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Ola Myklebosts bilde

Ola Myklebost

Professor, Tel +47-5597-4573, -9008-7139
  • E-postOla.Myklebost@uib.no
  • Telefon+47 55 58 45 65+47 900 87 139
  • Besøksadresse
    Klinisk medisin II, 5. et. Laboratoriebygget
    Haukeland Sykehus
    5020 Bergen
    Rom 
    5365
  • Postadresse
    Postboks 7804
    5020 Bergen

Se mer informasjon på myklebost.uib.no.

Jeg vil gjerne komme i kontakt med kandidater til postdocstipend!

Jeg leder forskningsgruppen for presisjonsonkologi, men også prosjekter knyttet til min gamle forskergruppe ved OUS - Radiumhospitalet, i hovdsak studier av kreft i binde- og støttevev, såkalte sarkomer. Dette er svulster med trekk fra mesenkymale vev, dvs. som stammer fra embryoets indre cellemasse. Vi har særlig konsentrert oss om osteo- og liposarkomer, svulster som ligner bein og fettvev.  Fra Bergen leder jeg to store nasjonale prosjekter der vi undersøker hvilke genskader som finnes i 9 forskjellige krefttyper, hvilke av disse som er viktige i kreftutviklingen, og om noen av dem kan brukes til å velge bedre og mer "persontilpasset" kreftbehanlding. Se mer på sidene til Norsk Kreftgenomikkonsortium (NCGC) og Norsk Sarkomkonsortium (NoSarC).

jeg har også en bistilling på Regionalt senter for arvelig kreft ved Haukeland Universitetssykehus.

Vitenskapelig artikkel
  • Vis forfatter(e) 2021. Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden. Nature Communications. 1-16.
  • Vis forfatter(e) 2021. Methylation-dependent SUMOylation of the architectural transcription factor HMGA2. Biochemical and Biophysical Research Communications - BBRC. 91-97.
  • Vis forfatter(e) 2021. Discovery of novel candidates for anti- liposarcoma therapies by medium-scale high-throughput drug screening. PLOS ONE.
  • Vis forfatter(e) 2021. Clinical and molecular implications of NAB2-STAT6 fusion variants in solitary fibrous tumour. Pathology (Sydney). 713-719.
  • Vis forfatter(e) 2020. Sex differences in oncogenic mutational processes. Nature Communications. 1-24.
  • Vis forfatter(e) 2020. Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nature Communications. 1-27.
  • Vis forfatter(e) 2020. Pan-cancer analysis of whole genomes. Nature. 82-93.
  • Vis forfatter(e) 2020. Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series. Blood Advances. 1859-1866.
  • Vis forfatter(e) 2020. Cell Fusion of Mesenchymal Stem/Stromal Cells and Breast Cancer Cells Leads to the Formation of Hybrid Cells Exhibiting Diverse and Individual (Stem Cell) Characteristics. International Journal of Molecular Sciences. 1-16.
  • Vis forfatter(e) 2020. Accurate 3-gene-signature for early diagnosis of liposarcoma progression. Clinical Sarcoma Research. 1-11.
  • Vis forfatter(e) 2019. Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma. Cells.
  • Vis forfatter(e) 2018. Sample-Index Misassignment Impacts Tumour Exome Sequencing. Scientific Reports. 1-6.
  • Vis forfatter(e) 2018. Real-time vital mineralization detection and quantification during in vitro osteoblast differentiation. Biological Procedures Online. 1-5.
  • Vis forfatter(e) 2018. Preclinical evaluation of vemurafenib as therapy for BRAFV600E mutated sarcomas. International Journal of Molecular Sciences. 1-15.
  • Vis forfatter(e) 2018. Patterns of genomic evolution in advanced melanoma. Nature Communications. 1-12.
  • Vis forfatter(e) 2018. Noninvasive Detection of ctDNA Reveals Intratumor Heterogeneity and Is Associated with Tumor Burden in Gastrointestinal Stromal Tumor. Molecular Cancer Therapeutics. 2473-2480.
  • Vis forfatter(e) 2018. Multifocal primary prostate cancer exhibits high degree of genomic heterogeneity. European Urology. 1-8.
  • Vis forfatter(e) 2018. Evaluation of commercial DNA and RNA extraction methods for high-throughput sequencing of FFPE samples. PLOS ONE. 1-12.
  • Vis forfatter(e) 2017. Use of liquid biopsies to monitor disease progression in a sarcoma patient: a case report. BMC Cancer. 1-6.
  • Vis forfatter(e) 2017. Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma. Nature Communications. 1-8.
  • Vis forfatter(e) 2017. PP2A regulatory subunit b55γ is a gatekeeper of osteoblast maturation and lineage maintenance. Stem Cells and Development. 1375-1383.
  • Vis forfatter(e) 2017. Multilevel genomics of colorectal cancers with microsatellite instability – clinical impact of JAK1 mutations and consensus molecular subtype 1. Genome Medicine.
  • Vis forfatter(e) 2017. Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies. Molecular Cancer. 1-16.
  • Vis forfatter(e) 2017. Monitoring multiple myeloma by quantification of recurrent mutations in serum. Haematologica. 1266-1272.
  • Vis forfatter(e) 2017. High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival. International Journal of Cancer. 184-190.
  • Vis forfatter(e) 2017. Analysis of the miR-34 family functions in breast cancer reveals annotation error of miR-34b. Scientific Reports. 1-10.
  • Vis forfatter(e) 2016. Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations. OncoTarget. 5273-5288.
  • Vis forfatter(e) 2016. The genomic landscape of pancreatic and periampullary adenocarcinoma. Cancer Research. 5092-5102.
  • Vis forfatter(e) 2016. TP53 mutation spectrum in smokers and never smoking lung cancer patients. Frontiers in Genetics.
  • Vis forfatter(e) 2016. Preclinical evaluation of potential therapeutic targets in dedifferentiated liposarcoma. OncoTarget. 54583-54595.
  • Vis forfatter(e) 2016. Monogenic and polygenic determinants of sarcoma risk: an international genetic study. The Lancet Oncology. 1261-1271.
  • Vis forfatter(e) 2016. Genome analysis of osteosarcoma progression samples identifies FGFR1 overexpression as a potential treatment target and CHM as a candidate tumor suppressor gene. PLOS ONE.
  • Vis forfatter(e) 2015. Metabolic reprogramming of metastatic breast cancer and melanoma by Let-7a microRNA. OncoTarget. 2451-2465.
  • Vis forfatter(e) 2015. HSP90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo. OncoTarget. 433-445.
  • Vis forfatter(e) 2015. Genomic landscape of liposarcoma. OncoTarget. 42429-42444.
  • Vis forfatter(e) 2015. Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells. Genome Research.
  • Vis forfatter(e) 2015. Bone marrow stroma-derived PGE<sub>2</sub> protects BCP-ALL cells from DNA damage-induced p53 accumulation and cell death. Molecular Cancer.
  • Vis forfatter(e) 2015. BRAF V600E mutation in early-stage multiple myeloma: good response to broad acting drugs and no relation to prognosis. Blood Cancer Journal. 1-7.
  • Vis forfatter(e) 2014. Workshop Report on the 2nd Joint ENCCA/EuroSARC European Bone Sarcoma Network Meeting: Integration of Clinical Trials with Tumour Biology. Clinical Sarcoma Research.
  • Vis forfatter(e) 2014. The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines. Cancer Medicine. 36-46.
  • Vis forfatter(e) 2014. The regulatory landscape of osteogenic differentiation. Stem Cells. 2780-2793.
  • Vis forfatter(e) 2014. The Architecture and Evolution of Cancer Neochromosomes. Cancer Cell. 653-667.
  • Vis forfatter(e) 2014. TRAP1 is a novel interaction partner of PML, localised with PML in nuclear bodies and relocating with PML to the cytoplasm following stress. Annual Research & Review in Biology. 3026-3036.
  • Vis forfatter(e) 2014. Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model. Molecular Cancer.
  • Vis forfatter(e) 2014. Performance comparison of four exome capture systems for deep sequencing. BMC Genomics.
  • Vis forfatter(e) 2014. Generation and characterization of an immortalized human mesenchymal stromal cell line. Stem Cells and Development. 2377-2389.
  • Vis forfatter(e) 2014. Generation and Characterisation of Novel Pancreatic Adenocarcinoma Xenograft Models and Corresponding Primary Cell Lines. PLOS ONE. 12 sider.
  • Vis forfatter(e) 2014. Extensive transduction of non-reptitive DNA mediated by L1 retrotransposition in cancer genomes. Science. 1251343-1251343.
  • Vis forfatter(e) 2013. Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. Biochimica et Biophysica Acta - General Subjects. 4235-4243.
  • Vis forfatter(e) 2013. Identification of PPAP2B as a novel recurrent translocation partner gene of HMGA2 in lipomas. Genes, Chromosomes and Cancer. 580-590.
  • Vis forfatter(e) 2013. IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma. BMC Cancer. 9 sider.
  • Vis forfatter(e) 2013. Functional characterization of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes. British Journal of Cancer. 2228-2236.
  • Vis forfatter(e) 2013. Epigenetic Regulation and Functional Characterization of MicroRNA-142 in Mesenchymal Cells. PLOS ONE.
  • Vis forfatter(e) 2013. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. Nature Genetics. 1479-U105.
  • Vis forfatter(e) 2013. Correlation of TP53 and MDM2 genotypes with response to therapy in sarcoma. Cancer. 1013-1022.
  • Vis forfatter(e) 2013. Comparison of glioma stem cells to neural stem cells from the adult human brain identifies dysregulated Wnt- signaling and a fingerprint associated with clinical outcome. Experimental Cell Research. 2230-2243.
  • Vis forfatter(e) 2013. Common fusion transcripts identified in colorectal cancer cell lines by high throughput RNA sequencing. Translational Oncology. 546-553.
  • Vis forfatter(e) 2013. A small molecule approach to engineering vascularized tissue. Biomaterials. 3053-3063.
  • Vis forfatter(e) 2012. Preclinical xenograft models of human sarcoma show nonrandom loss of aberrations. Cancer. 558-570.
  • Vis forfatter(e) 2012. Modulation of the Osteosarcoma Expression Phenotype by MicroRNAs. PLOS ONE. 12 sider.
  • Vis forfatter(e) 2012. Integrative Analysis Reveals Relationships of Genetic and Epigenetic Alterations in Osteosarcoma. PLOS ONE. 20 sider.
  • Vis forfatter(e) 2012. Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data. Genes, Chromosomes and Cancer. 696-706.
  • Vis forfatter(e) 2012. Global gene expression profiling of human osteosarcomas reveals metastasis-associated chemokine pattern. Sarcoma. 12 sider.
  • Vis forfatter(e) 2012. Characterization of liposarcoma cell lines for preclinical and biological studies. Sarcoma.
  • Vis forfatter(e) 2012. Adipocyte Differentiation of Human Bone Marrow-Derived Stromal Cells Is Modulated by MicroRNA-155, MicroRNA-221, and MicroRNA-222. Stem Cells and Development. 873-883.
  • Vis forfatter(e) 2011. mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts. BMC Medical Genomics. 11 sider.
  • Vis forfatter(e) 2011. Tumor-Infiltrating Macrophages Are Associated with Metastasis Suppression in High-Grade Osteosarcoma: A Rationale for Treatment with Macrophage Activating Agents. Clinical Cancer Research. 2110-2119.
  • Vis forfatter(e) 2011. Metastasis suppression by tumor-infiltrating macrophages in high-grade osteosarcoma. Clinical Cancer Research. 2110-2119.
  • Vis forfatter(e) 2011. MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines. BMC Cancer. 11 sider.
  • Vis forfatter(e) 2011. Genomic validation of preclinical xenograft models of human sarcoma reveals recurrent loss of aberrations. Cancer. 558-570.
  • Vis forfatter(e) 2011. Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma. BMC Cancer. 8 sider.
  • Vis forfatter(e) 2011. Combined ALDH and CD133 expression defines a stem-like cancer cell population in liposarcoma xenograft. Clinical Sarcoma Research. 8.
  • Vis forfatter(e) 2011. Adipocyte Differentiation of Immortalized Human Bone Marrow-Derived Stromal Cells is Modulated by microRNA-155, microRNA-221 and microRNA-222. Stem Cells and Development.
  • Vis forfatter(e) 2010. Molecular Characterization of Commonly Used Cell Lines for Bone Tumor Research: A Trans-European EuroBoNet Effort. Genes, Chromosomes and Cancer. 40-51.
  • Vis forfatter(e) 2010. Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells. BMC Cancer. 14 sider.
  • Vis forfatter(e) 2010. Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones. Blood. 1489-1497.
  • Vis forfatter(e) 2010. Extensive adipogenic and osteogenic differentiation of patterned human mesenchymal stem cells in a microfluidic device. Lab on a Chip. 1401-1409.
  • Vis forfatter(e) 2010. Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours. BMC Research Notes. 223.
  • Vis forfatter(e) 2010. DNA Copy Number Changes in Human Malignant Fibrous Histiocytomas by Array Comparative Genomic Hybridisation. PLOS ONE. 10 sider.
  • Vis forfatter(e) 2010. Characterization of Treatment Response to Recombinant Interferon-α2b in Osteosarcoma Xenografts. Journal of Cancer Science & Therapy. 16-25.
  • Vis forfatter(e) 2010. A Tissue Microarray Study of Osteosarcoma: Histopathologic and Immunohistochemical Validation of Xenotransplanted Tumors as Preclinical Models. Applied immunohistochemistry & molecular morphology (Print). 453-461.
  • Vis forfatter(e) 2009. Upregulation of stem cell genes in multidrug resistant K562 leukemia cells. Leukemia Research. 1379-1385.
  • Vis forfatter(e) 2009. Molecular characterization of commonly used cell lines for bone tumor research. A trans-European EuroBoNet effort. Genes, Chromosomes and Cancer. 40-51.
  • Vis forfatter(e) 2009. LSAMP, a Novel Candidate Tumor Suppressor Gene in Human Osteosarcomas, Identified by Array Comparative Genomic Hybridization. Genes, Chromosomes and Cancer. 679-693.
  • Vis forfatter(e) 2008. High-resolution analysis of genetic stability of human adipose tissue stem cells cultured to senescence. Journal of Cellular and Molecular Medicine. 553-563.
  • Vis forfatter(e) 2008. GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array comparative genomic hybridization data. Genome Biology. R86.
  • Vis forfatter(e) 2008. DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH. Molecular Cancer. 11 sider.
  • Vis forfatter(e) 2008. Chromosomal aberrations in head and neck squamous cell carcinomas in Norwegian and Sudanese populations by array comparative genomic hybridization. Oncology Reports. 825-843.
  • Vis forfatter(e) 2008. Chromosomal aberrations in head and neck squamous cell carcinomas in Norwegian and Sudanese populations by array comparative genomic hybridization. Oncology Reports. 825-843.
  • Vis forfatter(e) 2007. Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A. International Journal of Cancer.
  • Vis forfatter(e) 2007. Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses. Molecular Cancer. 16 sider.
  • Vis forfatter(e) 2007. Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential. BMC Genomics.
  • Vis forfatter(e) 2006. Sampling effects on gene expression data from a human tumour xenograft. Scandinavian Journal of Laboratory Animal Science. 17-34.
  • Vis forfatter(e) 2006. Array comparative genomic hybridization reveals distinct DNA copy number differences between gastrointestinal stromal tumors and leiomyosarcomas. Cancer Research.
  • Vis forfatter(e) 2006. Array comparative genomic hybridization reveals distinct DNA copy number differences between gastrointestinal stromal tumors and leiomyosarcomas. Cancer Research. 8984-8993.
  • Vis forfatter(e) 2005. Translocation t(14;18)and gain of chromosome 18/BCL2: effects on BCL2 exression and apoptosis in B-cell non-Hodgkin's lymphomas. Leukemia. 2313-2323.
  • Vis forfatter(e) 2005. Molekylærbiologisk diagnostikk ved bein- og bløtvevssvulster. Tidsskrift for Den norske legeforening. 3286-3289.
  • Vis forfatter(e) 2005. Mapping and characterizatin of the amplicon near APOA2 in Iq23 in human sarcomas by FISH and array CGH. Molecular Cancer. 39-50.
  • Vis forfatter(e) 2005. Limitations of mRNA amplification from small-size cell samples. BMC Genomics. 147.
  • Vis forfatter(e) 2005. Expression patterns of cell cycle components in sporadic and neurofibromatosis type 1 related malignant peripheral nerve sheath tumors. Journal of Neuropathology and Experimental Neurology. 74-81.
  • Vis forfatter(e) 2004. Tumor classification and marker gene prediction by feature selection and fuzzy c-means clustering using microarray data. BMC Bioinformatics. art. no.-60.
  • Vis forfatter(e) 2004. The response of malignant B lymphocytes to ionizing radiation: Geneexpression and genotype. International Journal of Cancer. 935-942.
  • Vis forfatter(e) 2004. Profound influence of microarray scanner characteristics on gene expression ratios: analysis and procedure for correction. BMC Genomics. 10.
  • Vis forfatter(e) 2004. M-CGH: analysing microarray-based CGH experiments. BMC Bioinformatics.
  • Vis forfatter(e) 2004. M-CGH: Analysing microarray-based CGH experiments. BMC Bioinformatics. art. no.-74.
  • Vis forfatter(e) 2004. Constitutive expression of the AP-1 transcription factors c-jun, junD, junB and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma. Journal of Molecular Diagnostics. 297-307.
  • Vis forfatter(e) 2004. Analysis of the humoral immune response to immunoselected phage-displayed peptides by a microarray-based method. Proteomics. 2572-2582.
  • Vis forfatter(e) 2003. Tumor classification and marker gene prediction by feature selection and fuzzy c-means clustering using microarray data. BMC Bioinformatics. 60.
  • Vis forfatter(e) 2003. Tumor classification and marker gene prediction by feature selection and fuzzy c-means clustering using microarray data. BMC Bioinformatics. 60.
  • Vis forfatter(e) 2003. Tumor classification and marker gene prediction by feature selection and fuzzy c-means clustering using microarray data. BMC Bioinformatics. 60.
  • Vis forfatter(e) 2003. MGraph: graphical models for microarray data analysis. Bioinformatics. 2210-2211.
  • Vis forfatter(e) 2003. Interferon-gamma suppresses S100A4 transciption independently of apoptosis or cell cycle arrest. British Journal of Cancer. 1995-2001.
  • Vis forfatter(e) 2003. Effects of mRNA amplification on gene expression ratios in cDNA experiments estimated by analysis of variance. BMC Genomics.
  • Vis forfatter(e) 2003. Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation. Oncogene. 5358-5361.
  • Vis forfatter(e) 2003. 11q13 alterations in two cases of hibernoma: large heterozygous deletions and rearrangement breakpoints near GARP in 11q13.5. Genes, Chromosomes and Cancer. 389-395.
  • Vis forfatter(e) 2002. The SYT-SSX1 fusion type of synovial sarcoma is associated with increased expression of cyclin A and D1. A link between t(X;18)(p11;2;q11.2) and the cell cycle machinery. Oncogene. 5791-5796.
  • Vis forfatter(e) 2002. Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21. Oncogene. 2261-2269.
  • Vis forfatter(e) 2002. Clustering of the SOM easily reveals distinct gene expression patterns: results of a reanalysis of lymphoma study. BMC Bioinformatics.
  • Vis forfatter(e) 2002. Clustering of the SOM easily reveals distinct gene expression patterns: results of a reanalysis of lymphoma study. BMC Bioinformatics.
  • Vis forfatter(e) 2002. Clustering of the SOM easily reveals distinct gene expression patterns: results of a reanalysis of lymphoma study. Bioinformatics. 36.
  • Vis forfatter(e) 2002. Analysis of repeatability in spotted cDNA microarrays. Nucleic Acids Research (NAR). 3235-3244.
  • Vis forfatter(e) 2001. Måling av genaktivitet med DNA mikromatriser (mikroarray). Molekylære og teknologiske prinsipper. Tidsskrift for Den norske legeforening. 1225-1228.
  • Vis forfatter(e) 2001. Måling av genaktivitet med DNA mikromatriser (mikroarray). Molekylære og teknologiske prinsipper. Tidsskrift for Den norske legeforening. 1225-1228.
  • Vis forfatter(e) 2001. Mikromatriser i kreftforskning: Nå trenger vi ikke å bare lete under gatelyktene! Tidsskrift for Den norske legeforening. 2498-2503.
  • Vis forfatter(e) 2001. Genterapi ved kreft. Tidsskrift for Den norske legeforening. 482-488.
  • Vis forfatter(e) 2001. Dedifferentiation of a well-differentiated liposarcoma to a highly malignant osteosarcoma:amplification of 12q14 at all stages and gain of 1q22-q24 associated with metastases. Cancer Genetics and Cytogenetics. 100-111.
  • Vis forfatter(e) 2001. Dedifferentiation of a well-differentiated liposarcoma to a highly malignant metastatic osteosarcoma: amplification of 12q14 at all stages and gain of 1q22-q24 associated with metastases. Cancer Genetics and Cytogenetics. 100-111.
  • Vis forfatter(e) 2001. Dedifferentiation of a WDLPS to a highly malignant osteogenic tumor is associated with high-level amplification og 12q14-q22 and gain of 1q22. Cancer Genetics and Cytogenetics. 100-111.
  • Vis forfatter(e) 2001. DNA mikroarray- vindu mot tusentals gen. NBS-nytt. 482-488.
  • Vis forfatter(e) 2001. A well-differentiated liposarcoma with a new type of chromosome 12-derived markers. Cancer Genetics and Cytogenetics. 13-18.
  • Vis forfatter(e) 2000. Frequent allelic loss of 9p21 (p16INK4A) and other genomic imbalances in human malignant fibruos histiocytoma. Cancer Genetics and Cytogenetics.
  • Vis forfatter(e) 2000. Frequent allelic loss of 9p21 (p16INK4A) and other genomic imbalances in human malignant fibruos histiocytoma. Cancer Genetics and Cytogenetics. 89-98.
  • Vis forfatter(e) 2000. Dedifferentiation of a WDLPS to a highly malignant osteogenic tumor is associated with high-level amplification of 12q14-q22 and gain of 1q22. Cancer Genetics and Cytogenetics.
  • Vis forfatter(e) 2000. DNA Mikroarray- molekylære og teknologiske prinsipper. Tidsskrift for Den norske legeforening.
  • Vis forfatter(e) 2000. Characterization of centromere alterations in liposarcomas. Genes, Chromosomes and Cancer. 117-129.
  • Vis forfatter(e) 2000. Characterization of centromere alterations in liposarcomas. Genes, Chromosomes and Cancer. 117-129.
  • Vis forfatter(e) 2000. Characterisation of etopic sequences from tumor-associated, truncated HMGIC genes shows recurrent involvement of spesific chromosomal regions. Genes, Chromosomes and Cancer.
  • Vis forfatter(e) 1999. Structure of ring and giant rod marker chromosomes in adipose tissue tumors: A study combining fluorescent in situ hybridization, comparative genomic hybridization, molecular analyses and immunohistochemistry. Genes, Chromosomes and Cancer. 30-41.
  • Vis forfatter(e) 1999. Sensitive method for FISH chracterisation of breast cancer cells in bone marrow aspirates. Molecular Pathology. 68-74.
  • Vis forfatter(e) 1999. Chromosome band 9p21 is frequently altered in malignant peripheral nerve sheath tumors from patients with neurofibromatosis type 1. Studies of CDKN2A and other genes og the pRB pathway. Genes, Chromosomes and Cancer. 151-160.
  • Vis forfatter(e) 1999. Characterization of the 17p amplicon inhuman sarcomas - microsatellite marker analysis. International Journal of Cancer. 329-333.
  • Vis forfatter(e) 1999. A novel chromosomal region of allelic loss, 4q32-q34, in human osteosarcomas revealed by representational difference analysis. Genes, Chromosomes and Cancer. 115-120.
  • Vis forfatter(e) 1998. Molecular characterisation of a novel amplicon at 1q21-q22 in human sarcomas. British Journal of Cancer. 495-503.
  • Vis forfatter(e) 1997. Recurrent gains of 1q, 8 and 12 in the Ewing family of tumors by cemparative genomic hybridisation. British Journal of Cancer. 1403-1409.
  • Vis forfatter(e) 1997. HMGIC, the gene for an architectural transcription factor, is amplified and rearranged in a subset of human sarcomas. Oncogene. 2935-2941.
  • Vis forfatter(e) 1997. Cytogenetics and molecular genetics of bone and soft tissue tumours. Cancer Genetics and Cytogenetics. 67-73.
  • Vis forfatter(e) 1997. Complexity of 12q13-22 amplicon in liposarcoma: Microsatellite repeat analysis. Genes, Chromosomes and Cancer. 66-70.
  • Vis forfatter(e) 1996. Separate amplified regions encompassing CDK4 and MDM2 in human sarcomas. Genes, Chromosomes and Cancer. 254-259.
  • Vis forfatter(e) 1996. Reversal of the in vivo metastatic phenotype of human tumor cells by an anti-CAPL (mts-1) ribozyme. Cancer Research. 5490-5498.
  • Vis forfatter(e) 1995. Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas - relationship to amplification and mRNA levels of CDK4 and CCND1. British Journal of Cancer. 393-398.
  • Vis forfatter(e) 1995. Cloning and Characterization of Two Forms of Bovine Polymeric Immunoglobulin Receptor cDNA. DNA and Cell Biology. 251-256.
  • Vis forfatter(e) 1994. The protooncogene CHOP/GADD153, involved in growth arrest and DNA damage response, is amplified in a subset of human sarcomas. Cancer Genetics and Cytogenetics. 165-171.
  • Vis forfatter(e) 1994. Expression of the neuroectodermal intermediate filament nestin in human melanomas. Cancer Research. 354-356.
  • Vis forfatter(e) 1993. Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: Some amplica do not include MDM2. Cell growth & differentiation. 1065-1070.
  • Vis forfatter(e) 1992. Uptake of chylomicron remnant retinyl esters in human leukocytes in vivo. European J. Clin.. 229-234.
  • Vis forfatter(e) 1992. Levels of mm23 mRNA in metastatic malignant melanomas. Inverse correlation to disease progression. Cancer Research. 6088-6091.
Vitenskapelig foredrag
  • Vis forfatter(e) 2018. Clonal Evolution of Multiple Myeloma After Treatment with Novel Agents .
  • Vis forfatter(e) 2017. Sarcomas: Genomic Landscape and potential targets.
  • Vis forfatter(e) 2017. Detection of mutations in Multiple Myeloma during different stages of disease.
  • Vis forfatter(e) 2012. Personalized cancer medicine.
  • Vis forfatter(e) 2005. Genome-Wide Screening of DNA Copy Number and Chromosomal Alterations in Oral Squamous Cell Carcinomas by Micro Array Comparative Genomic Hybridizations.
  • Vis forfatter(e) 2005. Chromosomal Aberrations in Oral Squamous Cell Carcinoma by µArray Comparative Genomic Hybridizations.
  • Vis forfatter(e) 2005. Chromosomal Aberrations in Oral Squamous Cell Carcinoma by µArray Comparative Genomic Hybridizations.
  • Vis forfatter(e) 2002. Investigating the linearity of an RNA-amplification protocol using analysis of variance on data from cDNA microarray experiments.
  • Vis forfatter(e) 2000. Positional cloning of novel genes form 1q21, a region frequently over-represented in human malignancies.
  • Vis forfatter(e) 2000. Molecular profiling of sarcomas: Microarray analysis of osteosarcomas and isolation of three novel candidate genes from the 1q21 amplicon.
  • Vis forfatter(e) 1999. Microarray-based analysis of gene expression. New tools for the diagnosis of problem cases? Invited plenary talk at the annual meeting of the Scandinavian sarcoma group.
  • Vis forfatter(e) 1999. Microarray-based analysis of gene expression. New tools for the diagnosis of problem cases? Acta Othop. Scand. 70 suppl. 289: 24-25.
  • Vis forfatter(e) 1999. Global gene activity profiling by cDNA microarrays.
  • Vis forfatter(e) 1999. FISHing cDNAs from a frequently amplified region of chromosome 1 in sarcomas.
  • Vis forfatter(e) 1998. Malignanat peripheral neve sheath tumours show frequent alterations of chromosome band 9p21. Studies of CDKN2A and other genes of the pRB pathway.
  • Vis forfatter(e) 1998. Characterization of a novel amplicon at 1q21-q22 frequently observed in human sarcomas by Fluorescent in situ Hybridization (FISH).
  • Vis forfatter(e) 1997. The HMGIC gene is amplified, rearranged and overexpressed in a subset of human sarcomas.
  • Vis forfatter(e) 1997. The HMGIC gene is amplified, rearranged and overexpressed in a subset of human sarcomas.
  • Vis forfatter(e) 1997. HMGIC, the gene for an architectural transcription factor, is amplified and rearranged in a subset of human sarcomas.
  • Vis forfatter(e) 1997. HMGIC, the gene for an architectural transcription factor, is amplified and rearranged in a subset of human sarcomas.
  • Vis forfatter(e) 1997. Fluorescent in situ hybridisation (FISH) in sarcoma research and diagnosis (Invited plenary lecture).
  • Vis forfatter(e) 1996. Mapping of Amplification Units Containing MDM2, CDK4 and SAS.
  • Vis forfatter(e) 1996. Chromosomal markers bearing chromosome 12 gene amplifications in adipose tissue tumours: FISH, molecular analysis and immunohistochemistry.
  • Vis forfatter(e) 1996. Chromosomal aberrations affecting cell cycle control genes in human sarcomas.
  • Vis forfatter(e) 1996. Characterisation of lq21q22 amplifications in human sarcomas by CGH and molecular analysis.
  • Vis forfatter(e) 1996. Characterisation of 1q21-q22 amplifications in human sarcomas by CGH and molecular analysis.
  • Vis forfatter(e) 1996. Amplification of MDM2, CDK4 and HMGIC in human sarcomas.
  • Vis forfatter(e) 1996. Amplification of MAR-Derived Sequences, Including HMGI-c, in Human Sarcomas.
  • Vis forfatter(e) 1996. A new method for sensitive detection and characterisation of malignant cells in blood and bone marrow of advanced breast cancer patients.
Populærvitenskapelig artikkel
  • Vis forfatter(e) 1998. Richard Seed vil klone mennesker. VG : Verdens gang.
Kronikk
  • Vis forfatter(e) 2017. Åpne Nordens grenser for forskning og behandling. Aftenposten (morgenutg. : trykt utg.).
  • Vis forfatter(e) 2015. Bør hver kreftpasient bli et eget forskningsprosjekt? Aftenposten (morgenutg. : trykt utg.).
  • Vis forfatter(e) 2012. Genomsekvensering for persontilpasset kreftbehandling. Tidsskrift for Den norske legeforening. 2406-2408.
Sammendrag/abstract
  • Vis forfatter(e) 2019. Deep profiling of genetic aberrations and clonal evolution in follicular lymphoma. Blood. 20-20.
  • Vis forfatter(e) 2018. Whole-Exome and mRNA Sequencing of Multiple Myeloma Reveal Transformation to a More High-Risk and Proliferative Tumor at Relapse. Blood.
  • Vis forfatter(e) 2012. Identification of Fusion Transcripts in Colorectal Cancer by Combined RNA-seq and Exon Microarray Analyses. European Journal of Cancer. S121-S121.
  • Vis forfatter(e) 2010. Integrative analysis of genome-wide genetic and epigenetic changes in human osteosarcomas. European Journal of Cancer. 200-200.
  • Vis forfatter(e) 2010. Integrated analysis reveals overexpression of miRNA clusters in osteosarcomas. European Journal of Cancer. 206-207.
  • Vis forfatter(e) 2010. Characterisation of LSAMP, a novel candidate tumour suppressor gene in osteosarcomas. European Journal of Cancer. 169-169.
  • Vis forfatter(e) 2005. Genome-Wide Screening of DNA Copy Number and Chromosomal Alterations in Oral Squamous Cell Carcinomas by Micro Array Comparative Genomic Hybridizations. European Journal of Medical Genetics. 513-514.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) 2016. The ENCCA-WP7/EuroSarc/EEC/PROVABES/EURAMOS 3rd European Bone Sarcoma Networking Meeting/Joint Workshop of EU Bone Sarcoma Translational Research Networks; Vienna, Austria, September 24-25, 2015. Workshop Report. Clinical Sarcoma Research.
  • Vis forfatter(e) 2015. Personalized cancer therapy for soft tissue sarcomas: progress and pitfalls. Personalized Medicine. 593-602.
  • Vis forfatter(e) 2014. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes. Science.
  • Vis forfatter(e) 2012. Workshop report on the European Bone Sarcoma Networking Meeting: integration of clinical trials with tumor biology. Journal of Adolescent and Young Adult Oncology.

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