Hjem
Spiros Kotopouliss bilde

Spiros Kotopoulis

Førsteamanuensis
  • E-postSpiros.Kotopoulis@uib.no
  • Telefon+47 450 80 085
  • Besøksadresse
    Haukeland Universitetssykehus Laboratoriebygget, 7. etg. Heis øst
  • Postadresse
    Postboks 7804
    5020 Bergen
Vitenskapelig artikkel
  • Bjånes, Tormod Karlsen; Kotopoulis, Spiros; Murvold, Elsa Thodesen; Kamceva, Tina; Gjertsen, Bjørn Tore; Gilja, Odd Helge; Schjøtt, Jan; Riedel, Bettina; McCormack, Emmet. 2020. Ultrasound‐ and Microbubble‐Assisted Gemcitabine Delivery to Pancreatic Cancer Cells. Pharmaceutics. 1-15.
  • Castle, Jason; Kotopoulis, Spiros; Forsberg, Flemming. 2020. Sonoporation for augmenting chemotherapy of pancreatic ductal adenocarcinoma. Methods in molecular biology. 191-205.
  • Bjånes, Tormod Karlsen; Jordheim, Lars Petter; Schjøtt, Jan; Kamceva, Tina; Cros-Perrial, Emeline; Langer, Anika; Ruiz de Garibay, Gorka; Kotopoulis, Spiros; McCormack, Emmet; Riedel, Bettina. 2020. Intracellular cytidine deaminase regulates gemcitabine metabolism in pancreatic cancer cell lines. Drug Metabolism And Disposition. 153-158.
  • Haugse, Ragnhild; Langer, Anika; Gullaksen, Stein-Erik; Sundøy, Silje Maria; Gjertsen, Bjørn Tore; Kotopoulis, Spiros; Mc Cormack, Emmet. 2019. Intracellular signaling in key pathways is induced by treatment with ultrasound and microbubbles in a leukemia cell line, but not in healthy peripheral blood mononuclear cells. Pharmaceutics. 1-17.
  • Bush, Nigel; Healey, Andrew; Shah, Anant; Box, Gary; Kirkin, Vladimir; Kotopoulis, Spiros; Kvale, Svein; van Wamel, Annemieke; Davies, Catharina de Lange; Sontum, Per Chrisian; Bamber, Jeffrey. 2019. Acoustic Cluster Therapy displays theranostic capability in enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice. Proceedings - IEEE Ultrasonics Symposium. 224-226.
  • Kotopoulis, Spiros; Stigen, Endre; Popa, Mihaela Lucia; Mayoral Safont, Mireia; Healey, Andrew; Kvåle, Svein; Sontum, Per; Gjertsen, Bjørn Tore; Gilja, Odd Helge; McCormack, Emmet. 2017. Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma. Journal of Controlled Release. 70-80.
  • Retz, Kathinka; Kotopoulis, Spiros; Kiserud, Torvid; Matre, Knut; Eide, Geir Egil; Sande, Ragnar. 2017. Measured acoustic intensities for clinical diagnostic ultrasound transducers and correlation with thermal index. Ultrasound in Obstetrics and Gynecology. 236-241.
  • Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; McCormack, Emmet; Postema, Michiel; Gjertsen, Bjørn Tore; Gilja, Odd Helge. 2016. Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: a phase I clinical trial. Journal of the Acoustical Society of America. 2092-2092.
  • Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; Mc Cormack, Emmet; Postema, Michiel; Gjertsen, Bjørn Tore; Gilja, Odd Helge. 2016. Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: A phase I clinical trial. Journal of the Acoustical Society of America.
  • Retz, Asta Kathinka H; Kotopoulis, Spiros; Kiserud, Torvid; Matre, Knut; Eide, Geir Egil; Sande, Ragnar. 2016. Measured acoustic intensities for clinical diagnostic ultrasound transducers and correlation with thermal index. Ultrasound in Obstetrics and Gynecology. 236-241.
  • Johansen, Kristoffer; Kotopoulis, Spiros; Poortinga, Albert T.; Postema, Michiel. 2016. Harmonic antibubbles. Archives of Acoustics. 364-364.
  • Yddal, Torstein; Gilja, Odd Helge; Cochran, Sandy; Postema, Michiel; Kotopoulis, Spiros. 2016. Glass-windowed ultrasound transducers. Ultrasonics. 108-119.
  • Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Bjånes, Tormod Karlsen; Hoem, Dag; Schjøtt, Jan; Gjertsen, Bjørn Tore; Biermann, Martin; Molven, Anders; Sorbye, Halfdan; McCormack, Emmet; Postema, Michiel; Gilja, Odd Helge. 2016. A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer. Journal of Controlled Release. 172-181.
  • Johansen, Kristoffer; Kotopoulis, Spiros; Postema, Michiel. 2015. Ultrasonically driven antibubbles encapsulated by Newtonian fluids for active leakage detection. Lecture Notes in Engineering and Computer Science. 750-754.
  • Yddal, Torstein; Cochran, Sandy; Gilja, Odd Helge; Postema, Michiel; Kotopoulis, Spiros. 2015. Open source, high throughput, ultrasound treatment chamber. Biomedizinische Technik. 77-87.
  • Johansen, Kristoffer; Kotopoulis, Spiros; Poortinga, Albert T.; Postema, Michiel. 2015. Nonlinear echoes from encapsulated antibubbles. Physics Procedia. 1079-1082.
  • Kotopoulis, Spiros; Johansen, Kristoffer; Gilja, Odd Helge; Poortinga, Albert T.; Postema, Michiel. 2015. Acoustically active antibubbles. Acta Physica Polonica. A. 99-102.
  • Yddal, Torstein; Kotopoulis, Spiros; Gilja, Odd Helge; Cochran, Sandy; Postema, Michiel. 2014. Transparent glass-windowed ultrasound transducers. IEEE International Ultrasonics Symposium Proceedings. 2079-2082.
  • Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; Gjertsen, Bjørn Tore; Gilja, Odd Helge; McCormack, Emmet ; Postema, Michiel. 2014. Sonoporation: from the lab to human clinical trials. IEEE International Ultrasonics Symposium Proceedings. 846-849.
  • Kotopoulis, Spiros; Delalande, Anthony; Popa, Mihaela Lucia; Mamaeva, Veronika; Dimcevski, Georg Gjorgji; Gilja, Odd Helge; Postema, Michiel; Gjertsen, Bjørn Tore; McCormack, Emmet. 2014. Sonoporation-enhanced chemotherapy significantly reduces primary tumour burden in an orthotopic pancreatic cancer xenograft. Molecular Imaging and Biology. 53-62.
  • Kotopoulis, Spiros; Haugse, Ragnhild; Mujic, Maja; Sulen, Andre; Gullaksen, Stein-Erik; McCormack, Emmet ; Gilja, Odd Helge; Postema, Michiel; Gjertsen, Bjørn Tore. 2014. Evaluation of the effects of clinical diagnostic ultrasound in combination with ultrasound contrast agents on cell stress: Single cell analysis of intracellular phospho-signaling pathways in blood cancer cells and normal blood leukocytes. IEEE International Ultrasonics Symposium Proceedings. 1186-1190.
  • Johansen, Kristoffer; Yddal, Torstein; Kotopoulis, Spiros; Postema, Michiel. 2014. Acoustic filtering of particles in a flow regime. IEEE International Ultrasonics Symposium Proceedings. 1436-1439.
  • Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; Gilja, Odd Helge; Hoem, Dag; Postema, Michiel. 2013. Treatment of human pancreatic cancer using combined ultrasound, microbubbles, and gemcitabine: a clinical case study. Medical Physics (Lancaster).
  • Kotopoulis, Spiros; Eder, Sabrina Daniela; Greve, Martin Møller; Holst, Bodil; Postema, Michiel. 2013. Lab-on-a-chip device for fabrication of therapeutic microbubbles on demand. Biomedizinische Technik. 2 sider.
  • Viola, Ivan; Birkeland, Åsmund; Šoltészová, Veronika; Helljesen, Linn Emilie Sævil; Hauser, Helwig; Kotopoulis, Spiros; Nylund, Kim; Ulvang, Dag Magne; Øye, Ola Kristoffer; Hausken, Trygve; Gilja, Odd Helge. 2013. High-quality 3D visualization of in-situ ultrasonography. Eurographics. 1-4.
  • Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal; Postema, Michiel. 2012. Real-time sonoporation through HeLa cells. AIP Conference Proceedings. 272-275.
  • Kotopoulis, Spiros; Wang, Han; Cochran, Sandy; Postema, Michiel. 2012. High-frequency transducer for MR-guided FUS. Biomedizinische Technik.
  • Delalande, Anthony; Bouakaz, Ayache; Renault, Gilles; Tabareau, Flore; Kotopoulis, Spiros; Midoux, Patrick; Arbelle, Brigitte; Uzbekov, Rustem; Chakravarti, Shukti; Postema, Michiel; Pichon, Chantal. 2011. Ultrasound and microbubbles assisted gene delivery in Achilles tendons: long lasting gene expression and restoration of fibromodulin KO phenotype. Journal of Controlled Release. 223-230.
  • Delalande, Anthony; Kotopoulis, Spiros; Rovers, Tijs; Pichon, Chantal; Postema, Michiel. 2011. Sonoporation at a low mechanical index. Bubble Science, Engineering and Technology. 3-11.
  • Delalande, Anthony; Kotopoulis, Spiros; Pichon, Chantal; Postema, Michiel. 2011. Sonoporation at a low MI. Ultrasound in Medicine and Biology. S61-S61.
  • Kotopoulis, Spiros; Wang, Han; Cochran, Sandy; Postema, Michiel. 2011. Lithium niobate transducers for MRI-guided ultrasonic microsurgery. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control. 1570-1576.
  • Gerold, Bjoern; Kotopoulis, Spiros; McDougall, Craig; McGloin, David; Postema, Michiel; Prentice, Paul. 2011. Laser-nucleated acoustic cavitation in focused ultrasound. Review of Scientific Instruments. 9 sider.
  • Kotopoulis, Spiros; Postema, Michiel. 2010. Microfoam formation in a capillary. Ultrasonics. 260-268.
  • Kotopoulis, Spiros; Wang, Han; Cochran, Sandy; Postema, Michiel. 2010. Lithium niobate ultrasound transducers for high-resolution focused ultrasound surgery. IEEE International Ultrasonics Symposium Proceedings. 72-75.
  • Kotopoulis, Spiros; Schommartz, Antje; Postema, Michiel. 2009. Sonic cracking of blue-green algae. Applied Acoustics. 1306-1312.
  • Kotopoulis, Spiros; Schommartz, Antje; Postema, Michiel. 2008. Safety radius for algae eradication at 200 kHz - 2.5 MHz. IEEE International Ultrasonics Symposium Proceedings. 1706-1709.
Faglig foredrag
  • Bjånes, Tormod Karlsen; Schjøtt, Jan; Kotopoulis, Spiros; McCormack, Emmet; Riedel, Bettina. 2019. Sonoporation and gemcitabine delivery in pancreatic cancer cell lines.
Vitenskapelig foredrag
  • Kotopoulis, Spiros; Popa, Mihaela Lucia; Safont, MJ; Stigen, Endre; Healey, Andrew; Kvåle, Svein; Sontum, Per Chrisian; Gjertsen, Bjørn Tore; Gilja, Odd Helge; McCormack, Emmet. 2015. Sonoporation using Acoustic Cluster Therapy in combination With chemotherapy transiently reduces tumour volume.
Leder
  • Postema, Michiel; Kotopoulis, Spiros; Delalande, Anthony; Gilja, Odd Helge. 2012. Sonoporation: why microbubbles create pores. Ultraschall in der Medizin. 97-98.
Oppslagsverk
  • Kotopoulis, Spiros; Delalande, Anthony; Godø, Olav Rune; Postema, Michiel. 2012. Micro-acoustics in marine and medical research.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
  • Søvig, Karoline Kjellsdotter; Kotopoulis, Spiros; Nylund, Kim; Hausken, Trygve; Gilja, Odd Helge; Dimcevski, Georg Gjorgji. 2015. Volume estimation of the Gallbladder - 2D vs 3D Ultrasound. 2 sider.
  • Johansen, Kristoffer; Kotopoulis, Spiros; Postema, Michiel. 2015. Ultrasonically driven antibubbles encapsulated by Newtonian fluids for active leakage detection.
  • Kotopoulis, Spiros; Popa, Mihaela Lucia; Safont, MJ; Stigen, Endre; Healey, Andrew; Kvåle, Svein; Sontum, Per Chrisian; Gjertsen, Bjørn Tore; Gilja, Odd Helge; McCormack, Emmet. 2015. Sonoporation using Acoustic Cluster Therapy in combination With chemotherapy transiently reduces tumour volume. 1 sider.
  • Kotopoulis, Spiros; Wang, Han; Yddal, Torstein; Cochran, Sandy; Gilja, Odd Helge; Postema, Michiel. 2015. Novel multipurpose, low cost, modular, ultrasound transducers. 2 sider.
  • Johansen, Kristoffer; Kotopoulis, Spiros; Postema, Michiel. 2015. Introduction to antibubbles.
  • Johansen, Kristoffer; Kotopoulis, Spiros; Poortinga, Albert T.; Postema, Michiel. 2015. Antibubbles. 1 sider.
  • Johansen, Kristoffer; Kotopoulis, Spiros; Postema, Michiel. 2015. Active leakage detection by searching for antibubbles. 2 sider.
  • Kotopoulis, Spiros; Johansen, Kristoffer; Poortinga, Albert; Gilja, Odd Helge; Postema, Michiel. 2014. Acoustically active antibubbles for ultrasound imaging and targeted drug delivery.
  • Kotopoulis, Spiros; Postema, Michiel. 2013. Using ultrasound to separate oil, gas, and water.
  • Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Hoem, Dag; Postema, Michiel; Gjertsen, Bjørn Tore; Bjånes, Tormod Karlsen; Biermann, Martin; Mccormack, Emmet Martin; Sorbye, Halfdan; Molven, Anders; Gilja, Odd Helge. 2013. Ultrasound-assisted treatment of an inoperable pancreatic cancer.
  • Mujic, Maja; Haugse, Ragnhild; Kotopoulis, Spiros; Sulen, Andre; Gilja, Odd Helge; Postema, Michiel; Gjertsen, Bjørn Tore. 2013. Ultrasound combined with microbubbles modulates signal transduction pathways in blood cells.
  • Kotopoulis, Spiros; Delalande, Anthony; Popa, Mihaela; Dimcevski, Georg Gjorgji; Gilja, Odd Helge; Postema, Michiel; Gjertsen, Bjørn Tore; McCormack, Emmet Martin. 2013. Ultrasound and microbubble enhanced therapy of orthotopic human pancreatic cancer in mice.
  • Kotopoulis, Spiros; Haugse, Ragnhild; Postema, Michiel. 2013. Sonoporation: the hurdles that need to be surpassed.
  • Delalande, Anthony; Kotopoulis, Spiros; Midoux, Patrick; Postema, Michiel; Pichon, Chantal. 2012. Ultrasound and microbubble-assisted gene delivery: insights for intracellular mechanism.
  • Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal; Postema, Michiel. 2012. Sonoporation: using ultrasound for targeted drug delivery.
  • Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal; Postema, Michiel. 2012. Real-time sonoporation through HeLa cells. 4 sider.
  • Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal; Postema, Michiel. 2012. Nonlinear microbubble behaviour for enhanced drug uptake.
  • Delalande, Anthony; Kotopoulis, Spiros; Pichon, Chantal; Gjertsen, Bjørn Tore; Postema, Michiel. 2012. Microbubbles and cell interactions.
  • Gerold, Bjoern; Kotopoulis, Spiros; Cochran, Sandy; Postema, Michiel; Prentice, Paul. 2012. Hybrid laser-ultrasound cavitation for cloud evolution studies.
  • Mujic, Maja; Kotopoulis, Spiros; Delalande, Anthony; Enger, Marianne; Gilja, Odd Helge; McCormack, Emmet Martin; Postema, Michiel; Gjertsen, Bjørn Tore. 2012. Flow cytometic characterization and sorting of ultrasound contrast agents.
  • Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal; Postema, Michiel. 2012. Biological and medical applications of low-intensity ultrasound.
  • Postema, Michiel; Kotopoulis, Spiros; Jenderka, Klaus-Vitold. 2012. Basic Principles: Basic physical principles of medical ultrasound.
  • Postema, Michiel; Kotopoulis, Spiros; Delalande, Anthony; Gilja, Odd Helge. 2011. Ultrasound-guided delivery and sonoporation.
  • Kotopoulis, Spiros; Postema, Michiel; Cochran, Sandy. 2011. Ultrasound transducers made with lithium niobate for HF HIFU.
  • Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal; Postema, Michiel. 2011. On cells and sound.
  • Delalande, Anthony; Midoux, Patrick; Pichon, Chantal; Kotopoulis, Spiros; Postema, Michiel. 2011. Investigations of microbubble-cell interactions during the sonoporation process.
  • Delalande, Anthony; Kotopoulis, Spiros; Midoux, Patrick; Postema, Michiel; Pichon, Chantal. 2011. Cell-microbubble interaction and intracellular fate of plasmid DNA and microbubbles during the sonoporation process.
  • Delalande, Anthony; Kotopoulis, Spiros; Pichon, Chantal; Postema, Michiel. 2011. Cancer cell sonoporation at low acoustic amplitudes.
  • Kotopoulis, Spiros; Postema, Michiel. 2011. Biomedical ultrasonics, cavitation, and sonoporation.
  • Kotopoulis, Spiros; Postema, Michiel. 2010. Forming morphing microfoam.
Annet
  • Yddal, Torstein; Kotopoulis, Spiros; Gilja, Odd Helge; Postema, Michiel. 2014. Ultrasound transducers with an optical window.
Sammendrag/abstract
  • Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Bjånes, Tormod Karlsen; Hoem, Dag; Schjøtt, Jan; Gjertsen, Bjørn Tore; Biermann, Martin; Molven, Anders; Sorbye, Halfdan; McCormack, Emmet; Postema, Michiel; Gilja, Odd Helge. 2016. Ultrasound and microbubble enhanced treatment of inoperable pancreatic adeonocarcinoma. Journal of Clinical Oncology.
  • Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; Hoem, Dag; Postema, Michiel; Gilja, Odd Helge. 2015. Ultrasound sonoporation in pancreatic adenocarcinoma. Ultrasound in Medicine and Biology. S94-S94.
  • Kotopoulis, Spiros; Postema, Michiel. 2013. High-speed photography of encapsulated microbubbles. Abstract of Papers of the American Chemical Society. 1 sider.
  • Kotopoulis, Spiros; Postema, Michiel. 2011. Therapeutic ultrasound and sonoporation. Biomedizinische Technik. 1 sider.
Poster
  • Bjånes, Tormod Karlsen; Jordheim, Lars Petter; Schjøtt, Jan; Langer, Anika; de Garibay, Gorka Ruiz; Kotopoulis, Spiros; McCormack, Emmet; Riedel, Bettina. 2019. role of intracellular cytidine deaminase activity for gemcitabine metabolism in pancreatic cancer cell lines.
  • Thodesen, Elisa Ulvøen; Bjånes, Tormod Karlsen; Haugse, Ragnhild; Gilja, Odd Helge; Kotopoulis, Spiros; McCormack, Emmet. 2019. in vitro optimisation of sonoporation conditions in pancreatic cancer.
  • Bjånes, Tormod Karlsen; Thodesen, Elisa Ulvøen; Schjøtt, Jan; Kotopoulis, Spiros; Riedel, Bettina; McCormack, Emmet. 2019. Sonoporation and gemcitabine delivery in pancreatic cell lines.
  • Bjånes, Tormod Karlsen; Schjøtt, Jan; Kotopoulis, Spiros; McCormack, Emmet; Riedel, Bettina. 2019. Sonoporation and gemcitabine delivery in pancreatic cancer cell lines.
  • Haugse, Ragnhild; Langer, Anika; Sundøy, Silje Maria; Kotopoulis, Spiros; McCormack, Emmet. 2019. Molecular mechanisms of sonoporation in pancreatic ductal adenocarcinoma (PDAC).
  • Bjånes, Tormod Karlsen; Jordheim, Lars Petter; Schjøtt, Jan; Langer, Anika; Ruiz de Garibay, Gorka; Kotopoulis, Spiros; McCormack, Emmet; Riedel, Bettina. 2019. Intracellular cytidine deaminase and gemcitabine metabolism in three pancreatic cancer cell lines.
  • Bjånes, Tormod Karlsen; Jordheim, Lars Petter; Schjøtt, Jan; Langer, Anika; Ruiz de Garibay, Gorka; Kotopoulis, Spiros; McCormack, Emmet; Riedel, Bettina. 2019. Intracellular cytidine deaminase and gemcitabine metabolism in three pancreatic cancer cell lines.
  • Bush, Nigel; Healey, Andrew; Shah, Anant; Box, Gary; Kirkin, Vladimir; Kotopoulis, Spiros; Kvåle, Svein; van Wamel, Annemieke; Davies, Catharina de Lange; Sontum, Per-Christian; Bamber, Jeffrey. 2019. Acoustic Cluster Therapy displays theranostic capability in enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice.
  • Søvig, Karoline Kjellsdotter; Kotopoulis, Spiros; Nylund, Kim; Hausken, Trygve; Gilja, Odd Helge; Dimcevski, Georg Gjorgji. 2015. Volume estimation of the Gallbladder - 2D vs 3D Ultrasound.
Vitenskapelig oversiktsartikkel/review
  • Delalande, Anthony; Kotopoulis, Spiros; Postema, Michiel; Midoux, Patrick; Pichon, Chantal. 2013. Sonoporation: mechanistic insights and ongoing challenges for gene transfer. 191-199.
Innledning
  • Kotopoulis, Spiros; Delalande, Anthony; Godø, Olav Rune; Postema, Michiel. 2012. Preface.

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