Silje Skredes bilde

Silje Skrede

Professor, Leder for innovasjon
  • E-postSilje.Skrede@uib.no
  • Besøksadresse
    Haukeland universitetssykehus, Laboratoriebygget
    5009 Bergen
  • Postadresse
    Postboks 7804
    5020 Bergen
Vitenskapelig artikkel
  • Vis forfatter(e) (2024). Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe. Basic & Clinical Pharmacology & Toxicology.
  • Vis forfatter(e) (2024). Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model. CNS Neuroscience & Therapeutics.
  • Vis forfatter(e) (2024). Association between cytokines and suicidality in patients with psychosis: A multicentre longitudinal analysis. Brain, Behavior, and Immunity - Health (BBI - Health).
  • Vis forfatter(e) (2023). Ocrelizumab and ofatumumab, but not rituximab, trigger complement induction in vitro. International Immunopharmacology. 1-5.
  • Vis forfatter(e) (2023). Depression trajectories and cytokines in schizophrenia spectrum disorders - A longitudinal observational study. Schizophrenia Research. 77-87.
  • Vis forfatter(e) (2022). Ocrelizumab quantitation by liquid chromatography-tandem mass spectrometry. Journal of Mass Spectrometry and Advances in the Clinical Lab. 53-60.
  • Vis forfatter(e) (2022). GLP-1 agonists: superior for mind and body in antipsychotic-treated patients? Trends in endocrinology and metabolism. 628-638.
  • Vis forfatter(e) (2022). Determination of methotrexate and its metabolites in human plasma by electromembrane extraction in conductive vials followed by LC-MS/MS. Advances in Sample Preparation. 8 sider.
  • Vis forfatter(e) (2021). Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness. Psychological Medicine. 1-10.
  • Vis forfatter(e) (2021). Illicit substances detected through high-resolution MS analysis in urine samples are associated with greater symptom burden in patients with psychosis. Emerging Trends in Drugs, Addictions, and Health.
  • Vis forfatter(e) (2020). Amisulpride, aripiprazole, and olanzapine in patients with schizophrenia-spectrum disorders (BeSt InTro): a pragmatic, rater-blind, semi-randomised trial. The Lancet Psychiatry. 945-954.
  • Vis forfatter(e) (2019). One-Year Treatment with Olanzapine Depot in Female Rats: Metabolic Effects. International Journal of Neuropsychopharmacology. 358-369.
  • Vis forfatter(e) (2019). Exploring lithium's transcriptional mechanisms of action in bipolar disorder: a multi-step study. Neuropsychopharmacology. 1-9.
  • Vis forfatter(e) (2018). Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis. Schizophrenia Research. 253-260.
  • Vis forfatter(e) (2017). Subchronic olanzapine exposure leads to increased expression of myelination-related genes in rat fronto-medial cortex. Translational Psychiatry.
  • Vis forfatter(e) (2017). No escaping the rat race: simulated night shift work alters the time-of-day variation in BMAL1 translational activity in the prefrontal cortex. Frontiers in Neural Circuits. 1-12.
  • Vis forfatter(e) (2017). Lack of ovarian secretions reverts the anabolic action of olanzapine in female rats. International Journal of Neuropsychopharmacology. 1005-1012.
  • Vis forfatter(e) (2016). Shift in food intake and changes in metabolic regulation and gene expression during simulated night-shiftwork: A rat model. Nutrients. 1-13.
  • Vis forfatter(e) (2016). Implication of NOTCH1 Gene in Susceptibility to Anxiety and Depression among Sexual Abuse Victims. Translational Psychiatry.
  • Vis forfatter(e) (2016). Genetic evidence for a role of the SREBP transcription system and lipid biosynthesis in schizophrenia and antipsychotic treatment. European Neuropsychopharmacology. 589-598.
  • Vis forfatter(e) (2016). Blue-blocking glasses as additive treatment for mania: A randomized placebo-controlled trial. Bipolar Disorders. 221-232.
  • Vis forfatter(e) (2016). A rodent model of night-shift work induces short-term and enduring sleep and electroencephalographic disturbances. Journal of Biological Rhythms. 48-63.
  • Vis forfatter(e) (2015). The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cells. Stem Cell Research. 530-541.
  • Vis forfatter(e) (2015). Olanzapine depot exposure in male rats: Dose-dependent lipogenic effects without concomitant weight gain. European Neuropsychopharmacology. 923-932.
  • Vis forfatter(e) (2015). Incident users of antipsychotic agents and future use of cholesterol-lowering drugs: An observational, pharmacoepidemiologic study. Journal of Clinical Psychiatry. e111-e116.
  • Vis forfatter(e) (2015). Antipsychotic-induced metabolic effects in the female rat: Direct comparison between long-acting injections of risperidone and olanzapine. Journal of Psychopharmacology. 1280-1289.
  • Vis forfatter(e) (2014). Olanzapine depot formulation in rat: a step forward in modelling antipsychotic-induced metabolic adverse effects. International Journal of Neuropsychopharmacology. 91-104.
  • Vis forfatter(e) (2014). Blocking blue light during mania - markedly increased regularity of sleep and rapid improvement of symptoms: A case report. Bipolar Disorders. 894-898.
  • Vis forfatter(e) (2014). Antileukaemic effect of PI3K-mTOR inhibitors in acute myeloid leukaemia-gene expression profiles reveal CDC25B expression as determinate of pharmacological effect. British Journal of Haematology. 200-211.
  • Vis forfatter(e) (2013). Neuropsychological deficits in mice depleted of the schizophrenia susceptibility gene CSMD1. PLOS ONE. 10 sider.
  • Vis forfatter(e) (2013). Antipsychotic-induced increase in lipid biosynthesis: activation through inhibition? Journal of Lipid Research.
  • Vis forfatter(e) (2012). Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats. International Journal of Neuropsychopharmacology. 163-179.
  • Vis forfatter(e) (2012). Lipid-lowering effects of tetradecylthioacetic acid in antipsychotic-exposed, female rats: challenges with long-term treatment. PLOS ONE. 11 sider.
  • Vis forfatter(e) (2012). Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat. Psychopharmacology. 783-794.
  • Vis forfatter(e) (2011). Olanzapine-induced hyperphagia and weight gain associate with crexigenic hypothalamic neuropeptide signaling without concomitant AMPK phosphorylation. PLOS ONE. 9 sider.
  • Vis forfatter(e) (2011). Lipogenic effects of psychotropic drugs: focus on the SREBP system. Frontiers in Bioscience. 49-60.
  • Vis forfatter(e) (2009). Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells. BMC Pharmacology.
  • Vis forfatter(e) (2009). Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver. Psychopharmacology. 73-84.
  • Vis forfatter(e) (2006). Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: Marked differences between various antipsychotic drugs. BMC Neuroscience.
  • Vis forfatter(e) (2005). Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? The Pharmacogenomics Journal. 298-304.
  • Vis forfatter(e) (2003). Schizofreni og membranpatologi - har antipsykotika en rolle i "membranteorien"? Tidsskrift for Den norske legeforening. in press.
  • Vis forfatter(e) (2015). Nye brukere av antipsykotika og utvikling av diabetes mellitus. SAMBA/14/15. SAMBA/14/15. .
Faglig foredrag
  • Vis forfatter(e) (2022). Elektromembran-ekstraksjon i Bergen.
Vitenskapelig foredrag
  • Vis forfatter(e) (2023). TDM for mAbs - prospects based on progress of analytical methods.
  • Vis forfatter(e) (2022). Rituximab in the treatment of multiple sclerosis: A pharmacokinetic-pharmacodynamic model.
  • Vis forfatter(e) (2016). Simulated night work alters clock gene expression in central and peripheral tissue in rats.
  • Vis forfatter(e) (2016). Implication of NOTCH1 Gene in Comorbid Anxiety and Depression Symptoms in a Sample of Sexual Abuse Victims.
  • Vis forfatter(e) (2015). Night work - disturbances in sleep and circadian rhythm parameters. An animal model.
  • Vis forfatter(e) (2013). Antipsychotic-induced increase in lipid biosynthesis: activation through inhibition? Journal of Lipid Research. 307-309.
Short communication
  • Vis forfatter(e) (2019). Short communication: Distribution of psychotropic drugs into lipoproteins. Therapeutic Drug Monitoring. 766-771.
  • Vis forfatter(e) (2023). Zebrafish Larvae as a Model Organism to Study Biotransformation.
  • Vis forfatter(e) (2022). Electromembrane extraction of immunosuppressants.
  • Vis forfatter(e) (2021). Electromembrane extraction of methotrexate and its metabolites.
  • Vis forfatter(e) (2020). Drug transport in blood: Lipoproteins as transporters of psychotropic drugs.
  • Vis forfatter(e) (2018). Gene Expression Changes in Rat Brain Following Long-term Antipsychotic Drug Exposure.
Populærvitenskapelig artikkel
  • Vis forfatter(e) (2018). Virker antipsykotika gjennom stimulering av myelinproduksjon i hjernen? BestPractice Psykiatri/Nevrologi/Geriatri.
  • Vis forfatter(e) (2018). Selektive serotonin-reopptaks-hemmere (SSRI) og blødningsrisiko. Utposten.
Brev til redaktøren
  • Vis forfatter(e) (2021). Therapeutic Drug Monitoring vs Standard Therapy during Infliximab Induction in Patients with Chronic Immune-Mediated Inflammatory Diseases. Journal of the American Medical Association (JAMA). 1068-1069.
  • Vis forfatter(e) (2019). Stability of antidepressants and antipsychotics in gel separator tubes. Therapeutic Drug Monitoring. 249-250.
  • Vis forfatter(e) (2020). Lipid effects during antipsychotic drug treatment and their relevance for clinical outcomes.
  • Vis forfatter(e) (2012). Developing a rodent model for antipsychotic-induced metabolic adverse effects.
  • Vis forfatter(e) (2016). Simulated night work alters clock gene expression in central and peripheral tissue in rats. Journal of Sleep Research. 57-57.
  • Vis forfatter(e) (2023). "Virtual Pharma" - a digital tool for visualizing pharmacokinetics and pharmacodynamics.
  • Vis forfatter(e) (2022). LC-MS/MS quantification of ocrelizumab in the treatment of multiple sclerosis .
  • Vis forfatter(e) (2021). Establishing an LC-MS/MS method as a tool in a TDM approach when treating multiple sclerosis with monoclonal antibodies.
  • Vis forfatter(e) (2018). Extending the photoperiod impacts circadian rhythmicity and gene expression in prefrontal cortex and retina- Impact of exposure to blue-enriched light. .
  • Vis forfatter(e) (2018). Extended photoperiod alters sleep and expression of synaptic plasticity-associated genes. The impact of blue-enriched light.
  • Vis forfatter(e) (2018). Extended photoperiod alters circadian rhythmicity and expression of neuroplasticity markers. The impact of blue-enriched light.
  • Vis forfatter(e) (2017). The influence of 3 weeks of antipsychotic treatment on cell adhesion molecules in drug naive patients with schizophrenia spectrum disorder .
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) (2023). Peripheral and central macrophages in obesity. Frontiers in Endocrinology.
  • Vis forfatter(e) (2023). Dog-assisted interventions for adults diagnosed with schizophrenia and related disorders: a systematic review. Frontiers in Psychiatry. 21 sider.
  • Vis forfatter(e) (2021). Understanding the Effects of Antipsychotics on Appetite Control. Frontiers in Nutrition.
  • Vis forfatter(e) (2014). A critical review of pro-cognitive drug targets in psychosis: convergence on myelination and inflammation. Frontiers in Psychiatry.
  • Vis forfatter(e) (2020). Norsk Psykiatrisk Forening: Kliniske råd for nedtrapping og seponering av antipsykotiske legemidler.

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