Hjem
Stephanie Le Hellards bilde

Stephanie Le Hellard

Professor, Professor in Human Genetics
  • E-postStephanie.LeHellard@uib.no
  • Besøksadresse
    Haukeland universitetssykehus, Laboratoriebygget
    Rom 
    5310
  • Postadresse
    Postboks 7804
    5020 Bergen

The aim of my research is to identify genetic and epigenetic factors implicated in the development of psychiatric disorders. 

I am a core researcher at the NORMENT, a Norwegian Centre of Excellence for Research on Mental Health. The NORMENT is described here: http://www.med.uio.no/norment/english/ In Bergen I am situated at the Dr Martens group for research on biological psychiatry, our research activity is described here: http://www.uib.no/en/rg/geneticsgroup/106397/martens-group#at-a-glance

Description of our group in the NORMENT centre:

Epigenetics and functional genomics

In the last decade, genetic studies of psychiatric disorders have identified numerous genomic regions that harbor genetic variants which are associated with increased risk to develop a psychiatric disorder (e.g. schizophrenia or bipolar disorder). One of the main challenges for understanding the effect of these variants is to first determine which of the genetic variants or the genes in those regions that have a functional effect. Our group bridges Molecular Genetics and Functional Genomics.

Aims

Our main aim is to better annotate regions of genetic susceptibility to mental disorders in order to narrow and identify the genetic variants with potential functional effects to move towards functional genomics studies.

We are also developing projects with epigenetic tools and datasets to try to understand how the environment can influence the genetic susceptibility to develop psychiatric disorders. We aim to:

  • Better annotate some candidate regions implicated in psychiatric disorders to move towards the functional characterization of these regions.
  • Integrate environmental information with epigenetic and genetic information to understand the gene by environment in susceptibility to mental disorders.

We particularly focus on schizophrenia and bipolar disorder. For the environment effects, we are focusing first on the effect of cannabis. We use mostly biostatistics and bioinformatics tools for the analysis of datasets.

We generate our own datasets for some epigenetic markers in patients and we also use publically available datasets to investigate the relation between epigenetic marks and loci of susceptibility for psychiatric disorders.

We integrate different level of information in patients: Genetic, epigenetic, transcriptomics and environment data.

Research projects

  • Identifying allelic heterogeneity at the gene level across mental disorders.
  • Cognition and imaging genetics: we participate in several large consortium efforts and have also a few in house projects.
  • An epigenetic investigation of schizophrenia and bipolar disorder.
  • Molecular mechanisms of cannabis exposure risk in patients with psychosis.
  • Identification of regions of differential methylation across psychiatric disorders and through the life span.

I teach Genetics and Evolution to medical students in their 3rd semester, at the Faculty of Medicine, UiB.

I teach a MSc course in Human Genetics (HUMGEN301) at the Faculty of Medicine, UiB.

I also participate in the IGSIN course for PhD students, UiB, and the Master course in Genetics of Cognitive Neuroscience at the University of Oslo.

Tidsskriftartikler
  • Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Bettella, Francesco; Beyer, Mona K.; Bøen, Erlend; Borgwardt, Stefan; Brandt, Christine Lycke; Buitelaar, Jan; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Còrdova Palomera, Aldo; Dale, Anders; de Quervain, Dominique J.F.; di Carlo, Pasquale; Djurovic, Srdjan; Dørum, Erlend Solberg; Eisenacher, Sarah; Elvsåshagen, Torbjørn; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Haatveit, Beathe; Håberg, Asta; Harbo, Hanne Flinstad; Hartman, Catharina A; Heslenfeld, Dirk J; Hoekstra, Pieter J; Høgestøl, Einar August; Jernigan, Terry L.; Jonassen, Rune; Jönsson, Erik Gunnar; Kirsch, Peter; Kłoszewska, Iwona; Kolskår, Knut-Kristian; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Lovestone, Simon; Lundervold, Arvid; Lundervold, Astri; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin Ester Torun; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Selbæk, Geir; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar Martin; Tsolaki, Magda; Ulrichsen, Kristine Moe; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas; Westlye, Lars Tjelta. 2019. Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience. 22: 1617-1623. doi: 10.1038/s41593-019-0471-7
  • Lam, Max; Hill, W. David; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Davies, Gail; Stahl, Eli; Huckins, Laura; Liewald, David C.; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil Søren; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri; Steen, Vidar Martin; Espeseth, Thomas; Räikkönen, Katri; Widén, Elisabeth; Palotie, Aarno; Eriksson, Johan G.; Giegling, Ina; Konte, Bettina; Hartmann, Annette M.; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William; Chiba-Falek, Ornit; Attix, Deborah K.; Need, Anna C.; Cirulli, Elizabeth T.; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios; Hatzimanolis, Alex; Arking, Dan E.; Smyrnis, Nikolaos; Bilder, Robert M.; Freimer, Nelson A.; Cannon, Tyrone D.; London, Edythe; Poldrack, Russell A.; Sabb, Fred W.; Congdon, Eliza; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary; Morris, Derek; Corvin, Aiden; Gill, Michael; Hariri, Ahmad R.; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Le Hellard, Stephanie; Keller, Matthew C.; Andreassen, Ole Andreas; Deary, Ian J.; Glahn, David C.; Malhotra, Anil K.; Lencz, Todd. 2019. Pleiotropic meta-analysis of cognition, education, and schizophrenia differentiates roles of early neurodevelopmental and adult synaptic pathways. American Journal of Human Genetics. 105: 334-350. doi: 10.1016/j.ajhg.2019.06.012
  • Watson, Hunna J.; Yilmaz, Zeynep; Thornton, Laura M.; Hübel, Christopher; Coleman, Jonathan R. I.; Gaspar, Héléna A.; Bryois, Julien; Hinney, Anke; Leppä, Virpi M.; Mattheisen, Manuel; Medland, Sarah E.; Ripke, Stephan; Yao, Shuyang; Giusti-Rodríguez, Paola; Hanscombe, Ken B.; Purves, Kirstin L.; Adan, Roger A.H.; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole Andreas; Baker, Jessica H; Berrettini, Wade H.; Boehm, Ilka; Boni, Claudette; Perica, Vesna Boraska; Buehren, Katharina; Burghardt, Roland; Cassina, Matteo; Cichon, Sven; Clementi, Maurizio; Cone, Roger D.; Courtet, Philippe; Crow, Scott; Crowley, James J.; Danner, Unna N.; Davis, Oliver S.P.; de Zwaan, Martina; Dedoussis, George; Degortes, Daniela; DeSocio, Janiece E.; Dick, Danielle M.; Dikeos, Dimitris; Dina, Christian; Dmitrzak-Weglarz, Monika; Docampo, Elisa; Duncan, Laramie E.; Egberts, Karin; Ehrlich, Stefan; Escaramis, Geòrgia; Esko, Tõnu; Estivill, Xavier; Farmer, Anne; Favaro, Angela; Fernández-Aranda, Fernando; Fichter, Manfred M.; Fischer, Krista; Föcker, Manuel; Foretova, Lenka; Forstner, Andreas J.; Forzan, Monica; Franklin, Christopher S.; Gallinger, Steven; Giegling, Ina; Giuranna, Johanna; Gonidakis, Fragiskos; Gorwood, Philip; Mayora, Monica Gratacos; Guillaume, Sebastien; Guo, Yiran; Hakonarson, Hakon; Hatzikotoulas, Konstantinos; Hauser, Joanna; Hebebrand, Johannes; Helder, Sietske G.; Herms, Stefan; Herpertz-Dahlmann, Beate; Herzog, Wolfgang; Huckins, Laura M.; Hudson, James I.; Imgart, Hartmut; Inoko, Hidetoshi; Janout, Vladimir; Jiménez-Murcia, Susana; Julià, Antonio; Kalsi, Gursharan; Kaminská, Deborah; Kaprio, Jaakko; Karhunen, Leila; Karwautz, Andreas; Kas, Martien J.H.; Kennedy, James L.; Keski-Rahkonen, Anna; Kiezebrink, Kirsty; Kim, Youl-Ri; Klareskog, Lars; Klump, Kelly L.; Knudsen, Gun Peggy S.; La Via, Maria C.; Le Hellard, Stephanie; Levitan, Robert D.; Li, Dong; Lilenfeld, Lisa; Lin, Bochao Danae; Lissowska, Jolanta; Luykx, Jurjen; Magistretti, Pierre J.; Maj, Mario; Mannik, Katrin; Marsal, Sara; Marshall, Christian R.; Mattingsdal, Morten; McDevitt, Sara; McGuffin, Peter; Metspalu, Andres; Meulenbelt, Ingrid; Micali, Nadia; Mitchell, Karen; Monteleone, Alessio Maria; Monteleone, Palmiero; Munn-Chernoff, Melissa A.; Nacmias, Benedetta; Navratilova, Marie; Ntalla, Ioanna; O'Toole, Julie K.; Ophoff, Roel A.; Padyukov, Leonid; Palotie, Aarno; Pantel, Jacques; Papezova, Hana; Pinto, Dalila; Rabionet, Raquel; Raevuori, Anu; Ramoz, Nicolas; Reichborn-Kjennerud, Ted; Ricca, Valdo; Ripatti, Samuli; Ritschel, Franziska; Roberts, Marion; Rotondo, Alessandro; Rujescu, Dan; Rybakowski, Filip; Santonastaso, Paolo; Scherag, André; Scherer, Stephen W.; Schmidt, Ulrike; Schork, Nicholas J.; Schosser, Alexandra; Seitz, Jochen; Slachtova, Lenka; Slagboom, P. Eline; Slof-Op `t Landt, Margarita C.T.; Slopien, Agnieszka; Sorbi, Sandro; Świątkowska, Beata; Szatkiewicz, Jin P.; Tachmazidou, Ioanna; Tenconi, Elena; Tortorella, Alfonso; Tozzi, Federica; Treasure, Janet; Tsitsika, Artemis; Tyszkiewicz-Nwafor, Marta; Tziouvas, Konstantinos; van Elburg, Annemarie A.; van Furth, Eric F.; Wagner, Gudrun; Walton, Esther; Widen, Elisabeth; Zeggini, Eleftheria; Zerwas, Stephanie; Zipfel, Stephan; Bergen, Andrew W.; Boden, Joseph M.; Brandt, Harry; Crawford, Steven; Halmi, Katherine A.; Horwood, L. John; Johnson, Craig; Kaplan, Allan S.; Kaye, Walter H.; Mitchell, James E.; Olsen, Catherine M.; Pearson, John F.; Pedersen, Nancy L.; Strober, Michael; Werge, Thomas; Whiteman, David C.; Woodside, D. Blake; Stuber, Garret D.; Gordon, Scott; Grove, Jakob; Henders, Anjali K.; Juréus, Anders; Kirk, Katherine M.; Larsen, Janne T.; Parker, Richard; Petersen, Liselotte; Jordan, Jennifer; Kennedy, Martin; Montgomery, Grant W.; Wade, Tracey D.; Birgegård, Andreas; Lichtenstein, Paul; Norring, Claes; Landén, Mikael; Martin, Nicholas G.; Mortensen, Preben Bo; Sullivan, Patrick F.; Breen, Gerome; Bulik, Cynthia M. 2019. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nature Genetics. 51: 1207-1214. doi: 10.1038/s41588-019-0439-2
  • Banerjee, Niladri; Polushina, Tatiana; Bettella, Francesco; Giddaluru, Sudheer; Steen, Vidar Martin; Andreassen, Ole Andreas; Le Hellard, Stephanie. 2018. Recently evolved human-specific methylated regions are enriched in schizophrenia signals. BMC Evolutionary Biology. 18:63: 1-11. doi: 10.1186/s12862-018-1177-2
  • Banerjee, Niladri; Polushina, Tatiana; Bettella, Francesco; Steen, Vidar Martin; Andreassen, Ole Andreas; Le Hellard, Stephanie. 2018. Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia. Schizophrenia Research. 8 sider. doi: 10.1016/j.schres.2018.11.025
  • Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle; Hill, W. David; Hagenaars, Saskia P.; Ritchie, Stuart J.; Marioni, Riccardo E.; Fawns-Ritchie, Chloe; Liewald, David C.M.; Okely, Judith A.; Ahola-Olli, Ari V.; Barnes, Catriona L.K.; Bertram, Lars; Bis, Joshua C.; Burdick, Katherine E.; Derosse, Pamela; Djurovic, Srdjan; Espeseth, Thomas; Giakoumaki, Stella; Giddaluru, Sudheer; Gustavson, Daniel E.; Hayward, Caroline; Hofer, Edith; Ikram, M. Arfan; Karlsson, Robert; Knowles, Emma; Lahti, Jari; Leber, Markus; Li, Shuo; Mather, Karen A.; Melle, Ingrid; Morris, Derek; Oldmeadow, Christopher; Palviainen, Teemu; Payton, Antony; Pazoki, Raha; Petrovic, Katja; Reynolds, Chandra A.; Sargurupremraj, Muralidharan; Scholz, Markus; Smith, Jennifer A.; Smith, Albert V.; Terzikhan, Natalie; Thalamuthu, Anbupalam; Trompet, Stella; van der Lee, Sven J.; Ware, Erin B.; Windham, B. Gwen; Wright, Margaret J.; Yang, Jingyun; Yu, Jin; Ames, David; Amin, Najaf; Amouyel, Philippe; Andreassen, Ole Andreas; Armstrong, Nicola J.; Assareh, Amelia A; Attia, John R.; Attix, Deborah; Avramopoulos, Dimitrios; Bennett, David A.; Böhmer, Anne C.; Boyle, Patricia A.; Brodaty, Henry; Campbell, Harry; Cannon, Tyrone D.; Cirulli, Elizabeth T.; Congdon, Eliza; Conley, Emily Drabant; Corley, Janie; Cox, Simon R.; Dale, Anders; Dehghan, Abbas; Dick, Danielle; Dickinson, Dwight; Eriksson, Johan G.; Evangelou, Evangelos; Faul, Jessica D.; Ford, Ian; Freimer, Nelson A.; Gao, He; Giegling, Ina; Gillespie, Nathan A.; Gordon, Scott D.; Gottesman, Rebecca F.; Griswold, Michael E.; Gudnason, Vilmundur; Harris, Tamara B.; Hartmann, Annette M.; Hatzimanolis, Alex; Heiss, Gerardo; Holliday, Elizabeth G.; Joshi, Peter K.; Kähönen, Mika; Kardia, Sharon L.R.; Karlsson, Ida; Kleineidam, Luca; Knopman, David S.; Kochan, Nicole A.; Konte, Bettina; Kwok, John B.; Le Hellard, Stephanie; Lee, Teresa; Lehtimäki, Terho; Li, Shu-Chen; Liu, Tian; Koini, Marisa; London, Edythe; Longstreth, Will T.; Lopez, Oscar L.; Loukola, Anu; Luck, Tobias; Lundervold, Astri; Lundquist, Anders; Lyytikäinen, Leo-Pekka; Martin, Nicholas G.; Montgomery, Grant W.; Murray, Alison D.; Need, Anna C.; Noordam, Raymond; Nyberg, Lars; Ollier, William; Papenberg, Göran; Pattie, Alison; Polasek, Ozren; Poldrack, Russell A.; Psaty, Bruce M.; Reppermund, Simone; Riedel-Heller, Steffi G.; Rose, Richard J.; Rotter, Jerome I.; Roussos, Panos; Rovio, Suvi P.; Saba, Yasaman; Sabb, Fred W.; Sachdev, Perminder S.; Satizabal, Claudia L.; Schmid, Matthias; Scott, Rodney J.; Scult, Matthew A.; Simino, Jeannette; Slagboom, P. Eline; Smyrnis, Nikolaos; Soumaré, Aïcha; Stefanis, Nikos C.; Stott, David J.; Straub, Richard E.; Sundet, Kjetil Søren; Taylor, Adele M.; Taylor, Kent D.; Tzoulaki, Ioanna; Tzourio, Christophe; Uitterlinden, André; Vitart, Veronique; Voineskos, Aristotle N.; Kaprio, Jaakko; Wagner, Michael; Wagner, Holger; Weinhold, Leonie; Wen, K. Hoyan; Widén, Elisabeth; Yang, Qiong; Zhao, Wei; Adams, Hieab H.H.; Arking, Dan E.; Bilder, Robert M.; Bitsios, Panos; Boerwinkle, Eric; Chiba-Falek, Ornit; Christoforou, Andrea; Corvin, Aiden; De Jager, Philip L.; Debette, Stéphanie; Donohoe, Gary; Elliott, Paul; Fitzpatrick, Annette L.; Gill, Michael; Glahn, David C.; Hägg, Sara; Hansell, Narelle K.; Hariri, Ahmad; Ikram, M. Kamran; Jukema, J. Wouter; Vuoksimaa, Eero; Keller, Matthew C.; Kremen, William S.; Launer, Lenore; Lindenberger, Ulman; Palotie, Aarno; Pedersen, Nancy L.; Pendleton, Neil; Porteous, David J.; Räikkönen, Katri; Raitakari, Olli T.; Ramirez, Alfredo; Reinvang, Ivar; Rudan, Igor; Rujescu, Dan; Schmidt, Reinhold; Schmidt, Helena; Schofield, Peter W.; Schofield, Peter R.; Starr, John M.; Steen, Vidar Martin; Trollor, Julian N.; Turner, Steven T.; Van Duijn, Cornelia M.; Villringer, Arno; Weinberger, Daniel R.; Weir, David R.; Wilson, James F.; Malhotra, Anil; McIntosh, Andrew M.; Gale, Catharine R.; Seshadri, Sudha; Mosley, Thomas H.; Bressler, Jan; Lencz, Todd; Deary, Ian J. 2018. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications. 9: 1-16. doi: 10.1038/s41467-018-04362-x
  • Fan, Chun Chieh; Schork, Andrew J.; Brown, Timothy T.; Spencer, Barbara E.; Akshoomoff, Natacha; Chen, Chi-Hua; Kuperman, Joshua M.; Hagler, Donald J.; Steen, Vidar Martin; Le Hellard, Stephanie; Håberg, Asta; Espeseth, Thomas; Andreassen, Ole Andreas; Dale, Anders; Jernigan, Terry L.; Halgren, Eric. 2018. Williams Syndrome neuroanatomical score associates with GTF2IRD1 in large-scale magnetic resonance imaging cohorts: A proof of concept for multivariate endophenotypes. Translational psychiatry. 8:114: 1-8. doi: 10.1038/s41398-018-0166-y
  • Hughes, Timothy; Sønderby, Ida Elken; Polushina, Tatiana; Hansson, Lars Johan Axel; Holmgren, Asbjørn; Athanasiu, Lavinia; Melbø-Jørgensen, Christian; Hassani, Sahar; Hoeffding, Louise K.; Herms, Stefan; Bergen, Sarah E.; Karlsson, Robert; Song, Jie; Rietschel, Marcella; Nöthen, Markus M.; Forstner, Andreas J.; Hoffmann, Per; Hultman, Christina M.; Landén, Mikael; Cichon, Sven; Werge, Thomas; Andreassen, Ole Andreas; Le Hellard, Stephanie; Djurovic, Srdjan. 2018. Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder. Translational psychiatry. 8: 1-10. doi: 10.1038/s41398-018-0175-x
  • Lam, Max; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil Søren; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri; Steen, Vidar Martin; Espeseth, Thomas; Räikkönen, Katri; Widén, Elisabeth; Palotie, Aarno; Eriksson, Johan G.; Giegling, Ina; Konte, Bettina; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William; Chiba-Falek, Ornit; Attix, Deborah K.; Need, Anna C.; Cirulli, Elizabeth T.; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios; Hatzimanolis, Alex; Arking, Dan E.; Smyrnis, Nikolaos; Bilder, Robert M.; Freimer, Nelson A.; Cannon, Tyrone D.; London, Edythe; Poldrack, Russell A.; Sabb, Fred W.; Congdon, Eliza; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary; Morris, Derek; Corvin, Aiden; Gill, Michael; Hariri, Ahmad R.; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Le Hellard, Stephanie; Keller, Matthew C.; Andreassen, Ole Andreas; Glahn, David C.; Malhotra, Anil K.; Lencz, Todd. 2018. Multi-Trait analysis of gwas and biological insights into cognition: A response to Hill (2018). Twin Research and Human Genetics. 21: 394-397. doi: 10.1017/thg.2018.46
  • Savage, Jeanne E.; Jansen, Philip R.; Stringer, Sven; Watanabe, Kyoko; Bryois, Julien; de Leeuw, Christiaan A.; Nagel, Mats; Awasthi, Swapnil; Barr, Peter B.; Coleman, Jonathan R.I.; Grasby, Katrina L.; Hammerschlag, Anke R.; Kaminski, Jakob A.; Karlsson, Robert; Krapohl, Eva; Lam, Max; Nygaard, Marianne; Reynolds, Chandra A.; Trampush, Joey W.; Young, Hannah; Zabaneh, Delilah; Hägg, Sara; Hansell, Narelle K.; Karlsson, Ida K.; Linnarsson, Sten; Montgomery, Grant W.; Muñoz-Manchado, Ana B.; Quinlan, Erin B.; Schumann, Gunter; Skene, Nathan G.; Webb, Bradley T.; White, Tonya; Arking, Dan E.; Avramopoulos, Dimitrios; Bilder, Robert M.; Bitsios, Panos; Burdick, Katherine E.; Cannon, Tyrone D.; Chiba-Falek, Ornit; Christoforou, Andrea; Cirulli, Elizabeth T.; Congdon, Eliza; Corvin, Aiden; Davies, Gail; Deary, Ian J.; DeRosse, Pamela; Dickinson, Dwight; Djurovic, Srdjan; Donohoe, Gary; Conley, Emily Drabant; Eriksson, Johan G.; Espeseth, Thomas; Freimer, Nelson A.; Giakoumaki, Stella; Giegling, Ina; Gill, Michael; Glahn, David C.; Hariri, Ahmad; Hatzimanolis, Alex; Keller, Matthew C.; Knowles, Emma; Koltai, Deborah; Konte, Bettina; Lahti, Jari; Le Hellard, Stephanie; Lencz, Todd; Liewald, David C.; London, Edythe; Lundervold, Astri; Malhotra, Anil K.; Melle, Ingrid; Morris, Derek; Need, Anna C.; Ollier, William; Palotie, Aarno; Payton, Antony; Pendleton, Neil; Poldrack, Russell A.; Räikkönen, Katri; Reinvang, Ivar; Roussos, Panos; Rujescu, Dan; Sabb, Fred W.; Scult, Matthew A; Smeland, Olav Bjerkehagen; Smyrnis, Nikolaos; Starr, John M; Steen, Vidar Martin; Stefanis, Nikos C.; Straub, Richard E.; Sundet, Kjetil Søren; Tiemeier, Henning; Voineskos, Aristotle N.; Weinberger, Daniel R.; Widén, Elisabeth; Yu, Jin; Abecasis, Goncalo; Andreassen, Ole Andreas; Breen, Gerome; Christiansen, Lene; Debrabant, Birgit; Dick, Danielle M.; Heinz, Andreas; Hjerling-Leffler, Jens; Ikram, M. Arfan; Kendler, Kenneth S.; Martin, Nicholas G.; Medland, Sarah E.; Pedersen, Nancy L.; Plomin, Robert; Polderman, Tinca J.C.; Ripke, Stephan; van der Sluis, Sophie; Sullivan, Patrick F.; Vrieze, Scott I; Wright, Margaret J.; Posthuma, Daniëlle. 2018. Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nature Genetics. 50: 912-919. doi: 10.1038/s41588-018-0152-6
  • Stokowy, Tomasz; Polushina, Tatiana; Sønderby, Ida Elken; Karlsson, Robert; Giddaluru, Sudheer; Le Hellard, Stephanie; Bergen, Sarah E.; Sullivan, Patrick F.; Andreassen, Ole Andreas; Djurovic, Srdjan; Hultman, Christina M.; Steen, Vidar Martin. 2018. Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes. Scientific Reports. 8: 1-8. Publisert 2018-05-02. doi: 10.1038/s41598-018-25280-4
  • Tronstad, Rune Rose; Polushina, Tatiana; Brattbakk, Hans-Richard; Stansberg, Christine; Volkmann, Hilde Løland Von; Hanevik, Kurt; Ellinghaus, Eva; Jørgensen, Silje Fjellgård; Ersland, Kari Merete; Pham, Khanh Do-Cong; Gilja, Odd Helge; Hovdenak, Nils; Hausken, Trygve; Vatn, Morten H; Franke, Andre; Knappskog, Per; Le Hellard, Stephanie; Karlsen, Tom Hemming; Fiskerstrand, Torunn. 2018. Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea. Scandinavian Journal of Gastroenterology. 53: 1264-1273. doi: 10.1080/00365521.2018.1521867
  • Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fred; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas. 2018. Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci. Scientific Reports. 8. 8 sider. doi: 10.1038/s41598-018-36429-6
  • van der Meer, Dennis; Rokicki, Jaroslav; Kaufmann, Tobias; Còrdova Palomera, Aldo; Moberget, Torgeir; Alnæs, Dag; Bettella, Francesco; Frei, Oleksandr; Doan, Nhat Trung; Sønderby, Ida Elken; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Bertolino, Alessandro; Bralten, Janita; Brandt, Christine Lycke; Buitelaar, Jan K.; Djurovic, Srdjan; van Donkelaar, Marjolein; Dørum, Erlend Solberg; Espeseth, Thomas; Faraone, Stephen V.; Fernandéz, Guillén; Fisher, Simon E.; Franke, Barbara; Haatveit, Beathe Christin; Hartman, Catharina A.; Hoekstra, Pieter J.; Håberg, Asta; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Le Hellard, Stephanie; Lund, Martina Jonette; Lundervold, Astri; Lundervold, Arvid; Melle, Ingrid; Monereo Sanchez, Jennifer; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique J.F.; Richard, Geneviéve´; Sanders, Anne-Marthe; Selvaggi, Pierluigi; Shumskaya, Elena; Steen, Vidar Martin; Tønnesen, Siren; Ulrichsen, Kristine Moe; Zwiers, Marcel P.; Andreassen, Ole Andreas; Westlye, Lars Tjelta. 2018. Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. Molecular Psychiatry. 1-13. doi: 10.1038/s41380-018-0262-7
  • Aas, Monica; Melle, Ingrid; Bettella, Francesco; Djurovic, Srdjan; Le Hellard, Stephanie; Bjella, Thomas; Ringen, Petter Andreas; Lagerberg, Trine Vik; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Andreassen, Ole Andreas; Tesli, Martin Steen. 2017. Psychotic patients who used cannabis frequently before illness onset have higher genetic predisposition to schizophrenia than those who did not. Psychological Medicine. 48: 43-49. Publisert 2017-10-03. doi: 10.1017/S0033291717001209
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  • Le Hellard, S; Muhleisen, TW; Djurovic, Srdjan; Fernø, J; Ouriaghi, Z; Mattheisen, M; Vasilescu, C; Raeder, MB; Hansen, T; Strohmaier, J; Georgi, A; Brockschmidt, FF; Melle, I; Nenadic, I; Sauer, H; Rietschel, M; Nothen, MM; Werge, T; Andreassen, Ole Andreas; Cichon, S; Steen, VM. 2008. Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples. Molecular Psychiatry.
  • Le Hellard, Stephanie; Theisen, F.M.; Haberhausen, M; Ræder, Maria Therese Barøy; Fernø, Johan; Gebhardt, S; Hinney, A.; Remschmidt, H.; Krieg, J.C.; Mehler-Wex, C.; Nöthen, Markus M.; Hebebrand, J.; Steen, Vidar Martin. 2008. Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: pertubation of SREBP-controlled lipogenesis in drug-realted metabolic adverse effects? Molecular Psychiatry. 14: 308-317. Publisert 2008-01-15.

Se fullstendig oversikt over publikasjoner i CRIStin.

See my ORCID page:  https://orcid.org/0000-0002-8085-051X