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Ruth Brenks bilde

Ruth Brenk

Professor, Forskningsleder i Institutt for biomedisin
  • E-postRuth.Brenk@uib.no
  • Telefon+47 55 58 60 70
  • Besøksadresse
    Jonas Lies vei 91
    5009 Bergen
    Rom 
    5A125B
  • Postadresse
    Postboks 7804
    5020 Bergen

Our overall research goal is to improve methods used for structure-based drug design and to apply these methods to design inhibitors for enzymes with biological relevance. A key point in our research is the interplay of theoretical and experimental methods.

To read more about what we do, check out our homepage.

For a full list of publications, click here.

Vitenskapelig artikkel
  • Vis forfatter(e) (2022). Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics. F1000 Research.
  • Vis forfatter(e) (2021). DrugPred_RNA—A Tool for Structure-Based Druggability Predictions for RNA Binding Sites. Journal of Chemical Information and Modeling. 4068-4081.
  • Vis forfatter(e) (2021). An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics . ChemMedChem. 2715.
  • Vis forfatter(e) (2020). Targeting the Class A Carbapenemase GES-5 via Virtual Screening. Biomolecules.
  • Vis forfatter(e) (2019). Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design. PLOS ONE. 1-19.
  • Vis forfatter(e) (2019). How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N-Myristoyltransferases as a Model System. Journal of Medicinal Chemistry.
  • Vis forfatter(e) (2018). In silico identification and experimental validation of hits active against KPC-2 β-lactamase. PLOS ONE.
  • Vis forfatter(e) (2015). To hit or not to hit, that is the question -genome-wide structure-based druggability predictions for pseudomonas aeruginosa proteins. PLOS ONE.
Vitenskapelig foredrag
  • Vis forfatter(e) (2021). Structure-based ligand design for protein and RNA targets for new antibiotics.
  • Vis forfatter(e) (2021). Structure-based ligand design for protein and RNA targets for new antibiotics.
  • Vis forfatter(e) (2021). Structure-based ligand design for protein and RNA targets for new antibiotics.
Mastergradsoppgave
  • Vis forfatter(e) (2021). The Search for Antibiotic Leads: Targeting Pantothenate Kinase in Pseudomonas aeruginosa.
  • Vis forfatter(e) (2021). Structure-based drug design of β-ketoacyl-[acyl carrier protein] synthase I (FabB) inhibitors as lead structures for new antibiotics.
  • Vis forfatter(e) (2020). Structure-based design of pantothenate kinase inhibitors as lead structures for new antibiotics.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) (2021). Riboswitches as Drug Targets for Antibiotics. Antibiotics. 1-22.
  • Vis forfatter(e) (2021). Fragment-Based Drug Discovery for RNA Targets. ChemMedChem.
  • Vis forfatter(e) (2017). Ligand design for riboswitches, an emerging target class for novel antibiotics. Future Medicinal Chemistry. 1649-1662.
Faglig kapittel
  • Vis forfatter(e) (2017). Structure-Based Discovery of Small Molecules Binding to RNA. . I:
    • Vis forfatter(e) (2017). RNA Therapeutics. Springer.

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