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Kimberley Joanne Hatfields bilde

Kimberley Joanne Hatfield

Forsker, Leukemia Research Group
  • E-postKimberley.Hatfield@uib.no
  • Telefon+47 55 97 30 37
  • Besøksadresse
    Haukeland universitetssykehus, Laboratoriebygget
  • Postadresse
    Postboks 7804
    5020 Bergen

Prosjektet undersøker effekten av ulike medikamenter som blokkerer sentrale metabolske signalveier i akutt myeloid leukemi (AML). Prosjektet har som mål å karakterisere ulike metabolske signalveier i leukemiceller, samt autofagi, og studere hvordan dette bidrar til kjemoresistens i AML. Prosjektet er støttet av midler fra Bergens forskningsstiftelse.

  • Nepstad, Ina; Hatfield, Kimberley Joanne; Grønningsæter, Ida Sofie; Reikvam, Håkon. 2020. The PI3K-AKT-MTOR signaling pathway in human acute myeloid leukemia (AML) cells. 1-22.
  • Grønningsæter, Ida Sofie; Fredly, Hanne Kristin; Gjertsen, Bjørn Tore; Hatfield, Kimberley Joanne; Bruserud, Øystein. 2019. Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy. Cells.
  • Nepstad, Ina; Hatfield, Kimberley Joanne; Grønningsæter, Ida Sofie; Aasebø, Elise; Hernandez-Valladares, Maria; Hagen, Karen Marie; Rye, Kristin Paulsen; Berven, Frode; Selheim, Frode; Reikvam, Håkon; Bruserud, Øystein. 2019. Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells. Signal Transduction and Targeted Therapy.
  • Nepstad, Ina; Hatfield, Kimberley Joanne; Aasebø, Elise; Hernandez-Valladares, Maria; Brenner, Annette; Bartaula-Brevik, Sushma; Berven, Frode; Selheim, Frode; Skavland, Jørn; Gjertsen, Bjørn Tore; Reikvam, Håkon; Bruserud, Øystein. 2018. Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic and transcriptomic comparison. Expert opinion on therapeutic targets. 639-653.
  • Melve, Guro Kristin; Ersvær, Elisabeth; Rye, Kristin Paulsen; Ahmed, Aymen B; Kristoffersen, Einar Klæboe; Hervig, Tor; Reikvam, Håkon; Hatfield, Kimberley Joanne; Bruserud, Øystein. 2018. The healthy donor profile of immunoregulatory soluble mediators is altered by stem cell mobilization and apheresis. Cytotherapy. 740-754.
  • Nepstad, Ina; Reikvam, Håkon; Brenner, Annette; Bruserud, Øystein; Hatfield, Kimberley Joanne. 2018. Resistance to the antiproliferative in vitro effect of PI3K-Akt-mTOR inhibition in primary human acute myeloid leukemia cells is associated with altered cell metabolism. International Journal of Molecular Sciences. 1-18.
  • Reikvam, Håkon; Grønningsæter, Ida Sofie; Mosevoll, Knut Anders; Lindås, Roald; Hatfield, Kimberley Joanne; Bruserud, Øystein. 2018. Patients with treatment-requiring chronic graft versus host disease after allogeneic stem cell transplantation have altered metabolic profiles due to the disease and immunosuppressive therapy: Potential implication for biomarkers. Frontiers in Immunology. 1-15.
  • Nepstad, Ina; Hatfield, Kimberley Joanne; Tvedt, Tor Henrik Anderson; Reikvam, Håkon; Bruserud, Øystein. 2018. Clonal heterogeneity reflected by pi3k-akt-mtor signaling in human acute myeloid leukemia cells and its association with adverse prognosis. Cancers. 1-15.
  • Hatfield, Kimberley Joanne; Melve, Guro Kristin; Bruserud, Øystein. 2017. Granulocyte colony-stimulating factor alters the systemic metabolomic profile in healthy donors. Metabolomics. 1-10.
  • Kallekleiv, Marit Selvik; Larun, Lillebeth; Bruserud, Øystein; Hatfield, Kimberley Joanne. 2016. Co-transplantation of multipotent mesenchymal stromal cells in allogeneic hematopoietic stem cell transplantation: A systematic review and meta-analysis. 172-185.

Se fullstendig oversikt over publikasjoner i CRIStin.

2016-2020: Metabolic phenotypes of leukemia cells.