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  • E-postJelena.Mrdalj@uib.no
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    Jonas LIesvei 91
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    9. etasje, Bygg for biologiske basalfag (BBB)
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Sammenheng mellom stress i ulike faser av livet og endringer i søvn og døgnrytmer i et translasjonelt prespektiv (dyremodeller og humane studier).

Jeg undersøker betydningen av ulike oppvekstbetingelser for helsemessige konsekvenser senere i livet (søvn, døgnrytmer, adferd og kognisjon), samt hvilke faktorer som kan moderere konsekvenser av negative tidlig livshendelser.

Et annet fokus er på konsekvenser av nattarbeid på søvn, døgnrytmer og våkenhetsfunksjon, samt hvordan eksponering til ulike lysforhold kan benyttes til å motvirke søvnighet og bedre kognitiv funksjon under nattarbeid.

 

Metoder:

Dyremodeller

  • Objektive målinger av søvn og døgnrytmer
  • Objektive målinger av våkenhetsfunksjon
  • Elektrofysiologi​
  • Polysomnografi
  • Adferdstester 

Humane studier

  • Subjektive og objektive mål av søvn og døgnrytmer
  • Subjektive og objektive målinger av våkenhetsfunksjon
  • Polysomnografi
  • Kognitive tester 

Emneansvarlig:

  • Adferd, helse og ernæring PSYK140

Andre kurs jeg underviser i:

  • Biologisk psykologi PROPSY303
  • Søvn, døgnrytmer og atferd PSYK115
  • Utviklings-, kognitiv og biologisk psykologi PSYK114
  • Døgnrytmer og søvn – deres rolle i mental og fysisk helse, sikkerhet og produktivitet (NRSN sommer skole 2017)

Noen emner jeg underviser i:

  • Nevroanatomi/fysiologi
  • Nervesystemets utvikling
  • Ernæring og hjernefunksjon
  • Søvn på tvers av arter
  • Søvn og døgnrytmer gjennom livet
  • Stressregulering

Her er min publikasjonsliste i PubMed

Vitenskapelig artikkel
  • Vis forfatter(e) (2023). Physical Exercise and Serum BDNF Levels: Accounting for the Val66Met Polymorphism in Older Adults. Cognitive and behavioral neurology.
  • Vis forfatter(e) (2022). Sleep homeostasis and night work: a polysomnographic study of daytime sleep following three consecutive simulated night shifts. Nature and Science of Sleep. 243-254.
  • Vis forfatter(e) (2022). Bright light exposure during simulated night work improves cognitive flexibility. Chronobiology International. 948-963.
  • Vis forfatter(e) (2020). Role of nocturnal light intensity on adaptation to three consecutive night shifts: a counterbalanced crossover study. Occupational and Environmental Medicine. 249-255.
  • Vis forfatter(e) (2020). Cognitive function and brain plasticity in a rat model of shift work: role of daily rhythms, sleep and glucocorticoids. Scientific Reports.
  • Vis forfatter(e) (2020). Blue-enriched white light improves performance but not subjective alertness and circadian adaptation during three consecutive simulated night shifts. Frontiers in Psychology. 1-16.
  • Vis forfatter(e) (2020). Alerting and Circadian Effects of Short-Wavelength vs. Long-Wavelength Narrow-Bandwidth Light during a Simulated Night Shift. Clocks & Sleep. 502-522.
  • Vis forfatter(e) (2018). Mathematical modeling of sleep state dynamics in a rodent model of shift work. Neurobiology of Sleep and Circadian Rhythms. 37-51.
  • Vis forfatter(e) (2018). Can night shift workers benefit from light exposure? Journal of Physiology.
  • Vis forfatter(e) (2017). No escaping the rat race: simulated night shift work alters the time-of-day variation in BMAL1 translational activity in the prefrontal cortex. Frontiers in Neural Circuits. 1-12.
  • Vis forfatter(e) (2017). Age and sex differences in bedroom habits and bedroom preferences. Sleep Medicine. 157-161.
  • Vis forfatter(e) (2016). Shift in food intake and changes in metabolic regulation and gene expression during simulated night-shiftwork: A rat model. Nutrients. 1-13.
  • Vis forfatter(e) (2016). Mild daily stressors in adulthood may counteract behavioural effects after constant presence of mother during early life. Physiology and Behavior. 313-321.
  • Vis forfatter(e) (2016). Lentiviral HSV-Tk.007-mediated suicide gene therapy is not toxic for normal brain cells. Journal of Gene Medicine. 234-243.
  • Vis forfatter(e) (2016). Implication of NOTCH1 Gene in Susceptibility to Anxiety and Depression among Sexual Abuse Victims. Translational Psychiatry.
  • Vis forfatter(e) (2016). A rodent model of night-shift work induces short-term and enduring sleep and electroencephalographic disturbances. Journal of Biological Rhythms. 48-63.
  • Vis forfatter(e) (2014). Hypothermia after chronic mild stress exposure in rats with a history of postnatal maternal separations. Chronobiology International. 252-264.
  • Vis forfatter(e) (2014). Effects of social defeat on sleep and behaviour: Importance of the confrontational behaviour. Physiology and Behavior. 54-63.
  • Vis forfatter(e) (2013). Early and later life stress alter brain activity and sleep in rats. PLOS ONE.
  • Vis forfatter(e) (2012). Neonatal maternal separation in male rats increases intestinal permeability and affects behavior after chronic social stress. Physiology and Behavior. 1058-1066.
  • Vis forfatter(e) (2012). Forekomsten av seksuelle overgrep i et representativt befolkningsutvalg i Norge. Tidsskrift for Norsk Psykologforening. 950-957.
  • Vis forfatter(e) (2011). Remote postconditioning by humoral factors in effluent from ischemic preconditioned rat hearts is mediated via PI3K/Akt-dependent cell-survival signaling at reperfusion. Basic Research in Cardiology. 135-145.
Vitenskapelig foredrag
  • Vis forfatter(e) (2022). Reversal learning and working memory scanning task performance improve with bright light exposure during simulated night work: a counterbalanced crossover study.
  • Vis forfatter(e) (2019). Effects of Different Light Intensities on Adaptation to Simulated Night Shifts: A Randomized Counterbalanced Crossover Study.
  • Vis forfatter(e) (2016). Simulated night work alters clock gene expression in central and peripheral tissue in rats.
  • Vis forfatter(e) (2016). Implication of NOTCH1 Gene in Comorbid Anxiety and Depression Symptoms in a Sample of Sexual Abuse Victims.
  • Vis forfatter(e) (2015). Night work - disturbances in sleep and circadian rhythm parameters. An animal model.
  • Vis forfatter(e) (2013). Hypothermia after chronic mild stress exposure in rats with ahistory of postnatal maternal separation.
  • Vis forfatter(e) (2013). Early and later life stress in rats. Effects on sleep EEG and circadian rhythmicity.
  • Vis forfatter(e) (2011). Lower brain activity during sleep and wakefullnes; induced by exposure to long maternal separation and chronic mild stress in rats.
  • Vis forfatter(e) (2011). Experiences with the 4ET transmitters in telemetric measurement of EEG, EMG, body temperature and motor activity in male rats exposed to early and later life stress.
  • Vis forfatter(e) (2011). Early and later life stress leads to a lower brain activity during sleep and wakefulness in rats.
  • Vis forfatter(e) (2011). Chronic mild stress potentiates a lower brain activity during sleep and wakefulness in rats exposed to long maternal separation.
  • Vis forfatter(e) (2010). Early Life Stress and the effect on circadian rhythmicity. The mother - infant relationship in rats as model.
  • Vis forfatter(e) (2009). Rhythms, sleep and biology after maternal separations. The mother – infant relationship.
Mastergradsoppgave
  • Vis forfatter(e) (2006). Meaning of motivation and spontaneous exploration for the firing properties of place cells in CA1 area of hippocampus: electrophysiological study in freely-moving rats.
Populærvitenskapelig artikkel
  • Vis forfatter(e) (2018). Kan man spise seg til bedre søvn? SØVN. 26-29.
  • Vis forfatter(e) (2016). Årets publikasjon 2015. SØVN. 5.
  • Vis forfatter(e) (2016). Hva skjer med søvn hos ungdom og hvordan kan vi lære dem at søvn er viktig? SØVN. 18-22.
  • Vis forfatter(e) (2016). Basalforskning på WorldSleep konferansen 2015. SØVN. 37.
  • Vis forfatter(e) (2016). Basalforskning på ESRS 2016. SØVN. 31.
Doktorgradsavhandling
  • Vis forfatter(e) (2014). The early life condition. Importance for sleep, circadian rhythmicity, behaviour and response to later life challenges.
Intervju
  • Vis forfatter(e) (2016). tips for å sovne raskere.
  • Vis forfatter(e) (2016). Slik får du sove i ferien.
  • Vis forfatter(e) (2016). Om å sove ute.
  • Vis forfatter(e) (2016). Om søvn i ferien hos barn.
  • Vis forfatter(e) (2016). Om sene kvelder og lyse netter på sommeren.
  • Vis forfatter(e) (2016). Om lyse netter og søvn.
  • Vis forfatter(e) (2016). Om det å sove ut i helgene.
  • Vis forfatter(e) (2016). Derfor sover du dårlig første natten hjemmefra.
Sammendrag/abstract
  • Vis forfatter(e) (2016). Use of electronic media in bed and reading in bed after bedtime – Age and sex differences in a representative adult population. Journal of Sleep Research. 377-377.
  • Vis forfatter(e) (2016). Simulated night work alters clock gene expression in central and peripheral tissue in rats. Journal of Sleep Research. 57-57.
  • Vis forfatter(e) (2016). A rat model for shiftwork: Effects on sleep architecture and sleep homeostasis. Journal of Sleep Research. 248-249.
  • Vis forfatter(e) (2012). Sleep architecture, behaviour, corticosterone and acoustic startle response after double exposure to social defeat in rats. Journal of Sleep Research. 212-212.
Poster
  • Vis forfatter(e) (2018). Prolonged photoperiod alters time in sleep and slow-wave activity. The impact of blue-enriched light.
  • Vis forfatter(e) (2018). Extending the photoperiod impacts circadian rhythmicity and gene expression in prefrontal cortex and retina- Impact of exposure to blue-enriched light. .
  • Vis forfatter(e) (2018). Extended photoperiod alters sleep and expression of synaptic plasticity-associated genes. The impact of blue-enriched light.
  • Vis forfatter(e) (2018). Extended photoperiod alters circadian rhythmicity and expression of neuroplasticity markers. The impact of blue-enriched light.
  • Vis forfatter(e) (2018). Effects of bright light on sleepiness and cognitive performance during simulated night shift work.
  • Vis forfatter(e) (2018). Daytime sleep following night shifts- impact of light intensity.
  • Vis forfatter(e) (2018). Daytime sleep following bright light exposure during simulated night shift work.
  • Vis forfatter(e) (2018). Bright light exposure during simulated night shift work- impact on daytime sleep.
  • Vis forfatter(e) (2016). Use of electronic media in bed and reading in bed after bedtime – Age and sex differences in a representative adult population.
  • Vis forfatter(e) (2016). A rat model for shiftwork: Effects on sleep architecture and sleep homeostasis.
  • Vis forfatter(e) (2013). Effects of Social Defeat on sleep and behaviour: The importance of the confrontational behaviour.
  • Vis forfatter(e) (2012). Sleep Architecture, Behaviour, Corticosterone and Acoustic Startle Response after Double Exposure to Social Defeat in Rats.
  • Vis forfatter(e) (2012). Early life stress modulates responses to chronic stress later in life; affective and behavioural outcomes in rats.
  • Vis forfatter(e) (2011). Short- and long- term effects on sleep architecture, behaviour, corticosterone and acoustic startle response after two exposures to social defeat in rats.
  • Vis forfatter(e) (2011). Animal model of early and later life stress alters body temperature rhythm and induces depression-like symptoms.
  • Vis forfatter(e) (2010). Chronic social stress increases colonic permeability in rats postnatally exposed to long maternal separation.
  • Vis forfatter(e) (2010). Chronic mild stress alters body temperature rhythm and induces depression-like symptoms in rats postnatally exposed to long maternal separations.
  • Vis forfatter(e) (2010). Chronic mild stress alters body temperature rhythm and induces depression-like symptoms in rats postnatally exposed to long maternal separation.
  • Vis forfatter(e) (2010). Altered Body Temperature Rhythm and Depression-like Symptoms following Early and Later Life Stress in Rats.
  • Vis forfatter(e) (2010). A study of long-term effects on body temperature rhythm after two exposures to social defeat in rats.
Fagartikkel
  • Vis forfatter(e) (2013). Normal utvikling av hjernen. SØVN. 14-15.
Faglig kapittel
  • Vis forfatter(e) (2021). Animal models for psychological disorders. 615-631. I:
    • Vis forfatter(e) (2021). Handbook of Laboratory Animal Science : Essential Principles and Practices. 4th ed. CRC Press.

Se fullstendig oversikt over publikasjoner i CRIStin.

2017: Postdoktor, Institutt for Biologisk og Medisinsk Psykologi, UiB

2015-2017: Førsteamanuensis vikar, Institutt for Biologisk og Medisinsk Psykologi, UiB

2014-2017: Rådgiver. Nasjonal Kompetansetjeneste for Søvnsykdommer

2010-2014: ph.d. utdanning, Institutt for Biologisk og Medisinsk Psykologi, UiB

2008-2009: Stipendiatkandidat innen søvnforskning, Nasjonal kompetansetjeneste for søvnsykdommer

2004-2006: MSc utdanning, humanfysiologi, Institutt for Biomedisin, UiB