- E-poststein.doskeland@uib.no
- BesøksadresseJonas Lies vei 915009 Bergen
- PostadressePostboks 78045020 Bergen
Vitenskapelig artikkel
- (2021). New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells. RSC Medicinal Chemistry. 767-778.
- (2020). The progression of acute myeloid leukemia from first diagnosis to chemoresistant relapse: A comparison of proteomic and phosphoproteomic profiles. Cancers. 1-13.
- (2020). Proteome and Phosphoproteome Changes Associated with Prognosis in Acute Myeloid Leukemia. Cancers.
- (2020). Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions. Acta Physiologica.
- (2020). Epac1 is crucial for maintenance of endothelial barrier function through a mechanism partly independent og Rac1. Cells.
- (2019). Proteome and phosphoproteome changes associated with prognosis in acute myeloid leukemia. bioRxiv.
- (2019). Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy. Scientific Reports. 1-17.
- (2019). Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis . eLIFE.
- (2019). A kinase inhibitor with anti-Pim kinase activity is a potent and selective cytotoxic agent toward acute myeloid leukemia. Molecular Cancer Therapeutics. 567-578.
- (2018). Preservation Method and Phosphate Buffered Saline Washing Affect the Acute Myeloid Leukemia Proteome. International Journal of Molecular Sciences. 1-11.
- (2018). Mathematical modelling of nitric oxide/cyclic GMP/cyclic AMP signalling in platelets. International Journal of Molecular Sciences. 1-21.
- (2018). Epac1−/− mice have elevated baseline permeability and do not respond to histamine as measured with dynamic contrast‐enhanced magnetic resonance imaging with contrast agents of different molecular weights. Acta Physiologica. 1-14.
- (2018). Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles. Journal of Enzyme Inhibition and Medicinal Chemistry. 370-375.
- (2018). Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice. PLOS ONE.
- (2017). Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives. Bioorganic & Medicinal Chemistry. 2285-2293.
- (2017). Increased microvascular permeability in mice lacking Epac1 (Rapgef3). Acta Physiologica. 441-452.
- (2017). Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. Scientific Reports. 1-15.
- (2016). Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling. Nutrition & Metabolism. 1-11.
- (2015). cAMP-dependent Protein Kinase A (PKA) - Mediated c-Myc degradation is dependent on the relative proportion of PKA-I and PKA-II isozymes. Molecular Pharmacology. 469-476.
- (2015). Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells. Bioorganic & Medicinal Chemistry. 7313-7323.
- (2015). Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds. Journal of Enzyme Inhibition and Medicinal Chemistry. 180-188.
- (2015). B56δ-related protein phosphatase 2A dysfunction identified in patients with intellectual disability. Journal of Clinical Investigation. 3051-3062.
- (2014). Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. Biochemical and Biophysical Research Communications - BBRC. 357-363.
- (2014). Performance of super-SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines. Proteomics. 1971-1976.
- (2014). New N-1,N-10 bridged pyrrolo[2,3-α]carbazole-3-carbaldehydes: synthesis and biological activities. Bioorganic chemistry (Print). 108-115.
- (2014). Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3. PLOS ONE.
- (2014). Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia. European journal of pharmaceutics and biopharmaceutics.
- (2014). Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells. Marine Drugs. 2036-2053.
- (2014). Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment. Applied Microbiology and Biotechnology. 603-610.
- (2014). 4-methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides. ACS Chemical Biology. 2646-2655.
- (2013). Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochemical and Biophysical Research Communications - BBRC. 603-608.
- (2013). Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. Marine Drugs. 332-349.
- (2013). Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen. BMC Cancer.
- (2013). DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms. PLOS ONE. 12 sider.
- (2013). Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. Cell Death & Disease.
- (2013). Activation of both protein kinase A (PKA) type I and PKA type II isozymes is required for retinoid-induced maturation of acute promyelocytic leukemia cells. Molecular Pharmacology. 1057-1065.
- (2012). The lipopeptide toxins Anabaenolysin A and B target biological membranes in a cholesterol-dependent manner. Biochimica et Biophysica Acta - Biomembranes. 3000-3009.
- (2012). Anabaenolysins, novel cytolytic lipopeptides from benthic anabaena cyanobacteria. PLOS ONE.
- (2012). Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells. PLOS ONE. 11 sider.
- (2011). The regulatory subunit of PKA-I remains partially structured and undergoes beta-aggregation upon thermal denaturation. PLOS ONE. 10 sider.
- (2011). The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity. Journal of Industrial Microbiology & Biotechnology. 489-501.
- (2011). Nostocyclopeptide-M1: A potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and 1B1. Molecular Pharmaceutics. 360-367.
- (2011). Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 8-19.
- (2011). Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription. Cell Death and Differentiation. 11 sider.
- (2010). UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity. PLOS ONE.
- (2010). UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity. PLOS ONE. 13 sider.
- (2010). Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes. Marine Drugs. 2659-2672.
- (2010). Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 7-18.
- (2010). Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR. Journal of Biological Chemistry. 14062-14070.
- (2010). A novel cyanobacterial nostocyclopeptide is a potent antitoxin against microcystins. ChemBioChem. 1594-1599.
- (2009). POSTMan (POST-translational modification analysis), a software application for PTM discovery. Proteomics. 1400-1406.
- (2009). Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity. Marine Drugs. 605-623.
- (2009). Epac-induced Alterations in the Proteome of Human SH-SY5Y Neuroblastoma Cells. Journal of Proteomics & Bioinformatics. 244-245.
- (2009). Biosynthesis of Macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit. Chemistry and Biology. 1109-1121.
- (2009). Acyloxymethyl esterification of Nodularin-R and Microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells. Journal of Medicinal Chemistry. 5758-5762.
- (2008). cAMP-dependent signaling regulates the adipogenic effect of n-6 polyunsaturated fatty acids. Journal of Biological Chemistry. 7196-7205.
- (2008). Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes. Molecular and Cellular Biology. 3804-3816.
- (2008). Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes. Journal of Biological Chemistry. 22723-22736.
- (2008). Abolition of stress-induced protein synthesis sensitizes leukemia cells to anthracycline-induced death. Blood. 2866-2877.
- (2007). LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro. Molecular Cancer.
- (2007). Cyclic adenosine 3 ',5 '-monophosphate(cAMP)-dependent protein kinases, but not exchange proteins directly activated by cAMP (Epac), mediate thyrotropin/cAMP-dependent regulation of thyroid cells. Endocrinology. 4612-4622.
- (2006). Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition. Journal of Biological Chemistry. 21500-21511.
- (2006). CaM-kinasell-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Cell Death and Differentiation. 1191-1202.
- (2005). Substrate enhances the sensitivity of type I protein kinase a to cAMP. Journal of Biological Chemistry. 13279-13284.
- (2005). Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast. Aquatic Toxicology. 294-306.
- (2005). A high proportion of Baltic Sea benthic cyanobacterial isolates contain apoptogens able to induce rapid death of isolated rat hepatocytes. Toxicon. 252-260.
- (2004). cAMP protects neutrophils against TNF?-induced apoptosis by activation of cAMP-dependent protein kinase, independently of exchange protein directly activated by cAMP (Epac). Journal of Leukocyte Biology. 641-647.
- (2004). Protein kinase A mediates inhibition of the thrombin-induced platelet shape change by nitric oxide. Blood. 2775-2782.
- (2004). Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis. Leukemia. 1989-1996.
- (2003). cAMP effector mechanisms. Novel twists for an "old" signaling system. FEBS Letters. 121-126.
- (2003). cAMP analog mapping of Epac1 and camp kinase: discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. Journal of Biological Chemistry. 35394-35402.
- (2003). Search for new cyclic AMP-binding proteins. FEBS Letters. 103-107.
- (2003). Mitochondrial-targeted fatty acid analog induces apoptosis with selective loss of mitochondrial glutathione in promyelocytic leukemia cells. Chemistry and Biology. 609-618.
- (2003). Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac. Journal of Biological Chemistry. 38548-38556.
- (2003). Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis. Molecular Biology of the Cell. 3292-3304.
- (2002). Use of marine toxins in combination with cytotoxic drugs for induction of apoptosis in acute myelogenous leukaemia cells. Expert Opinion on Biological Therapy. 197-210.
- (2002). Ca2+/calmodulin dependent protein kinase II is required for microcystin-induced apoptosis. Journal of Biological Chemistry. 2804-2811.
- (2002). Analysis of acute myelogenous leukemia: preparation of samples for genomic and proteomic analyses. Journal of Hematotherapy & Stem Cell Research. 469-481.
- (2002). A Novel Extraneuronal Role for Cylin-dependent Protein Kinase 5 (CDK5), Modulation of cAMP-induced apoptosis in rat leukemia cells. Journal of Biological Chemistry. 20783-20793.
- (2001). Establishment of okadaic acid resistant cell clones using a cDNA expression library. Cell Death and Differentiation. 754-766.
- (2001). Apoptotic effect of cyanobacterial extract on rat hepatocytes and human lymphocytes. Environmental Toxicology. 225-233.
- (2001). Apoptotic effect of cyanobacterial blooms collected from Polish water reservoirs. International Journal of Occupational Medicine and Environmental Health. 335-344.
- (2001). Alterations in platelet phospholipid metabolism by substances from a marine microalgae. Chemistry and Physics of Lipids. 139-140.
- (2000). Membrane permeant, bioactivatable analogues of cGMP as inducers of cell death in IPC-81 leukemia cells. Bioorganic & Medicinal Chemistry Letters. 571-573.
- (2000). Ectopic expression of Bcl-2 switches over nuclear signalling for cAMP-inducd apoptosis to granulocytic differentiation. Cell Death and Differentiation. 1081-1089.
- (2000). Apoptosemekanismen - mulige vinklinger for kreftbehandling. Tidsskrift for Den norske legeforening. 61.
- (2000). An ultrasensitive competitive binding assay for the detection of protein phosphatase directed toxins. Toxicon. 347-360.
- (2000). 8-Substituted cAMP analogues reveal marked differences in adaptability, hydrogen bonding, and charge accommodation between homologous binding sites (AI/AII and BI/BII) in cAMP kinase I and II. Biochemistry. 8803-8812.
- (1999). cAMP induces co-translational modification of proteins in IPC-81 cells. Biochemical Journal. 369-377.
- (1999). Ultrarapid apoptosis inducted by phosphatase inhibitors. Cell Death Differ. Cell Death and Differentiation. 1099-1108.
- (1999). An ultrasensitive competitive binding assay for the detection of toxins affecting protein phosphatases. Toxicon. 347-360.
- (1998). Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes. Toxicon. 1101-1114.
- (1998). Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inibited by Bcl-2. Cell Death and Differentiation. 660-668.
- (1998). A number of morphologically distinct types of regulated (apoptotic) cell death can be induced in leukemia cells, depending on the nature and intens the death-inducing agent. (invited review). Scanning microscopy.
- (1997). Transcriptional regulation of the bovine CYP17 gene by cAMP. Steroids. 43-45.
- (1997). Synergistic antiproliferative actions of cyclic adenosine 3',5'-monophosphate, interleukin-1beta, and activators of Ca%2%+/calmodulin-dependent protein kinase in primary hepatocytes. Endocrinology. 4373-4383.
- (1997). Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. Hepatology. 847-855.
- (1997). Fas/APO-1 (CD95)-Induced Apoptosis of Primary Hepatocytes Is Inhibited by cAMP. Biochemical and Biophysical Research Communications - BBRC. 20-25.
- (1996). Divergence towards a dead end? Cleavage of the divergent domains of ribosomal RNA in apoptosis. Experientia. 963-967.
- (1994). Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cells. Proc Nat Acad Sci U S A Biol Sci. 8428-8432.
- (1994). Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line. Journal of Cell Science, Supplement. 3363-3377.
- (1994). Cleaved intracellular plasminogen activator inhibitor-2 is a marker of apoptosis present in human myeloid leukemia cells. British Journal of Cancer. 834-840.
- (1994). Apoptotic Cell Death analyzed at the molecular level by two-dimensional gel electrophoresis. Electrophoresis. 503-510.
- (1994). (Rp)- and (Sp)-8-pideridino-cAMP@<S@> discriminate completely between site A and site B of the regulatory subunits of cAMP-dependent protein kinase type I and II. European Journal of Biochemistry (EJB). 1089-1094.
- (1994). (Rp)- and (Sp)-8-pideridino 3', 5'-(cyclic)thiophosphates discriminate completely between site A and site B of the regulatory subunits of cAMP-dependent protein kinase typeI and II. European Journal of Biochemistry (EJB). 1089-1094.
- (1993). The genetic subtypes of cAMP-dependent protein kinase - functionally different or redundant? Biochimica et Biophysica Acta. 249-258.
- (1993). Selective cleavage of 28S rRNA variable regions V3 and V13 in myeloid leukemia cell apoptosis. FEBS Letters. 16-20.
- (1993). Microinjected catalytic subunit of cAMP-dependent protein kinase induces apoptosis in myeloid leukemic (IPC-81) cells. Exp Cell Res. 157-161.
- (1993). Hepatocyte DNA replication is abolished by inhibitors selecting protein phosphatase 2A rather than phosphatase 1. Exp Cell Res. 293-301.
- (1993). Exogenous substrate stimulate autodephosphorylation of cyclic-AMP-dependent protein kinase II. Biochemical Journal. 497-503.
- (1993). Elevated cAMP gives short-term inhibition and long-term stimulation of hepatocyte DNA replication: Roles of the cAMP-dependent protein kinase subunits. Journal of Cellular Physiology. 160-170.
- (1993). Apoptotisk celledød. NBS-nytt. 6-12.
- (1993). Anti-apoptotic effect of heterozygously expressed mutant RI (Ala%3%3%6 ->Asp) subunit of cAMP-kinase I in a rat leukaemia cell line. Journal of Biological Chemistry. 8332-8340.
- (1992). cAmp-dependent protein kinase type I mediates the inhibitory effects of cAMP on cell replication in human T lymphocytes. Journal of Biological Chemistry. 15707-15714.
- (1992). Phenylatanine modulates positively the cAMP-dependant phosphorylation and modulates negatively the vasopressin-and okadeic acid-induced phosphorylation of phenylalanine 4-monoxygenase in intact rat hepatocytes. European Journal of Biochemistry (EJB). 161-170.
- (1992). Phenylalanine modulates differently the phosphorylation of phenylalanine 4-monooxygenase in intact rat hepatocytes exposed to cAMP and Ca2+-elevating agents. European Journal of Biochemistry (EJB). 161-170.
- (1992). Differential expression of cAMPkinase subunits is correlated with growth in rat mammary carcinmas and uterus. British Journal of Cancer. 1022-1029.
- (1992). Derivatives of 1-_b-D-ribofuranosylbenzimidazole 3',5'-phosphate that mimick the actions of adenosine 3',5'-phosphate (cAMP) and guanosine 3',5'phosphate (cGMP). Carbohydrate Research. 217-235.
- (1992). Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3',5'-cyclic adenosine monophosphate on cell replication in human T lymphocytes. Journal of Biological Chemistry. 15707-15714.
- (1991). The protein phosphatase inhibator okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Experimental Cell Research. 237-246.
- (1991). Supramolecular complexes of cAMP-dependent protein kinase isozymes in bovine adrenal cortex and medulla. Biochemical Society Transactions. 1163-1165.
- (1991). Restricted effusion of the type 2 isoform of cAMP dependent protein kinase in rat hepatocytes permabilized by digitonin. Biochemical Society Transactions. 1161-1162.
- (1991). Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate-kinase I in a myeloid leukemia cell line. Journal of Cellular Physiology. 73-80.
- (1991). Mutations that alter the charge of type I regulatory subunit and modify activation properties of cAMP-kinase from S49-mouse lymphoma cells. Journal of Biological Chemistry. 3547-3553.
- (1991). Hormonial activation of gene transcription in rat-transformed NIH 3T3 cells overexpressing the R2a and R2b subunits of the cAMP dependent protein kinase. Journal of Biological Chemistry. 23074-23082.
- (1991). High-molecular-mass complexes of the regulatory subunits of cyclic AMP-dependent protein kinase. Biochemical Society Transactions. 1163-1165.
- (1988). Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth. Proceedings of the National Academy of Sciences of the United States of America. 6319-6233.
Populærvitenskapelig foredrag
- (2002). Bioprospektering.
- (2002). Apoptose - kommersielle aspekter.
Vitenskapelig foredrag
- (2009). SMALL-RING MACROLACTAMS WITH ACYL SIDE CHAIN: NEW INSIGHTS INTO THE BIOSYNTHESIS AND ITS EVOLUTION.
- (2004). cAMP protects neutrophils against TNFa-induced apoptosis by activation of cAMP-dependent protein kinase (cA-PK), independently of exchange protein directly activated by cAMP (Epac).
- (2004). Development of a sensitive PP2A binding assay for microcystin and nodularin.
- (2003). cAMP-dependent protein kinase signaling. A potential drug target.
- (2003). cAMP induced protein phosphorylation in acute myelogenous leukemia cells.
- (2003). cAMP effector mechanisms. Novel twists for an "old" signalling system.
- (2003). Proteomics. Possibilities and role of PROBE unit.
- (2003). Protein kinases involved in leukemia cell apoptosis.
- (2003). PROBE. Progress report and visions for proteomics.
- (2003). Identification of phosphorylated targets in ultrarapidly induced apoptosis.
- (2003). Apoptosisd methodology. Clinical aspects.
- (2003). Apoptosis. mechanistic and clinical aspects.
- (2002). cAMP signalling related to apoptosis.
- (2002). cAMP protects neutrophils against TNF_-induced apoptosis by activation of cAMP-dependent protein kinase (cA-PK), independently of exchange protein directly activated by cAMP (Epac).
- (2002). cAMP and okadaic acid induced apoptosis.
- (2002). The cAMP-binding site of EPAC-1.
- (2002). Regulated cell death.
- (2002). New apoptosis-modulating substances from marine microalgae.
- (2002). Cyclin-dependent protein kinases and cell death.
- (2002). Cell death induced by natural compounds. The significance of distinct phenotypes.
- (2002). Bioactive compounds from cyanobacteria.
- (2002). Apoptose. Klinisk relevans og metodikk.
- (2001). Use of retroviral expression in the elucidation of PKA in cell signaling and apoptosis pathways.
- (2001). Establishment of Okadaic acid resistant cell clones using a cDNA expression library.
- (2001). Cell death in HeLa cells.
- (2001). 3-Thia fatty acid induces mitochondrial alterations and triggers apoptosis in cancer cells.
- (1998). Ultrarapid apoptosis induction in a variety of cell types injected with phosphatase inhibitors is mediated through Ca2 /calmodulin dependent protei kinase activity.
- (1998). Membranpermeable und bioaktivierbare Analoga von cGMP als Aktivatoren von Apoptosis in IPC-81 Leukämiezellen,.
- (1998). Marine cyanobacteria as a source for bioactive (apoptosis-modifying) compounds with potential as cell biology reagents and drugs.
- (1998). Distinct apoptotic death forms. Distinct pathways and functions?
- (1993). Signal-induced Apoptosis in Myeloid Leukemia. Apoptosis or Programmed Cell Death. From Basic Research to Clinical Application.
- (1993). "Cyclic AMP dependent protein kinase and phosphatase inhibitors induces different phenotypic forms of cell death.".
- (1989). Characterization and hormonal regulation of cAMP-dependent protein kinase in rat Sertoli cells.
Kronikk
- (1999). cAMP inhibits translation by inducing Ca2+/calmodulin-independent elongation factor 2 kinase activity in IPC-81 cells. FEBS Letters. 97-101.
- (1998). Injected cytochrome c induces apoptosis. Nature. 449-450.
Doktorgradsavhandling
- (2017). Exchange Proteins directly Activated by cAMP (Epac): Physiological roles and Regulation of expression .
- (2015). Cell death induction by free and encapsulated cancer drug candidates.
- (2007). New lessons from an "old" drug: A proteomic study of anthracycline-induced apoptosis in acute myelogenous leukemia.
- (1980). Binding proteins for cyclic AmP in mammalian tissues : some aspects of their interaction with cyclic AMP and their use in competitive binding assays for cyclic AMP.
Intervju
- (2002). Giftalger tar livet av kreftceller.
- (2002). Celledødsbødler fra havet.
- (2002). "Nobelprisen i Medisin 2002".
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
- (2009). Cyclic nucleotide analogs.
- (2007). Serine/Threonine Protein Phosphatases in Apoptosis. 16 sider.
- (2004). Cyclic Nucleotide Analogs as Tools to investigate Cyclic Nucleotide Signalling. 6 sider.
- (1996). Sensitive and rapid detection of B-galactosidase expression in intact cells by microinjection of fluorecent substrate.
- (1991). Criteria used to judge that a cellular response is mediated by cAMP. 12 sider.
Sammendrag/abstract
- (2013). Development and in vitro efficacy of liposomes carrying anthracyclines and emetine for enhanced therapeutic effect. The FEBS Journal. 322-322.
- (2012). Microvascular permeability in the absence of Epac1 activity. The FASEB Journal. 1 sider.
- (2008). Cyclic nucleotide analogs as probes for signaling pathways. Naunyn-Schmiedeberg's Archives of Pharmacology. 31-31.
- (2006). Camp-dependent protein kinase. European Journal of Pharmaceutical Sciences. S4-S5.
- (2006). A staurosporine story: Indolocarbazole orthoamides and fluorinated analogs of LY333531. European Journal of Pharmaceutical Sciences. S3-S3.
- (2006). 14-3-3 proteins as substrates for cAMP-dependent protein kinase. European Journal of Pharmaceutical Sciences. S27-S27.
Poster
- (2010). Liver specific transporters of microcystins as a tool to find novel inhibitors of OATP1B1 and OATP1B3.
- (2009). The biosynthesis of macrolactam BE-14106: a new way of generating an aminoacyl starter unit.
- (2007). Compartment modeling of nitric-oxide mediated activation of the cAMP-dependent protein kinase in platelets.
- (2003). Myeloid leukemia cell differentiation by bcl-2 and camp involves induction of ccaat/enhancer binding protein ? (c/ebp?), nuclear accumulation of c/ebp?, and direct interaction between bcl-2 and c/ebp?
- (2003). Differential Expression of Splicing factor SR proteins and Their phosphorylation in Cell Stress leading to Apoptosis.
- (2002). Protein phosphatase 2A as a receptor for diarrhetic shellfish poisoning (DSP) toxins- Development of a sensitive in vitro assay.
- (2002). Protein phosphatase 2A as a receptor for diarrhetic shellfish poisoning (DSP) toxins - development of a sensitive in vitro bioassay.
- (2002). Phosphorylated targets in ultrarapidly induced apoptosis.
- (2002). Comparison of the cAMP binding sites of EPAC-1 and cAMP-kinase. Development of a new compound selective for EPAC 1 activation.
- (2002). Comparison of the cAMP binding sites of EPAC-1 and cAMP-kinase.
- (2001). New apoptosis-modulating substances from marine microalgae.
- (2001). Establishment of Okadaic acid resistant cell clones using a cDNA expression library.
- (2001). Differential Affinities of C-subunit Isozymes of the cAMP-Dependent Protein Kinase for Pseudosubstrates and Substrates.
- (1997). Detedtion of toxins from marine cyanobacteria based on their affinity for protein phosphatase 2A and their ability to induce apoptosis in salmon hepatocytes.
- (1993). Morphometrical and morphological characterization of cell death induced by cAMP dependent protein kinase in rat myeloid leukemia cell line.
Vitenskapelig oversiktsartikkel/review
- (2015). Cell Death inducing microbial protein phosphatase inhibitors-mechanisms of action. Marine Drugs. 6505-6520.
- (2011). The cAMP-dependent protein kinase pathway as therapeutic target - possibilities and pitfalls. Current Topics in Medicinal Chemistry. 1393-1405.
- (2011). The 14-3-3 proteins in regulation of cellular metabolism. Seminars in Cell and Developmental Biology. 713-719.