Hjem
Universitetet i Bergen
Silke Appels bilde

Silke Appel

Professor
Klinisk institutt 2
  • E-postSilke.Appel@uib.no
  • Telefon+47 55 97 46 33
  • Besøksadresse
    Haukeland universitetssykehus, Laboratoriebygget
    5009 Bergen
    Rom 
    5395
  • Postadresse
    Postboks 7804
    5020 Bergen

Dendritic cell biology with special emphasis on aspects that enable their use in immunotherapeutic strategies, both for cancer and autoimmune diseases

Medlem av organisasjonskommitteen for den årlige "Immunologiens dag" (29.4.)

 

Emneansvarlig for

  • Translational Immunology (HUIMM901)
  • Molecular and cellular methods in immunology (HUIMM306/HUIMM906)
  • Basic course in flow cytometry (HUIMM307)
Vitenskapelig artikkel
  • Vis forfatter(e) (2022). Variability of Primary Sjögren's Syndrome Is Driven by Interferon α and Interferon α Blood Levels Are Associated With the Class II HLA–DQ Locus. Arthritis & Rheumatology. 1991-2002.
  • Vis forfatter(e) (2022). Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome. Arthritis Research & Therapy. 12 sider.
  • Vis forfatter(e) (2022). Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases. Arthritis & Rheumatology. 1440-1450.
  • Vis forfatter(e) (2022). Aberrant signaling of immune cells in Sjögren's syndrome patient subgroups upon interferon stimulation. Frontiers in Immunology. 13 sider.
  • Vis forfatter(e) (2021). Inflammatory Stratification in Primary Sjögren’s Syndrome Reveals Novel Immune Cell Alterations in Patients’ Minor Salivary Glands. Frontiers in Immunology. 1-16.
  • Vis forfatter(e) (2021). Evaluation of β-catenin inhibition of axitinib and nitazoxanide in human monocyte-derived dendritic cells. Biomedicines. 1-18.
  • Vis forfatter(e) (2020). Mass cytometry analysis of blood immune cells from psoriasis patients on biological therapy. European Journal of Immunology. 694-702.
  • Vis forfatter(e) (2020). Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms. Frontiers in Endocrinology. 1-13.
  • Vis forfatter(e) (2020). Dual pro- and anti-inflammatory features of monocyte-derived dendritic cells. Frontiers in Immunology. 1-15.
  • Vis forfatter(e) (2019). The Culture Dish Surface Influences the Phenotype and Cytokine Production of Human Monocyte-Derived Dendritic Cells. Frontiers in Immunology.
  • Vis forfatter(e) (2019). Single cell based phosphorylation profiling identifies alterations in toll-like receptor 7 and 9 signaling in patients with primary sjogren's syndrome. Frontiers in Immunology. 1-18.
  • Vis forfatter(e) (2018). Serum cytokine measurements and biological therapy of psoriasis - Prospects for personalized treatment? Scandinavian Journal of Immunology. 1-7.
  • Vis forfatter(e) (2018). Phosphorylation of intracellular signaling molecules in peripheral blood cells from psoriasis patients on originator or biosimilar infliximab. British Journal of Dermatology. 371-380.
  • Vis forfatter(e) (2018). Minimum information about T regulatory cells: A step toward reproducibility and standardization. Frontiers in Immunology. 1-15.
  • Vis forfatter(e) (2018). Aberrant cell signalling in PBMCs upon IFN-? stimulation in primary Sjogren's syndrome patients associates with type I interferon signature. European Journal of Immunology. 1217-1227.
  • Vis forfatter(e) (2018). 3-Day monocyte-derived dendritic cells stimulated with a combination of OK432, TLR7/8 ligand, and prostaglandin E2 are a promising alternative for cancer immunotherapy. Cancer Immunology and Immunotherapy. 1-10.
  • Vis forfatter(e) (2017). Patients with primary Sjögren's syndrome have alterations in absolute quantities of specific peripheral leucocyte populations. Scandinavian Journal of Immunology. 491-502.
  • Vis forfatter(e) (2017). Expression of Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Patients with Primary Sjogren's Syndrome. Scandinavian Journal of Immunology. 220-226.
  • Vis forfatter(e) (2016). Minimum information about tolerogenic antigen-presenting cells (MITAP): A first step towards reproducibility and standardisation of cellular therapies. PeerJ.
  • Vis forfatter(e) (2016). An optimized multiplex flow cytometry protocol for the analysis of intracellular signaling in peripheral blood mononuclear cells. JIM - Journal of Immunological Methods. 58-63.
  • Vis forfatter(e) (2015). TLR-7 and -9 Stimulation of Peripheral Blood B Cells Indicate Altered TLR Signalling in Primary Sjögren's Syndrome Patients by Increased Secretion of Cytokines. Scandinavian Journal of Immunology. 523-531.
  • Vis forfatter(e) (2015). Surface-mediated priming during in vitro generation of monocyte-derived dendritic cells. Scandinavian Journal of Immunology. 56-65.
  • Vis forfatter(e) (2015). Peritumoral dermis of squamous cell carcinomas in renal transplant recipients contains less CD11c+ myeloid dendritic cells and FoxP3+ T cells compared to immunocompetent controls. Journal of the European Academy of Dermatology and Venereology. 2128-2135.
  • Vis forfatter(e) (2015). Expression of toll-like receptor -7 and -9 in B cell subsets from patients with primary Sjögren's syndrome. PLOS ONE. 13 sider.
  • Vis forfatter(e) (2014). CD11c+ dendritic cells rather than Langerhans cells are reduced in normal skin of immunosuppressed renal transplant recipients. Acta Dermato-Venereologica. 173-178.
  • Vis forfatter(e) (2014). Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren's syndrome. Arthritis Research & Therapy.
  • Vis forfatter(e) (2014). Activation of peroxisome proliferator-activated receptor gamma leads to upregulation of ESE-3 expression in human monocyte-derived dendritic cells. Scandinavian Journal of Immunology. 20-26.
  • Vis forfatter(e) (2013). Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells. Scandinavian Journal of Immunology. 246-254.
  • Vis forfatter(e) (2013). No association of primary Sjögren's syndrome with Fcγ receptor gene variants. Genes and Immunity. 234-237.
  • Vis forfatter(e) (2013). In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome. Arthritis Research & Therapy. 12 sider.
  • Vis forfatter(e) (2013). Effective polyethylene glycol passivation for the inhibition of surface interactions of peripheral blood mononuclear cells and platelets. Biointerphases. 12 sider.
  • Vis forfatter(e) (2013). Characterization of monocyte-derived dendritic cells from immunosuppressed renal transplant recipients with and without squamous cell carcinomas. Scandinavian Journal of Immunology. 291-297.
  • Vis forfatter(e) (2012). The bacterial preparation OK432 induces IL-12p70 secretion in human dendritic cells in a TLR3 dependent manner. PLOS ONE. 7 sider.
  • Vis forfatter(e) (2012). Expression of ESE-3 isoforms in immunogenic and tolerogenic human monocyte-derived dendritic cells. PLOS ONE. 9 sider.
  • Vis forfatter(e) (2012). Differential regulation of MHC II and invariant chain expression during maturation of monocyte-derived dendritic cells. Journal of Leukocyte Biology. 729-737.
  • Vis forfatter(e) (2011). Potential association of muscarinic receptor 3 gene variants with primary Sjögren's syndrome. Annals of the Rheumatic Diseases. 1327-1329.
  • Vis forfatter(e) (2011). Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses. BMC Immunology. 10 sider.
  • Vis forfatter(e) (2011). Dendritic cell populations in patients with self-reported food hypersensitivity. International Journal of General Medicine. 389-396.
  • Vis forfatter(e) (2011). Bromelain Treatment Leads to Maturation of Monocyte-derived Dendritic Cells but Cannot Replace PGE(2) in a Cocktail of IL-1 beta, IL-6, TNF-alpha and PGE(2). Scandinavian Journal of Immunology. 135-143.
  • Vis forfatter(e) (2011). Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome. Genes and Immunity. 100-109.
  • Vis forfatter(e) (2010). Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome. Annals of the Rheumatic Diseases. 1235-1238.
  • Vis forfatter(e) (2009). Levels of dendritic cell populations and regulatory T cells vary significantly between two commonly used mouse strains. Scandinavian Journal of Immunology. 541-546.
  • Vis forfatter(e) (2008). New Concepts in the Pathogenesis of Sjogren's Syndrome. Rheumatic Disease Clinics of North America. 833-+.
  • Vis forfatter(e) (2007). Development of novel compounds to treat autoimmune and inflammatory diseases and graft versus host reactions. Endocrine, Metabolic & Immune Disorders - Drug Targets. 93-97.
  • Vis forfatter(e) (2006). Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs. Blood. 3265-3270.
Leserinnlegg
  • Vis forfatter(e) (2013). Reply to 'Comment on No association of primary Sjogren's syndrome with Fc gamma receptor gene variants'. Genes and Immunity. 532-532.
  • Vis forfatter(e) (2012). Quantification of Plasmacytoid Dendritic Cells and Type 1 Myeloid Dendritic Cells in Peripheral Blood of Renal Transplant Recipients With and Without Squamous Cell Carcinoma. Acta Dermato-Venereologica. 623-624.
  • Vis forfatter(e) (2012). Anti-Ro and anti-La autoantibody profiling in Norwegian patients with primary Sjogren's syndrome using luciferase immunoprecipitation systems (LIPS). Scandinavian Journal of Rheumatology. 314-315.
  • Vis forfatter(e) (2010). The First Dendritic Cell-Based Therapeutic Cancer Vaccine is Approved by the FDA. Scandinavian Journal of Immunology. 554-554.
Doktorgradsavhandling
  • Vis forfatter(e) (2019). Systemic inflammation in psoriasis: Circulating immune cells and cytokines.
  • Vis forfatter(e) (2017). Flow cytometry based analyses as a tool in biomarker discovery for patient stratification in primary Sjögren’s syndrome.
  • Vis forfatter(e) (2015). Toll-like receptors in primary Sjögren’s syndrome. Special emphasis on B cells.
  • Vis forfatter(e) (2011). Epidemiological, clinical, and immunogenetic aspects of primary Sjögren's syndrome.
Sammendrag/abstract
  • Vis forfatter(e) (2013). Type 1 Regulatory T cells and Regulatory B Cells Induced by Dexamethasone and 1,25-Dihydroxyvitamin D3 Treated Monocyte-Derived Dendritic Cells. Scandinavian Journal of Immunology. 299-300.
  • Vis forfatter(e) (2012). No association of primary Sjögren's Syndrome with Fc gamma? Receptor gene variants. Scandinavian Journal of Immunology. 198-198.
  • Vis forfatter(e) (2012). Expression of Toll-like receptors 7 and 9 in B cell populations of patients with Sjogren's syndrome. Immunology. 331-331.
  • Vis forfatter(e) (2012). Comparison of different protocols for the generation of monocytes-derived tolerogenic dendritic cells for immunotherapy. Immunology. 679-679.
  • Vis forfatter(e) (2011). The Epithelial Specific Transcription Factor ESE-3 is Expressed in Immature Dendritic Cells and Occurs Primarily as the ESE-3b Isoform. Scandinavian Journal of Immunology. 366-366.
  • Vis forfatter(e) (2011). Maturation of Dendritic Cells with the Bacterial Compound OK432 Induces High Secretion of IL-12p70 in a TLR3 Dependent Manner. Scandinavian Journal of Immunology. 387-388.
  • Vis forfatter(e) (2011). Generation of Tolerogenic Monocyte-Derived Dendritic Cells. Scandinavian Journal of Immunology. 378-379.
  • Vis forfatter(e) (2011). Can Levels of Blood Plasmacytoid Dendritic Cells be used as a Prognostic Factor for Development of Squamous Cell Carcinomas in Organ Transplant Recipients? Scandinavian Journal of Immunology. 394-394.
  • Vis forfatter(e) (2010). Patients with Primary Sjogren's Syndrome have Significantly Reduced Amounts of Plasmacytoid and Type 2 Myeloid Dendritic Cells in Peripheral Blood. Scandinavian Journal of Immunology. 479-479.
  • Vis forfatter(e) (2010). Maturation of Monocyte Derived Dendritic Cells With OK432 Leads to Altered Expression of Surface Markers. Scandinavian Journal of Immunology. 504-504.
  • Vis forfatter(e) (2010). Gene Variants in Fam167A-Blk and Tnfsf4 are associated with Primary Sjogren's Syndrome. Scandinavian Journal of Rheumatology. 32-32.
  • Vis forfatter(e) (2010). Fc gamma receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fc gamma receptor IIIB copy number variation: No association with primary Sjögren's syndrome. Scandinavian Journal of Rheumatology. 36-36.
  • Vis forfatter(e) (2010). Dendritic cell populations in patients with self-reported food hypersensitivity. Gut. A394.
  • Vis forfatter(e) (2010). Bromelain Treatment Leads to Maturation of Monocyte Derived Dendritic Cells. Scandinavian Journal of Immunology. 506-507.
  • Vis forfatter(e) (2008). Maturation of monocyte derived dendritic cells with OK432 leads to altered expression of surface markers. Scandinavian Journal of Immunology. 217-217.
  • Vis forfatter(e) (2008). Characterization of Gene p306 Expressed in Monocyte Derived Dendritic Cells. Blood. 891-891.
  • Vis forfatter(e) (2008). Age-related distribution of cDC and pDC in salivary glands of NOD mice. Scandinavian Journal of Immunology. 206-207.
Poster
  • Vis forfatter(e) (2009). Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome.
  • Vis forfatter(e) (2009). Fc receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fc receptor IIIB copy number variation: No association with primary Sjögren’s syndrome.
  • Vis forfatter(e) (2009). Dendritic cells from patients with primary Sjögren's syndrome have slightly enhanced endocytic capacity.
  • Vis forfatter(e) (2009). Association of C8orf13-BLK and TNFSF4 Gene Variants with Primary Sjögren's Syndrome.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) (2020). The TNF/IL-23/IL-17 axis-Head-to-head trials comparing different biologics in psoriasis treatment. Scandinavian Journal of Immunology.
  • Vis forfatter(e) (2020). Current knowledge on autoantigens and autoantibodies in psoriasis. Scandinavian Journal of Immunology.
  • Vis forfatter(e) (2013). Current status and future perspectives of dendritic cell-based cancer immunotherapy. Scandinavian Journal of Immunology. 167-171.
  • Vis forfatter(e) (2012). The 2011 Nobel Prize in physiology or medicine. Scandinavian Journal of Immunology. 1-4.
  • Vis forfatter(e) (2011). The complexity of Sjögren's syndrome: Novel aspects on pathogenesis. Immunology Letters. 1-9.
  • Vis forfatter(e) (2006). Role of dendritic cells in Sjögren´s syndrome. Scandinavian Journal of Immunology. 219-226.

Se fullstendig oversikt over publikasjoner i CRIStin.

Kompetansefelt 
Immunologi
Dendrittiske celler
Autoimmunitet
Sjögrens syndrom

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