Hjem
  • E-postSylvia.Varland@uib.no
  • Telefon+47 55 58 66 93
  • Besøksadresse
    Instiutt for Biomedisin, Bygg for biologiske basalfag (BBB), 6 etg
    Jonas Lies vei 91
    5009 Bergen
  • Postadresse
    Postboks 7804
    5020 Bergen

Sylvia Varland fullførte en doktorgrad i molekylærbiologi ved Universitetet i Bergen høsten 2016. Hun fikk et personlig mobilitetsstipend fra Norsk forskningsråd et og var på et toårig forskningsopphold ved Donnelly Center for Cellular og Biomolecular Research i Toronto, Canada. Nå arbeider hun ved Arnesen laboratoriumet ved Institutt for Biomedisin.

Sylvia er webansvarlig for arnesenlab.com.

Formidling av forskingsarbeidet til Sylvia Varland inkluderer

 

 

 

MOL399 Masteroppgåve i molekylærbiologi (veileder)

MOL231 Prosjektoppgåve i molekylærbiologi

 

Tidligere har Sylvia Varland deltatt i undervisningen av

MOL100 Innføring i molekylærbiologi

MOL221 Eksperimentell molekylærbiologi I

MOL300 Praktisk biokjemi og molekylærbiologi

12.  Tarsha Ward, Warren Tai, Sarah Morton, Francis Impens, Petra Van Damme, Delphi Van Haver, Evy Timmerman, Gabriela Venturini, Kehan Zhang, Min Young Jang, Jon A.L. Willcox, Alireza Haghighi, Bruce D. Gelb, Wendy K. Chung, Elizabeth Goldmuntz, George A. Porter Jr, Richard P. Lifton, Martina Brueckner, H. Joseph Yost, Benoit G. Bruneau, Joshua Gorham, Yuri Kim, Alexandre Pereira, Jason Homsy, Craig C. Benson, Steven R. DePalma, Sylvia Varland, Christopher S. Chen, Thomas Arnesen, Kris Gevaert, Christine E. Seidman, and Jonathan G. Seidman

Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency

Circ Res. 2021 Apr 16;128(8):1156-1169.

PubMed | PDF

 

11.  Adrian Drazic and Sylvia Varland

Human NAA30 can rescue yeast mak3∆ mutant growth phenotypes

Biosci Rep. 2021 Mar 26;41(3):BSR20202828.

PubMed | PDF

 

10.  Rasmus Ree*, Laura Kind*, Anna Kaziales, Sylvia Varland, Minglu Dai, Klaus Richter, Adrian Drazic, and Thomas Arnesen

PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin

J Biol Chem. 2020 Dec 4;295(49):16713-16731.

PubMed | PDF

 

9.  Sylvia Varland, Joël Vandekerckhove, and Adrian Drazic

Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control

Trends Biochem Sci. 2019 Jun;44(6):502-516.

PubMed | PDF

 

8.  Sylvia Varland, Henriette Aksnes, Fedor Kryuchkov, Francis Impens, Delphi Van Haver, Veronique Jonckheere, Mathias Ziegler, Kris Gevaert, Petra Van Damme, and Thomas Arnesen

N-terminal acetylation levels are maintained during acetyl-CoA deficiency in Saccharomyces cerevisiae

Mol Cell Proteomics. 2018 Dec;17(12):2309-2323

PubMed | PDF

 

7.  Rasmus Ree, Sylvia Varland, and Thomas Arnesen

Spotlight on protein N-terminal acetylation

Exp Mol Med. 2018 Jul 27;50(7):1-13.

PubMed | PDF

 

6.  Sylvia Varland and Thomas Arnesen

Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae

BMC Res Notes. 2018 Jun 22;11(1):404.

PubMed | PDF

 

5.  Hanyin Cheng*, Avinash V. Dharmadhikari*, Sylvia Varland, Ning Ma, Deepti Domingo, Robert Kleyner, Alan F. Rope, Margaret Yoon, Asbjørg Stray-Pedersen, Jennifer E. Posey, Sarah R. Crews, Mohammad K. Eldomery, Zeynep Coban Akdemir, Andrea M. Lewis, Vernon R. Sutton, Jill A. Rosenfeld, Erin Conboy, Katherine Agre, Fan Xia, Magdalena Walkiewicz, Mauro Longoni, Frances A. High, Marjon A. van Slegtenhorst, Grazia M.S. Mancini, Candice R. Finnila, Arie van Haeringen, Nicolette den Hollander, Claudia Ruivenkamp, Sakkubai Naidu, Sonal Mahida, Elizabeth E. Palmer, Lucinda Murray, Derek Lim, Parul Jayakar, Michael J. Parker, Stefania Giusto, Emanuela Stracuzzi, Corrado Romano, Jennifer S. Beighley, Raphael A. Bernier, Sébastien Küry, Mathilde Nizon, Mark A. Corbett, Marie Shaw, Alison Gardner, Christopher Barnett, Ruth Armstrong, Karin S. Kassahn, Anke Van Dijck, Geert Vandeweyer, Tjitske Kleefstra, Jolanda Schieving, Marjolijn J. Jongmans, Bert B.A. de Vries, Rolph Pfundt, Bronwyn Kerr, Samantha K. Rojas, Kym M. Boycott, Richard Person, Rebecca Willaert, Evan E. Eichler, R. Frank Kooy, Yaping Yang, Joseph C. Wu, James R. Lupski, Thomas Arnesen, Gregory M. Cooper, Wendy K. Chung, Jozef Gecz, Holly A.F. Stessman, Linyan Meng**✉, and Gholson J. Lyon**✉

Truncating Variants in NAA15 Are Associated with Variable Levels of Intellectual Disability, Autism Spectrum Disorder, and Congenital Anomalies

Am J Hum Genet. 2018 May 3;102(5):985-994.

PubMed | PDF

 

4.  Marianne Goris*, Robert S. Magin*, Håvard Foyn*, Line M. Myklebust, Sylvia Varland, Rasmus Ree, Adrian Drazic, Parminder Bhambra, Svein I. Støve, Markus Baumann, Bengt Erik Haug, Ronen Marmorstein, and Thomas Arnesen

Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4405-4410.

PubMed | PDF

 

3.  Adrian Drazic*, Henriette Aksnes*, Michaël Marie*, Malgorzata Boczkowska, Sylvia Varland, Evy Timmerman, Håvard Foyn, Nina Glomnes, Grzegorz Rebowski, Francis Impens, Kris Gevaert, Roberto Dominguez, and Thomas Arnesen

NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4399-4404.

PubMed | PDF

 

2.  Sylvia Varland*, Line M. Myklebust*, Siri Øfsthus Goksøyr, Nina Glomnes, Janniche Torsvik, Jan Erik Varhaug, and Thomas Arnesen

Identification of an alternatively spliced nuclear isoform of human N-terminal acetyltransferase Naa30

Gene. 2018 Feb 20;644:27-37.

PubMed | PDF 

 

1.  Sylvia Varland*, Camilla Osberg*, and Thomas Arnesen

N-terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects

Proteomics. 2015 Jul;15(14):2385-401.

PubMed | PDF

 

* shared first authorship, correspondence // Updated November 8, 2021.

Vitenskapelig artikkel
  • Vis forfatter(e) (2021). Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency. Circulation Research. 1156-1169.
  • Vis forfatter(e) (2021). Human NAA30 can rescue yeast mak3∆ mutant growth phenotypes . Bioscience Reports. 1-15.
  • Vis forfatter(e) (2020). PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin. Journal of Biological Chemistry. 16713-16731.
  • Vis forfatter(e) (2018). Truncating variants in NAA15 are associated with variable levels of intellectual disability, autism spectrum disorder, and congenital anomalies. American Journal of Human Genetics. 985-994.
  • Vis forfatter(e) (2018). Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80. Proceedings of the National Academy of Sciences of the United States of America. 4405-4410.
  • Vis forfatter(e) (2018). NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. Proceedings of the National Academy of Sciences of the United States of America. 4399-4404.
  • Vis forfatter(e) (2018). N-terminal acetylation levels are maintained during acetyl-CoA deficiency in Saccharomyces cerevisiae. Molecular & Cellular Proteomics. 2309-2323.
  • Vis forfatter(e) (2018). Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae. BMC Research Notes.
  • Vis forfatter(e) (2018). Identification of an alternatively spliced nuclear isoform of human N-terminal acetyltransferase Naa30. Gene. 27-37.
Faglig foredrag
  • Vis forfatter(e) (2015). Metabolic Regulation of N-Terminal Acetylation in Saccharomyces cerevisiae.
Vitenskapelig foredrag
  • Vis forfatter(e) (2020). Exploring N-terminal acetyltransferases using functional genomics.
  • Vis forfatter(e) (2018). Protein N-terminal acetylation: when the start matters.
Leserinnlegg
  • Vis forfatter(e) (2016). Forskere og modellorganismer i skjønn forening. NBS-nytt. 34-36.
Mastergradsoppgave
  • Vis forfatter(e) (2012). Investigating Potential Functional Effects of Glucose- Dependent Dynamic N-Terminal Acetylation in Saccharomyces cerevisiae.
Populærvitenskapelig artikkel
  • Vis forfatter(e) (2021). N-terminal acetylering. Store Norske Leksikon (Nettutgaven).
Doktorgradsavhandling
  • Vis forfatter(e) (2016). Regulation of protein N-terminal acetylation.
Poster
  • Vis forfatter(e) (2019). NAA80 – a novel regulator of cytoskeleton dynamics.
  • Vis forfatter(e) (2019). Mechanism of actin N-terminal acetylation by NAA80-profilin.
  • Vis forfatter(e) (2018). N-terminal acetylation of actin by NAA80 impacts cell migration.
  • Vis forfatter(e) (2018). Discovery of NAA80 as actin’s N-terminal acetyltransferase – a novel regulator of cytoskeleton dynamics.
  • Vis forfatter(e) (2018). Actin Acetylation.
  • Vis forfatter(e) (2018). A Yeast Model for Genetic Variants in Human NAA15 associated with Autism Spectrum Disorder.
  • Vis forfatter(e) (2016). Dynamic aspects of protein N-terminal acetylation in response to changes in nutrient availability.
  • Vis forfatter(e) (2015). The N-terminal acetyltransferase NatC has a role in cellular stress response in yeast.
  • Vis forfatter(e) (2015). Metabolic Regulation of Protein N-terminal Acetylation.
  • Vis forfatter(e) (2012). GLUCOSE DEPENDENT DYNAMIC N-TERMINAL ACETYLATION IN SACCHAROMYCES CEREVISIAE.
  • Vis forfatter(e) (2012). Dynamicity and functional implications of N-terminal acetylation in S. cerevisiae.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) (2019). Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control . TIBS -Trends in Biochemical Sciences. Regular ed.. 1-15.
  • Vis forfatter(e) (2018). Spotlight on protein N-terminal acetylation. Experimental and Molecular Medicine. 13 sider.
  • Vis forfatter(e) (2015). N-terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects. Proteomics. 2385-2401.

Se fullstendig oversikt over publikasjoner i CRIStin.

Sylvia Varland er prosjektleder for det NFR finansierte prosjektet "NatFUGE: Exploring N-terminal acetyltransferases with FUnctional GEnomics"

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