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Simona Cheras bilde

Simona Chera

Professor, NCMM Young Associate Investigator
  • E-postSimona.Chera@uib.no
  • Telefon+47 55 97 12 62
  • Besøksadresse
    Haukelandsbakken 15
    Glasblokkene
    5021 Bergen
    Rom 
    6110, 6th floor
  • Postadresse
    Postboks 7804
    5020 Bergen

Simona Chera fullførte sin PhD ved the Department of Genetics and Evolution, at the Faculty of Science, University of Geneva, i 2008, hvor hun studerte mekanismer som er involvert i regnerasjon. Etterfølgende, arbeidet hun som postdoktor i i Prof. Pedro Herreras lab i Geneve, hvor arbeidet dreide seg om identifisering av mekanisme involvert i spontan regenerering av insulin produserende β-celler. (Thorel et al. 2010, Nature and Chera et al. 2014, Nature). 

I mars 2015 flyttet Chera til bergen, hvor hun fortsatte arbeidet som postdoktor i labgruppen til Prof. Helge Ræder. Her forsket hun på differensiering av β-celler fra pluripotente stam-celler fra patienter med Mature Onset Diabetes of the Young (MODY). Nå er hun Førsteamanuensis ved Klinisk institutt, UiB og NCMM Young associate Investigator. 

 

Hovedfokuset gjennom hennes karriere har vært å karakterisere cellulære og molekylære signaler som regulerer balansen mellom regeneration og homeostase i vev. Dette arbeidet har resultert i flere publikasjoner

Utvalgte publikasjoner
  • Cigliola, Valentina; Ghila, Luiza; Chera, Simona; Herrera, Pedro L. 2019. Tissue repair brakes: A common paradigm in the biology of regeneration: Concise review. Stem Cells. 38: 330-339. doi: 10.1002/stem.3118
  • Furuyama, Kenichiro; Chera, Simona; van Gurp, Leon; Oropeza, Daniel; Ghila, Luiza; Damond, Nicolas; Vethe, Heidrun; Paulo, Joao A.; Joosten, Antoinette M.; Berney, Thierry; Bosco, Domenico; Dorrell, Craig; Grompe, Markus; Ræder, Helge; Roep, Bart O.; Thorel, Fabrizio; Herrera, Pedro L. 2019. Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. Nature. 567: 43-48. doi: 10.1038/s41586-019-0942-8
  • Cigliola, Valentina; Ghila, Luiza; Thorel, Fabrizio; van Gurp, Leon; Baronnier, Delphine; Oropeza, Daniel; Gupta, Simone; Miyatsuka, Takeshi; Kaneto, Hideaki; Magnuson, Mark A; Osipovich, Anna B; Sander, Maike; Wright, Christopher EV; Thomas, Melissa K; Furuyama, Kenichiro; Chera, Simona; Herrera, Pedro L. 2018. Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells. Nature Cell Biology. 20: 1267-1277. doi: 10.1038/s41556-018-0216-y
  • Chera, Simona; Herrera, Pedro L. 2016. Regeneration of pancreatic insulin-producing cells by in situ adaptive cell conversion. Current Opinion in Genetics and Development. 40: 1-10. doi: 10.1016/j.gde.2016.05.010
Vitenskapelig artikkel
  • Vis forfatter(e) 2021. Chronically elevated exogenous glucose elicits antipodal effects on the proteome signature of differentiating human ipsc-derived pancreatic progenitors. International Journal of Molecular Sciences.
  • Vis forfatter(e) 2021. A Method for Encapsulation and Transplantation into Diabetic Mice of Human Induced Pluripotent Stem Cells (hiPSC)-Derived Pancreatic Progenitors. Methods in molecular biology.
  • Vis forfatter(e) 2020. The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas. Genes & Development. 1650-1665.
  • Vis forfatter(e) 2020. In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism. Frontiers in Cell and Developmental Biology. 1-14.
  • Vis forfatter(e) 2020. Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling . Scientific Reports. 1-16.
  • Vis forfatter(e) 2020. Bioinformatic analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4α mutation. Biomedicines. 1-20.
  • Vis forfatter(e) 2019. The effect of WnT pathway modulators on human iPSC-derived pancreatic beta cell maturation. Frontiers in Endocrinology. 1-13.
  • Vis forfatter(e) 2019. Reprogrammed cells display distinct proteomic signaturesAssociated with colony morphology variability. Stem Cells International. 1-16.
  • Vis forfatter(e) 2019. In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. Acta Physiologica. 1-16.
  • Vis forfatter(e) 2019. Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. bioRxiv - the preprint server for biology.
  • Vis forfatter(e) 2019. Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. Nature. 43-48.
  • Vis forfatter(e) 2018. Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells. Nature Cell Biology. 1267-1277.
  • Vis forfatter(e) 2018. Novel protein signatures suggest progression to muscular invasiveness in bladder cancer. PLOS ONE. 1-15.
  • Vis forfatter(e) 2017. Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells. Scientific Reports. 1-14.
  • Vis forfatter(e) 2017. Converting adult pancreatic islet α cells into β cells by targeting both Dnmt1 and Arx. Cell Metabolism. 622-634.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) 2019. Tissue repair brakes: A common paradigm in the biology of regeneration: Concise review. Stem Cells. 330-339.
  • Vis forfatter(e) 2016. Stress-induced adaptive islet cell identity changes. Diabetes, obesity and metabolism. 87-96.
  • Vis forfatter(e) 2016. Regeneration of pancreatic insulin-producing cells by in situ adaptive cell conversion. Current Opinion in Genetics and Development. 1-10.

Se fullstendig oversikt over publikasjoner i CRIStin.

Selected publications:

  1. Legøy TA*, Vethe H*, Abadpour S, Strand BL, Scholz H, Paulo JA, Ræder H, Ghila LChera S. Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signaling. Scientific Reports 2020 Jan 15;10(1):414. doi: 10.1038/s41598-019-57305-x [BioRxiv 2019 Oct 04, preprint doi: 10.1101/791442]
  2. Legøy TA, Mathisen AF, Salim Z, Vethe H, Bjørlykke Y, Abadpour S, Paulo JA, Scholz H, Raeder H, Ghila L, Chera S. In vivo Environment Swiftly Restricts Human Pancreatic Progenitors Toward Mono-Hormonal Identity via a HNF1A/HNF4A Mechanism. Frontiers in Cell and Developmental Biology 2020 Feb 25;8:109. eCollection 2020. doi: 10.3389/fcell.2020.00109
  3. Legøy TA, Ghila L, Vethe H, Abadpour S, Mathisen AF, Paulo JA, Scholz H, Raeder H, Chera S. In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. Acta Physiologica (Oxf) 2020 Apr;228(4):e13433. Epub 2020 Jan 8. doi: 10.1111/apha.13433. PMID:31872528

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