Hjem
Kristin Moberg Aakres bilde

Kristin Moberg Aakre

Professor
  • E-postkristin.aakre@uib.no
  • Telefon+4755974387
  • Besøksadresse
    Haukeland universitetssykehus, Laboratoriebygget
    5009 Bergen
  • Postadresse
    Postboks 7804
    5020 Bergen

Kristin M Aakre is a medical doctor. She is board certified in laboratory medicine since 2009 and completed her PhD in 2011 (University of Bergen). 

She is PI of several large research trials manly focusing on diagnostic and prognostic properties of cardiac biomarkers, with a particular focus on acute coronary syndrome. She has also published within biological variation and analytical quality specifications, mainly related to cardiac biomarkers. She is interested in guideline development and currently chair of the International Federation of Clinical Chemistry Committee on Clinical Application of Cardiac Markers, and has participated in several national and international working groups within laboratory medicine.

Kristin Aakre is Chair of the research group Cardiac markers, see:

Cardiac markers - Helse Bergen HF (helse-bergen.no)

 

Supervision

 

PhD fellows 

1. Hilde L Tjora: Early rule-out of acute coronary syndrome in the emergency department-the WESTCOR study. 3 year PhD grant from Western Norway Regional Health Authority. August 2022, University of Bergen (main supervisor).

2. Ole-Thomas Steiro Andresen: Early identification of coronary disease: Clinical risk scores, symptom typicality and novel cardiac biomarkers. June 2023, University of Bergen (co-supervisor).

3. Magnus F Bjørkavoll-Bergseth. The relationship between exercise induced cardiac Troponin increase and physical workload during prolonged strenuous exercise (NEEDED 2018). June 2024, University of Bergen (co-supervisor).

 

Ongoing PhD fellows (main supervisor)

4. Ingar Z Restan: Safe and efficient follow-up of patients with chest pain-the WESTCOR-study. 6 year PhD grant from Western Norway Regional Health Authority

5. Gard MS Myrmel: Growth Differentiation Factor - 15 as a predictor of atherosclerotic coronary artery disease, chronic myocardial injury and long-term prognosis 

6. Ingrid Viola Lavesson Thulin: Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain using Point Of Care testing (WESTCOR-POC) 

 

Ongoing PhD fellows (co-supervisor)

7. Iman Karaji. Advanced Coronary CT Angiography in Suspected Coronary Heart Disease

8. Eirik Røys. Novel methods for estimating biological variation

9. Erik Vinnes: Investigation of the clinical utility of GDF-15 as a biomarker in the assessment of cardio-metabolic health

10. Hildegunn Frønningen: Drug prescriptions and prognosis in patients with chest pain and nonobstructive coronary artery disease

 

 

Medical Student Research Program

1. Nasir Saeed: Follow-up of Patients after Admission for Acute Chest Pain - a sub-study of the WESTCOR-study

 

Master degrees

1. Eirik Røys: Stability of components measured in venous blood gas analyses.

2. Vegard Ø Bonsaksen and Magnus Abrahamsen: Master thesis for medical students: Establishing reference intervals for 5HIAA

Vitenskapelig artikkel
  • Vis forfatter(e) (2024). The relationship between workload and exercise-induced cardiac troponin elevations is influenced by non-obstructive coronary atherosclerosis. Scandinavian Journal of Medicine & Science in Sports.
  • Vis forfatter(e) (2024). Reference intervals of circulating secretoneurin concentrations determined in a large cohort of community dwellers: the HUNT study. Clinical Chemistry and Laboratory Medicine.
  • Vis forfatter(e) (2024). Imprecision of high-sensitivity cardiac troponin assays at the female 99th-percentile. Clinical Biochemistry.
  • Vis forfatter(e) (2024). Implementation of high sensitivity troponin into routine clinical practice - results of the extended CARdiac MArkers guideline uptake in Europe group (CARMAGUE) survey. Clinica Chimica Acta.
  • Vis forfatter(e) (2023). The liver-heart axis in patients with severe obesity: The association between liver fibrosis and chronic myocardial injury may be explained by shared risk factors of cardiovascular disease. Clinical Biochemistry. 8 sider.
  • Vis forfatter(e) (2023). Sex Hormones and Adrenal Steroids: Biological Variation Estimated Using Direct and Indirect Methods. Clinical Chemistry. 100-109.
  • Vis forfatter(e) (2023). Prognostic value of growth differentiation factor-15 3 months after an acute chest pain admission. Heart. 9 sider.
  • Vis forfatter(e) (2023). Prognostic significance of chronic myocardial injury diagnosed by three different cardiac troponin assays in patients admitted with suspected acute coronary syndrome. Clinical Chemistry and Laboratory Medicine. 729-739.
  • Vis forfatter(e) (2023). Growth Differentiation Factor 15: A Prognostic Marker in Patients with Acute Chest Pain without Acute Myocardial Infarction. Clinical Chemistry. 649-660.
  • Vis forfatter(e) (2023). Cardiac troponin measurement at the point of care: educational recommendations on analytical and clinical aspects by the IFCC Committee on Clinical Applications of Cardiac Bio-Markers (IFCC C-CB). Clinical Chemistry and Laboratory Medicine. 989-998.
  • Vis forfatter(e) (2023). Antibody-mediated interferences affecting cardiac troponin assays: recommendations from the IFCC Committee on Clinical Applications of Cardiac Biomarkers. Clinical Chemistry and Laboratory Medicine. 1411-1419.
  • Vis forfatter(e) (2022). Predictors of long-term symptom burden and quality of life in patients hospitalised with chest pain: a prospective observational study. BMJ Open. 1-10.
  • Vis forfatter(e) (2022). Implementing screening for myocardial injury in non-cardiac surgery: perspectives of an ad-hoc interdisciplinary expert group. Scandinavian Cardiovascular Journal. 31-39.
  • Vis forfatter(e) (2022). Association between symptoms and risk of non-ST segment elevation myocardial infarction according to age and sex in patients admitted to the emergency department with suspected acute coronary syndrome: a single-centre retrospective cohort study. BMJ Open. 1-12.
  • Vis forfatter(e) (2022). Analytical considerations in deriving 99th percentile upper reference limits for high-sensitivity cardiac troponin assays: Educational recommendations from the IFCC committee on clinical application of cardiac bio-markers. Clinical Chemistry. 1022-1030.
  • Vis forfatter(e) (2022). Adding stress biomarkers to high-sensitivity cardiac troponin for rapid non-ST-elevation myocardial infarction rule-out protocols. European Heart Journal: Acute Cardiovascular Care. 201-212.
  • Vis forfatter(e) (2021). The association between serum high-sensitivity cardiac troponin T and acute myocardial infarction in patients with suspected chronic coronary syndrome is modified by body mass index. International Journal of Cardiology: Cardiovascular Risk and Prevention (IJCCRP).
  • Vis forfatter(e) (2021). Regular consumption of cod liver oil is associated with reduced basal and exercise-induced C-reactive protein levels; a prospective observational trial: A NEEDED (The North Sea Race Endurance Exercise Study) 2014 sub-study. Journal of the International Society of Sports Nutrition (JISSN). 1-10.
  • Vis forfatter(e) (2021). Quality benchmarking of smartphone laboratory medicine applications: Comparison of laboratory medicine specialists' and non-laboratory medicine professionals' evaluation. Clinical Chemistry and Laboratory Medicine. 693-699.
  • Vis forfatter(e) (2021). How Well Do Laboratories Adhere to Recommended Guidelines for Cardiac Biomarkers Management in Europe? The CArdiac MARker Guideline Uptake in Europe (CAMARGUE) Study of the European Federation of Laboratory Medicine Task Group on Cardiac Markers. Clinical Chemistry. 1144-1152.
  • Vis forfatter(e) (2021). Diagnostic performance of novel troponin algorithms for the rule-out of non-ST-elevation acute coronary syndrome. Clinical Chemistry. 291-302.
  • Vis forfatter(e) (2021). Determinants of interindividual variation in exercise-induced cardiac troponin I levels. Journal of the American Heart Association (JAHA). 1-14.
  • Vis forfatter(e) (2021). Clinical risk scores identify more patients at risk for cardiovascular events within 30 days as compared to standard ACS risk criteria: The WESTCOR study. European Heart Journal: Acute Cardiovascular Care. 287-301.
  • Vis forfatter(e) (2021). Biomarker Testing Considerations in the Evaluation and Management of Patients With Heart Failure: Perspectives From the International Federation of Clinical Chemistry and Laboratory Medicine Committee. Journal of Cardiac Failure. 1456-1461.
  • Vis forfatter(e) (2021). Biological variation, reference change values and index of individuality of GDF-15. Clinical Chemistry and Laboratory Medicine. 1-4.
  • Vis forfatter(e) (2021). Biological variation of cardiac myosin-binding protein C in healthy individuals. Clinical Chemistry and Laboratory Medicine. 8 sider.
  • Vis forfatter(e) (2020). Update on current practice in laboratory medicine in respect of natriuretic peptide testing for heart failure diagnosis and management in Europe. The CARdiac MArker guideline Uptake in Europe (CARMAGUE) study. Clinica Chimica Acta. 59-66.
  • Vis forfatter(e) (2020). Systemic Cardiac Troponin T Associated With Incident Atrial Fibrillation Among Patients With Suspected Stable Angina Pectoris. American Journal of Cardiology.
  • Vis forfatter(e) (2020). Lot-to-lot variation for commercial high-sensitivity cardiac troponin: Can we realistically report down to the assay's limit of detection? Clinical Chemistry. 1146-1149.
  • Vis forfatter(e) (2020). How well do laboratories adhere to recommended guidelines for dyslipidaemia management in Europe? The CArdiac MARker Guideline Uptake in Europe (CAMARGUE) study. Clinica Chimica Acta. 267-272.
  • Vis forfatter(e) (2020). High-Sensitivity Cardiac Troponin I and T Response Following Strenuous Activity is Attenuated by Smokeless Tobacco: NEEDED (North Sea Race Endurance Exercise Study) 2014. Journal of the American Heart Association (JAHA). 14 sider.
  • Vis forfatter(e) (2020). Gastric bypass surgery is associated with reduced subclinical myocardial injury and greater activation of the cardiac natriuretic peptide system than lifestyle intervention. Clinical Biochemistry. 36-44.
  • Vis forfatter(e) (2020). Endurance exercise training volume is not associated with progression of coronary artery calcification. Scandinavian Journal of Medicine & Science in Sports. 1024-1032.
  • Vis forfatter(e) (2020). Duration of elevated heart rate Is an important predictor of exercise-induced troponin elevation. Journal of the American Heart Association (JAHA). 1-19.
  • Vis forfatter(e) (2020). Cardiac Troponin Assays With Improved Analytical Quality: A Trade‐Off Between Enhanced Diagnostic Performance and Reduced Long‐Term Prognostic Value. Journal of the American Heart Association (JAHA). 23 sider.
  • Vis forfatter(e) (2019). Race duration and blood pressure are major predictors of exercise-induced cardiac troponin elevation. International Journal of Cardiology. 1-8.
  • Vis forfatter(e) (2019). Physical activity, exercise and cardiac troponins: Clinical implications. Progress in cardiovascular diseases. 108-115.
  • Vis forfatter(e) (2019). Occult obstructive coronary artery disease is associated with prolonged cardiac troponin elevation following strenuous exercise. European Journal of Preventive Cardiology (EJPC). 1-10.
  • Vis forfatter(e) (2019). Impact of different preanalytical conditions on results of lupus anticoagulant tests. International Journal of Laboratory Hematology (IJLH). 745-753.
  • Vis forfatter(e) (2019). Handling of hemolyzed serum samples in clinical chemistry laboratories: The Nordic hemolysis project. Clinical Chemistry and Laboratory Medicine. 1699-1711.
  • Vis forfatter(e) (2019). Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain-the WESTCOR study: study design. Scandinavian Cardiovascular Journal. 280-285.
  • Vis forfatter(e) (2018). Usefulness of higher levels of cardiac troponin T in patients with stable angina pectoris to predict risk of acute myocardial infarction. American Journal of Cardiology. 1142-1147.
  • Vis forfatter(e) (2018). The copeptin response after physical activity is not associated with cardiac biomarkers or asymptomatic coronary artery disease: The North Sea Race Endurance Exercise Study (NEEDED) 2013. Clinical Biochemistry. 8-12.
  • Vis forfatter(e) (2018). The cardiac troponin response following physical exercise in relation to biomarker criteria for acute myocardial infarction; the North Sea Race Endurance Exercise Study (NEEDED) 2013. Clinica Chimica Acta. 155-159.
  • Vis forfatter(e) (2017). Within-day biological variation and hour-to-hour reference change values for hematological parameters. Clinical Chemistry and Laboratory Medicine. 1013-1024.
  • Vis forfatter(e) (2017). Could accreditation bodies facilitate the implementation of medical guidelines in laboratories? Clinical Chemistry and Laboratory Medicine. 806-808.
  • Vis forfatter(e) (2017). Are Heart Failure Management Recommendations and Guidelines Followed in Laboratory Medicine in Europe and North America? The Cardiac Marker Guideline Uptake in Europe (CARMAGUE) Study. The Journal of Applied Laboratory Medicine (JALM). 483-493.
  • Vis forfatter(e) (2017). A survey of patients' views from eight European countries of interpretive support from Specialists in Laboratory Medicine. Clinical Chemistry and Laboratory Medicine. 1496-1500.
  • Vis forfatter(e) (2016). The variation in high sensitive cardiac troponin concentration during haemodialysis treatment is not similar to the biological variation observed in stable end stage renal disease patients. Scandinavian Journal of Clinical and Laboratory Investigation. 645-652.
  • Vis forfatter(e) (2016). Analytical bias exceeding desirable quality goal in 4 out of 5 common immunoassays: Results of a native single serum sample external quality assessment program for cobalamin, folate, ferritin, thyroid-stimulating hormone, and free t4 analyses. Clinical Chemistry. 1255-1263.
  • Vis forfatter(e) (2014). Weekly and 90-minute biological variations in cardiac troponin T and cardiac troponin I in hemodialysis patients and healthy controls. Clinical Chemistry. 838-847.
  • Vis forfatter(e) (2014). The quality of laboratory aspects of troponin testing in clinical practice guidelines and consensus documents needs to be improved. Clinica Chimica Acta. 58-61.
  • Vis forfatter(e) (2013). PSA-måling og prostatakreft – overdiagnostisering og overbehandling? Tidsskrift for Den norske legeforening. 1711-1716.
  • Vis forfatter(e) (2013). Nasjonale anbefalinger for tolkning av troponinverdier ved diagnostikk av akutt hjerteinfarkt. Tidsskrift for Den norske legeforening.
  • Vis forfatter(e) (2013). Critical review of laboratory investigations in clinical practice guidelines: proposals for the description of investigation. Clinical Chemistry and Laboratory Medicine. 1217-1226.
  • Vis forfatter(e) (2012). Reflective testing: adding value to laboratory testing. Clinical Chemistry and Laboratory Medicine. 1249-1252.
  • Vis forfatter(e) (2012). How do laboratory specialists advise clinicians concerning the use and interpretation of renal tests? Scandinavian Journal of Clinical and Laboratory Investigation. 143-151.
  • Vis forfatter(e) (2011). Laboratory investigation and follow-up of chronic kidney disease stage 3 in primary care. Clinica Chimica Acta. 1138-1142.
  • Vis forfatter(e) (2010). Monitoring renal function in children with Fabry disease: comparisons of measured and creatinine-based estimated glomerular filtration rate. Nephrology, Dialysis and Transplantation. 1507-1513.
  • Vis forfatter(e) (2010). Diagnosing microalbuminuria and consequences for the drug treatment of patients with type 2 diabetes: A European survey in primary care. Diabetes Research and Clinical Practice. 103-109.
  • Vis forfatter(e) (2009). Validation of the Hemo_Control instrument for determination of B-haemoglobin concentration in primary health care. Scandinavian Journal of Clinical and Laboratory Investigation. 817-821.
  • Vis forfatter(e) (2009). Monitoring renal Function in Fabry children: comparisons of measured and creatinine-based estimated Glomerular Filtration Rate. Nephrology, Dialysis and Transplantation. 7 sider.
Leder
  • Vis forfatter(e) (2023). Cardiac Troponin Reporting in Children and Young Adults: Time to Change Clinical Practice. Circulation. 17-19.
  • Vis forfatter(e) (2019). The rise and fall of the 99th percentile decision limit for cardiac troponins? International Journal of Cardiology. 25-26.
  • Vis forfatter(e) (2019). Cardiac troponin increase after endurance exercise: A new marker of cardiovascular risk? Circulation. 815-818.
  • Vis forfatter(e) (2010). Can changes in troponin results be useful in diagnosing myocardial infarction? Clinical Chemistry. 1047-1049.
Leserinnlegg
  • Vis forfatter(e) (2013). Week-to-Week Biological Variation in the N-terminal Prohormone of Brain Natriuretic Peptide in Hemodialysis Patients and Healthy Individuals. Clinical Chemistry. 1813-1814.
Brev til redaktøren
  • Vis forfatter(e) (2023). Week-to-week within-subject and between-subject biological variation of copeptin. Clinical Chemistry and Laboratory Medicine. e29-e33.
  • Vis forfatter(e) (2021). Impact of different sampling and storage procedures on stability of acid/base parameters in venous blood samples. Clinical Chemistry and Laboratory Medicine. E370-E373.
  • Vis forfatter(e) (2019). How does the analytical quality of the high-sensitivity cardiac troponin T assay affect the ESC rule out algorithm for NSTEMI? Clinical Chemistry. 494-496.
Doktorgradsavhandling
  • Vis forfatter(e) (2011). Use and Interpretation of Urinary Albumin and Estimated Glomerular Filtration Rate Findings in Primary Health Care.
Sammendrag/abstract
  • Vis forfatter(e) (2009). Monitoring renal Function in Fabry children; estimated or measured glomerular Filtration rate? Molecular Genetics and Metabolism. 74-75.
Poster
  • Vis forfatter(e) (2024). Long-term effect of bariatric surgery on circulating GDF15 concentrations.
Errata
  • Vis forfatter(e) (2022). Erratum to ‘The association between serum high-sensitivity cardiac troponin T and acute myocardial infarction in patients with suspected chronic coronary syndrome is modified by body mass index☆,☆☆’ International Journal of Cardiology Cardiovascular Risk and Prevention. Volume 11, December 2021, 200,109 (International Journal of Cardiology Cardiovascular Risk and Prevention (2021) 11, (S2772487521000118), (10.1016/j.ijcrp.2021.200109)). International Journal of Cardiology: Cardiovascular Risk and Prevention (IJCCRP).
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) (2024). Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification. Clinical Chemistry. 497-505.
  • Vis forfatter(e) (2023). Single Troponin Measurement to Rule Out Myocardial Infarction: JACC Review Topic of the Week. Journal of the American College of Cardiology. 60-69.
  • Vis forfatter(e) (2023). Point-of-care high-sensitivity troponin assays: Advancements, clinical applications, and implementation considerations. Journal of Laboratory and Precision Medicine.
  • Vis forfatter(e) (2021). Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis. Clinical Biochemistry. 74-77.
  • Vis forfatter(e) (2020). Quantifying atherogenic lipoproteins for lipid-lowering strategies: Consensus-based recommendations from EAS and EFLM. Atherosclerosis. 46-61.
  • Vis forfatter(e) (2020). Analytical performance of cardiac troponin assays – Current status and future needs. Clinica Chimica Acta. 149-155.
  • Vis forfatter(e) (2016). Why are clinical practice guidelines not followed?: The European Federation of Clinical Chemistry and Laboratory Medicine and European Union of Medical Specialists joint working group on Guidelines. Clinical Chemistry and Laboratory Medicine. 1133-1139.
  • Vis forfatter(e) (2016). How well do laboratories adhere to recommended clinical guidelines for the management of myocardial infarction: The cardiac marker guidelines uptake in Europe study (carmague). Clinical Chemistry. 1264-1271.
  • Vis forfatter(e) (2014). How to conduct External Quality Assessment Schemes for the pre-analytical phase? Biochemia Medica. 114-122.
  • Vis forfatter(e) (2012). Self-monitoring of blood glucose in patients with diabetes who do not use insulinuare guidelines evidence-based? Diabetic Medicine. 1226-1236.
  • Vis forfatter(e) (2009). Evaluation of prescription and interpretation of microalbuminuria by general practitioners. Annales de Biologie Clinique. 47-53.
  • Vis forfatter(e) (2009). Current Issues in Measurement and Reporting of Urinary Albumin Excretion. Clinical Chemistry. 24-38.
Fagartikkel
  • Vis forfatter(e) (2023). Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain using Point of Care Testing (WESTCOR- POC): study design. Scandinavian Cardiovascular Journal.
  • Vis forfatter(e) (2013). Varsling av sterkt avvikende analyseresultater til rekvirenter utenfor sykehus. Tidsskrift for Den norske legeforening.

Se fullstendig oversikt over publikasjoner i CRIStin.

1.           The relationship between workload and exercise-induced cardiac troponin elevations is influenced by non-obstructive coronary atherosclerosis. Magnus Bjorkavoll-Bergseth, Christine Erevik, Øyunn Kleiven, Thomasz Wiktorski, Bjørn Auestad, Øyvind Skadberg, Kristin M. Aakre, Thijs M.H. Eijsvogels, Stein Ørna. Accepted for publication in Scandinavian Journal of Medicine and Science in Sports, May 2024.

2.           Assay precision and risk of misclassification at rule-out cut-offs for high-sensitivity cardiac troponin. Kavsak PA, Mills NL, Clark L, Ko DT, Sharif S, Chen-Tournoux A, Friedman SM, Belley-Cote EP, Worster A, Cox J, Thiruganasambandamoorthy V, Lou A, Taher J, Scheuermeyer F, McCudden C, Abramson BL, Eintracht S, Shea JL, Yip PM, Huang Y, Chen M, Tsui AKY, Thorlacius L, Aakre KM, Raizman JE, Fung AWS, Humphries KH, Arnoldo S, Bhayana V, Djiana R, Beriault DR, St-Cyr J, Booth RA, Blank DW, Sivilotti MLA, Jaffe AS. Can J Cardiol. 2024 May 13:S0828-282X(24)00361-1. doi: 10.1016/j.cjca.2024.05.007

3.           Implementation of high sensitivity troponin into routine clinical practice - results of the extended  CARdiac MArkers Guideline Uptake in Europe group (CARMAGUE). P. Collinson, A. Hammerer-Lercher, K.M. Aakre, M. Langlois, C. Duff, D. Gruson, J. Suvisaari, K. Pulkki, S. Stankovic, H. Baum, M Lowry, N Mills, P. Laitinen. Accepted for publication in Clin Chim Acta, April 2024.

4.           Reference intervals of circulating secretoneurin concentrations determined in a large cohort of community dwellers: The HUNT Study. Kristin M Aakre, Magnus N Lyngbakken, Arne L Faaren, Helge Røsjø, Havard Dalen, Torbjørn Omland. Accepted for publication in Clin Chem Lab Med, March 2024.

5.           Imprecision of high-sensitivity cardiac troponin assays at the female 99th-percentile. Kavsak PA, Clark L, Arnoldo S, Lou A, Shea JL, Eintracht S, Lyon AW, Bhayana V, Thorlacius L, Raizman JE, Tsui A, Djiana R, Chen M, Huang Y, Haider A, Booth RA, McCudden C, Yip PM, Beriault D, Blank D, Fung AWS, Taher J, St-Cyr J, Sharif S, Belley-Cote E, Abramson BL, Friedman SM, Cox JL, Sivilotti MLA, Chen-Tournoux A, McLaren J, Mak S, Thiruganasambandamoorthy V, Scheuermeyer F, Humphries KH, Worster A, Ko D, Aakre KM, Mills NL, Jaffe AS. Clin Biochem. 2024 Feb 13:110731. doi: 10.1016/j.clinbiochem.2024.110731

6.           Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification. Kristin M Aakre, Fred S Apple, Nicolas L Mills, Steven JR Meex and Paul O Collinson. Clin Chem. 2023 Dec 15:hvad185. doi: 10.1093/clinchem/hvad185.

7.           Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain using Point Of Care testing (WESTCOR-POC): study design. Ingrid Viola Lavesson Thulin, Silje Marie Farestveit Jordalen, Ole Christian Lekven, Jeyaseelan Krishnapillai, Ole Thomas Steiro, Paul Collinson, Fred Apple, Louise Cullen, Tone M Norekvål, Torbjørn Wisløff, Kjell Vikenes, Torbjørn Omland, Rune O Bjørneklett, Kristin Moberg Aakre. Scand Cardiovasc J. 2023 Dec;57(1):2272585.

8.           High-sensitivity cardiac Troponin T predicts short-term mortality in patients ≥ 75 years undergoing emergency abdominal surgery; A prospective observational study.  Elin K. Aakre, Kristin M. Aakre, Hans Flaatten, Karl Ove Hufthammer, Anette H. Ranhoff, Ib Jammer. Anesth Analg. 2024 Feb 26. doi: 10.1213/ANE.0000000000006845.

9.           Chronic myocardial injury diagnosed by three high-sensitivity cardiac troponin assays; differences in prevalence and prognostic implications. Ole-Thomas Steiro, Jørund Langørgen, Hilde L Tjora, Rune Bjørneklett, Øyvind Skadberg, Vernon V S Bonarjee, Øistein R Mjelva, Trude Steinsvik, Bertil Lindahl, Torbjørn Omland, Kristin M Aakre*, Kjell Vikenes*. Clin Chem Lab Med. 2023 Nov 9. doi: 10.1515/cclm-2023-0336.

10.        Prognostic value of Growth Differentiation Factor - 15 three months after an acute chest pain admission. Gard Mikael Sæle Myrmel, Ole Thomas Steiro, Hilde Lunde Tjora, Jørund Langørgen, Rune Oskar Bjørneklett, Øyvind Skadberg, Vernon Vijay Singha Bonarjee, Øistein Rønneberg Mjelva, Eva Ringdal Pedersen, Kjell Vikenes, Torbjørn Omland, Kristin Moberg Aakre. Heart. 2023 Nov 24:heartjnl-2023-323260. doi: 10.1136/heartjnl-2023-323260

11.        Week-to-week within-subject and between-subject biological variation of copeptin. Guldhaug NA, Røys EÅ, Viste K, Thorsby PM, Sylte MS, Torsvik J, Strand H, Alaour B, Marber M, Omland T, Aakre KM. Clin Chem Lab Med. 2023 Aug 3. doi: 10.1515/cclm-2023-0673.

12.        Point-of-Care High Sensitivity Troponin Assays: Advancements, Clinical Applications, and Implementation Considerations. Ingrid Viola Lavesson Thulin, Gard Mikael Sæle Myrmel, Silje Marie Farestveit Jordalen, Paul Collinson and Kristin Moberg Aakre. J Lab Precis Med, Vol 8 (July 30, 2023); doi: 10.21037/jlpm-23-3 https://jlpm.amegroups.org/issue/view/443#.

13.        Single Troponin Measurement to Rule-out Myocardial Infarction. Allan S. Jaffe, Rick Body, Nicholas L. Mills, Kristin M Aakre, Paul O. Collinson, Amy Saenger, Ole Hammarsten, Ryan Wereski, Torbjørn Omland, Yader Sandoval, Jordi Ordonez-Lanos, Fred S Apple. J Am Coll Cardiol. 2023 Jul 4;82(1):60-69. doi: 10.1016/j.jacc.2023.04.040.

14.        Cardiac troponin reporting in children and young adults: time to change clinical practice. Kristin M Aakre, Steven JR Meex, Nicholas L Mills. Circulation. 2023 Jul 4;148(1):17-19. doi: 10.1161/CIRCULATIONAHA.123.065297

15.        Growth Differentiation Factor 15: A Prognostic Marker in Patients with Acute Chest Pain without Acute Myocardial Infarction. Myrmel GMS, Steiro OT, Tjora HL, Langørgen J, Bjørneklett R, Skadberg Ø, Bonarjee VVS, Mjelva ØR, Pedersen EKR, Vikenes K, Omland T, Aakre KM. Clin Chem. 2023 Jun 1;69(6):649-660

16.        Antibody-mediated interferences affecting cardiac troponin assays: recommendations from the IFCC Committee on Clinical Applications of Cardiac Biomarkers. Hammarsten O, Warner JV, Lam L, Kavsak P, Lindahl B, Aakre KM, Collinson P, Jaffe AS, Saenger AK, Body R, Mills NL, Omland T, Ordonez-Llanos J, Apple FS. Clin Chem Lab Med. 2023 Mar 24. doi: 10.1515/cclm-2023-0028

17.        Cardiac troponin measurement at the point of care: educational recommendations on analytical and clinical aspects by the IFCC Committee on Clinical Applications of Cardiac Bio-Markers (IFCC C-CB). Collinson P, Aakre KM, Saenger A, Body R, Hammarsten O, Jaffe AS, Kavsak P, Omland T, Ordonez-Lianos J, Karon B, Apple FS. Clin Chem Lab Med. 2023 Jan 16;61(6):989-998.

18.        Sex hormones and adrenal steroids: biological variation estimated using direct and indirect methods. Eirik Åsen Røys, Nora Alicia Guldhaug, Kristin Viste, Graham Dallas Jones, Bashir Alaour, Marit Sverresdotter Sylte, Janniche Torsvik, Ralf Kellmann, Heidi Strand, Elvar Theodorsson, Michael Marber, Torbjørn Omland, Kristin Moberg Aakre. Clin Chem. 2023 Jan 4;69(1):100-109.

19.        Implementing screening for myocardial injury in non-cardiac surgery: Perspectives of an ad-hoc interdisciplinary expert group. Dan Atar, Leiv Arne Rosseland, Ib Jammer, Kristin Moberg Aakre, Rune Wiseth, Marius Molund, Danielle Menosi Gualandro, Torbjørn Omland. Scand Cardiovasc J. 2023 Dec;57(1):31-39.

20.        Predictors of long-term symptom burden and quality of life in patients hospitalized with chest pain: A prospective observational study. Nasir Saeed, Tone M Norekvål, Ole Thomas Steiro, Hilde L Tjora, Jørund Langørgen, Rune Bjørneklett, Øyvind Skadberg, Vernon V S Bonarjee, Øistein R Mjelva, Torbjørn Omland, Kjell Vikenes, Kristin M Aakre. BMJ Open. 2022 Jul 13;12(7):e062302.

21.        Analytical Considerations in Deriving 99th Percentile Upper Reference Limits for High-Sensitivity Cardiac Troponin Assays: Educational Recommendations from the IFCC Committee on Clinical Application of Cardiac Bio-Markers. Kristin M Aakre, Amy K Saenger, Rick Body, Paul Collinson, Ola Hammarsten, Allan S. Jaffe, Pete Kavsak, Torbjørn Omland, Jordi Ordonez-Lianos, Fred S Apple. Clin Chem. 2022 Jul 27;68(8):1022-1030.

22.        Association between symptoms and risk of non-ST segment elevation myocardial infarction according to age and sex in patients admitted to the emergency department with suspected acute coronary syndrome: a single-center retrospective cohort study. Ole-Thomas Steiro, Kristin M Aakre, Hilde L Tjora, Rune Bjørneklett, Øyvind Skadberg, Vernon V S Bonarjee, Øistein R Mjelva, Torbjørn Omland, Kjell Vikenes, Jørund Langørgen. BMJ Open. 2022 May 12;12(5):e054185.

23.        Adding stress biomarkers to high sensitivity cardiac troponin for rapid NSTEMI rule-out protocols. Ingar Ziad Restan, Ana Yufera Sanchez, Ole-Thomas Steiro, Pedro Lopez-Ayala, Hilde L. Tjora, Jørund Langørgen, Torbjørn Omland, Jasper Boeddinghaus, Thomas Nestelberger, Luca Koechlin, Paul Collinson, Rune Bjørneklett, Kjell Vikenes, Heidi Strand, Øyvind Skadberg, Øistein R. Mjelva, Alf Inge Larsen, Vernon V. S. Bonarjee, Christian Mueller, Kristin M. Aakre. Eur Heart J Acute Cardiovasc Care. 2022 Jan 13:zuab124. doi: 10.1093/ehjacc/zuab124.

24.        The association between serum high-sensitivity cardiac troponin T and acute myocardial infarction in patients with suspected chronic coronary syndrome is modified by body mass index. Vavik V, Aakre KM, Pedersen EKR, Svingen GST, Tell GS, Nygård OK, Vikenes K. Int J Cardiol Cardiovasc Risk Prev. Volume 11, December 2021, 200109

25.        Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis. Kristin M Aakre, Anett Hellebø Ottesen, Heidi Strand, Arne Ludvig Faaren, Bashir Alaour, Janniche Torsvik, Marit S Sylte, Michael Marber, Geir Christensen, Helge Røsjø, Torbjørn Omland. Clin Biochem. 2021 Dec;98:74-77. doi:10.1016/j.clinbiochem.2021.09.014.

26.        Biological variation, reference change values and index of individuality of GDF-15. Cindhya Sithiravel, Ragnhild Røysland, Bashir Alaour, Marit Sverresdotter Sylte, Janniche Torsvik, Heidi Strand, Michael Marber, Torbjørn Omland, Kristin Moberg Aakre. Clin Chem Lab Med. 2021 Oct 14. doi: 10.1515/cclm-2021-0769.

27.        Diagnostic performance of novel troponin algorithms for the rule-out of Non ST elevation acute coronary syndrome. Hilde L Tjora, Ole-Thomas Steiro, Jørund Langørgen, Rune Bjørneklett, Øyvind Skadberg, Vernon V S Bonarjee, Øistein R Mjelva, Paul Collinson, Torbjørn Omland, Kjell Vikenes, Kristin M Aakre. Clin Chem. 2021 Dec 13:hvab225. doi: 10.1093/clinchem/hvab225.

28.        Biomarker Testing Considerations in the Evaluation and Management of Patients With Heart Failure: Perspectives From the International Federation of Clinical Chemistry and Laboratory Medicine Committee. Peter A. Kavsak, Carolyn S.P. Lam, Amy K. Saenger, Kristin Moberg Aakre, Richard Body, Ola. Hammarsten, Paul Collinson, Jordi Ordóñez-Llanos, Torbjørn Omland, Allan S. Jaffe,  Fred S. Apple. J Card Fail. 2021 Jul 10:S1071-9164(21)00266-9

29.        Biological Variation of Cardiac Myosin-Binding Protein C in Healthy Individuals. Bashir Alaour, Torbjørn Omland, Janniche Torsvik, Thomas E Kaier, Marit S Sylte, Heidi Strand, Sam McGrath, Luke Williams, Steven Meex, Simon Redwood, Michael Marber and Kristin M Aakre. Clin Chem Lab Med. 2021 Jun 23. doi: 10.1515/cclm-2021-0306.

30.        The Determinants of Inter-Individual Variation in Exercise-Induced Cardiac Troponin I Levels. Magnus Bjørkavoll-Bergseth, Christine Bjørkvik, Øyunn Kleiven, Thijs M.H. Eijsvogels, Øyvind Skadberg, Vidar Frøysa, Tomasz Wiktorski, Bjørn Auestad, Thor Edvardsen, Kristin Moberg Aakre and Stein Ørn. J Am Heart Assoc. 2021 Sep 7;10(17):e021710.

31.        Regular consumption of cod liver oil is associated with reduced basal and exercise-induced C-reactive protein levels; a prospective observational trial. Mette Wærstad Hansen, Stein Ørn, Christine Bjorkvik Erevik, Magnus Friestad Bjorkavoll-Bergseth, Øyvind Skadberg, Tor Harald Melberg, Kristin Moberg Aakre and Øyunn Kleiven. J Int Soc Sports Nutr. 2021 Jun 28;18(1):51

32.        How well do laboratories adhere to recommended guidelines for cardiac biomarkers management in Europe? The CArdiac MARker Guideline Uptake in Europe (CAMARGUE) Study of the EFLM Task Group on Cardiac Markers. Paul Collinson, Janne Suvisaari, Kristin M. Aakre, Hannsjörg Baum, Christopher J. Duff, Damien Gruson, Angelika Hammerer-Lercher, Kari Pulkki, Sanja Stankovic, Ana Stavljenic-Rukavina, Michel R. Langlois, Fred Apple and Päivi Laitinen. Clin Chem. 2021 Aug 5;67(8):1144-1152.

33.        Impact of different sampling and storage procedures on stability of acid/base parameters in venous blood samples. Røys EÅ, Husøy AM, Brun A, Aakre KM. Clin Chem Lab Med. 2021 Mar 12. doi: 10.1515/cclm-2021-0202

34.        Quality benchmarking of smartphone laboratory medicine applications: comparison of laboratory medicine specialists’ and non-laboratory medicine professionals’ evaluation. Snežana Jovičić, Joanna Siodmiak, Marta Duque Alcorta, Maximillian Kittel, Wytze Oosterhuis, Kristin Moberg Aakre, Per Jørgensen, Vladimir Palicka, Marge Kutt, Mikko Anttonen, Mileva Georgieva Velizarova and Jania Marc. Clin Chem Lab Med. DOI: https://doi.org/10.1515/cclm-2020-0869 | Published online: 23 Nov 2020

35.        Cardiac troponin assays with improved analytical quality – a trade-off between enhanced diagnostic performance and reduced long-term prognostic value. Hilde L Tjora, Ole-Thomas Steiro, Jørund Langørgen, Rune Bjørneklett, Ottar K Nygård,  Øyvind Skadberg, Vernon V S Bonarjee, Paul Collinson, Torbjørn Omland, Kjell Vikenes, Kristin M Aakre. J Am Heart Assoc. 2020 Dec;9(23):e017465.

36.        Update of common practice in laboratory medicine concerning natriuretic peptides testing for heart failure management in Europe. The CARdiac MArker Guideline Uptake in Europe (CARMAGUE). Angelika Hammerer-Lercher, Damien Gruson, Sanja Stankovic, Paul Collinson, Janne Suvisaari, Kari Pulkki, Christopher J. Duff, Hannsjörg Baum, Ana Stavljenic-Rukavina, Kristin M. Aakre, Michel R. Langlois, Paivi Laitinen for the EFLM Task Group on Cardiac Markers. Clin Chim Acta. 2020 Sep 28:S0009-8981(20)30462-9. doi: 10.1016/j.cca.2020.09.030

37.        Gastric bypass surgery is associated with reduced subclinical myocardial injury and greater activation of the cardiac natriuretic peptide system than lifestyle intervention. Kristin M. Aakre, Torbjørn Omland, Njord Nordstrand, Espen S. Gjevestad, Kirsten B. Holven, Magnus N. Lyngbakken and Jøran Hjelmesæth. Clin Biochem. 2020 Sep 25:S0009-9120(20)30845-6. doi: 10.1016/j.clinbiochem.2020.09.006.

38.        Clinical risk scores identify more patients at risk for cardiovascular events within 30 days as compared to standard ACS risk criteria: The WESTCOR study. Ole-Thomas Steiro, Hilde L Tjora, Jørund Langørgen, Rune Bjørneklett, Ottar K Nygård, Øyvind Skadberg, Vernon V S Bonarjee, Bertil Lindahl, Torbjørn Omland, Kjell Vikenes, Kristin M Aakre. Eur Heart J Acute Cardiovasc Care. 2021 May 11;10(3):287-301. doi: 10.1093/ehjacc/zuaa016

39.        Lot-to-Lot Variation for Commercial High-Sensitivity Cardiac Troponin: Can We Realistically Report Down to the Assay’s Limit of Detection? Alan H B Wu, Peter A Kavsak, Kristin Moberg Aakre, Robert H Christenson, Fred S Apple, W Frank Peacock, Judd E Hollander, James A de Lemos, David Morrow, James Januzzi, Allan S Jaffe. Clin Chem. 2020 Sep 1;66(9):1146-1149

40.        The high-sensitivity cardiac troponin I and T response following strenuous activity is attenuated by smokeless tobacco: The North Sea Race Endurance Exercise Study (NEEDED) 2014. Julia Skranes, Øyunn Kleiven, Kristin M Aakre, Øyvind Skadberg, Tor Melberg, Torbjørn Omland, and Stein Ørn. J Am Heart Assoc. 2020 Sep 15:e017363. doi: 10.1161/JAHA.120.017363.

41.        Analytical performance of cardiac troponin assays – current status and future needs. Kristin M Aakre, Nasir Saeed, Alan HB Wu and Peter A Kavsak. Clin Chim Acta. 2020 Oct;509:149-155.

42.        How well do laboratories adhere to recommended guidelines for dyslipidaemia management in Europe? The CArdiac MARker Guideline Uptake in Europe (CAMARGUE) Study. Hélène A. De Wolf, Michel R. Langlois, Janne Suvisaari, Kristin M. Aakre, Hannsjörg Baum, Paul Collinson, Christopher J. Duff, Damien Gruson, Angelika Hammerer-Lercher, Kari Pulkki, Sanja Stankovic, Ana Stavljenic-Rukavina, and Päivi Laitinen for the EFLM Task Group on Cardiac Markers. Clin Chim Acta. 2020 Sep;508:267-272.

43.        Systemic Cardiac Troponin T is Associated with Incident Atrial Fibrillation among Patients with Suspected Stable Angina Pectoris. Vegard Vavik, Eva Kristine Ringdal Pedersen, Gard FT Svingen, Eivind Solheim, Kristin Moberg Aakre, Grethe S. Tell, Ottar Nygård, Kjell Vikenes. Am J Cardiol. 2020 Jul 15;127:30-35.

44.        The duration of elevated heart rate is an important predictor of exercise-induced Troponin elevation. Magnus Bjørkavoll-Bergseth, Øyunn Kleiven, Bjørn Auestad, Trygve Eftestøl, Kay Oskal, Martin Nygård, Øyvind Skadberg, Kristin Moberg Aakre, Tor Melberg, Knut Gjesdal, Stein Ørn. J Am Heart Assoc. 2020 Feb 18;9(4):e014408. DOI: 10.1161/JAHA.119.014408.

45.        Endurance exercise training volume is not associated with progression of coronary artery calcification. Øyunn Kleiven, Magnus F. Bjørkavoll-Bergseth, Torbjørn Omland, Kristin M. Aakre, Vidar Frøysa, Christine B. Erevik, Ole J. Greve, Tor H. Melberg, Bjørn Auestad, Øyvind Skadberg, Thor Edvardsen, Stein Ørn. Scand J Med Sci Sports. 2020 Feb 25. doi: 10.1111/sms.13643.

46.        Quantifying atherogenic lipoproteins for lipid-lowering strategies: consensus-based recommendations from EAS and EFLM. Michel R. Langlois, Børge G. Nordestgaard, Anne Langsted, M. John Chapman, Kristin M. Aakre, Hannsjörg Baum, Jan Borén, Eric Bruckert, Alberico Catapano, Christa Cobbaert, Paul Collinson, Olivier S. Descamps, Christopher J. Duff, Arnold von Eckardstein, Angelika Hammerer-Lercher, Pia R. Kamstrup, Genovefa Kolovou, Florian Kronenberg, Samia Mora, Kari Pulkki, Alan T. Remaley, Nader Rifai, Emilio Ros, Sanja Stankovic, Ana Stavljenic-Rukavina, Grazyna Sypniewska, Gerald F. Watts, Olov Wiklund, and Päivi Laitinen for the European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Joint Consensus Initiative. Atherosclerosis. 2020 Feb;294:46-61.

47.        Impact of different preanalytical conditions on results of lupus anticoagulant tests.  Kristoffersen, AH, Hammer IJ, Vannes S, Åsberg A, Aakre KM. Int J Lab Hematol. 2019 Dec;41(6):745-753

48.        Editorial: Cardiac Troponin Increase after Endurance Exercise: A New Marker of Cardiovascular Risk? Torbjørn Omland and Kristin Moberg Aakre. Circulation, 2019 Sep 9;140(10):815-818

49.        Handling of hemolyzed serum samples in clinical chemistry laboratories: The Nordic hemolysis project. Gro Gidske, Kristin Moberg Aakre, Pål Rustad, Sverre Sandberg, Anna Norling, Jonna Pelanti, Gitte Henriksen, Ingunn Thorsteinsdottir, Gunn B.B. Kristensen. Clin Chem Lab Med. 2019 Oct 25;57(11):1699-1711

50.        Editorial: The rise and fall of the 99th percentile decision limit for cardiac troponins? Kristin Moberg Aakre and Torbjørn Omland. Int J Cardiol. 2019 Aug 1;288:25-26.

51.        Aiming towards evidence based interpretation of cardiac biomarkers in patients presenting with chest pain - the WESTCOR study: Study design. Hilde L Tjora, Ole-Thomas Steiro, Jørund Langørgen, Rune Bjørneklett, Ottar K Nygård, Renate Renstrøm, Øyvind Skadberg, Vernon V S Bonarjee, Bertil Lindahl, Paul Collinson, Torbjørn Omland, Kjell Vikenes and Kristin M Aakre. Scand Cardiovasc J. 2019 Jul 1:1-6.

52.        Occult obstructive coronary artery disease is associated with prolonged cardiac troponin elevation following strenuous exercise. Øyunn Kleiven, Torbjørn Omland, Øyvind Skadberg, Tor Harald Melberg, Magnus Friestad Bjørkavoll-Bergseth, Bjørn Auestad, Rolf Bergseth, Ole Jakob Greve, Kristin Moberg Aakre, Stein Ørn. Eur J Prev Cardiol. 2019 Jun 1:2047487319852808. doi: 10.1177/2047487319852808. 2019.

53.        Race duration and blood pressure are major predictors of exercise-induced cardiac troponin elevation. Øyunn Kleiven, Torbjørn Omland, Øyvind Skadberg, Tor Harald Melberg, Magnus Friestad Bjørkavoll-Bergseth, Bjørn Auestad, Rolf Bergseth, Ole Jakob Greve, Kristin Moberg Aakre and Stein Ørn. Int J Cardiol, 2019 May 15;283:1-8.

54.        How does the analytical quality of the high sensitivity cardiac troponin T assay affect the ESC rule out algorithm for NSTEMI? Kristin Haagensen, Paul Collinson, Arne Åsberg and Kristin M Aakre. Clin Chem, 2019 Mar;65(3):494-496

55.        Review: Physical Activity, Exercise and Cardiac Troponins: Clinical Implications. Kristin M. Aakre and Torbjørn Omland. Prog Cardiovasc Dis, January 2019. https://doi.org/10.1016/j.pcad.2019.02.005

56.        Editorial: Does recurrent endogenous hypoxia protect the heart? Kristin M Aakre  and Torbjørn Omland. Journal of Laboratory and Precision Medicine. January 2018 doi: 10.21037/jlpm.2018.01.12

57.        The cardiac troponin response following physical exercise in relation to biomarker criteria for acute myocardial infarction; The North Sea Race Endurance Exercise Study (NEEDED) 2013. Øyvind Skadberg, Øyunn Kleiven, Stein Ørn, Magnus F Bjørkavoll-Bergseth, Tor H Melberg, Torbjørn Omland and Kristin M Aakre. Clin Chim Acta. 2018 Apr;479:155-159

58.        Usefulness of Higher Levels of Cardiac Troponin T in Patients with Stable Angina Pectoris to Predict Risk of Acute Myocardial Infarction. Vegard Vavik, Eva Kristine Ringdal Pedersen, Gard Frodahl Tveitevåg Svingen, Grethe Seppola Tell, Hall Schartum Hansen, Kristin Moberg Aakre, Ottar Nygård and Kjell Vikenes. Am J Cardiol. 2018 Oct 1;122(7):1142-1147

59.        The copeptin response after physical activity is not associated with cardiac biomarkers or asymptomatic coronary artery disease: The North Sea Race Endurance Exercise Study (NEEDED) 2013. Kristin M Aakre, Øyunn Kleiven, Øyvind Skadberg, Magnus F Bjørkavoll-Bergseth, Tor Melberg, Heidi Strand, Tor-Arne Hagve and Stein Ørn. Clin Biochem. 2018 Feb;52:8-12.

60.        A Survey of Patients views from Eight European Countries of Interpretive Support from Specialists in Laboratory Medicine. Watson ID, Oosterhuis WP,  Jorgensen PE, Dikmen GZ, Siodmiak J, Jovicic S, Aakre KM, Palicka V, Kutt M Clin Chem Lab Med. 2017 Aug 28;55(10):1496-1500

61.        Could accreditation bodies facilitate the implementation of medical guidelines in laboratories?  Aakre KM, Oosterhuis WP, Misra S, Langlois MR, Watine J, Twomey PJ, Barth JH. Clin Chem Lab Med. 2017 May 1;55(6):806-808.

62.        Within-day biological variation and hour-to-hour reference change values for hematological parameters. Judith M. Hilderink, Lieke J. J. Klinkenberg, Kristin M. Aakre, Norbert C.J. de Wit, Yvonne M.C. Henskens, Noreen van der Linden, Otto Bekers, Roger J.M.W. Rennenberg, Richard P. Koopmans, Steven J. R. Meex. Clin Chem Lab Med. 2017 Jun 27;55(7):1013-1024.

63.        How well do laboratories adhere to recommended clinical guidelines for the management of myocardial infarction-the CARdiac MArker Guidelines Uptake in Europe study (CARMAGUE). Paul Collinson, Angelika Hammerer-Lercher, Janne Suvisaari, Fred S. Apple, Rob H. Christenson , Kari Pulkki, Marja P van Dieijen-Visser, Christopher J. Duff, Hannsjörg Baum , Ana Stavljenic-Rukavina, Kristin M. Aakre, Michel R. Langlois, Sanja Stankovic, Paivi Laitinen on behalf of the Working Group for Cardiac Markers (WG-CM), European Federation of Clinical Chemistry and Laboratory Medicine (EFLM). Clin Chem. 2016 62 (9): p. 1264

64.        The variation in high sensitive cardiac troponin concentration during haemodialysis treatment is not similar to the biological variation observed in stable end stage renal disease patients. Øyvind Skadberg, Sverre Sandberg, Thomas Røraas, Per Hyltoft Petersen, Hilde Sellevoll, Einar Svarstad, Kristin Sæle and Kristin M Aakre. Scand J Clin Lab Invest. 2016 Dec;76(8):645-652.

65.        Are heart failure management recommendations and guidelines followed in laboratory medicine in Europe and North America? The CARdiac MArker Guideline Uptake in Europe (CARMAGUE). Angelika Hammerer-Lercher, Paul Collinson, Janne Suvisaari, Fred S. Apple, Rob H. Christenson, Kari Pulkki, Marja P van Dieijen-Visser, Christopher J. Duff, Hannsjörg Baum , Ana Stavljenic-Rukavina, Kristin M. Aakre, Michel R. Langlois, Sanja Stankovic , Paivi Laitinen on behalf of the Working Group for Cardiac Markers (WG-CM), European Federation of Clinical Chemistry and Laboratory Medicine (EFLM). J Appl Lab Med, DOI: 10.1373/jalm.2016.021345            

66.        Analytical bias exceeding desirable quality goal in four out of five common immunoassays: Results of a native single serum sample EQA program for cobalamin, folate, ferritin, TSH and free T4 analyses. Gunn B B Kristensen, Pål Rustad, Jens P Berg and Kristin M Aakre. Clin Chem 2016 Sep;62(9):1255-63.

67.        Why are clinical practice guidelines not followed? Barth JH, Misra S, Aakre KM, Langlois MR, Watine J, Twomey PJ, Oosterhuis WP. Clin Chem Lab Med. 2016 Jul 1;54(7):1133-9.

68.        How to conduct External Quality Assessment Schemes for the pre-analytical phase? Gunn BB Kristensen, Kristin M Aakre, Ann Helen Kristoffersen and Sverre Sandberg. Biochem Med. 2014 Feb 15;24(1):114-122.

69.        Weekly and 90-minute biological variations in cardiac troponin T and cardiac troponin I in hemodialysis patients and healthy controls. Kristin M. Aakre, Thomas Røraas, Per Hyltoft Petersen, Einar Svarstad, Hilde Sellevoll, Øyvind Skadberg, Kristin Sæle, and Sverre Sandberg. Clin Chem. 2014 Jun;60:838-47.

70.        The quality of laboratory aspects of troponin testing in clinical practice guidelines and consensus documents needs to be improved. Kristin M Aakre, Michel R Langlois, Julian H Barth, Shivani Misra, Joseph Watine and Wytze P Oosterhuis. Clin Chim Acta. 2014 Nov 1;437:58-61.

71.        PSA measurement and prostate cancer - overdiagnosis and overtreatment? Hans Johan Breidablik, Eivind Meland, Kristin Moberg Aakre og Olav Helge Førde. Tidsskr Nor Laegeforen. 2013 Sep 3;133(16):1711-1716

72.        Week-to-week biological variation of NT-proBNP in hemodialysis patients and healthy subjects. Kristin M. Aakre, Thomas Røraas, Per Hyltoft Petersen, Einar Svarstad, Kristin Sæle and Sverre Sandberg. Clin Chem. 2013 Dec;59(12):1813-4.

73.        Reflective testing: adding value to laboratory testing. Wilhelmine PHG Verboeket-van de Venne, Kristin M Aakre, Joseph Watine, Wytze P Oosterhuis. Clin Chem Lab Med 2012 Apr 28;50(7):1249-52

74.        Critical review of laboratory investigations in clinical practice guidelines; proposals for the description of investigation. Kristin M Aakre, Michel R Langlois, Joseph Watine, Julian H Barth, Hannsjörg Baum, Paul Collinson, Païvi Laitinen and Wytze P Oosterhuis. Clin Chem Lab Med. 2012 Oct 5;0(0):1-10. doi: 10.1515/cclm-2012-0574.

75.        Self monitoring of blood glucose in patients with diabetes who do not use insulin - Are guidelines evidence-based? Kristin M. Aakre, Joseph Watine, Peter S. Bunting, Sverre Sandberg and Wytze P. Oosterhuis. Diabet Med. 2012 Mar 21. doi: 10.1111/j.1464-5491.2012.03659.x.

76.        How do laboratory specialists advice clinicians concerning the use and interpretation of “renal” tests? Kristin M. Aakre, Wytze P. Oosterhuis and Sverre Sandberg. Scand J Clin Lab Invest. 2012 Apr;72(2):143-51

77.        Laboratory investigation and follow-up of chronic kidney disease stage 3 in primary care. Kristin M. Aakre, Geir Thue, Einar Svarstad, Øyvind Skadberg and Sverre Sandberg. Clin Chim Acta. 2011 May 12;412(11-12):1138-42

78.        Use of troponin analysis in Norwegian hospitals. Kristin Moberg Aakre, Sverre Landaas, Tor-Arne Hagve. Tidsskr Nor Laegeforen. 2010 January 3; 278-282

79.        Diagnosing microalbuminuria and consequences for the drug treatment of patients with type 2 diabetes: an international survey in primary care. Kristin M. Aakre, Geir Thue, Sumathi Subramaniam-Haavik, Tone Bukve, Howard Morris, Mathias Müller,  Marijana V. Lovrencic, Inger Plum, Kaja Kallion, Alar Aab, Marge Kutt, Phillipe Gillery, Nathalie Schneider, Andrea R. Horvath, Rita Onody, Wytze Oosterhuis, Carmen Ricos, Carmen Perich, Gunnar Nordin and Sverre Sandberg. Diabetes Res Clin Pract. 2010 Apr 19.

80.        Editorial: Can changes between troponin results be useful in diagnosing myocardial infarction? Kristin M. Aakre and Sverre Sandberg. Clin Chem 2010. June 56: 1047-1049

81.        Review: Current Issues in Measurement and Reporting of Urinary Albumin Excretion. Greg Miller, David E Bruns, Glen L Hortin, Sverre Sandberg, Kristin M Aakre, Matthew J McQueen, Yoshihisa Itoh, John C Lieske, David W Seccombe, Graham R Jones, David M Bunk, Gary C Curhan and Andrew S Narva. Clin Chem. 2009 Jan 55(1):24-38.

82.        The MDRD equation may mask decline of glomerular filtration rate in Fabry patients with normal or near normal kidney function.  Kristin Moberg Aakre, Camilla Tøndel, Atle Brun and Einar Svarstad. Clin Nephrol, 2009: Febr 2; 71: 118-124

83.        Evaluation of prescription and interpretation of microalbuminuria by general practitioners. Schneider N, Aakre K, Thue G, Sandberg S, Durlach V, Gillery P. Ann Biol Clin (Paris) 2009, Jan 4;67(1):47-53.

84.        Validation of the Hemo_Control instrument for determination of B-haemoglobin concentration in primary health care. Aakre KM, Bliksrud YT, Frøyshov BM, Hager HB, Hansen ASV, Janukonyte J, Lauterlein JJ, Lilleholt K, Løhne K,  Männistö T, Miettola S, Pelanti J, Samson MH, Skauby RH, Tuuti E, Zelvyte I. Scand J Clin Lab Invest. 2009;69(8):817-21.

85.        Monitoring renal function in children with Fabry disease; comparisons of measured and estimated creatinine-based Glomerular Filtration Rate. Camilla Tøndel, Uma Ramaswami, Kristin Moberg Aakre, Frits Wijburg, Machtelt Bouwman, Einar Svarstad. Nephrol Dial Transplant. 2010 May;25(5):1507-13

86.        Postanalytical External Quality Assessment of Urine Albumin in Primary Health Care: An International Survey. Kristin M. Aakre, Geir Thue, Sumathi Subramaniam-Haavik, Tone Bukve, Howard Morris, Mathias Müller,  Marijana V. Lovrencic, Inger Plum, Kaja Kallion, Alar Aab, Marge Kutt, Phillipe Gillery, Nathalie Schneider, Andrea R. Horvath, Rita Onody, Wytze Oosterhuis, Carmen Ricos, Carmen Perich, Gunnar Nordin, and Sverre Sandberg. Clin Chem. 2008 Oct;54(10):1630-6.

 

2023-

The WESTCOR-POC study, PI, Western Norway Regional Health Authority 

2019-

The Bergen Atherosclerosis and Cardiac bIOmarker (BACIO) Study, utility of cardiac biomarkers in acute chest pain, Co-PI, Trond Mohn Foundation, Western Norway Regional Health Authority 

2018-

Biological variation of cardiac and endocrine biomarkers, PI, Haukeland University Hospital, Kings College, University of Oslo, Western Norway Regional Health Authority 

2015-

Aiming towards evidence based interpretation of cardiac biomarkers in patients presenting with chest pain (the WESTCOR-study), PI, Western Norway Regional Health Authority 

2012-2016

EQA for detecting analytical bias for five common immunoassays, analytical quality spesifications, PI, The Norwegain Clinical Chemistry EQA program

2010-2016

Biological variation of cardiac biomarkers in ESRD patients and healthy controls, PI, Haukeland University Hospital