika; Levitsky, Konstantin; Lorens, James; Micklem, David Robert; Ruurs, Paulina; Sylvain, Catherine; Lu, Yan; Shenk, Kevin D.; Bennett, Mark K. 2009. Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood. 3439-3447.
  • Evensen, Lasse; Micklem, David Robert; Link, W; Lorens, James. 2009. A novel imaging-based high-throughput screening approach to anti-angiogenic drug discovery. Cytometry Part A. 41-51.
  • Blø, Magnus; Micklem, David Robert; Lorens, James. 2008. Enhanced gene expression from retroviral vectors. BMC Biotechnology. 6 sider.
  • Stapnes, Camilla I; Døskeland, Anne Paulus; Hatfield, Kimberley Joanne; Ersvær, Elisabeth; Ryningen, Anita; Lorens, James; Gjertsen, Bjørn Tore; Bruserud, Øystein. 2007. The proteasome inhibitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells. British Journal of Haematology. 814-828.
  • Blø, Magnus; Micklem, David Robert; Lorens, James. 2007. Target discovery using retroviruses. Expert Opinion on Drug Discovery. 1285-1300.
  • Bjørndal, Bodil; Myklebust, Line Merethe; Rosendal, Ken Roger; Myromslien, Frøydis Deinboll; Lorens, James; Nolan, Gary P; Bruland, Ove; Lillehaug, Johan. 2007. RACK1 regulates Ki-Ras-mediated signaling and morphological transformation of NIH 3T3 cells. International Journal of Cancer. 961-969.
  • McCormack, Emmet Martin; Micklem, David Robert; Pindard, Lars Erik; Silden, Elisabeth; Gallant, Pascal; Belenkov, Alexandre; Lorens, James; Gjertsen, Bjørn Tore. 2007. In vivo optical Imaging of acute myeloid leukemia by green fluorescent protein: Time-domain autofluorescence decoupling, fluorophore quantification, and localization. Molecular Imaging. 193-204.
  • Blø, Magnus; Bogenberger, Jakob M.; Swift, Susan E.; Micklem, David Robert; Lorens, James. 2007. Expanding the spectrum of genetic elements transferable by retroviral vectors. DNA and Cell Biology. 773-779.
  • Lorens, James; Pearsall, DM; Swift, SE; Peelle, B; Armstrong, R; Demo, SD; Ferrick, DA; Hitoshi, Y; Payan, DG; Anderson, D. 2004. Stable, stoichiometric delivery of diverse protein functions. Journal of Biochemical and Biophysical Methods. 101-110.
  • Hitoshi, Y; Demo, SD; Masuda, E; Payan, DG; Lorens, James. 2004. Isolation of Genetic Effectors using the Tetracycline-Regulatable System. Genomu Igaku : Genome Medicine.
  • Oppen-Berntsen, Dag Oskar; Arukwe, Augustine; Yadetie, Fekadu; Lorens, James; Male, Rune. 1999. Salmon eggshell protein expression: A marker for environmental estrogens. Marine Biotechnology. 252-260.
  • Oppen-Berntsen, Dag Oscar; Arukwe, Augustine; Yadetie, Fekadu; Lorens, James; Male, Rune. 1999. Salmon Eggshell Protein Expression: A Marker for Environmental Estrogens. Marine Biotechnology. 252-260.
  • Amirthalingam, K.; Lorens, James; Sætre, B. O.; Salaneck, E.; Fjose, Anders. 1995. Embryonic expression and DNA-binding properties of zebrafish pax-6. Biochemical and Biophysical Research Communications - BBRC. 122-128.
  • Lorens, James; Nerland, Audun H.; Aasland, Rein; Lossius, Ivar; Male, Rune. 1993. Expression of growth hormone genes in Atlantic salmon. Journal of Molecular Endocrinology. 167-179.
  • Male, Rune; Lorens, James; Nerland, Audun H.; Slinde, E. 1993. Biotechnology in Aquaculture, with Special Reference to Transgenic Salmon. Biotechnology & Genetic Engineering Reviews. 31-56.
  • Male, Rune; Nerland, Audun H.; Lorens, James; Telle, Wenche; Lossius, Ivar; Totland, Geir Kåre. 1992. The complete nucleotide sequence of the Atlantic salmon growth hormone I gene. Biochimica et Biophysica Acta. 345-348.
Vitenskapelig foredrag
  • Pedersen, Torbjørn Østvik; Blois, Anna; Xue, Ying; Xing, Zhe; Finne-Wistrand, Anna; Lorens, James; Fristad, Inge; Leknes, Knut N.; Mustafa, Kamal Babikeir Eln. 2013. Prevascularization of tissue-engineered constructs with endothelial and mesenchymal stem cells.
Mastergradsoppgave
  • Rayford, Austin James. 2019. The Role of Axl in Cancer and Stem Cell Plasticity: in vivo Lineage Tracing and Imaging Mass Cytometry Analysis.
  • Siraji, Muntequa Ishtiaq. 2018. Investigating the role of vitamin K in Axl-mediated melanoma progression and chemotherapeutic resistance.
  • Dhakal, Sushil. 2017. Axl Inhibition Enhances Sensitivity of BRAF Mutant Melanoma Cells to Vemurafenib.
  • Kang, Jing. 2015. The role of Axl in melanoma metastasis.
  • Dyrstad, Sissel Elisabeth. 2013. Metabolic reprogramming in Slug and Twist overexpressing MCF10A cells.
  • Lie, Maria Kolnes. 2013. In vitro phenotypic patterning of vascular cells by nano- and micro-design of the matrix substatum.
  • Manandar, Dina. 2012. A study of mitochondrial function, ROS and signaling in Twist overexpressing cells.
  • Håvardstun, Agathe. 2010. Effekten av arakidonsyremetabolitten prostaglandin E2 (PGE2) på humane endotelceller.
  • Witsø, Solveig Lund. 2008. The disruption of VEGF signalling by the inhibition of delta 5- fatty acid desaturase (dFADS) in HUVECs.
  • Hellesøy, Monica. 2008. Assessing Blood Vessel Formation and Maturation in Tissue Engineering Implants -The Role of Akt Kinase.
  • Heggland, Ragnhild. 2006. Knockdown of p110β subunit of phosphatidylinositol 3-kinase in human umbilical vein endothelial cells with small interfering RNA.
Brev til redaktøren
  • Haaland, Gry Sandvik; Falk, Ragnhild Sørum; Lorens, James. 2018. In reply. JAMA Internal Medicine. 585-586.
Doktorgradsavhandling
  • Lotsberg, Maria Lie. 2019. The role of AXL and the microenvironment in cancer cell plasticity and therapy responses. A study in non-small cell lung cancer models.
  • Davidsen, Kjersti. 2019. The receptor tyrosine kinase AXL in tumor phenotypic plasticity and acquired resistance to cancer targeted- and immunotherapy.
  • Ertsås, Henriette Christie. 2018. The effects of ageing on microenvironment-contextual epithelial cell signalling .
  • Hinz, Stefan. 2017. Mechanisms of AXL Mediated Cell Plasticity and Drug Resistance .
  • Haaland, Gry Sandvik. 2017. Investigations of the cancer therapeutic and protective effects of warfarin-mediated inhibition of the receptor tyrosine kinase AXL.
  • Pelissier, Fanny. 2016. The Role of Age in Cellular Responses to Microenvironmental Cues as a Breast Cancer Susceptibility Factor.
  • Wnuk-Lipinska, Katarzyna. 2015. The role of Axl signaling in phenotypic plasticity in normal and neoplastic epithelial cells.
  • Lorens, James. 1993. Molecular studies on the gene structure and expression of Atlantic salmon growth hormone. (dr.scient).
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
  • Davidsen, Kjersti; Haaland, Gry Sandvik; Lie, Maria Kolnes; Lorens, James; Svendsen, Agnete. 2017. The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance. 28 sider.
  • Mora-Blanco, Lorena E.; Lorens, James; LaBarge, Mark A. 2013. The Tumor Microenvironment as a Transient Niche: A Modulator of Epigenetic States and Stem Cell Funct. 16 sider.
  • Evensen, Lasse; Link, Wolfgang; Lorens, James. 2013. Image-based high-throughput screening for inhibitors of angiogenesis. 13 sider.
  • Gjertsen, Bjørn Tore; Lorens, James. 2008. Comprehensive Analysis of Gene Function: RNA interference and Chemical Genomics. 13 sider.
  • Lossius, Ivar; Kryvi, Harald; Lorens, James; Male, Rune; Nerland, Audun H.; Olsen, L.; Telle, Wenche; Totland, Geir Kåre; Aasland, Rein. 1993. Cloning and characterization of growth regulating genes from Atlantic salmon: A strategy for increasing growth rate by microinjection of a modified growth hormone gene into fertilized salmon eggs.
Sammendrag/abstract
  • Schuster, Cornelia; Gausdal, Gro; Gjertsen, Bjørn Tore; Lorens, James; Straume, Oddbjørn. 2018. Update on the randomised phase Ib/II study of the selective small molecule AXL inhibitor bemcentinib (BGB324) in combination with either dabrafenib/trametinib or pembrolizumab in patients with metastatic melanoma. Annals of Oncology. viii452-viii452.
  • Kirane, Amanda R.; Dellinger, Michael T.; Toombs, Jason E.; Schwarz, Roderich E.; Lorens, James; Brekken, Rolf A. 2013. Warfarin blocks Gas6-mediated Axl activation required for pancreatic tumor EMT and metastasis. Annals of Surgical Oncology. S133-S133.
  • Ben Batalla, I; Schultze, A; Wroblewski, Mark; Erdmann, R; Heuser, M; Riecken, Kristoffer; Binder, M; Cubas-Cordova, M; Janning, M; Wellbrock, J; Fehse, B; Hagel, C; Krauter, J; Ganser, A; Lorens, James; Fiedler, W; Carmeliet, P; Pantel, K; Bokemeyer, C; Loges, S. 2013. Axl, a therapeutic target in AML mediates stroma-induced chemoresistance. Onkologie (Basel). 44-44.
  • Tiron, Crina Elena; Gjerdrum, Christine; Høiby, Torill; Maugen, Hallvard; Stefansson, Ingunn Marie; Sandal, Tone; Collett, Karin; Li, Shan; McCormack, Emmet Martin; Gjertsen, Bjørn Tore; Micklem, David Robert; Akslen, Lars A.; Glackin, Carlotta A.; Lorens, James. 2011. Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. Clinical and Experimental Metastasis. 234-235.
  • Gjerdrum, Christine; Tiron, Crina Elena; Haugen, Hallvard; Berge, Sissel Vik; Micklem, D; Høiby, Torill; Holland, S; Hitoshi, Y; Bruserud, O; Glackin, Carlotta A.; Lorens, James. 2009. The receptor tyrosine kinase Axl controls breast carcinoma cell invasiveness and tumor formation by regulating E-cadherin. Clinical and Experimental Metastasis. 863-863.
  • Parlati, F; Lee, S; Aujay, M; Levitsky, K; Lorens, James; Lu, Yan; Micklem, David Robert; Rurrs, P; Shenk, K; Sun, Chenping; Suzuki, E; Sylvain, C; Bennett, Mark K. 2009. CARFILZOMIB: A SELECTIVE INHIBITOR OF THE CHYMOTRYPSIN-LIKE ACTIVITY OF THE CONSTITUTIVE PROTESOME AND IMMUNOPROTEASOME HAS ANTI-TUMOR ACTIVITY ON MULTIPLE MYELOMA, LYMPHOMA AND LEUKEMIA CELLS WITH MINIMAL EFFECTS ON NORMAL CELLS. Haematologica. 148-149.
  • Myklebust, Line Merethe; Bjørndal, Bodil; Rosendal, Ken Roger; Myromslien, Frøydis Deinboll; Lorens, James; Nolan, Gary; Bruland, Ove; Lillehaug, Johan. 2008. The scaffold protein RACK1 regulates Ki-Ras-mediated signaling and morphological transformation of NIH 3T3 cells. The FEBS Journal. 315-315.
  • Parlati, Francesco; Aujay, Monette; Bedringaas, Siv Lise; Demo, Susan; Gjertsen, Bjørn Tore; Goldstein, Eileen; Jiang, Jing; Kirk, Christopher; Laidig, Guy; Lorens, James; Lu, Yan; Micklem, David Robert; Ruurs, Paulina; Shenk, Kevin; Sylvain, Catherine; Sun, Congcong; Woo, Tina; Zhou, Han-Jie; Bennett, Mark. 2007. Anti-tumor activity of immunoproteasome selective inhibitors. Blood. 477A-478A.
Poster
  • Pedersen, Torbjørn Østvik; Blois, Anna; Xing, Zhe; Xue, Ying; Sun, Yang; Finne-Wistrand, Anna; Lorens, James; Leknes, Knut N.; Fristad, Inge; Mustafa, Kamal Babikeir Eln. 2013. Endothelial Microvascular Networks Influence Gene Expression Profiles in MSCs.
  • Pedersen, Torbjørn; Blois, Anna; Xue, Ying; Xing, Zhe; Cottler-Fox, Michele; Fristad, Inge; Leknes, Knut N.; Lorens, James; Mustafa, Kamal Babikeir Eln. 2012. Osteogenic conditions stimulate microvascular networks – establishing culture conditions for stem cell based reconstruction of bone defects.
  • Xing, Zhe; Xue, Ying; Ibrahim, Salah Osman; Yang, Z-Q; Hellem, Sølve; Tiron, Crina Elena; Hegen, Anja; Arvidson, Kristina Fyrberg; Lorens, James; Mustafa, Kamal. 2008. Co-culuture of endothelial cells and mesenchymal stem cells on 3D scaffolds.
  • Silden, Elisabeth; McCormack, Emmet Martin; Micklem, David Robert; Gjertsen, Bjørn Tore; Lorens, James. 2007. Development of a near infrared reporter system for in vivo imaging.
  • Parlati, F; Aujay, M; Bedringaas, Siv Lise; Demo, S; Gjertsen, Bjørn Tore; Goldstein, E; Jiang, J; Kirk, C; Laidig, G; Lorens, James; Lu, YS; Micklem, David Robert; Ruurs, Paulina; Shenk, K; Sylvain, C; Congcong, Sun C; Woo, T; Xhou, H-J; Bennet, M. 2007. Anti-Tumor Activity of Immunoproteasome Selective Inhibitors.
Errata
  • Hodneland Nilsson, Linn Iren; Pettersen, Ina Katrine Nitschke; Nikolaisen, Julie; Micklem, David Robert; Dale, Hege Avsnes; Røsland, Gro Vatne; Lorens, James; Tronstad, Karl Johan. 2016. Corrigendum: A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology. Scientific Reports.
Vitenskapelig oversiktsartikkel/review
  • Ferreira, Bibiana I.; Lie, Maria Kolnes; Svendsen, Agnete; Machado, Susana; Link, Wolfgang; Lorens, James. 2017. Adaptive mechanisms of resistance to anti-neoplastic agents. 53-66.
  • LaBarge, Mark A.; Parvin, Bahram; Lorens, James. 2014. Molecular deconstruction, detection, and computational prediction of microenvironment-modulated cellular responses to cancer therapeutics. 123-131.
  • Evensen, Lasse; Link, Wolfgang; Lorens, James. 2010. Image-based high-throughput screening for anti-angiogenic drug discovery. 3958-3963.
  • Zanella, Fabian; Lorens, James; Link, Wolfgang. 2010. High content screening: seeing is believing. 237-245.
  • Micklem, David Robert; Lorens, James. 2007. RNAi screening for therapeutic targets in human malignancies. 337-343.
  • Skaftnesmo, Kai Ove; Prestegarden, Lars; Micklem, David Robert; Lorens, James. 2007. MicroRNAs in tumorigenesis. 320-325.

Se fullstendig oversikt over publikasjoner i CRIStin.

Prof. Lorens completed undergraduate studies at Carleton College (USA) and University of Bergen (UiB), and graduate studies in chemistry (MS) and molecular biology (PhD) at UiB in 1993. He did postdoctoral work with Prof. Garry Nolan at Stanford University studying tumor and immune cell apoptosis mechanisms, before joining Rigel Pharmaceuticals in 1997. As one of the first scientists at Rigel, Prof. Lorens led technology development and was later Director of Oncology R&D. He returned to UiB as a Professor in the Medical Faculty, starting his academic laboratory in the Dept. Biomedicine in 2004 to focus on cancer research. Prof. Lorens is a principal investigator at the Center for Cancer Biomarkers, Norwegian Center of Excellence. He founded BerGenBio AS in 2008 to facilitate clinical translation of his group’s pioneering research on the Axl receptor tyrosine kinase. He continues to serve as Chief Scientific Officer. BerGenBio’s Axl inhibitor (BGB324) is currently in Phase I/II clinical trials to treat cancer.

In addition to his university research, teaching and supervisory activities, Prof. Lorens serves on the Editorial Board of Cancer Research and is an Affiliate at Lawrence Berkeley National Laboratory (USA). He has held several research administration and scientific advisory positions, including a current appointment to the board of the Research Council Division of Innovation. He has received several awards recognizing his achievements in innovation and holds several patents. A full bibliography is available here

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