- E-postSimona.Chera@uib.no
- BesøksadresseHaukelandsbakken 15Glasblokkene5021 BergenRom6110, 6th floor
- PostadressePostboks 78045020 Bergen
Simona Chera fullførte sin PhD ved the Department of Genetics and Evolution, at the Faculty of Science, University of Geneva, i 2008, hvor hun studerte mekanismer som er involvert i regnerasjon. Etterfølgende, arbeidet hun som postdoktor i i Prof. Pedro Herreras lab i Geneve, hvor arbeidet dreide seg om identifisering av mekanisme involvert i spontan regenerering av insulin produserende β-celler. (Thorel et al. 2010, Nature and Chera et al. 2014, Nature).
I mars 2015 flyttet Chera til bergen, hvor hun fortsatte arbeidet som postdoktor i labgruppen til Prof. Helge Ræder. Her forsket hun på differensiering av β-celler fra pluripotente stam-celler fra patienter med Mature Onset Diabetes of the Young (MODY). Nå er hun Førsteamanuensis ved Klinisk institutt, UiB og NCMM Young associate Investigator.
Hovedfokuset gjennom hennes karriere har vært å karakterisere cellulære og molekylære signaler som regulerer balansen mellom regeneration og homeostase i vev. Dette arbeidet har resultert i flere publikasjoner
Utvalgte publikasjoner
- 2019. Tissue repair brakes: A common paradigm in the biology of regeneration: Concise review. Stem Cells. 38: 330-339. doi: 10.1002/stem.3118
- 2019. Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. Nature. 567: 43-48. doi: 10.1038/s41586-019-0942-8
- 2018. Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells. Nature Cell Biology. 20: 1267-1277. doi: 10.1038/s41556-018-0216-y
- 2016. Regeneration of pancreatic insulin-producing cells by in situ adaptive cell conversion. Current Opinion in Genetics and Development. 40: 1-10. doi: 10.1016/j.gde.2016.05.010
Vitenskapelig artikkel
- (2024). Targeted Gene Silencing by Using GapmeRs in Differentiating Human-Induced Pluripotent Stem Cells (hiPSC) Toward Pancreatic Progenitors. Methods in molecular biology. 23-38.
- (2024). Glucose Concentration in Regulating Induced Pluripotent Stem Cells Differentiation Toward Insulin-Producing Cells. Transplant International.
- (2023). Modulation of Unfolded Protein Response Restores Survival and Function of β-Cells Exposed to the Endocrine Disruptor Bisphenol A. International Journal of Molecular Sciences.
- (2023). Global proteomics reveals insulin abundance as a marker of human islet homeostasis alterations. Acta Physiologica. 15 sider.
- (2023). Circadian organization of lipid landscape is perturbed in type 2 diabetic patients. Cell Reports Medicine.
- (2022). Type 2 diabetes disrupts circadian orchestration of lipid metabolism and membrane fluidity in human pancreatic islets. PLoS Biology. 28 sider.
- (2022). Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells. Diabetes. 862-869.
- (2022). Mapping Proteome Changes in Microsatellite Stable, Recurrent Colon Cancer Reveals a Significant Immune System Signature. Cancer Genomics & Proteomics. 130-144.
- (2022). Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes. Scientific Reports.
- (2021). Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss. BMC Genomics.
- (2021). Chronically elevated exogenous glucose elicits antipodal effects on the proteome signature of differentiating human ipsc-derived pancreatic progenitors. International Journal of Molecular Sciences.
- (2021). A Method for Encapsulation and Transplantation into Diabetic Mice of Human Induced Pluripotent Stem Cells (hiPSC)-Derived Pancreatic Progenitors. Methods in molecular biology.
- (2020). The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas. Genes & Development. 1650-1665.
- (2020). In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism. Frontiers in Cell and Developmental Biology. 1-14.
- (2020). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling . Scientific Reports. 1-16.
- (2020). Bioinformatic analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4α mutation. Biomedicines. 1-20.
- (2019). The effect of WnT pathway modulators on human iPSC-derived pancreatic beta cell maturation. Frontiers in Endocrinology. 1-13.
- (2019). Reprogrammed cells display distinct proteomic signaturesAssociated with colony morphology variability. Stem Cells International. 1-16.
- (2019). In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. Acta Physiologica. 1-16.
- (2019). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. bioRxiv.
- (2019). Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. Nature. 43-48.
- (2018). Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells. Nature Cell Biology. 1267-1277.
- (2018). Novel protein signatures suggest progression to muscular invasiveness in bladder cancer. PLOS ONE. 1-15.
- (2017). Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells. Scientific Reports. 1-14.
- (2017). Converting adult pancreatic islet α cells into β cells by targeting both Dnmt1 and Arx. Cell Metabolism. 622-634.
Faglig foredrag
- (2023). The beta cell in ageing.
- (2023). Mapping master regulators of regeneration rhythms in the pancreatic islet.
- (2023). Hnf1a Is An Important Regulator in Ageing And Maturation Of Pancreatic Islets.
- (2023). Exploring the role of transcription factors HNF1A, HNF1B, and HNF4A in human pancreatic islet cell differentiation.
- (2023). Exploring the role of transcription factors HNF1A, HNF1B, and HNF4A in human induced pluripotent stem cell-derived pancreatic islet cell differentiation.
- (2022). Using patient-derived iPSC multi-omics to demultiplex pancreatic islet cell fate confinement.
- (2022). Regeneration, Rhythms, Regulators.
- (2022). Mammalian Regeneration Rhythms.
- (2022). Investigating islet cell-fate dynamic during in vitro differentiation.
- (2022). Investigating islet cell plasticity dynamics by exploiting monogenic diabetes contexts.
- (2022). Beta to alpha cells and back.
- (2022). And some that die deserve life: in vivo mechanisms regulating cell identity during beta-cell decay and regeneration.
- (2021). Using patient-derived iPSC to demultiplex cell fate confinement.
Vitenskapelig foredrag
- (2023). Islet maturation and ageing is governed by the Hnf1a transcription factor.
- (2022). Mapping Master Regulators of Regeneration Rhythms.
- (2021). Mapping cell identity shifts in the adult pancreatic islet .
- (2021). Islet cell identity and diabetes development.
Leder
- (2023). Stem cells: The cell that does it all. Current Biology.
- (2022). Editorial: Beta-Cell Fate: From Gene Circuits to Disease Mechanisms. Frontiers in Genetics.
Populærvitenskapelig artikkel
- (2021). Islet transplantation tolerance in animals with defined histocompatibility and diabetes. bioRxiv.
Sammendrag/abstract
- (2021). 402.2: High Glucose Concentration Increases KATP Channel Activity but Suppresses Mitochondrial Respiration Ability in Insulin-producing Cells Regenerated From Stem Cells. Transplantation. S27-S27.
Poster
- (2023). Mapping predictive bladder cancer signatures in a mouse model.
- (2023). Mapping islet architecture changes upon high fat diet challenge in a HNF1A-MODY mouse model.
- (2023). Investigating the developmental role of HNF1A, HNF1B and HNF4A in human pancreatic islet cell differentiation.
- (2023). Human induced pluripotent stem cells as a model for environmental impact on diabetes.
- (2022). Molecular mechanisms affecting islet like cell fate acquisition in differentiating iPSC derived β-like cells”.
- (2022). Mind your background!
- (2022). Know your background, know your data.
- (2022). Investigating the developmental role of HNF1A, HNF1B and HNF4A in human pancreatic islet cell differentiation.
- (2022). Investigating the developmental role of HNF1A in human pancreatic islet cell differentiation.
- (2022). Hnf1a is a key regulator of β-cell identity and function.
- (2021). Glucose during in vitro pancreatic beta cells regeneration: friends or for?
Vitenskapelig oversiktsartikkel/review
- (2019). Tissue repair brakes: A common paradigm in the biology of regeneration: Concise review. Stem Cells. 330-339.
- (2016). Stress-induced adaptive islet cell identity changes. Diabetes, obesity and metabolism. 87-96.
- (2016). Regeneration of pancreatic insulin-producing cells by in situ adaptive cell conversion. Current Opinion in Genetics and Development. 1-10.
Se fullstendig oversikt over publikasjoner i CRIStin.
Selected publications:
- Legøy TA*, Vethe H*, Abadpour S, Strand BL, Scholz H, Paulo JA, Ræder H, Ghila L, Chera S. Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signaling. Scientific Reports 2020 Jan 15;10(1):414. doi: 10.1038/s41598-019-57305-x [BioRxiv 2019 Oct 04, preprint doi: 10.1101/791442]
- Legøy TA, Mathisen AF, Salim Z, Vethe H, Bjørlykke Y, Abadpour S, Paulo JA, Scholz H, Raeder H, Ghila L, Chera S. In vivo Environment Swiftly Restricts Human Pancreatic Progenitors Toward Mono-Hormonal Identity via a HNF1A/HNF4A Mechanism. Frontiers in Cell and Developmental Biology 2020 Feb 25;8:109. eCollection 2020. doi: 10.3389/fcell.2020.00109
- Legøy TA, Ghila L, Vethe H, Abadpour S, Mathisen AF, Paulo JA, Scholz H, Raeder H, Chera S. In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. Acta Physiologica (Oxf) 2020 Apr;228(4):e13433. Epub 2020 Jan 8. doi: 10.1111/apha.13433. PMID:31872528