Hjem
Olav Martin Kvalheims bilde

Olav Martin Kvalheim

Professor
  • E-postOlav.Kvalheim@uib.no
  • Telefon+47 55 58 33 66
  • Besøksadresse
    Realfagbygget, Allégt. 41
  • Postadresse
    Postboks 7803
    5020 BERGEN

I am mainly working with i) instrumental characterization/profiling of complex multicomponent systems (body fluids and tissue) and development of data-analytical methods and algorithms for resolution, exploration, pattern recognition, discrimination and classification of such systems, and, ii) applications of such methods to solve multifaceted problems of medical and pharmaceutical origin. Typically, spectral or chromatographic fingerprints of whole or fractionated samples are used to select features characterizing and/or discriminating groups of samples or to predict properties such as e.g. bioactivity of natural products or disease states for patients. Feature selection provides a strategy to reveal so-called biomarkers, molecules carrying specific information about biological processes such as pathogenesis. This can be molecules displaying the disease pattern in a way that can be utilized for diagnostic or therapeutic purposes. Collaboration with medical research groups is established in obesity research, and, for neurological diseases (multiple sclerosis). Analytical instrumentation such as NMR, chromatography and mass spectroscopy combined with chemometrics represents key technologies for pattern recognition and biomarker discovery for early diagnosis, risk analysis, and, monitoring of disease development and therapeutic effects.

Master and PhD projects are provided within the areas of new algortihms and methods for profiling and data analysis of complex systems, and, application of such methods to solve medical and pharmaceutical problems.

Examples of recent master theses:

1. Analysis of Brain Lipids Using NMR and Multivariate Methods

2. Multivariate characterization and analysis of brain lipids

Vitenskapelig artikkel
  • Aadland, Eivind; Kvalheim, Olav Martin; Anderssen, Sigmund Alfred; Resaland, Geir Kåre; Andersen, Lars Bo. 2018. The multivariate physical activity signature associated with metabolic health in children. International Journal of Behavioral Nutrition and Physical Activity.
  • Resaland, Geir Kåre; Rajalahti, Tarja; Aadland, Eivind; Kvalheim, Olav Martin. 2018. Strong association between cardiorespiratory fitness and serum lipoprotein subclass pattern in prepubertal healthy children. Scandinavian Journal of Medicine & Science in Sports. 220-227.
  • Caesar, Lindsay K.; Kellogg, Joshua J.; Kvalheim, Olav Martin; Cech, Richard A.; Cech, Nadja B. 2018. Integration of Biochemometrics and Molecular Networking to Identify Antimicrobials in Angelica keiskei. Planta Medica. 721-728.
  • Caesar, Lindsay K.; Kvalheim, Olav Martin; Cech, Nadja B. 2018. Hierarchical Cluster Analysis of Technical Replicates to Identify Interferents in Untargeted Mass Spectrometry Metabolomics. Analytica Chimica Acta. 69-77.
  • Kvalheim, Olav Martin; Arneberg, Reidar; Grung, Bjørn; Rajalahti, Tarja. 2018. Determination of optimum number of components in partial least squares regression from distributions of the root‐mean‐squared error obtained by Monte Carlo resampling. Journal of Chemometrics. 1-12.
  • Britton, Emily R.; Kellogg, Joshua J.; Kvalheim, Olav Martin; Cech, Nadja B. 2018. Biochemometrics to Identify Synergists and Additives from Botanical Medicines: A Case Study with Hydrastis canadensis (Goldenseal). Journal of natural products. 484-493.
  • Aadland, Eivind; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Resaland, Geir Kåre; Kvalheim, Olav Martin. 2018. Associations of volumes and patterns of physical activity with metabolic health in children: A multivariate pattern analysis approach. Preventive Medicine. 12-18.
  • Kellogg, Joshua J.; Graf, Tyler N.; Paine, Mary F.; McCune, Jeannine S.; Kvalheim, Olav Martin; Oberlies, Nicholas H.; Cech, Nadja B. 2017. Comparison of metabolomics approaches for evaluating the variability of complex botanical preparations: green tea (Camellia sinensis) as a case study. Journal of natural products. 1457-1466.
  • Aadland, Eivind; Kvalheim, Olav Martin; Rajalahti, Tarja; Skrede, Turid; Resaland, Geir Kåre. 2017. Aerobic fitness and metabolic health in children: A clinical validation of directly measured maximal oxygen consumption versus performance measures as markers of health. Preventive Medicine Reports. 74-76.
  • Rajalahti, Tarja; Lin, Chenchen; Mjøs, Svein Are; Kvalheim, Olav Martin. 2016. Serum fatty acid and lipoprotein subclass concentrations and their associations in prepubertal healthy Norwegian children. Metabolomics.
  • Lin, Chenchen; Rajalahti, Tarja; Mjøs, Svein Are; Kvalheim, Olav Martin. 2016. Predictive associations between serum fatty acids and lipoproteins in healthy non-obese Norwegians: implications for cardiovascular health. Metabolomics.
  • Lin, Chenchen; Andersen, John Roger; Våge, Villy; Rajalahti, Tarja; Mjøs, Svein Are; Kvalheim, Olav Martin. 2016. Intensive lifestyle intervention provides rapid reduction of serum fatty acid levels in women with severe obesity without lowering omega-3 to unhealthy levels. Clinical Obesity. 259-267.
  • Resaland, Geir Kåre; Aadland, Eivind; Moe, Vegard Fusche; Aadland, Katrine Nyvoll; Skrede, Turid; Stavnsbo, Mette; Suominen, Laura; Steene-Johannessen, Jostein; Glosvik, Øyvind; Andersen, John Roger; Kvalheim, Olav Martin; Engelsrud, Gunn; Andersen, Lars Bo; Holme, Ingar Morten K; Ommundsen, Yngvar; Kriemler, Susi; van Mechelen, Willem; McKay, Heather A.; Ekelund, Ulf; Anderssen, Sigmund Alfred. 2016. Effects of physical activity on schoolchildren's academic performance: The Active Smarter Kids (ASK) cluster-randomized controlled trial. Preventive Medicine. 322-328.
  • Rajalahti, Tarja; Lin, Chenchen; Mjøs, Svein Are; Kvalheim, Olav Martin. 2016. Changes in serum fatty acid and lipoprotein subclass concentrations from prepuberty to adulthood and during aging. Metabolomics. 10 sider.
  • Kellogg, Joshua J.; Todd, Daniel A.; Egan, Joseph M.; Raja, Huzefa A.; Oberlies, Nicholas H.; Kvalheim, Olav Martin; Cech, Nadja B. 2016. Biochemometrics for Natural Products Research: Comparison of Data Analysis Approaches and Application to Identification of Bioactive Compounds. Journal of natural products. 376-386.
  • Bleie, Olav; Roberto, Michael F.; Dearing, Thomas I.; Branham, Charles W.; Kvalheim, Olav Martin; Marquardt, Brian J. 2015. Moffat-swern oxidation of alcohols: Translating a batch reaction to a continuous-flow reaction. Journal of Flow Chemistry. 183-189.
  • Lin, Chenchen; Våge, Villy; Mjøs, Svein Are; Kvalheim, Olav Martin. 2015. Changes in Serum Fatty Acid Levels During the First Year After Bariatric Surgery. Obesity Surgery.
  • Resaland, Geir Kåre; Moe, Vegard Fusche; Aadland, Eivind; Steene-Johannessen, Jostein; Glosvik, Øyvind; Andersen, John Roger; Kvalheim, Olav Martin; McKay, Heather A.; Anderssen, Sigmund Alfred. 2015. Active Smarter Kids (ASK): Rationale and design of a cluster-randomized controlled trial investigating the effects of daily physical activity on children's academic performance and risk factors for non-communicable diseases. BMC Public Health.
  • Kvalheim, Olav Martin; Arneberg, Reidar; Bleie, Olav L.; Rajalahti, Tarja; Smilde, Age K.; Westerhuis, Johan A. 2014. Variable importance in latent variable regression models. Journal of Chemometrics. 615-622.
  • Aadland, Eivind; Andersen, John Roger; Anderssen, Sigmund Alfred; Kvalheim, Olav Martin. 2013. Physical activity versus sedentary behavior: associations with lipoprotein particle subclass concentrations in healthy adults. PLOS ONE. 9 sider.
  • Meling, Siv; Kvalheim, Olav Martin; Arneberg, Reidar; Bårdsen, Kjetil; Hjelle, Anne; Ulvund, Martha. 2013. Investigation of serum protein profiles in scrapie infected sheep by means of SELDI-TOF-MS and multivariate data analysis. BMC Research Notes. 14 sider.
  • Aadland, Eivind; Andersen, John Roger; Anderssen, Sigmund Alfred; Kvalheim, Olav Martin. 2013. Impact of physical activity and diet on lipoprotein particle concentrations in severely obese women participating in a 1-year lifestyle intervention. Clinical Obesity. 202-213.
  • Kvalheim, Olav Martin. 2012. History, philosophy and mathematical basis of the latent variable approach - from a peculiarity in psychology to a general method for analysis of multivariate data. Journal of Chemometrics. 210-217.
  • Zhang, Liangxiao; Zhang, Wan; Cao, Dongsheng; Zeng, Maomao; Liang, Yizeng; Kvalheim, Olav Martin. 2011. Resolving co-eluting chromatographic patterns by means of dissimilarity analysis in iterative target transformation factor analysis. Journal of Chromatography A. 7219-7225.
  • Kvalheim, Olav Martin; Chan, Hoi-Yan; Benzie, Iris; Szeto, Yim-tong; Tzang, Alexander Hing-chung ; Mok, Daniel Kim-wah; Chau, Foo-Tim. 2011. Chromatographic profiling and multivariate analysis for screening and quantifying the contributions from individual components to the bioactive signature in natural products. Chemometrics and Intelligent Laboratory Systems. 98-105.
  • Zhang, Liangxiao; Mjøs, Svein Are; Meier, Sonnich; Kvalheim, Olav Martin; Liang, Yizeng. 2010. The vector of calibration ratios: A simple transfer method for mass spectra. Journal of Chromatography A. 5986-5994.
  • Kvalheim, Olav Martin. 2010. Interpretation of partial least squares regression models by means of target projection and selectivity ratio plots. Journal of Chemometrics. 9 sider.
  • Zhang, Liangxiao; Dai, Hui; Liang, Yizeng; Kvalheim, Olav Martin. 2010. Detection and use of selective ions for providing initial estimates of the concentration vectors in iterative target transformation factor analysis. Journal of Chromatography A. 3128-3135.
  • Kvalheim, Tarja Anniki Rajalahti; Kroksveen, Ann Cathrine; Arneberg, Reidar; Berven, Frode; Vedeler, Christian A.; Myhr, Kjell-Morten; Kvalheim, Olav Martin. 2010. A multivariate approach to reveal biomarker signatures for disease classification: application to mass spectral profiles of cerebrospinal fluid from patients with multiple sclerosis. Journal of Proteome Research. 3608-3620.
  • Kvalheim, Olav Martin; Rajalahti, Tarja; Arneberg, Reidar. 2009. X-tended target projection (XTP) - comparison with orthogonal partial least squares (OPLS) and PLS post-processing by similarity transformation (PLS + ST). Journal of Chemometrics. 49-55.
  • Chau, Foo-Tim; Chan, Hoi-Yan; Cheung, Chui-Yee; Liang, Yizeng; Liang, Y; Kvalheim, Olav Martin. 2009. Recipe for Uncovering the Bioactive Components in Herbal Medicine. Analytical Chemistry. 7217-7225.
  • Rajalahti, Tarja; Arneberg, Reidar; Kroksveen, Ann Cathrine; Berle, Magnus Foldal; Myhr, Kjell-Morten; Kvalheim, Olav Martin. 2009. Discriminating Variable Test and Selectivity Ratio Plot: Quantitative Tools for Interpretation and Variable (Biomarker) Selection in Complex Spectral or Chromatographic Profiles. Analytical Chemistry. 2581-2590.
  • Rajalahti, Tarja; Arneberg, Reidar; Berven, Frode; Myhr, Kjell-Morten; Ulvik, Rune Johan; Kvalheim, Olav Martin. 2009. Biomarker discovery in mass spectral profiles by means of selectivity ratio plot. Chemometrics and Intelligent Laboratory Systems. 35-48.
  • Yuan, Dalin; Liang, Yizeng; Yi, Lunzhao; Xu, Qingsong; Kvalheim, Olav Martin. 2008. Uncorrelated linear discriminant analysis (ULDA): A powerful tool for exploration of metabolomics data. Chemometrics and Intelligent Laboratory Systems. 70-79.
  • Liang, Yizeng; Yuan, Dalin; Xu, Qingsong; Kvalheim, Olav Martin. 2008. Modeling based on subspace orthogonal projections for QSAR and QSPR research. Journal of Chemometrics. 23-36.
  • Flåten, Geir Rune; Botnen, Helge; Grung, Bjørn; Kvalheim, Olav Martin. 2007. Quantifying disturbances in benthic communities - comparison of the community disturbance index (CDI) to other multivariate methods. Ecological Indicators. 254-276.
  • Arneberg, Reidar; Rajalahti, Tarja; Flikka, Kristian; Berven, Frode; Kroksveen, Ann Cathrine; Berle, Magnus Foldal; Myhr, Kjell-Morten; Vedeler, Christian A.; Ulvik, Rune Johan; Kvalheim, Olav Martin. 2007. Pretreatment of mass spectral profiles: Application to proteomic data. Analytical Chemistry. 7014-7026.
  • Berven, Frode; Kroksveen, Ann Cathrine; Berle, Magnus Foldal; Rajalahti, Tarja; Flikka, Kristian; Arneberg, Reidar; Myhr, Kjell-Morten; Vedeler, Christian A.; Kvalheim, Olav Martin; Ulvik, Rune Johan. 2007. Pre-analytical influence on the low molecular weight cerebrospinal fluid proteome. PROTEOMICS - Clinical Applications. 699-711.
  • Flåten, Geir Rune; Grung, Bjørn; Kvalheim, Olav Martin. 2007. A comparison of different pre-treatment procedures for reducing heteroscedasticity and other irrelevant features in data prior to modelling of benthic count profiles. Journal of Chemometrics. 386-396.
  • Eide, Ingvar; Neverdal, Gunhild; Thorvaldsen, Bodil; Arneberg, Reidar; Grung, Bjørn; Kvalheim, Olav Martin. 2004. Toxicological evaluation of complex mixtures: fingerprinting and multivariate analysis. Environmental Toxicology and Pharmacology. 127-133.
  • Flaten, GR; Grung, Bjørn; Kvalheim, Olav Martin. 2004. Quantification of pollution levels by multiway modelling. Journal of Chemometrics. 173-182.
  • Flåten, Geir Rune; Grung, Bjørn; Kvalheim, Olav Martin. 2004. Quantification of pollution levels by multiway modelling. Journal of Chemometrics. 173-182.
  • Flåten, Geir Rune; Botnen, Helge; Grung, Bjørn; Kvalheim, Olav Martin. 2004. Assigning environmental variables to observed biological changes. Analytical and Bioanalytical Chemistry. 453-466.
  • Flaten, GR; Grung, Bjørn; Kvalheim, Olav Martin. 2004. A method for validation of reference sets in SIMCA modelling. Chemometrics and Intelligent Laboratory Systems. 101-109.
  • Flåten, Geir Rune; Grung, Bjørn; Kvalheim, Olav Martin. 2004. A method for validation of reference sets in SIMCA modelling. Chemometrics and Intelligent Laboratory Systems. 101-109.
  • Idborg-Björkman, H.; Edlund, P.-O.; Kvalheim, Olav Martin; Scuppe-Koistinen, I.; Jacobsen, S.P. 2003. Screening of biomakers in rat urine using LC/MC electrospray ionization-MS and two-way data analysis. Analytical Chemistry. 4784-4792.
  • Ingvar, Eide; Neverdal, Gunhild; Thorvaldsen, Bodil; Grung, Bjørn; Kvalheim, Olav Martin. 2002. Toxicological evaluation of complex mixtures by pattern recognition: Correlating chemical fingerprints to mutagenicity. Environmental Health Perspectives. 985-988.
  • Stordrange, Laila; Christy, Alfred Anthony; Kvalheim, Olav Martin; Shen, Hailin; Liang, Yi-zeng. 2002. Study of the Self-Association of Alcohols by Near-Infrared Spectroscopy and Multivariate 2D Techniques. Journal of Physical Chemistry A. 8543-8553.
  • Stordrange, Laila; Libnau, Fred Olav; Malthe-Sørensen, Dick; Kvalheim, Olav Martin. 2002. Feasibility study of NIR for surveillance of a pharmaceutical process, including a study of different preprocessing techniques. Journal of Chemometrics. 529-541.
  • Eide, Ingvar; Neverdal, Gunhild; Thorvaldsen, Bodil; Shen, Hailin; Grung, Bjørn; Kvalheim, Olav Martin. 2001. Resolution of GC-MS Data of Complex PAC Mixtures and Regression Modeling of Mutagenicity by PLS. Environmental Science and Technology. 2314-2318.
  • Midttun, Øyvind; Kvalheim, Olav Martin. 2001. Interactions in chromatographic separation of resins from deasphaltened crude oils studied by means of infrared spectroscopy and principal component analysis. Fuel. 717-730.
  • Shen, Hailin; Grung, Bjørn; Kvalheim, Olav Martin; Eide, Ingvar. 2001. Automated curve resolution applied to data from multi-detection instruments. Analytica Chimica Acta. 313-328.
  • Kallevik, Harald; Kvalheim, Olav Martin; Sjöblom, Johan. 2000. Quantitative determination of asphaltenes and resins in solution by means of near-infrared spectroscopy. Correlations to emulsion stability. Journal of Colloid and Interface Science. 494-504.
  • Midttun, Øyvind; Kallevik, H.; Sjøblom, J.; Kvalheim, Olav Martin. 2000. Multivarite screening analysis of water-in-oil emulsions in high external electric fields as studied by means of dielectric time domain spectroscopy - III emulsions containing asphaltenes and resins. Journal of Colloid and Interface Science. 262-271.
  • Shen, Hailin; Storedrange, Laila; Manne, Rolf ; Kvalheim, Olav Martin; Liang, Y. 2000. Morphological score and its application to chemical rank determination. Chemometrics and Intelligent Laboratory Systems. 37-47.
  • Shen, Hailin; Liang, Y.; Kvalheim, Olav Martin; Manne, Rolf. 2000. Determination of chemical rank of two-way data from subspace comparisons. Chemometrics and Intelligent Laboratory Systems. 49-59.
  • Kallevik, H.; Hansen, S. B.; Sæther, O.; Kvalheim, Olav Martin; Sjøblom, J. 2000. Crude oil model emulsion characterised by means of near infrared spectroscopy and multivariate techniques. Journal of Dispersion Science and Technology. 245-262.
  • Christry, Alfred A.; Nyhus, Anne K.; Grung, Bjørn; Kvalheim, Olav Martin; Hagen, Steinar; Schanche, Jon S. 1998. Friedel-Crafts Acylation on Porous Divinyl Benzene Polymer Particles: A Reaction Kinetic Process Studied by Mid-and Near-Infrared spectroscopy. Applied Spectroscopy. 1230-1239.
  • Sæten, B.G.; Sjöblom, Johan; Toft, J.; Kvalheim, Olav Martin. 1997. Complexation between benzoic acid and fatty amines. An adsorption and chemometric study. Colloids and Surfaces. 135-144.
  • Førland, Geir Martin; Liang, Yi-zeng; Kvalheim, Olav Martin; Høiland, Harald; Chazy, A. 1997. Associative bahaviour of benzyl alcohol in carbon tetrachloride solutions. Journal of Physical Chemistry A. 6960-6969.
  • Førland, Geir Martin; Liang, Yi-Zeng; Kvalheim, Olav Martin; Høiland, Harald; Chazy, Annick. 1997. Associative Behavior of Benzyl Alcohol in Carbon Tetrachloride Solutions. Journal of Physical Chemistry. 6960-6969.
  • Førland, Geir Martin; Libnau, Fred Olav; Kvalheim, Olav Martin; Høiland, Harald. 1996. Self-Association of Medium-Chain Alcohols in n-Decane Solutions. Applied Spectroscopy. 1264-1272.
  • Nodland, Egil; Libnau, Fred Olav; Kvalheim, Olav Martin. 1996. Resolution of infrared profiles from variable temperature experiments on mixtures and conformers in rapid equilibrum by compensating for thermal and solvent effects. Vibrational Spectroscopy. 163-176.
  • Fluge, Øystein; Gilje, K.; Sletten, Einar; Kvalheim, Olav Martin; Skaarland, E.; Halvorsen, Jan F.; Farstad, Mikael; Søreide, Odd. 1996. Proton nuclear magnetic resonance spectroscopy of serum from patients with colorectal neoplasia. European Journal of Surgical Oncology. 78-83.
  • Fluge, Øystein; Gilje, K.; Sletten, Einar; Kvalheim, Olav Martin; Skaarland, E.; Halvorsen, Jan F.; Farstad, Mikael; Søreide, Odd. 1996. Proton nuclear magnetic resonance spectroscopy of serum from patients with colorectal neoplasia. European Journal of Surgical Oncology. 78-83.
  • Fluge, Øystein; Gilje, K.; Sletten, Einar; Kvalheim, Olav Martin; Skaarland, E.; Halvorsen, Jan F.; Farstad, Mikael; Søreide, Odd. 1996. Proton nuclear magnetic resonance spectroscopy of serum from patients with colorectal neoplasia. European Journal of Surgical Oncology. 78-83.
  • Fluge, Øystein; Gilje, K.; Sletten, Einar; Kvalheim, Olav Martin; Skaarland, E.; Halvorsen, Jan F.; Farstad, Mikael; Søreide, Odd. 1996. Proton nuclear magnetic resonance spectroscopy of serum from patients with colorectal neoplasia. European Journal of Surgical Oncology. 78-83.
  • Massart, B.; Libnau, Fred Olav; Kvalheim, Olav Martin; Ugland, K.I.; Tjessem, K.; Bryne, K. 1996. Projective modelling by SIMCA - a new dynamic strategy for cost-efficient environmental monitoring around offshore installations. Aquatic Sciences. 120-138.
  • Liang, Yi-zeng; Kvalheim, Olav Martin. 1996. Methods for multivariate analysis. Chemometrics and Intelligent Laboratory Systems. 1-10.
  • Nodland, Egil; Libnau, Fred Olav; Kvalheim, Olav Martin; Luinge, H.J.; Klæboe, Peter. 1996. Influence and correction of peak shift and band broadening observed by rank analysis on vibrational bands from variable-temperature measurement. Vibrational Spectroscopy. 105-123.
  • Førdedal, Harald; Midttun, Bjørn Øivind; Sjøblom, Johan; Kvalheim, Olav Martin; Schildberg, Yannick; Volle, J.L. 1996. A multivariate analysis of w/o emulsions in high external electric fields, as studied by means of dielectric time domain spectroscopy. Part II. Model emulsions stabilised by interfacially active fractions from crude oils. Journal of Colloid and Interface Science. 396-405.
  • Førdedal, Harald; Midttun, Bjørn Øivind; Sjøblom, Johan; Kvalheim, Olav Martin; Schildberg, Yannick; Volle, J.L. 1996. A multivariate analysis of w/o emulsions in high external electric fields, as studied by means of dielectric time domain spectroscopy. Journal of Colloid and Interface Science. 117-125.
  • Christy, A. A.; Kvalheim, Olav Martin. 1995. Particle size effect on diffuse reflectance spectra: Modification of Kubelka-Munk equation. Vibrational Spectroscopy. 19-27.
  • Barth, Tanja; Seim, M.; Christy, A. A.; Kvalheim, Olav Martin. 1995. Maturity trends in asphaltenes from pyrolysed source rocks and natural coals-Multivariate modelling of diffuse reflectance Fourier transform infrared spectra. Organic Geochemistry. 139-158.
  • Libnau, F. O.; Christy, A. A.; Kvalheim, Olav Martin. 1995. Determination of the equilibrium constant and resolution of the HOD spectrum by alternating least squares. Applied Spectroscopy. 561-568.
  • Libnau, F. O.; Toft, J.; Christy, A. A.; Kvalheim, Olav Martin. 1994. Structure of liquid water determined from infrared temperature profiling and evolutionary curve resolution. Journal of the American Chemical Society. 8311-8316.
  • Alsberg, B. K.; Kvalheim, Olav Martin. 1994. Speed improvement of multivariate algorithms by the method of postponed basis matrix multiplication method. Part II. Three-mode principal component analysis. Chemometrics and Intelligent Laboratory Systems. 43-54.
  • Alsberg, B. K.; Kvalheim, Olav Martin. 1994. Speed improvement of multivariate algorithms by the method of postponed basis matrix multiplication method. Part 1. Principal component analysis. Chemometrics and Intelligent Laboratory Systems. 31-42.
  • Libnau, F. O.; Kvalheim, Olav Martin; Christy, A. A. 1994. Spectra of water in the near- and mid-infrared region. Vibrational Spectroscopy. 243-254.
  • Libnau, F. O.; Christy, A. A.; Kvalheim, Olav Martin. 1994. Resolution of infrared spectra and kinetic analysis of mutarotation of D-Glucose in water by sequential rank analysis. Vibrational Spectroscopy. 139-148.
  • Liang, Yi-zeng; Manne, Rolf ; Kvalheim, Olav Martin. 1994. Resolution of embedded chromatographic peaks by sequential rank analysis of the firs-order differentiated elution profile in the domiain. Chemometrics and Intelligent Laboratory Systems. 229-240.
  • Grung, Bjørn; Kvalheim, Olav Martin. 1994. Rank determination of spectroscopi data by means of cross validation - The effect of replicated measurements on the degrees of fredom. Chemometrics and Intelligent Laboratory Systems. 115-125.
  • Kvalheim, Olav Martin; Brakstad, F.; Liang, Yi-zeng. 1994. Preprocessing of analytical profiles in the presence of homoscedastic or heteroscedastic noise. Analytical Chemistry. 43-51.
  • Brakstad, F.; Kvalheim, Olav Martin; Ugland, K. I.; Tjessem, K.; Bryne, K. 1994. Prediction of the Shannon Wiener index from trace element profiles in sediments around the Statfjord platforms. Chemosphere. 1441-1465.
  • Toft, J.; Kvalheim, Olav Martin. 1994. Nonlinear curve fitting of bilinear data by ortogonal projections for rank analysis. Applications to GC-IR and temperature IR studies. Vibrational Spectroscopy. 125-137.
  • Toft, Jostein; Kvalheim, Olav Martin; Libnau, Fred Olav; Nodland, Egil. 1994. Non-linear curvefitting of bilinear data using orthogonal projections for rank analysis. Applications to gas chromatography/ infrared spectrometry and variable temperature infrared studies. Vibrational Spectroscopy. 125-137.
  • Toft, Jostein; Kvalheim, Olav Martin; Libnau, Fred Olav; Nodland, Egil. 1994. Non-linear curvefitting of bilinear data using orthogonal projections for rank analysis. Applications to gas chromatography/ infrared spectrometry and variable temperature infrared studies. Vibrational Spectroscopy. 125-137.
  • Toft, J.; Kvalheim, Olav Martin. 1994. Multi-array resolution parameter for multidetection chromatography. Performance of alternating regression, iterative target transformation factor analysis and heuristic evolving latent projections. Chemometrics and Intelligent Laboratory Systems. 61-75.
  • Brereton, R. G.; Rahmani, A.; Liang, Yi-zeng; Kvalheim, Olav Martin. 1994. Investigation of the allomerization reaction of chlorophyll a: use of diode array HPLC, mass spectrometry and chemometric factor analysis for the detection of early products. Photochemistry and Photobiology. 99-110.
  • Liang, Yi-zeng; Kvalheim, Olav Martin. 1994. Diagnosis and resolution of multiwavelength chromatograms by rank map, orthogonal projections and sequential rank analysis. Analytica Chimica Acta. 5-15.
  • Christy, A. A.; Nodland, Egil; Kvalheim, Olav Martin. 1994. Determination of kinetic parameters for the dehydration of calcium oxalate monohydrate by diffuse reflectance infrared FT-IR spectroscopy. Applied Spectroscopy. 561-568.
  • Alsberg, B. K.; Kvalheim, Olav Martin. 1994. Compression of three-mode data arrays by B-splines prior to three-mode principal component analysis (PCA). Chemometrics and Intelligent Laboratory Systems. 29-38.
  • Alsberg, B. K.; Nodland, Egil; Kvalheim, Olav Martin. 1994. Compression of an order data arrays by B-splines. Part 2. Application to second- order FT-IR data. Journal of Chemometrics. 127-145.
  • Christy, A. A.; Kvalheim, Olav Martin; Høiland, Harald. 1994. Bulk compositional variations of coal asphaltenes studied by latent variable analysis of infrared microspectroscopic data. Chemometrics and Intelligent Laboratory Systems. 197-204.
  • Liang, Yi-zeng; Hämäläinen, M. D.; Kvalheim, Olav Martin; Andersson, R. 1994. Assessment of peak origin and purity by orthogonal design and Heuristic evolving latent projections. Journal of Chromatography A. 113-122.
  • Liang, Yi-zeng; Kvalheim, Olav Martin; Manne, Rolf. 1993. White, grey and black - A classification of methods for quantitative analysis of multicomponent analytical systems. Chemometrics and Intelligent Laboratory Systems. 235-250.
  • Liang, Yi-zeng; Brereton, R. G.; Kvalheim, Olav Martin; Rahmani, A. 1993. Use of chemometrics factor analysis for chromatographic integration: Application to diode-array high-performance liquid chroma tography of mixtures of chlorophyll a degradation products. The Analyst. 779-790.
  • Liang, Yi-zeng; Kvalheim, Olav Martin. 1993. Unique resolution of hidden peaks in multidetection chromatography by first-order differentiation and orthogonal projectio ns. Analytica Chimica Acta. 425-440.
  • Toft, J.; Kvalheim, Olav Martin. 1993. Resolution parameter for multidetection chromatography. Analytical Chemistry. 2270-2275.
  • Liang, Yi-zeng; Kvalheim, Olav Martin; Ramani, A.; Brereton, R. G. 1993. Resolution of strongly overlapping two-way multicomponent data by means of Heuristic Evolving Latent Projections. Journal of Chemometrics. 15-43.
  • Christy, A. A.; Kvalheim, Olav Martin; Libnau, F. O.; Aksnes, G.; Toft, J. 1993. Interpretation of chemical structural changes by target-projection analysis of infrared profiles. Vibrational Spectroscopy. 1-14.
  • Liang, Yi-zeng; Kvalheim, Olav Martin. 1993. Heuristic evolving latent projections: Resolving hyphenated chromatographic profiles by component stripping. Chemometrics and Intelligent Laboratory Systems. 115-125.
  • Toft, J.; Kvalheim, Olav Martin. 1993. Eigenstructure tracking analysis for demonstration of heteroscedastic noise in instrumental profiles - application to transm ittance and aborbance IR. Chemometrics and Intelligent Laboratory Systems. 65-73.
  • Christy, A. A.; Liang, Yi-zeng; Hui, C.; Kvalheim, Olav Martin; Velapoldi, R. A. 1993. Effect of particle size on diffuse reflectance Fourier-transform infrared spectra of polystyrene spheres. Vibrational Spectroscopy. 233-244.
  • Liang, Yi-zeng; Kvalheim, Olav Martin; Höskuldsson, A. 1993. Determination of detection limit and local chemical rank by designing a nonparametric test from the zero-component regions. Journal of Chemometrics. 277-289.
  • Hämäläinen, M. D.; Liang, Yi-zeng; Kvalheim, Olav Martin; Andersson, R. 1993. Deconvolution in one-dimensional chromomatography by heuristic evolving latent projections of whole profiles retention time shifted b y Simplex optimization of cross correlation between target peaks. Analytica Chimica Acta. 101-114.
  • Alsberg, B. K.; Kvalheim, Olav Martin. 1993. Compression of n-order data arrays by B-splines. Part 1. Theory. KJ. Chemometrics. 61-73.
  • Liang, Yi-zeng; Kvalheim, Olav Martin. 1993. A two-way procedure for background correction of chromatographic/spectroscopic data by means of congruence analysis and least-squares fit of the zero-component regions, comparison with double-centering. Chemometrics and Intelligent Laboratory Systems. 265-279.
  • Christy, A. A.; Nodland, Egil; Kvalheim, Olav Martin. 1993. A gas cell for on-line transmission Fourier-transform infrared spectrometry. Vibrational Spectroscopy. 365-371.
  • Liang, Yi-zeng; Kvalheim, Olav Martin; Manne, Rolf. 1992. White, grey and black - A classification of methods for quantitative and qualitative analysis of multicomponent analytical systems. Chemometrics and Intelligent Laboratory Systems.
  • Kvalheim, Olav Martin. 1992. The latent variable. Chemometrics and Intelligent Laboratory Systems. 1-3.
  • Liang, Yi-zeng; Kvalheim, Olav Martin; Ramani, A.; Brereton, R. G. 1992. Resolution of strongly overlapping two-way multicomponent data by means of Heuristic Evolving Latent Projections. Journal of Chemometrics.
  • Christy, Alfred A.; Liang, Yi-zeng; Kvalheim, Olav Martin. 1992. On-line pyrolysis of asphaltenes studied by Diffuse reflectance Fourier transform infrared spectroscopy. Fuel. 125-127.
  • Kvalheim, Olav Martin. 1992. Laboratory Profile. Journal of Chemometrics. 113-116.
  • Brereton, R. G.; Rahmani, A.; Liang, Yi-zeng; Kvalheim, Olav Martin. 1992. Investigation of the allomerization reaction of chlorophylla: use of diode array HPLC, mass spectrometry and chemometrics factor analysis for the detection of early products. Photochem.
  • Brereton, R. G.; Rahmani, A.; Liang, Yi-zeng; Kvalheim, Olav Martin. 1992. Investigation of the allomerization reaction of chlorophylla: use of diode array HPLC, mass spectrometry and chemometrics factor analysis for the detection of early products. Photobiol.
  • Liang, Yi-zeng; Kvalheim, Olav Martin; Keller, H. R.; Massart, D. L.; Kiechle, [Mangler fornavn]; Ernie, F. 1992. Heuristic Evolving Latent Projection - resolving two-way multicomponent data. Part 2. Detection and resolution of minor component. Analytical Chemistry. 946-953.
  • Kvalheim, Olav Martin; Liang, Yi-zeng. 1992. Heuristic Evolving Latent Projection - resolving two-way multicomponent data. Part 1. Selectivity, latent-projective graph, datascope, local rank analysis and unique resolution. Analytical Chemistry. 936-946.
  • Keller, H. R.; Liang, Yi-zeng; Kvalheim, Olav Martin; Massart, D. L. 1992. Evolving factor analysis in the presence of heteroscedastic noise. Analytica Chimica Acta. 29-36.
  • Karstang, Terje V.; Toft, Jostein; Kvalheim, Olav Martin. 1992. Estimation of prediction error for samples within the calibration range. Journal of Chemometrics. 177-188.
  • Toft, Jostein; Kvalheim, Olav Martin. 1992. Eigenstructure tracking analysis for demonstration of heteroscedastic noise in instrumental profiles - application to transmittance and oborbance IR. Chemometrics and Intelligent Laboratory Systems.
  • Christy, Alfred A.; Liang, Yi-zeng; Velapoldi, R.; Kvalheim, Olav Martin. 1992. Effect of particle size on diffuse reflectance infrared spectra of polysterene spheres. Vibrational Spectroscopy.
  • Hämäläinen, M. D.; Liang, Yi-zeng; Kvalheim, Olav Martin; Andersson, R. 1992. Deconvolution in one-dimensional chromotography by heuristic evolving latent projections of whole profiles retention time shifted by Simplex optimization of cross correlation between target peaks. Analytica Chimica Acta.
  • Liang, Yi-zeng; Manne, Rolf ; Kvalheim, Olav Martin. 1992. Constrained background bilinearization. Chemometrics and Intelligent Laboratory Systems. 175-184.
  • Alsberg, Bjørn K.; Kvalheim, Olav Martin. 1992. Compression of n-order data arrays by B-plines. Part. theory. Journal of Chemometrics.
  • Christy, Alfred A.; Kvalheim, Olav Martin. 1992. Applications of diffuse reflectance Fourier-transform infrared spectroscopy in petroleum geochemistry. Scan Time.
  • Christy, A. A.; Kvalheim, Olav Martin. 1992. Applications of diffuse reflectance Fourier-transform infrared spectroscopy in petroleum geochemistry. Scan Time, Spectra-Tech.
  • Christy, Alfred A.; Kvalheim, Olav Martin. 1992. Applications of diffuse reflectance Fourier transform infrared spectroscopy in petroleum geochemistry. Spectra-Tech.
  • Toft, Jostein; Kvalheim, Olav Martin; Christy, Alfred A.; Kleveland, Karl Torbjørn; Henriksen, A.; Karstang, Terje V. 1992. Analysis of nontransparent polymers-mixture design, 2nd derivative attenuated total internal reflectance FT-IR and multivariate calibration. Applied Spectroscopy. 1002-1008.
  • Toft, J.; Kvalheim, Olav Martin; Christy, A. A.; Kleveland, Karl Torbjørn; Henriksen, A.; Karstang, T. V. 1992. Analysis of non transparent polymers: Mixture design, 2nd derivate attenuated total internal reflectance FT-IR and multivariate calibration. Applied Spectroscopy. 1002-1008.
  • Liang, Yi-zeng; Kvalheim, Olav Martin. 1992. A two-way procedure for background correction of chromatographic/ spectroscopic data by means of congruence analysis and least-squares fit of the zerocomponent regions, comparison with double-centering. Chemometrics and Intelligent Laboratory Systems.
  • Keller, H. R.; Liang, Yi-zeng; Kvalheim, Olav Martin; Massart, D. L. 1992. A comparison of the Heuristic envolving latent projection and evolving factor analysis methods for peak purity control in HPLCDAD. Analytica Chimica Acta. 63-71.
  • Christy, A. A.; Liang, Yi-zeng; Kvalheim, Olav Martin. 1991. On-Line pyrolysis of asphaltenes studied by Diffuse reflectance Fourier-transform infrared spectroscopy. Fuel. 125-127.
  • Christy, A. A.; Kvalheim, Olav Martin; Øygard, K.; Dahl, Birger; Karstang, T. V. 1991. Maturity of Kerogen and asphaltenes determined by Partial-Least -Squares (PLS) calibration and target projection of diffuse reflectance Fourier-transformed infrared spectra. Organic Geochemistry. 63-74.
  • Karstang, T. V.; Christy, A. A.; Kvalheim, Olav Martin. 1991. Diffuse reflectance Fourier-transformed infrared spectroscopy in petroleum exploration: A multivariate approach to maturity determination. Journal of Geochemical Exploration. 213-226.
  • Sletten, Einar; Kvalheim, Olav Martin; Kruse, S.; Farstad, Marit; Søreide, Odd. 1990. Detection of malignant tumors by multivariate analysis of proton magnetic resonance spectra of serum. European Journal of Cancer. 615-618.
  • Christy, A. A.; Dahl, Birger; Kvalheim, Olav Martin. 1989. Structural features of resins, asphaltenes and kerogen studied by diffuse reflectance Fourier-transform infrared spectroscopy. Fuel. 429-435.
  • Christy, A. A.; Hopland, A. L.; Barth, Tanja; Kvalheim, Olav Martin. 1989. Quantitative determination of thermal maturity in sedimentary organic matter by diffuse reflectance infrared spectroscopy of asphaltenes. Organic Geochemistry. 77-81.
  • Christy, A. A.; Velapoldi, R. A.; Kvalheim, Olav Martin; Telnæs, N.; Karstang, T. V.; Sletten, Einar. 1987. Multivariate calibration of diffuse reflectance Fourier-transform infrared spectra of coals as an alternative to rank determination by vitrinite reflectance. Chemometrics and Intelligent Laboratory Systems. 199-207.
  • Kvalheim, Olav Martin; Christy, A. A.; Bjørseth, A.; Telnæs, N. 1987. Maturity determination of organic matter in coals using the methyl phenanthrene distribution. Geochimica et Cosmochimica Acta. 1883-1888.
  • Telnæs, N.; Bjørseth, A.; Christy, A. A.; Kvalheim, Olav Martin. 1987. Interpretation of multivariate data: Relationship between phenanthrenes in crude oils. Chemometrics and Intelligent Laboratory Systems. 149-153.
Vitenskapelig foredrag
  • Kvalheim, Olav Martin. 2019. What is the best measure(s) of variable importance for interpretation and variable selection in multivariate regression models?
  • Kvalheim, Olav Martin; Kellogg, Joshua J.; Caesar, Lindsay K.; Cech, Nadja B. 2019. Using chromatography and chemometrics for detecting bioactive components in very complex extracts of natural products.
  • Kvalheim, Olav Martin; Grung, Bjørn; Rajalahti, Tarja. 2019. Optimal partial least squares models and predictions of properties using Monte Carlo resampling strategies.
  • Kvalheim, Olav Martin; Grung, Bjørn; Rajalahti, Tarja. 2019. Optimal Partial Least Squares models and predictions of properties using Monte Carlo resampling strategies.
  • Kvalheim, Olav Martin; Arneberg, Reidar; Grung, Bjørn; Rajalahti, Tarja. 2018. Development and maintenance of process models - automating the selection and updating of models.
  • Kvalheim, Olav Martin; Rajalahti, Tarja. 2018. Bruk av kjemometri til persontilpasset forebygging av livsstilssykdommer.
  • Kvalheim, Olav Martin; Grung, Bjørn. 2017. Variable selection in process modeling.
  • Kvalheim, Olav Martin. 2017. Selecting the “right” variables in latent variable regression (LVR) modelling in the presence of multicolinearity and orthogonal variation - optimal interpretation and prediction at the same time .
  • Kvalheim, Olav Martin. 2017. Revealing the bioactive signature in multicomponent profiles.
  • Kvalheim, Olav Martin; Arneberg, Reidar; Rajalahti, Tarja. 2017. Monte Carlo Cross validation for component selection and determination of prediction error in latent-variable regression.
  • Kvalheim, Olav Martin; Arneberg, Reidar; Grung, Bjørn; Rajalahti, Tarja. 2017. Determination of optimum number of components in partial least squares regression.
  • Kvalheim, Olav Martin. 2016. Which factors impact the lipid metabolism and how?
  • Kvalheim, Olav Martin. 2016. Analysis of metabolomics data – examples from the study of the lipid metabolism.
  • Kvalheim, Olav Martin. 2015. Predictive and orthogonal variation in latent variable regression and implications for the concept of model quality and model reduction.
  • Kellogg, J.; Todd, D. A.; Egan, J. M.; Raja, H. A.; Oberlies, N. H.; Kvalheim, Olav Martin; Cech, Nadja B. 2015. Chemometric-directed bioexploration of natural products.
  • Kvalheim, Olav Martin. 2014. Variable importance and variable selection in spectral profiles from process analysers.
  • Kvalheim, Olav Martin. 2014. Predictive and orthogonal variation in latent variable regression – model quality and model reduction .
  • Kvalheim, Olav Martin. 2014. Optimal strategies and tools for interpretation and variable selection in spectral profiles from process analysers .
  • Kvalheim, Olav Martin. 2014. Optimal strategies and tools for interpretation and variable selection in spectral profiles from process analysers.
  • Kvalheim, Olav Martin. 2014. Model performance, interpretation, prediction performance and SOLV-DPM for process control.
  • Aadland, Eivind; Andersen, John Roger; Kvalheim, Olav Martin; Anderssen, Sigmund Alfred. 2013. Relationship between physical activity and lipoprotein subclass changes in severely obese women.
  • Kvalheim, Olav Martin; Rajalahti, Tarja; Arneberg, Reidar; Berven, Frode; Kroksveen, Ann Cathrine; Berle, Magnus; Flikka, Kristian; Myhr, Kjell-Morten; Vedeler, Christian A.; Ulvik, Rune Johan. 2007. Target projection and proper data pre-treatment for the analysis of proteomic profiles.
  • Rajalahti, Tarja; Arneberg, Reidar; Flikka, Kristian; Berven, Frode; Kroksveen, Ann Cathrine; Berle, Magnus; Myhr, Kjell-Morten; Vedeler, Christian A.; Ulvik, Rune Johan; Kvalheim, Olav Martin. 2007. Preteatment of Mass Spectral Profiles: Application to proteomic data.
  • Kvalheim, Olav Martin. 2007. Analysis of Proteomic Profiles: Pretreatment and Biomarker Discovery for early diagnosis of diseases.
  • Kvalheim, Olav Martin. 2007. Analysis of Proteomic Profiles - Biomarker Discovery and Early Diagnosis.
  • Kvalheim, Olav Martin; Rajalahti, Tarja; Arneberg, Reidar; Berven, Frode; Kroksveen, Ann Cathrine; Berle, Magnus; Flikka, Kristian; Myhr, Kjell-Morten; Vedeler, Christian A.; Ulvik, Rune Johan. 2007. Analysis of Proteomic Profiles.
  • Kvalheim, Olav Martin. 2003. Resolution of GC-MS and LC-MS profiles of very complex biomedical samples.
  • Kvalheim, Olav Martin. 2003. Medical application of GC- and LC- MS and MS resolver.
  • Kvalheim, Olav Martin. 2003. Introduction to design, Design of Experiments.
  • Kvalheim, Olav Martin. 2003. Introduction of NOx-handling (pre & post, existing context, R&D, where are we today?) Handling of NOx in exhaust gases.
  • Kvalheim, Olav Martin. 2001. Identification of and solution to the problem of lurking variables in industrial processes.
  • Høiland, Harald; Førland, Geir Martin; Kvalheim, Olav Martin; Liang, Y.; Chazy, A. 1997. The associative behaviour of benzyl alcohol in carbon tetrachloride solutions.
  • Kvalheim, Olav Martin. 1997. PVA and related methods applied to improvement of industrial processes and product quality.
  • Kvalheim, Olav Martin. 1997. Multivariate information extraction as a strategic and communication tool in the industrial enterprise.
  • Kvalheim, Olav Martin. 1997. Kjemometri og kvalitet processes and product quality.
  • Kvalheim, Olav Martin. 1997. Environmental monitoring and forecasting by means of multivariate methods.
  • Kvalheim, Olav Martin. 1997. En innføring i multikomponentanalyse.
  • Kvalheim, Olav Martin. 1997. Detection and resolution of overlapping peaks in multidetection chromatography.
  • Kvalheim, Olav Martin. 1997. Chemometrics - advanced methods.
  • Kvalheim, Olav Martin. 1997. 2-D multicomponent analysis by means of Extricator.
  • Libnau, O.; Christy, A. A.; Aksnes, G.; Kvalheim, Olav Martin. 1993. Temperature dependency of the infrared spectra of water studied by Fourier-transform infrared spectroscopy.
  • Christy, A. A.; Kvalheim, Olav Martin. 1993. Particle size problem in diffuse reflectance spectrometry.
  • Christy, A. A.; Kvalheim, Olav Martin. 1993. Particle size problem in diffuse reflectance Fourier-transform infrared spectrometry. Plenary lecture.
  • Christy, Alfred A.; Kvalheim, Olav Martin. 1992. Multivariate analysis of infrared spectroscopic data: Application to the chemical transformation of sedimentary organic matter.
  • Christy, Alfred A.; Liang, Yi-zeng; Kvalheim, Olav Martin. 1992. Determination of activation energy for the thermal decomposition of kerogen by on-line pyrolysis infrared spectroscopy.
  • Christy, Alfred A.; Kvalheim, Olav Martin. 1992. Applications of chemometrics in infrared microspectroscopy.
Sammendrag/abstract
  • Aadland, Eivind; Kvalheim, Olav Martin; Anderssen, Sigmund Alfred; Resaland, Geir Kåre; Andersen, Lars Bo. 2018. The multivariate physical activity signature associated with metabolic health in children. Journal of Physical Activity and Health. 248-249.
  • Jones, Paul Remy; Kvalheim, Olav Martin; Resaland, Geir Kåre; Anderssen, Sigmund Alfred; Ekelund, Ulf. 2018. Lipoprotein subclasses and their associations with physical activity and sedentary time in Norwegian schoolchildren: The Active Smarter Kids study. Journal of Physical Activity and Health. 109-110.
  • Aadland, Eivind; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Resaland, Geir Kåre; Kvalheim, Olav Martin. 2018. Associations for volumes and patterns of physical activity with metabolic health in children: a multivariate pattern analysis approach. Preventive Medicine.
  • Resaland, Geir Kåre; Rajalahti, Tarja; Aadland, Eivind; Kvalheim, Olav Martin. 2017. Strong association between cardiorespiratory fitness and serum lipoprotein subclass pattern in prepubertal healthy children. Medicine & Science in Sports & Exercise. 640-640.
  • Britton, Emily R.; Kellogg, Joshua J.; Kvalheim, Olav Martin; Cech, Nadja B. 2016. New strategies to identify synergists from Hydrastis canadensis (goldenseal). Planta Medica. 1 sider.
  • Kellogg, Joshua J.; Kvalheim, Olav Martin; Cech, Nadja B. 2016. Biochemometric analysis reveals complimentary bacterial inhibitory functionalities of the medicinal lichen Usnea barbata. Planta Medica. 1 sider.
  • Lin, Chenchen; Mjøs, Svein Are; Våge, Villy; Kvalheim, Olav Martin. 2014. Effect of two types of bariatric surgery on the fatty acid profile in serum. The Complexity of obesity proceedings.
  • Rajalahti, Tarja; Aadland, Eivind; Andersen, John Roger; Våge, Villy; Kvalheim, Olav Martin. 2014. A multivariate approach to reveal biomarker signatures in instrumental profiles of body fluids. The Complexity of obesity proceedings.
  • Jepsen, Randi; Andersen, John Roger; Aadland, Eivind; Aasprang, Anny; Kvalheim, Olav Martin; Natvig, Gerd Karin. 2011. Health Related Quality of Life in in-patients undergoing lifestyle treatment for morbid obesity. Obesity Reviews. 87-87.
  • Kvalheim, Olav Martin; Arneberg, Reidar; Marquardt, Brian. 2008. PAT - Optimal prediction of properties by means of tailormade modelling of spectroscopic/chromatographic profiles. European Journal of Pharmaceutical Sciences. S16-S16.
  • Rajalahti, Tarja; Arneberg, Reidar; Berven, Frode; Kroksveen, Ann Cathrine; Berle, Magnus Foldal; Myhr, Kjell-Morten; Vedeler, Christian A.; Ulvik, Rune Johan; Kvalheim, Olav Martin. 2008. Early diagnosis and biomarker discovery from mass spectral profiles: application to multiple sclerosis. Multiple Sclerosis. S285-S285.
  • Rajalahti, Tarja; Arneberg, Reidar; Berven, Frode; Kroksveen, Ann Cathrine; Berle, Magnus Foldal; Myhr, Kjell-Morten; Vedeler, Christian A.; Ulvik, Rune Johan; Kvalheim, Olav Martin. 2008. Biomarker discovery from mass spectral profiles: A combined proteomics and multivariate analysis. European Journal of Pharmaceutical Sciences. S27-S27.
Vitenskapelig oversiktsartikkel/review
  • Rajalahti, Tarja; Kvalheim, Olav Martin. 2011. Multivariate data analysis in pharmaceutics: A tutorial review. 280-290.

Se fullstendig oversikt over publikasjoner i CRIStin.

Arneberg R., Rajalahti T., Flikka K., Berven F.S., Kroksveen A.C., Berle M., Myhr K.-M., Vedeler C., Ulvik  R.J., Kvalheim O.M. (2007) Pretreatment of mass spectral profiles: Applications to proteomic data, Anal. Chem., 79, 7014-7026.

Kvalheim O.M., Rajalahti T., Arneberg R. (2009) X-tended Target Projection (XTP) – comparison with ortogonal partial least squares (OPLS) and PLS post-processing by similarity transformation (PLS+ST), J. Chemometrics, 23, 49-55.

Rajalahti T., Arneberg R., Berven F.S., Myhr K.-M., Ulvik R.J., Kvalheim O.M. (2009) Biomarker discovery in mass spectral profiles by means of selectivity ratio plot, Chemometrics & Intell. Lab. Syst., 95, 35-48.

Rajalahti T., Arneberg R, Kroksveen A.C., Berle M., Myhr K.-M., Kvalheim O.M. (2009) Discriminating variables test and selectivity ratio plot – Quantitative tools for interpretation and variable (biomarker) selection in complex spectral or chromatographic profiles, Analytical Chemistry, 81, 2581-90.

Chau F.-T., Chan H.-Y., Cheung C.-Y., Xu C.-J., Liang Y., Kvalheim O.M. (2009) Recipe for Uncovering the Bioactive Components in Herbal Medicine, Analytical Chemistry, 81, 7217-7225.

Rajalahti T., Kroksveen A.C., Arneberg R., Berven F.S., Vedeler C., Myhr K.-M., Kvalheim O.M. (2010) A multivariate approach to reveal biomarker signatures for disease classification: Application to mass spectral profiles of cerebrospinal fluid from patients with multiple sclerosis, J. Proteome Res., 9, 3608-3620.

Kvalheim O.M. (2010) Interpretation of partial least squares regression models by means of target projection and selectivity ratio plots, J. Chemometrics, 24, 496-504.

Kvalheim O.M., Chan H.-Y., Lau T.-Y., Benzie I.F.F, Szeto Y.-T., Tzang A.H.-C., Chau F.-T. (2011) Chromatographic Profiling and Multivariate analysis for revealing and quantifying the contributions from individual components to the Bioactive Signature in Natural Products, Chemom. & Intell. Lab. Syst., in press.

Rajalahti T., Kvalheim O.M. (2011), Multivariate data analysis in pharmaceutics: a tutorial review, Intern. J. Pharmaceutics, in press.