Hjem
Karianne Fjelds bilde
Foto:
Jørgen Barth

Karianne Fjeld

Forsker
  • E-postKarianne.Fjeld@uib.no
  • Telefon+47 55 97 70 32+47 924 29 152
  • Besøksadresse
    Haukeland Universitetssykehus
    Laboratoriebygget, 8 etg
    Rom 
    8480
  • Postadresse
    Postboks 7804
    5020 Bergen
  • Pankreatitt (betennelse i bukspyttkjertelen)
  • Pancreas-cancer (kreft i bukspyttkjertelen)
  • MODY-diabetes (arvelig diabetes)

Tilknyttet følgende forskningsgrupper:

https://www.uib.no/diabetes

https://pancreas.w.uib.no

Vitenskapelig artikkel
  • Vis forfatter(e) 2020. Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding. Human Mutation. 1967-1978.
  • Vis forfatter(e) 2020. Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells . Cells. 1-19.
  • Vis forfatter(e) 2020. Functional evaluation of 16 SCHAD missense variants: Only amino acid substitutions causing congenital hyperinsulinism of infancy lead to loss-of-function phenotypes in vitro. The Journal of Inherited Metabolic Disease (JIMD). 1-13.
  • Vis forfatter(e) 2020. Characterization of CEL-DUP2: Complete duplication of the carboxyl ester lipase gene is unlikely to influence risk of chronic pancreatitis. Pancreatology (Print). 377-384.
  • Vis forfatter(e) 2019. The hybrid allele 1 of carboxyl-ester lipase (CEL-HYB1) in Polish pediatric patients with chronic pancreatitis. Pancreatology (Print). 531-534.
  • Vis forfatter(e) 2018. The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 O-glycans that can be modified by ABO blood group determinants. Journal of Biological Chemistry. 19476-19491.
  • Vis forfatter(e) 2017. Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation. Molecular and Cellular Endocrinology. 146-157.
  • Vis forfatter(e) 2017. Copy number variants and VNTR length polymorphisms of the carboxyl-ester lipase (CEL) gene as risk factors in pancreatic cancer. Pancreatology (Print). 83-88.
  • Vis forfatter(e) 2016. Length of variable numbers of tandem repeats in the carboxyl ester lipase (CEL) gene may confer susceptibility to alcoholic liver cirrhosis but not alcoholic chronic pancreatitis. PLOS ONE.
  • Vis forfatter(e) 2016. Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry. 4636-4641.
  • Vis forfatter(e) 2015. Glycogenin-2 is dispensable for liver glycogen synthesis and glucagon-stimulated glucose release. Journal of Clinical Endocrinology and Metabolism. E767-E775.
  • Vis forfatter(e) 2015. A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis. Nature Genetics. 518-522.
  • Vis forfatter(e) 2014. Endocytosis of secreted carboxyl ester lipase in a syndrome of diabetes and pancreatic exocrine dysfunction. Journal of Biological Chemistry. 29097-29111.
  • Vis forfatter(e) 2013. The number of tandem repeats in the carboxyl-ester lipase (CEL) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis. Pancreatology (Print). 29-32.
  • Vis forfatter(e) 2011. Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. Journal of Biological Chemistry. 34593-34605.
  • Vis forfatter(e) 2005. Dynamic expression of Wnt signaling-related Dickkopf1,-2, and-3 mRNAs in the developing mouse tooth. Developmental Dynamics. 161-166.
  • Vis forfatter(e) 2005. Developmental expression of Dkk1-3 and Mmp9 and apoptosis in cranial base of mice. Journal of Molecular Histology. 419-426.
  • Vis forfatter(e) 2005. Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfβ1 regulate semaphorin 3a expression in the dental mesenchyme. Development. 323-334.
  • Vis forfatter(e) 2004. Glial cell line-derived neurotrophic factor (GDNF) from adult rat tooth serves a distinct population of large-sized trigeminal neurons. European Journal of Neuroscience. 2089-2098.
  • Vis forfatter(e) 2003. NK1-, NK2-, NK3-, and CGRP1-receptors identified in rat oral soft tissues, bone- and hard tissue cells. Cell and Tissue Research. 383-391.
  • Vis forfatter(e) 2003. Identification of a novel putative signaling center, the tertiary enamel knot in the postnatal mouse molar tooth. Mechanisms of Development. 270-276.
  • Vis forfatter(e) 2003. Identification of a novel putative signaling center, the tertiary enamel knot in the postnatal mouse molar tooth. Mechanisms of Development. 270-276.
Vitenskapelig foredrag
  • Vis forfatter(e) 2003. Wnt signaling in tooth morphogenesis.
  • Vis forfatter(e) 2003. Functions of SLIT1 in tooth morphogenesis.
Leder
  • Vis forfatter(e) 2016. Lipase genetic variants in chronic pancreatitis: when the end is wrong, all's not well. Gastroenterology. 1515-1518.
Hovedfagsoppgave
  • Vis forfatter(e) 2000. The effect of beta1-integins on the phenotype of human gliomas.
  • Vis forfatter(e) 2000. The effect of Beta1-integrins on the invasive phenotype of human gliomas.
Kronikk
  • Vis forfatter(e) 2015. Du vet nesten ingenting om det, men dette er et av kroppens mest sentrale organer. Aftenposten (morgenutg. : trykt utg.).
Doktorgradsavhandling
  • Vis forfatter(e) 2006. The Wnt pathway. Studies on Wnt signaling and regulation in the developing tooth.
Intervju
  • Vis forfatter(e) 2004. Dyrking av det Perfekte Smil.
Sammendrag/abstract
  • Vis forfatter(e) 2013. Cellular re-uptake of secreted carboxyl-ester lipase protein in CEL-MODY, a syndrome of diabetes and pancreatic exocrine dysfunction. Diabetologia. S152-S152.
  • Vis forfatter(e) 2008. Structural changes in the repeated region of the carboxyl-ester lipase (CEL) gene and the development of diabetes. Diabetologia. S123-S123.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) 2018. The role of the carboxyl ester lipase (CEL) gene in pancreatic disease. Pancreatology (Print). 12-19.

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