Hjem
Universitetet i Bergen
Lars A. Akslens bilde

Lars A. Akslen

Professor, Leder for CCBIO
Klinisk institutt 1
Centre for Cancer Biomarkers CCBIO
  • E-postLars.Akslen@uib.no
  • Telefon+47 55 97 31 82
  • Besøksadresse
    Patologisk avdeling, Sentralblokka 2 etg., Haukeland Universitetssjukehus (HUS)
    evt. CCBIO, Sentralblokka 2 etg., HUS
  • Postadresse
    Postboks 7804
    5020 Bergen

Akslen er en sertifisert spesialist i kirurgisk patologi og leder forskningsgruppen Tumor Biology Research Group (etablert i 1995) ved Klinisk Institutt 1, Universitetet i Bergen. Siden 2013 har Akslen vært senterleder for Centre for Cancer Biomarkers CCBIO. Akslens gruppe og CCBIO arbeider med translasjonell kreftforskning med fokus på nye kreftmarkører og målrettet behandling og særlig mekanismer knyttet til hvordan kreftceller påvirkes av mikromiljøet i svulstene, og den betydning dette har for kreftspredning og dårlig prognose. Gruppen har prosjekter på ulike kreftformer, som brystkreft, ondartet melanom, prostatakreft og gynekologisk kreft. Gruppen kombinerer studier av humane tumorprøver med eksperimentelle celle- og dyremodeller. Det overordnede målet er å finne nye biomarkører som kan hjelpe oss til å forutse hvordan aggressive svulster vil utvikle seg og dermed bedre kunne skreddersy behandling.

Bøker
  • Akslen, Lars A.; Watnick, Randolph S. 2017. Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications. Springer. 534 sider. ISBN: 978-3-319-39145-8.
Tidsskriftartikler
  • Bhargava, Sameer; Akslen, Lars A.; Bukholm, Ida Rashida Khan; Hofvind, Solveig. 2019. Performance measures among non-immigrants and immigrants attending BreastScreen Norway: a population-based screening programme. European Radiology. doi: 10.1007/s00330-019-6009-2
  • Hofvind, Solveig; Holen, åsne Sørlien; Aase, Hildegunn Siv; Houssami, Nehmat; Sebuødegård, Sofie; Moger, Tron Anders; Haldorsen, Ingfrid S.; Akslen, Lars A. 2019. Two-view digital breast tomosynthesis versus digital mammography in a population-based breast cancer screening programme (To-Be): a randomised, controlled trial. The Lancet Oncology. 20: 795-805. doi: 10.1016/S1470-2045(19)30161-5
  • Hugdahl, Emilia Signe; Bachmann, Ingeborg M.; Schuster, Cornelia; Ladstein, Rita Grude; Akslen, Lars A. 2019. Prognostic value of uPAR expression and angiogenesis in primary and metastatic melanoma. PLOS ONE. 14:e0210399: 1-18. doi: 10.1371/journal.pone.0210399
  • Opsahl, Else Marie; Akslen, Lars A.; Schlichting, Ellen; Aas, Turid; Brauckhoff, Katrin; Hagen, Anne Irene; Rosenlund, Alf Friman; Sigstad, Eva; Kotanska-Grøholt, Krystyna; Jørgensen, Lars Hilmar; Bjøro, Trine. 2019. The Role of Calcitonin in Predicting the Extent of Surgery in Medullary Thyroid Carcinoma: A Nationwide Population-Based Study in Norway. European Thyroid Journal. 8: 159-166. doi: 10.1159/000499018
  • Schuster, Cornelia; Akslen, Lars A.; Stokowy, Tomasz; Straume, Oddbjørn. 2019. Predictive value of angiogenic proteins in patients with metastatic melanoma treated with bevacizumab monotherapy. The journal of pathology. Clinical research. 5: 53-62. doi: 10.1002/cjp2.116
  • Tsuruda, Kaitlyn; Bhargava, Sameer; Akslen, Lars A.; Bjørndal, Hilde; Hofvind, Solveig. 2019. Forløpstider i Mammografi-programmet før og etter innføring av pakkeforløp for brystkreft. Tidsskrift for Den norske legeforening. 139. doi: 10.4045/tidsskr.18.0322
  • Tsuruda, Kaitlyn; Hofvind, Solveig; Akslen, Lars A.; Hoff, Solveig Roth; Veierød, Marit Bragelien. 2019. Terminal digit preference: a source of measurement error in breast cancer diameter reporting. Acta Oncologica. doi: 10.1080/0284186X.2019.1669817
  • Dimitrakopoulou, Konstantina; Wik, Elisabeth; Akslen, Lars A.; Jonassen, Inge. 2018. Deblender: A semi-/unsupervised multi-operational computational method for complete deconvolution of expression data from heterogeneous samples. BMC Bioinformatics. 19: 1-17. doi: 10.1186/s12859-018-2442-5
  • Fonnes, Tina; Trovik, Jone; Edqvist, Per-Henrik D.; Fasmer, Kristine Eldevik; Marcickiewicz, Janusz; Tingulstad, Solveig; Staff, Anne Cathrine; Bjørge, Line; Amant, Frédéric; Haldorsen, Ingfrid S.; Werner, Henrica Maria Johanna; Akslen, Lars A.; Tangen, Ingvild Løberg; Krakstad, Camilla. 2018. Asparaginase-like protein 1 expression in curettage independently predicts lymph node metastasis in endometrial carcinoma: a multicentre study. BJOG: an International Journal of Obstetrics and Gynaecology. 125: 1695-1703. doi: 10.1111/1471-0528.15403
  • Jokela, Tiina; Svendsen, Agnete; Rybicka, Agata; Pelissier, Fanny; Garbe, James C.; Miyano, Masaru; Tiron, Crina Elena; Ferariu, Dan; Akslen, Lars A.; Stampfer, Martha R.; Lorens, James; LaBarge, Mark A. 2018. Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance. Frontiers in Cell and Developmental Biology. 6. doi: 10.3389/fcell.2018.00041
  • Lofterød, Trygve; Mortensen, Elin Synnøve; Nalwoga, Hawa; Wilsgaard, Tom; Frydenberg, Hanne; Risberg, Terje; Eggen, Anne Elise; McTiernan, Anne; Aziz, Sura Mohammed; Wist, Erik; Stensvold, Andreas; Reitan, Jon Brinchmann; Akslen, Lars A.; Thune, Inger. 2018. Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes. BMC Cancer. 18. 11 sider. doi: 10.1186/s12885-018-4568-2
  • Moshina, Nataliia; Sebuødegård, Sofie; Lee, Christoph I.; Akslen, Lars A.; Tsuruda, Kaitlyn; Elmore, Joann G.; Hofvind, Solveig. 2018. Automated volumetric analysis of mammographic density in a screening setting: Worse outcomes for women with dense breasts. Radiology. 288: 343-352. doi: 10.1148/radiol.2018172972
  • Opsahl, Else Marie; Akslen, Lars A.; Schlichting, Ellen; Aas, Turid; Brauckhoff, Katrin; Hagen, Anne Irene; Rosenlund, Alf Friman; Sigstad, Eva; Kotanska-Grøholt, Krystyna; Mæhle, Lovise Olaug; Engebretsen, Lars Fredri; Jørgensen, Lars Hilmar; Varhaug, Jan Erik; Bjøro, Trine. 2018. Trends in diagnostics, surgical treatment, and prognostic factors for outcomes in medullary thyroid carcinoma in Norway: A nationwide population-based study. European Thyroid Journal. 8: 31-40. doi: 10.1159/000493977
  • Pilskog, Martin; Bostad, Leif; Edelmann, Reidunn Jetne; Akslen, Lars A.; Beisland, Christian; Straume, Oddbjørn. 2018. Tumour cell expression of interleukin 6 receptor a is associated with response rates in patients treated with sunitinib for metastatic clear cell renal cell carcinoma. The journal of pathology. Clinical research. 4: 114-123. Publisert 2018-01-24. doi: 10.1002/cjp2.96
  • Robsahm, Trude Eid; Helsing, Per; Nilssen, Yngvar; Vos, Linda; Rizvi, Syed Mohammad Husain; Akslen, Lars A.; Veierød, Marit Bragelien. 2018. High mortality due to cutaneous melanoma in norway: A study of prognostic factors in a nationwide cancer registry. Clinical Epidemiology. 10: 537-548. doi: 10.2147/CLEP.S151246
  • Valla, Marit; Mjønes, Patricia; Engstrøm, Monica J; Ytterhus, Borgny; Bordin, Diana Lilian; van Loon, Barbara; Akslen, Lars A.; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M. 2018. Characterization of FGD5 expression in primary breast cancers and lymph node metastases. Journal of Histochemistry and Cytochemistry. 1-13. doi: 10.1369/0022155418792032
  • Aziz, Sura Mohammed; Wik, Elisabeth; Knutsvik, Gøril; Klingen, Tor Audun; Chen, Ying; Davidsen, Benedicte; Aas, Hans; Aas, Turid; Akslen, Lars A. 2017. Extra-nodal extension is a significant prognostic factor in lymph node positive breast cancer. PLOS ONE. 12:e0171853: 1-15. doi: 10.1371/journal.pone.0171853
  • Berg, Anna; Gulati, Ankush; Ytre-Hauge, Sigmund; Fasmer, Kristine Eldevik; Mauland, Karen Klepsland; Høivik, Erling Andre; Husby, Jenny Hild Aase; Tangen, Ingvild Løberg; Trovik, Jone; Halle, Mari Kyllesø; Stefansson, Ingunn; Akslen, Lars A.; Woie, Kathrine; Bjørge, Line; Salvesen, Helga; Salvesen, Øyvind; Werner, Henrica Maria Johanna; Haldorsen, Ingfrid S.; Krakstad, Camilla. 2017. Preoperative imaging markers and PDZ-binding kinase tissue expression predict low-risk disease in endometrial hyperplasias and low grade cancers. OncoTarget. 8: 68530-68541. doi: 10.18632/oncotarget.19708
  • Fang, Jun; Jia, Jinping; Makowski, Matthew; Xu, Mai; Wang, Zhaoming; Zhang, Tongwu; Hoskins, Jason W.; Choi, Jiyeon; Han, Younghun; Zhang, Mingfeng; Thomas, Janelle; Kovacs, Michael; Collins, Irene; Dzyadyk, Marta; Thompson, Abbey; O'Neill, Maura; Das, Sudipto; Lan, Qi; Koster, Roelof; Stolzenberg-Solomon, Rachael S.; Kraft, Peter; Wolpin, Brian M; Jansen, Pascal W. T. C.; Olson, Sara; McGlynn, Katherine A.; Kanetsky, Peter A.; Chatterjee, Nilanjan; Barrett, Jennifer H.; Dunning, Alison M.; Taylor, John C.; Newton-Bishop, Julia A.; Bishop, D Timothy; Andresson, Thorkell; Petersen, Gloria M.; Amos, Christopher I.; Iles, Mark M.; Nathanson, Katherine L; Landi, Maria Teresa; Vermeulen, Michiel; Brown, Kevin M.; Amundadottir, Laufey T.; Molven, Anders; Helsing, Per; Andresen, Per Arne; Rootwelt, Helge; Akslen, Lars A. 2017. Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148. Nature Communications. 8:15034: 1-15. doi: 10.1038/ncomms15034
  • Fonnes, Tina; Berg, Hege Fredriksen; Onyango, Therese Bredholt; Edquist, Per-Henrik D.; Sortland, Kristina; Berg, Anna; Salvesen, Helga; Akslen, Lars A.; Werner, Henrica Maria Johanna; Trovik, Jone; Tangen, Ingvild Løberg; Krakstad, Camilla. 2017. Asparaginase-like protein 1 is an independent prognostic marker in primary endometrial cancer, and is frequently lost in metastatic lesions. Gynecologic Oncology. 148: 197-203. doi: 10.1016/j.ygyno.2017.10.025
  • Hugdahl, Emilia Signe; Kalvenes, May Britt; Mannelqvist, Monica; Ladstein, Rita Grude; Akslen, Lars A. 2017. Prognostic impact and concordance of TERT promoter mutation and protein expression in matched primary and secondary cutaneous melanoma. British Journal of Cancer. 118: 98-105. doi: 10.1038/bjc.2017.384
  • Klingen, Tor Audun; Chen, Ying; Aas, Hans; Wik, Elisabeth; Akslen, Lars A. 2017. Tumor-associated macrophages are strongly related to vascular invasion, non-luminal subtypes, and interval breast cancer. Human Pathology. 69: 72-80. doi: 10.1016/j.humpath.2017.09.001
  • Kraby, Maria Ryssdal; Opdahl, Signe; Akslen, Lars A.; Bofin, Anna M. 2017. Quantifying tumour vascularity in non-luminal breast cancers. Journal of Clinical Pathology. 70: 766-774. doi: 10.1136/jclinpath-2016-204208
  • Krüger, Kristi; Wik, Elisabeth; Knutsvik, Gøril; Nalwoga, Hawa; Klingen, Tor Audun; Arnes, Jarle; Chen, Ying; Mannelqvist, Monica; Dimitrakopoulou, Konstantina; Stefansson, Ingunn; Birkeland, Even; Aas, Turid; Tobin, Nicholas P.; Jonassen, Inge; Bergh, Jonas; Foulkes, William D; Akslen, Lars A. 2017. Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer. Scientific Reports. 7:1089: 1-12. doi: 10.1038/s41598-017-00862-w
  • Pilskog, Martin; Beisland, Christian; Akslen, Lars A.; Bostad, Leif; Haug, Åse; Heinrich, Daniel; Hjelle, Karin Margrethe; Straume, Oddbjørn. 2017. Predictive value of C-reactive protein in patients treated with sunitinib for metastatic clear cell renal cell carcinoma. BMC Urology. 17:74: 1-11. doi: 10.1186/s12894-017-0267-6
  • Ramnefjell, Maria; Aamelfot, Christina; Aziz, Sura Mohammed; Helgeland, Lars; Akslen, Lars A. 2017. Microvascular proliferation is associated with aggressive tumour features and reduced survival in lung adenocarcinoma. The journal of pathology. Clinical research. 3: 249-257. doi: 10.1002/cjp2.78
  • Ramnefjell, Maria; Aamelfot, Christina; Helgeland, Lars; Akslen, Lars A. 2017. Vascular invasion is an adverse prognostic factor in resected non?small-cell lung cancer. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 125: 197-206. doi: 10.1111/apm.12652
  • Ramnefjell, Maria; Aamelfot, Christina; Helgeland, Lars; Akslen, Lars A. 2017. Low expression of SerpinB2 is associated with reduced survival in lung adenocarcinomas. OncoTarget. 8: 90706-90718. doi: 10.18632/oncotarget.21456
  • Reisæter, Lars Anders Rokne; Futterer, Jürgen J.; Losnegård, Are; Nygård, Yngve; Monssen, Jan Anker; Gravdal, Karsten; Halvorsen, Ole Johan; Akslen, Lars A.; Biermann, Martin; Haukaas, Svein Andreas; Rørvik, Jarle; Beisland, Christian. 2017. Optimising preoperative risk stratification tools for prostate cancer using mpMRI. European Radiology. 28: 1016-1026. Publisert 2017-10-06. doi: 10.1007/s00330-017-5031-5
  • Strand, Roger; Akslen, Lars A. 2017. Hva er ansvarlig kreftforskning? Tidsskrift for Den norske legeforening. 137: 292-294. doi: 10.4045/tidsskr.16.0295
  • Tangen, Ingvild Løberg; Venereis, Jennifer Taylor; Halle, Mari Kyllesø; Werner, Henrica Maria Johanna; Trovik, Jone; Akslen, Lars A.; Salvesen, Helga; Conzen, Suzanne D.; Fleming, Gini F.; Krakstad, Camilla. 2017. Expression of glucocorticoid receptor is associated with aggressive primary endometrial cancer and increases from primary to metastatic lesions. Gynecologic Oncology. 147: 672-677. doi: 10.1016/j.ygyno.2017.09.013
  • Valla, Marit; Engstrøm, Monica J; Ytterhus, Borgny; Hansen, Åse Kristin Skain; Akslen, Lars A.; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M. 2017. FGD5 amplification in breast cancer patients is associated with tumor proliferation and a poorer prognosis. Breast Cancer Research and Treatment. 162: 243-253. doi: 10.1007/s10549-017-4125-8
  • Aziz, Sura Mohammed; Wik, Elisabeth; Knutsvik, Gøril; Klingen, Tor Audun; Chen, Yingshan; Davidsen, Benedicte; Aas, Hans; Aas, Turid; Akslen, Lars A. 2016. Evaluation of Tumor Cell Proliferation by Ki-67 Expression and Mitotic Count in Lymph Node Metastases from Breast Cancer. PLOS ONE. 11. doi: 10.1371/journal.pone.0150979
  • Frydenberg, Hanne; Thune, Inger; Lofterød, Trygve; Mortensen, Elin Synnøve; Eggen, Anne Elise; Risberg, Terje; Wist, Erik; Flote, Vidar Gordon; Furberg, Anne-Sofie; Wilsgaard, Tom; Akslen, Lars A.; McTiernan, Anne. 2016. Pre-diagnostic high-sensitive C-reactive protein and breast cancer risk, recurrence, and survival. Breast Cancer Research and Treatment. 155: 345-354. doi: 10.1007/s10549-015-3671-1
  • Helsing, Per; Robsahm, Trude Eid; Vos, Linda; Rizvi, Syed Mohammad H.; Akslen, Lars A.; Veierød, Marit Bragelien. 2016. Cutaneous head and neck melanoma (CHNM): A population-based study of the prognostic impact of tumor location. Journal of American Academy of Dermatology. 75: 975-982.
  • Hofvind, Solveig; Holen, åsne Sørlien; Roman, Martha; Sebuødegård, Sofie; Puig-Vives, M; Akslen, Lars A. 2016. Mode of detection: an independent prognostic factor for women with breast cancer. Journal of Medical Screening. 23: 89-97. doi: 10.1177/0969141315604006
  • Hugdahl, Emilia Signe; Kalvenes, May Britt; Puntervoll, Hanne Eknes; Ladstein, Rita Grude; Akslen, Lars A. 2016. BRAF-V600E expression in primary nodular melanoma is associated with aggressive tumour features and reduced survival. British Journal of Cancer. 114: 801-808. doi: 10.1038/bjc.2016.44
  • Klingen, Tor Audun; Chen, Ying; Stefansson, Ingunn; Knutsvik, Gøril; Collett, Karin; Abrahamsen, Anne Line; Aase, Hildegunn Siv; Aas, Hans; Aas, Turid; Wik, Elisabeth; Akslen, Lars A. 2016. Tumour cell invasion into blood vessels is significantly related to breast cancer subtypes and decreased survival. Journal of Clinical Pathology. 70: 313-319. doi: 10.1136/jclinpath-2016-203861
  • Knutsvik, Gøril; Collett, Karin; Arnes, Jarle; Akslen, Lars A.; Stefansson, Ingunn. 2016. QSOX1 expression is associated with aggressive tumor features and reduced survival in breast carcinomas. Modern Pathology. Dec;29: 1485-1491. doi: 10.1038/modpathol.2016.148
  • Mauland, Karen Klepsland; Wik, Elisabeth; Høivik, Erling Andre; Kusonmano, Kanthida; Halle, Mari Kyllesø; Berg, Anna; Haugland, Hans Kristian; Øyan, Anne Margrete; Kalland, Karl-Henning; Stefansson, Ingunn; Akslen, Lars A.; Krakstad, Camilla; Trovik, Jone; Werner, Henrica Maria Johanna; Salvesen, Helga. 2016. Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival. OncoTarget. 8: 9696-9707. doi: 10.18632/oncotarget.14201
  • Nalwoga, Hawa; Ahmed, Lavina; Arnes, Jarle; Wabinga, Henry; Akslen, Lars A. 2016. Strong expression of hypoxia-inducible factor-1α (HIF-1α) is associated with Axl expression and features of aggressive tumors in African breast cancer. PLOS ONE. 11. doi: 10.1371/journal.pone.0146823
  • Nygård, Yngve; Haukaas, Svein Andreas; Halvorsen, Ole Johan; Gravdal, Karsten; Frugård, Jannicke; Akslen, Lars A.; Beisland, Christian. 2016. A positive Real-Time Elastography (RTE) combined with a Prostate Cancer Gene 3 (PCA3) score above 35 convey a high probability of intermediate- or high-risk prostate cancer in patient admitted for primary biopsy. BMC Urology. 16:39: 1-8. doi: 10.1186/s12894-016-0159-1
  • Opsahl, Else Marie; Brauckhoff, Michael; Schlichting, Ellen; Helset, Kristin; Svartberg, Johan; Brauckhoff, Katrin; Mæhle, Lovise Olaug; Engebretsen, Lars Fredri; Sigstad, Eva; Kotanska-Grøholt, Krystyna; Akslen, Lars A.; Jørgensen, Lars Hilmar; Varhaug, Jan Erik; Bjøro, Trine. 2016. A nationwide study of multiple endocrine neoplasia type 2A in Norway: predictive and prognostic factors for the clinical course of medullary thyroid carcinoma. Thyroid. 26: 1225-1238. doi: 10.1089/thy.2015.0673
  • Schuster, Cornelia; Akslen, Lars A.; Straume, Oddbjørn. 2016. Expression of Heat Shock Protein 27 in melanoma metastases is associated with overall response to bevacizumab monotherapy: Analyses of predictive markers in a clinical phase II study. PLOS ONE. 11. doi: 10.1371/journal.pone.0155242
  • Valla, Marit; Vatten, Lars Johan; Engstrøm, Monica J; Haugen, Olav Anton; Akslen, Lars A.; Bjørngaard, Johan Håkon; Hagen, Anne Irene; Ytterhus, Borgny; Bofin, Anna M.; Opdahl, Signe. 2016. Molecular subtypes of breast cancer: Long-term incidence trends and prognostic differences. Cancer Epidemiology, Biomarkers and Prevention. 25: 1625-1634. doi: 10.1158/1055-9965.EPI-16-0427
  • Wang, Suming; Blois, Anna; El Rayes, Tina; Liu, Joyce F.; Hirsch, Michelle S.; Gravdal, Karsten; Palakurthi, Sangeetha; Bielenberg, Diane R.; Akslen, Lars A.; Drapkin, Ronny; Mittal, Vivek; Watnick, Randolph S. 2016. Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment. Science Translational Medicine. 8. doi: 10.1126/scitranslmed.aad5653
  • Ahmed, Lavina; Nalwoga, Hawa; Arnes, Jarle; Wabinga, Henry; Micklem, David Robert; Akslen, Lars A. 2015. Increased tumor cell expression of Axl is a marker of aggressive features in breast cancer among African women. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 123: 688-696. doi: 10.1111/apm.12403
  • Barrett, Jennifer H.; Taylor, John C.; Bright, C; Harland, Mark; Dunning, Alison M; Akslen, Lars A.; Andresen, Per Arne; Avril, Marie-Francoise; Azizi, Esther; Scarra, Giovanna Bianchi; Brossard, Myriam; Brown, Kevin M.; Debniak, Tadeusz; Elder, David E.; Friedman, Eitan; Ghiorzo, Paola; Gillanders, Elizabeth M.; Gruis, Nelleke A.; Hansson, Johan; Helsing, Per; Hočevar, Marko; Höiom, Veronica; Ingvar, Christian; Landi, Maria Teresa; Lang, Julie L.; Lathrop, G. Mark; Lubinski, Jan; Mackie, Rona M.; Molven, Anders; Novakovic, Srdjan; Olsson, Håkan; Puig, Susana; Puig-Butille, Joan Anton; van der Stoep, Nienke; van Doorn, Remco; van Workum, Wilberg; Goldstein, Alisa M.; Kanetsky, Peter A.; Pharoah, Paul D.P.; Demenais, Florence; Hayward, Nicholas K.; Bishop, Julia A. Newton; Bishop, D. Timothy; Iles, Mark M. 2015. Fine mapping of genetic susceptibility loci for melanoma reveals a mixture of single variant and multiple variant regions. International Journal of Cancer. 136: 1351-1360. doi: 10.1002/ijc.29099
  • Biermann, Martin; Kråkenes, Jostein; Brauckhoff, Katrin; Haugland, Hans Kristian; Heinecke, Achim; Akslen, Lars A.; Varhaug, Jan Erik; Brauckhoff, Michael. 2015. Post-PET ultrasound improves specificity of 18F-FDG-PET for recurrent differentiated thyroid cancer while maintaining sensitivity. Acta Radiologica. 56: 1350-1360. doi: 10.1177/0284185115574298
  • Bredholt, Geir; Mannelqvist, Monica; Stefansson, Ingunn; Birkeland, Even; Bø, Trond Hellem; Øyan, Anne Margrete; Trovik, Jone; Kalland, Karl-Henning; Jonassen, Inge; Salvesen, Helga; Wik, Elisabeth; Akslen, Lars A. 2015. Tumor necrosis is an important hallmark of aggressive endometrial cancer and associates with hypoxia, angiogenesis and inflammation responses. OncoTarget. 6: 39676-39691. doi: 10.18632/oncotarget.5344
  • Hofvind, Solveig; Holen, Åsne Sørlien; Aas, Turid; Roman, Martha; Sebuødegård, Sofie; Akslen, Lars A. 2015. Women treated with breast conserving surgery do better than those with mastectomy independent of detection mode, prognostic and predictive tumor characteristics. European Journal of Surgical Oncology. 41: 1417-1422. doi: 10.1016/j.ejso.2015.07.002
  • Knappskog, Stian; Berge, Elisabet Ognedal; Chrisanthar, Ranjan; Geisler, Stephanie; Staalesen, Vidar; Leirvaag, Beryl; Yndestad, Synnøve; de Faveri, Elise Norheim; Karlsen, Bård Ove; Wedge, David C.; Akslen, Lars A.; Lilleng, Peer Kåre; Løkkevik, Erik; Lundgren, Steinar; Østenstad, Bjørn; Risberg, Terje; Mjaaland, Ingvil; Aas, Turid; Lønning, Per Eystein. 2015. Concomitant inactivation of the p53- and pRB- functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo. Molecular Oncology. 9: 1553-1564. doi: 10.1016/j.molonc.2015.04.008
  • Kraby, Maria Ryssdal; Krüger, Kristi; Opdahl, Signe; Vatten, Lars Johan; Akslen, Lars A.; Bofin, Anna M. 2015. Microvascular proliferation in luminal A and basal-like breast cancer subtypes. Journal of Clinical Pathology. 68: 891-897. doi: 10.1136/jclinpath-2015-203037
  • Law, Matthew H.; Bishop, D. Timothy; Lee, Jeffrey E.; Brossard, Myriam; Martin, Nicholas G.; Moses, Eric; Song, Fengju; Barrett, Jennifer H.; Kumar, Rajiv; Easton, Douglas F.; Pharoah, Paul D.P.; Swerdlow, Anthony J.; Kypreou, Katerina P.; Taylor, John C.; Harland, Mark; Randerson-Moor, Juliette; Akslen, Lars A.; Andresen, Per Arne; Avril, Marie-Francoise; Azizi, Esther; Scarra, Giovanna Bianchi; Brown, Kevin M; Debniak, Tadeusz; Duffy, David L.; Elder, David E.; Fang, Shenying; Friedman, Eitan; Galan, Pilar; Ghiorzo, Paola; Gillanders, Elizabeth M.; Goldstein, Alisa M.; Gruis, Nelleke A.; Hansson, Johan; Helsing, Per; Hocevar, Marko; Höiom, Veronica; Ingvar, Christian; Kanetsky, Peter A.; Chen, Wei V.; Landi, Maria Teresa; Lang, Julie; Lathrop, G. Mark; Lubinski, Jan; Mackie, Rona M.; Mann, Graham J.; Molven, Anders; Montgomery, Grant W.; Novakovic, Srdjan; Olsson, Håkan; Puig, Susana; Puig-Butille, Joan Anton; Qureshi, Abrar A.; Radford-Smith, Graham L; Van Der Stoep, Nienke; Van Doorn, Remco; Whiteman, David C.; Craig, Jamie E.; Schadendorf, Dirk; Simms, Lisa A.; Burdon, Kathryn P.; Nyholt, Dale R.; Pooley, Karen A.; Orr, Nick; Stratigos, Alexander J.; Cust, Anne E.; Ward, Sarah V.; Hayward, Nicholas K.; Han, Jiali; Schulze, Hans-Joachim; Dunning, Alison M.; Bishop, Julia A. Newton; Demenais, Florence; Amos, Christopher I.; MacGregor, Stuart; Iles, Mark M. 2015. Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Nature Genetics. 47: 987-995. doi: 10.1038/ng.3373
  • Moshina, Nataliia; Ursin, Giske; Hoff, Solveig Roth; Akslen, Lars A.; Roman, Martha; Sebuødegård, Sofie; Hofvind, Solveig. 2015. Mammographic density and histopathologic characteristics of screen-detected tumors in the Norwegian Breast Cancer Screening Program. Acta radiologica open.
  • Nygård, Yngve; Haukaas, Svein Andreas; Eide, Geir Egil; Halvorsen, Ole Johan; Gravdal, Karsten; Frugård, Jannicke; Akslen, Lars A.; Beisland, Christian. 2015. Prostate cancer antigen-3 (PCA3) and PCA3-based nomograms in the diagnosis of prostate cancer: an external validation of Hansen's nomogram on a Norwegian cohort. Scandinavian journal of urology. 49: 8-15. doi: 10.3109/21681805.2014.949841
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  • Bachmann, Ingeborg M.; Puntervoll, Hanne Eknes; Otte, Arie P.; Akslen, Lars A. 2008. Loss of BMI-1 expression is associated with clinical progress of malignant melanoma. Modern Pathology. 21: 583-590. doi: 10.1038/modpathol.2008.17
  • Borkamo, Erling Dahl; Fluge, Øystein; Mella, Olav; Akslen, Lars A.; Bruland, Ove; Dahl, Olav. 2008. Hyperthermia improves the antitumour effect of metronomic cyclophosphamide in a rat transplantable brain tumour. Radiotherapy and Oncology. 86: 435-442. doi: 10.1016/j.radonc.2008.01.022
  • Dutt, Amit; Salvesen, Helga; Chent, Tzu-Hsiu; Ramos, Alex H.; Onofrio, Robert C.; Hatton, Charlie; Nicoletti, Richard; Winckler, Wendy; Grewal, Rupinder; Hanna, Megan; Wyhs, Nicolas; Ziaugra, Liuda; Richter, Daniel J.; Trovik, Jone; Engelsen, Ingeborg Bøe; Stefansson, Ingunn Marie; Fennell, Tim; Cibulskis, Kristian; Zody, Michael C.; Akslen, Lars A.; Gabriel, Stacey; Wong, Kwok-Kin; Sellers, William R.; Meyerson, Matthew; Greulich, Heidi. 2008. Drug-sensitive FGFR2 mutations in endometrial carcinoma. Proceedings of the National Academy of Sciences of the United States of America. 105: 8713-8717. doi: 10.1073/pnas.0803379105
  • Engelsen, Ingeborg Bøe; Mannelqvist, Monica; Stefansson, Ingunn Marie; Carter, Scott L.; Beroukhim, Rameen; Øyan, Anne Margrete; Otte, Ariel P.; Kalland, Karl-Henning; Akslen, Lars A.; Salvesen, Helga. 2008. Low BMI-1 expression is associated with an activated BMI-1-driven signature, vascular invasion, and hormone receptor loss in endometrial carcinoma. British Journal of Cancer. 98: 1662-1669. doi: 10.1038/sj.bjc.6604360
  • Engelsen, Ingeborg Bøe; Stefansson, IM; Akslen, Lars A.; Salvesen, Helga Birgitte. 2008. GATA3 expression in estrogen receptor alpha-negative endometrial carcinomas identifies aggressive tumors with high proliferation and poor patient survival. American Journal of Obstetrics and Gynecology. 199: e 1-7. doi: 10.1016/j.ajog.2008.04.043
  • Engelsen, Ingeborg Bøe; Stefansson, Ingunn Marie; Beroukhim, Rameen; Sellers, William R.; Meyerson, Matthew; Akslen, Lars A.; Salvesen, Helga. 2008. HER-2/neu expression is associated with high tumor cell proliferation and aggressive phenotype in a population based patient series of endometrial carcinomas. International Journal of Oncology. 32: 307-316.
  • Gravdal, Karsten; Halvorsen, Ole Johan; Haukaas, Svein Andreas; Akslen, Lars A. 2008. Vascular proliferation by Nestin/Ki-67 is a novel predictor of the clinical progress of prostate cancer. Histopathology. 53: 276-277.
  • Helsing, Per; Nyrnoen, Dag André; Ariansen, Sarah; Steine, Solrun; Mæhle, Lovise; Aamdal, Steinar; Langmark, Frøydis; Loeb, Mitchell; Akslen, Lars A.; Molven, Anders; Andresen, Per Arild Kjølseth. 2008. Population-based prevalence of CDKN2A and CDK4 mutations in patients with multiple primary melanomas. Genes, Chromosomes and Cancer. 47: 175-184. doi: 10.1002/gcc.20518
  • Ke, Xisong; Qu, Yi; Goldfinger, Naomi; Rostad, Kari; Hovland, Randi; Akslen, Lars A.; Rotter, Varda; Øyan, Anne Margrete; Kalland, Karl-Henning. 2008. Epithelial to Mesenchymal Transition of a Primary Prostate Cell Line with Switches of Cell Adhesion Modules but without Malignant Transformation. PLOS ONE. 3. doi: 10.1371/journal.pone.0003368
  • Lin, Biaoyang; Utleg, Angelita G.; Gravdal, Karsten; White, James T.; Halvorsen, Ole Johan; Lu, Wei; True, Lawrence D.; Vessella, Robert; Lange, Paul H.; Nelson, Peter S.; Hood, Leroy; Kalland, Karl-Henning; Akslen, Lars A. 2008. WDR19 expression is increased in prostate cancer compared with normal cells, but low-intensity expression in cancers is associated with shorter time to biochemical failures and local recurrence. Clinical Cancer Research. 14: 1397-1406. doi: 10.1158/1078-0432.CCR-07-1535
  • Nalwoga, Hawa; Arnes, Jarle; Wabinga, Henry; Akslen, Lars A. 2008. Expression of EGFR and c-kit is associated with the basal-like phenotype in breast carcinomas of African women. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 116: 515-525. doi: 10.1111/j.1600-0463.2008.01024.x
  • Naumov, George N.; Folkman, Judah; Straume, Oddbjørn; Akslen, Lars A. 2008. Tumor-vascular interactions and tumor dormancy. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 116: 569-585. doi: 10.1111/j.1600-0463.2008.01213.x
  • Naumov, George N.; Heymach, John; Akslen, Lars A. 2008. Dr. Folkman's legacy - a life of angiogenesis research. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 116: 89-92. doi: 10.1111/j.1600-0463.2008.00123.x
  • Bachmann, Ingeborg M.; Eknes, HE; Otte, Ariel P.; Akslen, Lars A. 2007. Loss of BMI-1 expression is associated with the clinical progress of malignant melanoma. Virchows Archiv. 451: 452-452.
  • Gravdal, Karsten; Halvorsen, Ole Johan; Haukaas, Svein Andreas; Akslen, Lars A. 2007. A Switch from E-Cadherin to N-Cadherin Expression Indicates Epithelial to Mesenchymal Transition and Is of Strong and Independent Importance for the Progress of Prostate Cancer. Clinical Cancer Research. 13: 7003-7011. doi: 10.1158/1078-0432.CCR-07-1263
  • Gravdal, Karsten; Halvorsen, Ole Johan; Haukaas, Svein Andreas; Akslen, Lars A. 2007. Epithelial to mesenchymal transition is of strong prognostic importance in prostate cancer. Virchows Archiv. 451: 344-344.
  • Halvorsen, Ole Johan; Rostad, Kari; Øyan, Anne Margrete; Puntervoll, Hanne Eknes; Bø, Trond Hellem; Stordrange, Laila; Olsen, Sue; Haukaas, Svein Andreas; Hood, Leroy; Jonassen, Inge; Kalland, Karl-Henning; Akslen, Lars A. 2007. Increased expression of sim2-s protein is a novel marker of aggressive prostate cancer. Clinical Cancer Research. 13: 892-897. doi: 10.1158/1078-0432.CCR-06-1207
  • Nalwoga, H; Arnes, Jarle; Wabinga, H; Akslen, Lars A. 2007. Basal-like phenotype is frequent in invasive breast carcinoma from Ugandan Africans and is strongly associated with a high expression of EGFR/c-Kit and features of aggressive tumors. Virchows Archiv. 451: 137-137.
  • Nalwoga, Hawa; Arnes, Jarle; Wabinga, Henry; Akslen, Lars A. 2007. Frequency of the basal-like phenotype in African breast cancer. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 115: 1391-1399. doi: 10.1111/j.1600-0463.2007.00862.x
  • Naumov, George N.; Watnick, Randolph S.; Almog, Nava; Akslen, Lars A.; Folkman, Judah. 2007. Re: A model of human tumor dormancy: An angiogenic escape from the nonangiogenic phenotype - Response. Journal of the National Cancer Institute. 99: 331-332. doi: 10.1093/jnci/djk056
  • Petersen, Kjell; Øyan, Anne Margrete; Rostad, Kari; Olsen, Sue; Bø, Trond Hellem; Salvesen, Helga; Gjertsen, Bjørn Tore; Bruserud, Øystein; Halvorsen, Ole Johan; Akslen, Lars A.; Steen, Vidar Martin; Jonassen, Inge; Kalland, Karl-Henning. 2007. Comparison of nucleic acid targets prepared from total RNA or poly(A) RNA for DNA oligonucleotide microarray hybridization. Analytical Biochemistry. 366: 46-58. doi: 10.1016/j.ab.2007.03.013
  • Rostad, Kari; Mannelqvist, Monica; Halvorsen, Ole Johan; Øyan, Anne Margrete; Bø, Trond Hellem; Stordrange, Laila; Olsen, Sue; Haukaas, Svein Andreas; Lin, Biaoyang; Hood, Leroy; Jonassen, Inge; Akslen, Lars A.; Kalland, Karl-Henning. 2007. ERG upregulation and related ETS transcription factors in prostate cancer. International Journal of Oncology. 30: 19-32.
  • Tischkowitz, Marc; Brunet, Jean-Sébastien; Bégin, Louis R.; Huntsman, David G.; Cheang, Maggie C.U.; Akslen, Lars A.; Nielsen, Torsten O.; Foulkes, William D. 2007. Use of immunohistochemical markers can refine prognosis in triple negative breast cancer. BMC Cancer. 7. 11 sider. doi: 10.1186/1471-2407-7-134
  • Bachmann, Ingeborg Margrethe; Halvorsen, Ole Johan; Collett, Karin; Stefansson, Ingunn Marie; Straume, Oddbjørn; Haukaas, Svein Andreas; Salvesen, Helga; Otte, Arie P.; Akslen, Lars A. 2006. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. Journal of Clinical Oncology. 24: 268-273. doi: 10.1200/JCO.2005.01.5180
  • Collett, Karin; Eide, Geir Egil; Arnes, Jarle; Stefansson, Ingunn Marie; Eide, Johan; Braaten, Audun; Aas, Turid; Otte, Ariel P.; Akslen, Lars A. 2006. Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer. Clinical Cancer Research. 12: 1168-1174. doi: 10.1158/1078-0432.CCR-05-1533
  • Engeland, Anders; Tretli, Steinar; Akslen, Lars Andreas; Bjørge, Tone. 2006. Body size and thyroid cancer in two million Norwegian men and women. British Journal of Cancer. 95: 366-370. doi: 10.1038/sj.bjc.6603249
  • Engelsen, Ingeborg; Stefansson, Ingunn Marie; Akslen, Lars A.; Salvesen, Helga. 2006. Pathologic expression of p53 or p16 in preoperative curettage specimens identifies high-risk endometrial carcinomas. American Journal of Obstetrics and Gynecology. 195: 979-986.
  • Fluge, Øystein; Bruland, Ove; Akslen, Lars A.; Lillehaug, Johan; Varhaug, Jan Erik. 2006. Gene expression in poorly differentiated papillary thyroid carcinomas. Thyroid. 16: 161-175.
  • Gravdal, Karsten; Halvorsen, Ole Johan; Haukaas, Svein Andreas; Akslen, Lars A. 2006. Expression of bFGF/FGFR-1 and vascular proliferation related to clinicopathologic features and tumor progress in localized prostate cancer. Virchows Archiv. 448: 68-74.
  • Haukaas, Svein Andreas; Halvorsen, Ole Johan; Dæhlin, Lars; Høstmark, Jens; Akslen, Lars A. 2006. Is preoperative serum prostate-specific antigen level significantly related to clinical recurrence after radical 14 retropubic prostatectomy for localized prostate cancer? BJU International. 97: 51-55. doi: 10.1111/j.1464-410X.2006.05886
  • Kalland, Karl-Henning; Rostad, Kari; Mannelqvist, Monica; Halvorsen, Ole Johan; Øyan, Anne Margrete; Bø, Trond Hellem; Olsen, Sue; Haukaas, Svein Andreas; Lin, Biaoyang; Hood, Leroy; Jonassen, Inge; Akslen, Lars A. 2006. Global gene expression analysis of transcription factors in prostate cancer and cell lines. International Journal of Molecular Medicine. 18: S27. Publisert 2006-10-14.
  • Naumov, George N.; Akslen, Lars A.; Folkman, Judah. 2006. Role of angiogenesis in human tumor dormancy - Animal models of the angiogenic switch. Cell Cycle. 5: 1779-1787.
Bokkapitler
  • Akslen, Lars A. 2017. Tissue-Based Biomarkers of Tumor-Vascular Interactions. 3, sider 55-76. I:
    • Akslen, Lars A.; Watnick, Randolph S. 2017. Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications. Springer. 534 sider. ISBN: 978-3-319-39145-8.
  • Akslen, Lars A.; Watnick, Randolph S. 2017. Preface. Preface. I:
    • Akslen, Lars A.; Watnick, Randolph S. 2017. Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications. Springer. 534 sider. ISBN: 978-3-319-39145-8.
  • Wik, Elisabeth; Akslen, Lars A. 2017. Gene expression signatures of the tumor microenvironment: relation to tumor progress in breast cancer. 16, sider 379-407. I:
    • Akslen, Lars A.; Watnick, Randolph S. 2017. Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications. Springer. 534 sider. ISBN: 978-3-319-39145-8.
  • Akslen, Lars A. 2008. Pathology of Breast Tumors in Hereditary Breast Cancer. Section 5: Cliical Management of Heredidtary Breast Cancer, Chapter 18, sider 319-332. I:
    • Isaacs, Claudine; Rebbeck, Timothy R. 2008. Hereditary Breast Cancer. 400 sider. ISBN: 978-0-8493-9022-7.

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