Hjem
Stein Ove Døskelands bilde

Stein Ove Døskeland

Emeritus
  • E-poststein.doskeland@uib.no
  • Besøksadresse
    Jonas Lies vei 91
    5009 Bergen
  • Postadresse
    Postboks 7804
    5020 Bergen
Vitenskapelig artikkel
  • Vis forfatter(e) (2021). New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells. RSC Medicinal Chemistry. 767-778.
  • Vis forfatter(e) (2020). The progression of acute myeloid leukemia from first diagnosis to chemoresistant relapse: A comparison of proteomic and phosphoproteomic profiles. Cancers. 1-13.
  • Vis forfatter(e) (2020). Proteome and Phosphoproteome Changes Associated with Prognosis in Acute Myeloid Leukemia. Cancers.
  • Vis forfatter(e) (2020). Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions. Acta Physiologica.
  • Vis forfatter(e) (2020). Epac1 is crucial for maintenance of endothelial barrier function through a mechanism partly independent og Rac1. Cells.
  • Vis forfatter(e) (2019). Proteome and phosphoproteome changes associated with prognosis in acute myeloid leukemia. bioRxiv - the preprint server for biology.
  • Vis forfatter(e) (2019). Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy. Scientific Reports. 1-17.
  • Vis forfatter(e) (2019). Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis . eLIFE.
  • Vis forfatter(e) (2019). A kinase inhibitor with anti-Pim kinase activity is a potent and selective cytotoxic agent toward acute myeloid leukemia. Molecular Cancer Therapeutics. 567-578.
  • Vis forfatter(e) (2018). Preservation Method and Phosphate Buffered Saline Washing Affect the Acute Myeloid Leukemia Proteome. International Journal of Molecular Sciences. 1-11.
  • Vis forfatter(e) (2018). Mathematical modelling of nitric oxide/cyclic GMP/cyclic AMP signalling in platelets. International Journal of Molecular Sciences. 1-21.
  • Vis forfatter(e) (2018). Epac1−/− mice have elevated baseline permeability and do not respond to histamine as measured with dynamic contrast‐enhanced magnetic resonance imaging with contrast agents of different molecular weights. Acta Physiologica. 1-14.
  • Vis forfatter(e) (2018). Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles. Journal of Enzyme Inhibition and Medicinal Chemistry. 370-375.
  • Vis forfatter(e) (2018). Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice. PLOS ONE.
  • Vis forfatter(e) (2017). Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives. Bioorganic & Medicinal Chemistry. 2285-2293.
  • Vis forfatter(e) (2017). Increased microvascular permeability in mice lacking Epac1 (Rapgef3). Acta Physiologica. 441-452.
  • Vis forfatter(e) (2017). Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. Scientific Reports. 1-15.
  • Vis forfatter(e) (2016). Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling. Nutrition & Metabolism. 1-11.
  • Vis forfatter(e) (2015). cAMP-dependent Protein Kinase A (PKA) - Mediated c-Myc degradation is dependent on the relative proportion of PKA-I and PKA-II isozymes. Molecular Pharmacology. 469-476.
  • Vis forfatter(e) (2015). Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells. Bioorganic & Medicinal Chemistry. 7313-7323.
  • Vis forfatter(e) (2015). Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds. Journal of Enzyme Inhibition and Medicinal Chemistry. 180-188.
  • Vis forfatter(e) (2015). B56δ-related protein phosphatase 2A dysfunction identified in patients with intellectual disability. Journal of Clinical Investigation. 3051-3062.
  • Vis forfatter(e) (2014). Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. Biochemical and Biophysical Research Communications - BBRC. 357-363.
  • Vis forfatter(e) (2014). Performance of super-SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines. Proteomics. 1971-1976.
  • Vis forfatter(e) (2014). New N-1,N-10 bridged pyrrolo[2,3-α]carbazole-3-carbaldehydes: synthesis and biological activities. Bioorganic chemistry (Print). 108-115.
  • Vis forfatter(e) (2014). Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3. PLOS ONE.
  • Vis forfatter(e) (2014). Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia. European journal of pharmaceutics and biopharmaceutics.
  • Vis forfatter(e) (2014). Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells. Marine Drugs. 2036-2053.
  • Vis forfatter(e) (2014). Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment. Applied Microbiology and Biotechnology. 603-610.
  • Vis forfatter(e) (2014). 4-methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides. ACS Chemical Biology. 2646-2655.
  • Vis forfatter(e) (2013). Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochemical and Biophysical Research Communications - BBRC. 603-608.
  • Vis forfatter(e) (2013). Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. Marine Drugs. 332-349.
  • Vis forfatter(e) (2013). Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen. BMC Cancer.
  • Vis forfatter(e) (2013). DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms. PLOS ONE. 12 sider.
  • Vis forfatter(e) (2013). Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. Cell Death & Disease.
  • Vis forfatter(e) (2013). Activation of both protein kinase A (PKA) type I and PKA type II isozymes is required for retinoid-induced maturation of acute promyelocytic leukemia cells. Molecular Pharmacology. 1057-1065.
  • Vis forfatter(e) (2012). The lipopeptide toxins Anabaenolysin A and B target biological membranes in a cholesterol-dependent manner. Biochimica et Biophysica Acta - Biomembranes. 3000-3009.
  • Vis forfatter(e) (2012). Anabaenolysins, novel cytolytic lipopeptides from benthic anabaena cyanobacteria. PLOS ONE.
  • Vis forfatter(e) (2012). Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells. PLOS ONE. 11 sider.
  • Vis forfatter(e) (2011). The regulatory subunit of PKA-I remains partially structured and undergoes beta-aggregation upon thermal denaturation. PLOS ONE. 10 sider.
  • Vis forfatter(e) (2011). The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity. Journal of Industrial Microbiology & Biotechnology. 489-501.
  • Vis forfatter(e) (2011). Nostocyclopeptide-M1: A potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and 1B1. Molecular Pharmaceutics. 360-367.
  • Vis forfatter(e) (2011). Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 8-19.
  • Vis forfatter(e) (2011). Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription. Cell Death and Differentiation. 11 sider.
  • Vis forfatter(e) (2010). UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity. PLOS ONE.
  • Vis forfatter(e) (2010). UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity. PLOS ONE. 13 sider.
  • Vis forfatter(e) (2010). Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes. Marine Drugs. 2659-2672.
  • Vis forfatter(e) (2010). Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 7-18.
  • Vis forfatter(e) (2010). Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR. Journal of Biological Chemistry. 14062-14070.
  • Vis forfatter(e) (2010). A novel cyanobacterial nostocyclopeptide is a potent antitoxin against microcystins. ChemBioChem. 1594-1599.
  • Vis forfatter(e) (2009). POSTMan (POST-translational modification analysis), a software application for PTM discovery. Proteomics. 1400-1406.
  • Vis forfatter(e) (2009). Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity. Marine Drugs. 605-623.
  • Vis forfatter(e) (2009). Epac-induced Alterations in the Proteome of Human SH-SY5Y Neuroblastoma Cells. Journal of Proteomics & Bioinformatics. 244-245.
  • Vis forfatter(e) (2009). Biosynthesis of Macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit. Chemistry and Biology. 1109-1121.
  • Vis forfatter(e) (2009). Acyloxymethyl esterification of Nodularin-R and Microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells. Journal of Medicinal Chemistry. 5758-5762.
  • Vis forfatter(e) (2008). cAMP-dependent signaling regulates the adipogenic effect of n-6 polyunsaturated fatty acids. Journal of Biological Chemistry. 7196-7205.
  • Vis forfatter(e) (2008). Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes. Molecular and Cellular Biology. 3804-3816.
  • Vis forfatter(e) (2008). Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes. Journal of Biological Chemistry. 22723-22736.
  • Vis forfatter(e) (2008). Abolition of stress-induced protein synthesis sensitizes leukemia cells to anthracycline-induced death. Blood. 2866-2877.
  • Vis forfatter(e) (2007). LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro. Molecular Cancer.
  • Vis forfatter(e) (2007). Cyclic adenosine 3 ',5 '-monophosphate(cAMP)-dependent protein kinases, but not exchange proteins directly activated by cAMP (Epac), mediate thyrotropin/cAMP-dependent regulation of thyroid cells. Endocrinology. 4612-4622.
  • Vis forfatter(e) (2006). Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition. Journal of Biological Chemistry. 21500-21511.
  • Vis forfatter(e) (2006). CaM-kinasell-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Cell Death and Differentiation. 1191-1202.
  • Vis forfatter(e) (2005). Substrate enhances the sensitivity of type I protein kinase a to cAMP. Journal of Biological Chemistry. 13279-13284.
  • Vis forfatter(e) (2005). Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast. Aquatic Toxicology. 294-306.
  • Vis forfatter(e) (2005). A high proportion of Baltic Sea benthic cyanobacterial isolates contain apoptogens able to induce rapid death of isolated rat hepatocytes. Toxicon. 252-260.
  • Vis forfatter(e) (2004). cAMP protects neutrophils against TNF?-induced apoptosis by activation of cAMP-dependent protein kinase, independently of exchange protein directly activated by cAMP (Epac). Journal of Leukocyte Biology. 641-647.
  • Vis forfatter(e) (2004). Protein kinase A mediates inhibition of the thrombin-induced platelet shape change by nitric oxide. Blood. 2775-2782.
  • Vis forfatter(e) (2004). Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis. Leukemia. 1989-1996.
  • Vis forfatter(e) (2003). cAMP effector mechanisms. Novel twists for an "old" signaling system. FEBS Letters. 121-126.
  • Vis forfatter(e) (2003). cAMP analog mapping of Epac1 and camp kinase: discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. Journal of Biological Chemistry. 35394-35402.
  • Vis forfatter(e) (2003). Search for new cyclic AMP-binding proteins. FEBS Letters. 103-107.
  • Vis forfatter(e) (2003). Mitochondrial-targeted fatty acid analog induces apoptosis with selective loss of mitochondrial glutathione in promyelocytic leukemia cells. Chemistry and Biology. 609-618.
  • Vis forfatter(e) (2003). Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac. Journal of Biological Chemistry. 38548-38556.
  • Vis forfatter(e) (2003). Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis. Molecular Biology of the Cell. 3292-3304.
  • Vis forfatter(e) (2002). Use of marine toxins in combination with cytotoxic drugs for induction of apoptosis in acute myelogenous leukaemia cells. Expert Opinion on Biological Therapy. 197-210.
  • Vis forfatter(e) (2002). Ca2+/calmodulin dependent protein kinase II is required for microcystin-induced apoptosis. Journal of Biological Chemistry. 2804-2811.
  • Vis forfatter(e) (2002). Analysis of acute myelogenous leukemia: preparation of samples for genomic and proteomic analyses. Journal of Hematotherapy & Stem Cell Research. 469-481.
  • Vis forfatter(e) (2002). A Novel Extraneuronal Role for Cylin-dependent Protein Kinase 5 (CDK5), Modulation of cAMP-induced apoptosis in rat leukemia cells. Journal of Biological Chemistry. 20783-20793.
  • Vis forfatter(e) (2001). Establishment of okadaic acid resistant cell clones using a cDNA expression library. Cell Death and Differentiation. 754-766.
  • Vis forfatter(e) (2001). Apoptotic effect of cyanobacterial extract on rat hepatocytes and human lymphocytes. Environmental Toxicology. 225-233.
  • Vis forfatter(e) (2001). Apoptotic effect of cyanobacterial blooms collected from Polish water reservoirs. International Journal of Occupational Medicine and Environmental Health. 335-344.
  • Vis forfatter(e) (2001). Alterations in platelet phospholipid metabolism by substances from a marine microalgae. Chemistry and Physics of Lipids. 139-140.
  • Vis forfatter(e) (2000). Membrane permeant, bioactivatable analogues of cGMP as inducers of cell death in IPC-81 leukemia cells. Bioorganic & Medicinal Chemistry Letters. 571-573.
  • Vis forfatter(e) (2000). Ectopic expression of Bcl-2 switches over nuclear signalling for cAMP-inducd apoptosis to granulocytic differentiation. Cell Death and Differentiation. 1081-1089.
  • Vis forfatter(e) (2000). Apoptosemekanismen - mulige vinklinger for kreftbehandling. Tidsskrift for Den norske legeforening. 61.
  • Vis forfatter(e) (2000). An ultrasensitive competitive binding assay for the detection of protein phosphatase directed toxins. Toxicon. 347-360.
  • Vis forfatter(e) (2000). 8-Substituted cAMP analogues reveal marked differences in adaptability, hydrogen bonding, and charge accommodation between homologous binding sites (AI/AII and BI/BII) in cAMP kinase I and II. Biochemistry. 8803-8812.
  • Vis forfatter(e) (1999). cAMP induces co-translational modification of proteins in IPC-81 cells. Biochemical Journal. 369-377.
  • Vis forfatter(e) (1999). Ultrarapid apoptosis inducted by phosphatase inhibitors. Cell Death Differ. Cell Death and Differentiation. 1099-1108.
  • Vis forfatter(e) (1999). An ultrasensitive competitive binding assay for the detection of toxins affecting protein phosphatases. Toxicon. 347-360.
  • Vis forfatter(e) (1998). Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes. Toxicon. 1101-1114.
  • Vis forfatter(e) (1998). Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inibited by Bcl-2. Cell Death and Differentiation. 660-668.
  • Vis forfatter(e) (1998). A number of morphologically distinct types of regulated (apoptotic) cell death can be induced in leukemia cells, depending on the nature and intens the death-inducing agent. (invited review). Scanning microscopy.
  • Vis forfatter(e) (1997). Transcriptional regulation of the bovine CYP17 gene by cAMP. Steroids. 43-45.
  • Vis forfatter(e) (1997). Synergistic antiproliferative actions of cyclic adenosine 3',5'-monophosphate, interleukin-1beta, and activators of Ca%2%+/calmodulin-dependent protein kinase in primary hepatocytes. Endocrinology. 4373-4383.
  • Vis forfatter(e) (1997). Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. Hepatology. 847-855.
  • Vis forfatter(e) (1997). Fas/APO-1 (CD95)-Induced Apoptosis of Primary Hepatocytes Is Inhibited by cAMP. Biochemical and Biophysical Research Communications - BBRC. 20-25.
  • Vis forfatter(e) (1996). Divergence towards a dead end? Cleavage of the divergent domains of ribosomal RNA in apoptosis. Experientia. 963-967.
  • Vis forfatter(e) (1994). Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cells. Proc Nat Acad Sci U S A Biol Sci. 8428-8432.
  • Vis forfatter(e) (1994). Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line. Journal of Cell Science, Supplement. 3363-3377.
  • Vis forfatter(e) (1994). Cleaved intracellular plasminogen activator inhibitor-2 is a marker of apoptosis present in human myeloid leukemia cells. British Journal of Cancer. 834-840.
  • Vis forfatter(e) (1994). Apoptotic Cell Death analyzed at the molecular level by two-dimensional gel electrophoresis. Electrophoresis. 503-510.
  • Vis forfatter(e) (1994). (Rp)- and (Sp)-8-pideridino-cAMP@<S@> discriminate completely between site A and site B of the regulatory subunits of cAMP-dependent protein kinase type I and II. European Journal of Biochemistry (EJB). 1089-1094.
  • Vis forfatter(e) (1994). (Rp)- and (Sp)-8-pideridino 3', 5'-(cyclic)thiophosphates discriminate completely between site A and site B of the regulatory subunits of cAMP-dependent protein kinase typeI and II. European Journal of Biochemistry (EJB). 1089-1094.
  • Vis forfatter(e) (1993). The genetic subtypes of cAMP-dependent protein kinase - functionally different or redundant? Biochimica et Biophysica Acta. 249-258.
  • Vis forfatter(e) (1993). Selective cleavage of 28S rRNA variable regions V3 and V13 in myeloid leukemia cell apoptosis. FEBS Letters. 16-20.
  • Vis forfatter(e) (1993). Microinjected catalytic subunit of cAMP-dependent protein kinase induces apoptosis in myeloid leukemic (IPC-81) cells. Exp Cell Res. 157-161.
  • Vis forfatter(e) (1993). Hepatocyte DNA replication is abolished by inhibitors selecting protein phosphatase 2A rather than phosphatase 1. Exp Cell Res. 293-301.
  • Vis forfatter(e) (1993). Exogenous substrate stimulate autodephosphorylation of cyclic-AMP-dependent protein kinase II. Biochemical Journal. 497-503.
  • Vis forfatter(e) (1993). Elevated cAMP gives short-term inhibition and long-term stimulation of hepatocyte DNA replication: Roles of the cAMP-dependent protein kinase subunits. Journal of Cellular Physiology. 160-170.
  • Vis forfatter(e) (1993). Apoptotisk celledød. NBS-nytt. 6-12.
  • Vis forfatter(e) (1993). Anti-apoptotic effect of heterozygously expressed mutant RI (Ala%3%3%6 ->Asp) subunit of cAMP-kinase I in a rat leukaemia cell line. Journal of Biological Chemistry. 8332-8340.
  • Vis forfatter(e) (1992). cAmp-dependent protein kinase type I mediates the inhibitory effects of cAMP on cell replication in human T lymphocytes. Journal of Biological Chemistry. 15707-15714.
  • Vis forfatter(e) (1992). Phenylatanine modulates positively the cAMP-dependant phosphorylation and modulates negatively the vasopressin-and okadeic acid-induced phosphorylation of phenylalanine 4-monoxygenase in intact rat hepatocytes. European Journal of Biochemistry (EJB). 161-170.
  • Vis forfatter(e) (1992). Phenylalanine modulates differently the phosphorylation of phenylalanine 4-monooxygenase in intact rat hepatocytes exposed to cAMP and Ca2+-elevating agents. European Journal of Biochemistry (EJB). 161-170.
  • Vis forfatter(e) (1992). Differential expression of cAMPkinase subunits is correlated with growth in rat mammary carcinmas and uterus. British Journal of Cancer. 1022-1029.
  • Vis forfatter(e) (1992). Derivatives of 1-_b-D-ribofuranosylbenzimidazole 3',5'-phosphate that mimick the actions of adenosine 3',5'-phosphate (cAMP) and guanosine 3',5'phosphate (cGMP). Carbohydrate Research. 217-235.
  • Vis forfatter(e) (1992). Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3',5'-cyclic adenosine monophosphate on cell replication in human T lymphocytes. Journal of Biological Chemistry. 15707-15714.
  • Vis forfatter(e) (1991). The protein phosphatase inhibator okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Experimental Cell Research. 237-246.
  • Vis forfatter(e) (1991). Supramolecular complexes of cAMP-dependent protein kinase isozymes in bovine adrenal cortex and medulla. Biochemical Society Transactions. 1163-1165.
  • Vis forfatter(e) (1991). Restricted effusion of the type 2 isoform of cAMP dependent protein kinase in rat hepatocytes permabilized by digitonin. Biochemical Society Transactions. 1161-1162.
  • Vis forfatter(e) (1991). Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate-kinase I in a myeloid leukemia cell line. Journal of Cellular Physiology. 73-80.
  • Vis forfatter(e) (1991). Mutations that alter the charge of type I regulatory subunit and modify activation properties of cAMP-kinase from S49-mouse lymphoma cells. Journal of Biological Chemistry. 3547-3553.
  • Vis forfatter(e) (1991). Hormonial activation of gene transcription in rat-transformed NIH 3T3 cells overexpressing the R2a and R2b subunits of the cAMP dependent protein kinase. Journal of Biological Chemistry. 23074-23082.
  • Vis forfatter(e) (1991). High-molecular-mass complexes of the regulatory subunits of cyclic AMP-dependent protein kinase. Biochemical Society Transactions. 1163-1165.
  • Vis forfatter(e) (1988). Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth. Proceedings of the National Academy of Sciences of the United States of America. 6319-6233.
Populærvitenskapelig foredrag
  • Vis forfatter(e) (2002). Bioprospektering.
  • Vis forfatter(e) (2002). Apoptose - kommersielle aspekter.
Vitenskapelig foredrag
  • Vis forfatter(e) (2009). SMALL-RING MACROLACTAMS WITH ACYL SIDE CHAIN: NEW INSIGHTS INTO THE BIOSYNTHESIS AND ITS EVOLUTION.
  • Vis forfatter(e) (2004). cAMP protects neutrophils against TNFa-induced apoptosis by activation of cAMP-dependent protein kinase (cA-PK), independently of exchange protein directly activated by cAMP (Epac).
  • Vis forfatter(e) (2004). Development of a sensitive PP2A binding assay for microcystin and nodularin.
  • Vis forfatter(e) (2003). cAMP-dependent protein kinase signaling. A potential drug target.
  • Vis forfatter(e) (2003). cAMP induced protein phosphorylation in acute myelogenous leukemia cells.
  • Vis forfatter(e) (2003). cAMP effector mechanisms. Novel twists for an "old" signalling system.
  • Vis forfatter(e) (2003). Proteomics. Possibilities and role of PROBE unit.
  • Vis forfatter(e) (2003). Protein kinases involved in leukemia cell apoptosis.
  • Vis forfatter(e) (2003). PROBE. Progress report and visions for proteomics.
  • Vis forfatter(e) (2003). Identification of phosphorylated targets in ultrarapidly induced apoptosis.
  • Vis forfatter(e) (2003). Apoptosisd methodology. Clinical aspects.
  • Vis forfatter(e) (2003). Apoptosis. mechanistic and clinical aspects.
  • Vis forfatter(e) (2002). cAMP signalling related to apoptosis.
  • Vis forfatter(e) (2002). cAMP protects neutrophils against TNF_-induced apoptosis by activation of cAMP-dependent protein kinase (cA-PK), independently of exchange protein directly activated by cAMP (Epac).
  • Vis forfatter(e) (2002). cAMP and okadaic acid induced apoptosis.
  • Vis forfatter(e) (2002). The cAMP-binding site of EPAC-1.
  • Vis forfatter(e) (2002). Regulated cell death.
  • Vis forfatter(e) (2002). New apoptosis-modulating substances from marine microalgae.
  • Vis forfatter(e) (2002). Cyclin-dependent protein kinases and cell death.
  • Vis forfatter(e) (2002). Cell death induced by natural compounds. The significance of distinct phenotypes.
  • Vis forfatter(e) (2002). Bioactive compounds from cyanobacteria.
  • Vis forfatter(e) (2002). Apoptose. Klinisk relevans og metodikk.
  • Vis forfatter(e) (2001). Use of retroviral expression in the elucidation of PKA in cell signaling and apoptosis pathways.
  • Vis forfatter(e) (2001). Establishment of Okadaic acid resistant cell clones using a cDNA expression library.
  • Vis forfatter(e) (2001). Cell death in HeLa cells.
  • Vis forfatter(e) (2001). 3-Thia fatty acid induces mitochondrial alterations and triggers apoptosis in cancer cells.
  • Vis forfatter(e) (1998). Ultrarapid apoptosis induction in a variety of cell types injected with phosphatase inhibitors is mediated through Ca2 /calmodulin dependent protei kinase activity.
  • Vis forfatter(e) (1998). Membranpermeable und bioaktivierbare Analoga von cGMP als Aktivatoren von Apoptosis in IPC-81 Leukämiezellen,.
  • Vis forfatter(e) (1998). Marine cyanobacteria as a source for bioactive (apoptosis-modifying) compounds with potential as cell biology reagents and drugs.
  • Vis forfatter(e) (1998). Distinct apoptotic death forms. Distinct pathways and functions?
  • Vis forfatter(e) (1993). Signal-induced Apoptosis in Myeloid Leukemia. Apoptosis or Programmed Cell Death. From Basic Research to Clinical Application.
  • Vis forfatter(e) (1993). "Cyclic AMP dependent protein kinase and phosphatase inhibitors induces different phenotypic forms of cell death.".
  • Vis forfatter(e) (1989). Characterization and hormonal regulation of cAMP-dependent protein kinase in rat Sertoli cells.
Kronikk
  • Vis forfatter(e) (1999). cAMP inhibits translation by inducing Ca2+/calmodulin-independent elongation factor 2 kinase activity in IPC-81 cells. FEBS Letters. 97-101.
  • Vis forfatter(e) (1998). Injected cytochrome c induces apoptosis. Nature. 449-450.
Doktorgradsavhandling
  • Vis forfatter(e) (2017). Exchange Proteins directly Activated by cAMP (Epac): Physiological roles and Regulation of expression .
  • Vis forfatter(e) (2015). Cell death induction by free and encapsulated cancer drug candidates.
  • Vis forfatter(e) (2007). New lessons from an "old" drug: A proteomic study of anthracycline-induced apoptosis in acute myelogenous leukemia.
  • Vis forfatter(e) (1980). Binding proteins for cyclic AmP in mammalian tissues : some aspects of their interaction with cyclic AMP and their use in competitive binding assays for cyclic AMP.
Intervju
  • Vis forfatter(e) (2002). Giftalger tar livet av kreftceller.
  • Vis forfatter(e) (2002). Celledødsbødler fra havet.
  • Vis forfatter(e) (2002). "Nobelprisen i Medisin 2002".
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
  • Vis forfatter(e) (2009). Cyclic nucleotide analogs.
  • Vis forfatter(e) (2007). Serine/Threonine Protein Phosphatases in Apoptosis. 16 sider.
  • Vis forfatter(e) (2004). Cyclic Nucleotide Analogs as Tools to investigate Cyclic Nucleotide Signalling. 6 sider.
  • Vis forfatter(e) (1996). Sensitive and rapid detection of B-galactosidase expression in intact cells by microinjection of fluorecent substrate.
  • Vis forfatter(e) (1991). Criteria used to judge that a cellular response is mediated by cAMP. 12 sider.
Sammendrag/abstract
  • Vis forfatter(e) (2013). Development and in vitro efficacy of liposomes carrying anthracyclines and emetine for enhanced therapeutic effect. The FEBS Journal. 322-322.
  • Vis forfatter(e) (2012). Microvascular permeability in the absence of Epac1 activity. The FASEB Journal. 1 sider.
  • Vis forfatter(e) (2008). Cyclic nucleotide analogs as probes for signaling pathways. Naunyn-Schmiedeberg's Archives of Pharmacology. 31-31.
  • Vis forfatter(e) (2006). Camp-dependent protein kinase. European Journal of Pharmaceutical Sciences. S4-S5.
  • Vis forfatter(e) (2006). A staurosporine story: Indolocarbazole orthoamides and fluorinated analogs of LY333531. European Journal of Pharmaceutical Sciences. S3-S3.
  • Vis forfatter(e) (2006). 14-3-3 proteins as substrates for cAMP-dependent protein kinase. European Journal of Pharmaceutical Sciences. S27-S27.
Poster
  • Vis forfatter(e) (2016). Total synthesis and initial antileukemic evaluation of the phenazine 5,10-dioxide natural products iodinin and myxin.
  • Vis forfatter(e) (2015). Indeno[1,2-b]indole derivatives as protein kinase CK2 inhibitors: comparison of in silico models for Tox prediction.
  • Vis forfatter(e) (2012). Development and in vitro efficacy of liposomes carrying anthracyclines and emetine for enhanced therapeutic effect.
  • Vis forfatter(e) (2010). Liver specific transporters of microcystins as a tool to find novel inhibitors of OATP1B1 and OATP1B3.
  • Vis forfatter(e) (2009). The biosynthesis of macrolactam BE-14106: a new way of generating an aminoacyl starter unit.
  • Vis forfatter(e) (2007). Compartment modeling of nitric-oxide mediated activation of the cAMP-dependent protein kinase in platelets.
  • Vis forfatter(e) (2003). Myeloid leukemia cell differentiation by bcl-2 and camp involves induction of ccaat/enhancer binding protein ? (c/ebp?), nuclear accumulation of c/ebp?, and direct interaction between bcl-2 and c/ebp?
  • Vis forfatter(e) (2003). Differential Expression of Splicing factor SR proteins and Their phosphorylation in Cell Stress leading to Apoptosis.
  • Vis forfatter(e) (2002). Effects of a new bioactive substance from a marine microalga on mammalian cells.
  • Vis forfatter(e) (2001). TWO NOVEL APOPTOSIS-MODULATION SUBSTANCES ISOLATED FROM MARINE MICRO-ALGAE.
  • Vis forfatter(e) (2001). New apoptosis-modulating substances from marine microalgae.
  • Vis forfatter(e) (2001). Establishment of Okadaic acid resistant cell clones using a cDNA expression library.
  • Vis forfatter(e) (2001). Differential Affinities of C-subunit Isozymes of the cAMP-Dependent Protein Kinase for Pseudosubstrates and Substrates.
  • Vis forfatter(e) (1997). Detedtion of toxins from marine cyanobacteria based on their affinity for protein phosphatase 2A and their ability to induce apoptosis in salmon hepatocytes.
  • Vis forfatter(e) (1993). Morphometrical and morphological characterization of cell death induced by cAMP dependent protein kinase in rat myeloid leukemia cell line.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) (2015). Cell Death inducing microbial protein phosphatase inhibitors-mechanisms of action. Marine Drugs. 6505-6520.
  • Vis forfatter(e) (2011). The cAMP-dependent protein kinase pathway as therapeutic target - possibilities and pitfalls. Current Topics in Medicinal Chemistry. 1393-1405.
  • Vis forfatter(e) (2011). The 14-3-3 proteins in regulation of cellular metabolism. Seminars in Cell and Developmental Biology. 713-719.

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