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Marion Kusche-Gullbergs bilde

Marion Kusche-Gullberg

Professor
  • E-postMarion.Kusche@uib.no
  • Telefon+47 55 58 66 90
  • Besøksadresse
    Jonas Lies vei 91
  • Postadresse
    Postboks 7804
    5020 Bergen
Vitenskapelig artikkel
  • 2019. Heparan sulfate in chronic kidney diseases: Exploring the role of 3-O-sulfation. Biochimica et Biophysica Acta - General Subjects. 839-848.
  • 2018. The exostosin family of glycosyltransferases: mRNA expression profiles and heparan sulphate structure in human breast carcinoma cell lines. Bioscience Reports. 1-12.
  • 2018. Potential role for Ext1-dependent heparan sulfate in regulating P311 gene expression in A549 carcinoma cells. Biochimica et Biophysica Acta - General Subjects. 1472-1481.
  • 2018. Endothelial heparan sulfate deficiency reduces inflammation and fibrosis in murine diabetic nephropathy. Laboratory Investigation. 427-438.
  • 2015. Reduced expression of EXTL2, a member of the exostosin (EXT) family of glycosyltransferases, in human embryonic kidney 293 cells results in longer heparan sulfate chains. Journal of Biological Chemistry. 13168-13177.
  • 2014. Role of 6-O-sulfated heparan sulfate in chronic renal fibrosis. Journal of Biological Chemistry. 20295-20306.
  • 2014. Fibroblast α11β1 integrin regulates tensional homeostasis in fibroblast/A549 carcinoma heterospheroids. PLOS ONE.
  • 2012. Heparan sulfate expression is affected by inflammatory stimuli in primary human endothelial cells. Glycoconjugate Journal. 67-76.
  • 2012. Fibroblast EXT1-levels influence tumor cell proliferation and migration in composite spheroids. PLOS ONE. 10 sider.
  • 2012. Drosophila heparan sulfate, a novel design. Journal of Biological Chemistry. 21950-21956.
  • 2010. Target selection of heparan sulfate hexuronic acid 2-O-sulfotransferase. Glycobiology. 1274-1282.
  • 2009. Mutation in the heparan sulfate biosynthesis enzyme EXT1 influences growth factor signaling and fibroblast interactions with the extracellular matrix. Journal of Biological Chemistry. 34935-34943.
  • 2009. Molecular analysis of heparan sulfate biosynthetic enzyme machinery and characterization of heparan sulfate structure in Nematostella vectensis. Biochemical Journal. 585-593.
  • 2008. Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation. Proceedings of the National Academy of Sciences of the United States of America. 4751-4756.
  • 2007. Syndecans promote integrin-mediated adhesion of mesenchymal cells in two distinct pathways. Experimental Cell Research. 3902-3913.
  • 2007. Sulfs are regulators of growth factor signaling for satellite cell differentiation and muscle regeneration. Developmental Biology. 464-477.
  • 2007. SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development. 3327-3338.
  • 2007. Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation. Journal of Biological Chemistry. 32802-32810.
  • 2006. Substrate specificity and domain functions of extracellular heparan sulfate 6-O-endosulfatases, QSulf1 and QSulf2. Journal of Biological Chemistry. 4969-4976.
  • 2006. Overexpression of heparan sulfate 6-O-sulfotransferases in human embryonic kidney 293 cells results in increased N-acetylglucosaminyl 6-O-sulfation. Journal of Biological Chemistry. 5348-5356.
  • 2006. Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation. Journal of Biological Chemistry. 35727-35734.
  • 2004. Purification of a 75 kDa protein-N-acetylglucosamine-6-sulphatase from the organelle matrix of human neutrophils. Biochemical Journal.
  • 2004. Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups. Journal of Biological Chemistry. 42355-42358.
  • 2004. Embryonic fibroblasts with a gene trap mutation in Ext1 produce short heparan sulfate chains. Journal of Biological Chemistry. 32134-32141.
  • 2004. Biosynthesis of hyaluronan: Direction of chain elongation. Journal of Biological Chemistry.
Mastergradsoppgave
  • 2012. Molecular mechanisms of integrin alpha 11.
  • 2011. Heparan sulfate proteoglycans: effects of NDST1 deficiency on fibroblast function.
Doktorgradsavhandling
  • 2018. EXT proteins: Role in heparan sulfate Assembly and in Tumor biology.
  • 2011. The Roles of EXT-Like Proteins in Heparan Sulphate Biosynthesis.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
  • 2017. Role of the Extracellular Matrix in Tumor Stroma: Barrier or Support? 36 sider.
  • 2016. Chapter Six – Heparan Sulfate: Biosynthesis, Structure, and Function. 59 sider.
Vitenskapelig oversiktsartikkel/review
  • 2014. The exostosin family: Proteins with many functions. 25-33.

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