Jarl Underhaugs bilde

Jarl Underhaug

Førsteamanuensis, Manager for den norske NMR-plattformen
Vitenskapelig artikkel
  • Vis forfatter(e) (2021). Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach. Cancers.
  • Vis forfatter(e) (2021). HTSDSF Explorer, A Novel Tool to Analyze High-throughput DSF Screenings. Journal of Molecular Biology (JMB).
  • Vis forfatter(e) (2021). An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics . ChemMedChem. 2715.
  • Vis forfatter(e) (2021). A Workup Protocol Combined with Direct Application of Quantitative Nuclear Magnetic Resonance Spectroscopy of Aqueous Samples from Large-Scale Steam Explosion of Biomass. ACS Omega. 6714-6721.
  • Vis forfatter(e) (2019). Anionic hafnium species: an active catalytic intermediate for the coupling of epoxides with CO2? . Chemical Communications. 7227- 7230.
  • Vis forfatter(e) (2019). A Pharmacological Chaperone Therapy for Acute Intermittent Porphyria. Molecular Therapy.
  • Vis forfatter(e) (2017). Pharmacological Chaperoning: A Potential Treatment for PMM2-CDG. Human Mutation. 160-168.
  • Vis forfatter(e) (2017). New perspectives for pharmacological chaperoning treatment in methylmalonic aciduria cblB type. Biochimica et Biophysica Acta - Molecular Basis of Disease. 640-648.
  • Vis forfatter(e) (2017). Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia. Scientific Reports.
  • Vis forfatter(e) (2015). Linking genotypes database with locus-specific database and genotype-phenotype correlation in phenylketonuria. European Journal of Human Genetics. 302-309.
  • Vis forfatter(e) (2015). Early Events in the Amyloid Formation of the A546T Mutant of Transforming Growth Factor β‑Induced Protein in Corneal Dystrophies Compared to the Nonfibrillating R555W and R555Q Mutants. Biochemistry. 5546-5556.
  • Vis forfatter(e) (2015). Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms. Biochimica et Biophysica Acta - Proteins and Proteomics. 1078-1089.
  • Vis forfatter(e) (2015). Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila. Journal of Medicinal Chemistry. 8402-8412.
  • Vis forfatter(e) (2013). Screening and evaluation of small organic molecules as ClpB inhibitors and potential antimicrobials. Journal of Medicinal Chemistry. 7177-7189.
  • Vis forfatter(e) (2013). Pharmacological chaperones as a potential therapeutic option in methylmalonic aciduria cblB type. Human Molecular Genetics. 3680-3689.
  • Vis forfatter(e) (2013). Mutation in transforming growth factor beta induced protein associated with granular corneal dystrophy type 1 reduces the proteolytic susceptibility through local structural stabilization. Biochimica et Biophysica Acta - Proteins and Proteomics. 2812-2822.
  • Vis forfatter(e) (2012). The peripheral binding of 14-3-3gamma to membranes involves isoform-specific histidine residues. PLOS ONE.
  • Vis forfatter(e) (2012). In situ solid-state NMR spectroscopy of protein in heterogeneous membranes: the baseplate antenna complex of chlorobaculum tepidum. Angewandte Chemie International Edition. 6891-6895.
  • Vis forfatter(e) (2012). A vitellogenin polyserine cleavage site: highly disordered conformation protected from proteolysis by phosphorylation. Journal of Experimental Biology. 1837-1846.
  • Vis forfatter(e) (2011). The binding of 14-3-3 gamma to membranes studied by intrinsic fluorescence spectroscopy. FEBS Letters. 1163-1168.
  • Vis forfatter(e) (2008). Large-scale modulation of thermodynamic protein folding barriers linked to electrostatics. Proceedings of the National Academy of Sciences of the United States of America. 8625-8630.
  • Vis forfatter(e) (2005). Conformational flexibility of alpha-lactalbumin related to its membrane binding capacity. Journal of Molecular Biology (JMB). 1072-1086.
Vitenskapelig foredrag
  • Vis forfatter(e) (2021). Targeting Bacterial Fatty Acid Synthesis using Fragment-Based Drug Design.
  • Vis forfatter(e) (2020). The solution structure of the human brain-protein arc studied by NMR.
  • Vis forfatter(e) (2015). Experimental structures of human 8-oxoguanine glycosylase 1 in complex with novel inhibitors.
  • Vis forfatter(e) (2010). Characterization of the molecular basis of acute intermittent porphyria. The FEBS Journal. 76-76.
  • Vis forfatter(e) (2010). CHARACTERIZATION OF THE MOLECULAR BASIS OF ACUTE INTERMITTENT PORPHYRIA. The Journal of Inherited Metabolic Disease (JIMD). S177-S177.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) (2016). Pharmacological chaperones that protect Tetrahydrobiopterin dependent aromatic amino acid hydroxylases through different mechanisms. Current Drug Targets. 1515-1526.
  • Vis forfatter(e) (2012). Phenylalanine hydroxylase misfolding and pharmacological chaperones. Current Topics in Medicinal Chemistry. 2534-2545.

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