Hjem
  • E-postSylvia.Varland@uib.no
  • Telefon+47 55 58 66 93
  • Besøksadresse
    Instiutt for Biomedisin, Bygg for biologiske basalfag (BBB), 6 etg
    Jonas Lies vei 91
    5009 Bergen
  • Postadresse
    Postboks 7803
    5020 Bergen

Sylvia Varland fullførte en doktorgrad i molekylærbiologi ved Universitetet i Bergen høsten 2016. Hun fikk et personlig mobilitetsstipend fra Norsk forskningsråd et og var på et toårig forskningsopphold ved Donnelly Center for Cellular og Biomolecular Research i Toronto, Canada. Nå arbeider hun ved Arnesen laboratoriumet ved Institutt for Biomedisin.

Sylvia er webansvarlig for arnesenlab.com.

Formidling av forskingsarbeidet til Sylvia Varland inkluderer

 

 

 

MOL231 Prosjektoppgåve i molekylærbiologi

 

Tidligere har Sylvia Varland deltatt i undervisningen av

MOL100 Innføring i molekylærbiologi

MOL221 Eksperimentell molekylærbiologi I

MOL300 Praktisk biokjemi og molekylærbiologi

Sylvia Varland, Joël Vandekerckhove and Adrian Drazic. "Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control". Trends Biochem Sci. 2019 Jun;44(6):502-516. 

PubMed | PDF

Sylvia Varland**, Henriette Aksnes, Fedor Kryuchkov, Francis Impens, Delphi Van Haver, Veronique Jonckheere, Mathias Ziegler, Kris Gevaert, Petra Van Damme**, and Thomas Arnesen. "N-terminal acetylation levels are maintained during acetyl-CoA deficiency in Saccharomyces cerevisiae". Mol Cell Proteomics. 2018;17(12):2308-2323.

PubMed | PDF 

Rasmus Ree, Sylvia Varland, and Thomas Arnesen. "Spotlight on protein N-terminal acetylation". Exp Mol Med. 2018;27;50(7):90.

PubMed | PDF

Sylvia Varland** and Thomas Arnesen. “Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae". BMC Res Notes. 2018;22;11(1):404.

PubMed | PDF

Hanyin Cheng*, Avinash V. Dharmadhikari*, Sylvia Varland, Ning Ma, Deepti Domingo, Robert Kleyner, Alan F. Rope, Margaret Yoon, Asbjørg Stray-Pedersen, Jennifer E. Posey, Sarah R. Crews, Mohammad K. Eldomery, Zeynep Coban Akdemir, Andrea M. Lewis, Vernon R. Sutton, Jill A. Rosenfeld, Erin Conboy, Katherine Agre, Fan Xia, Magdalena Walkiewicz, Mauro Longoni, Frances A. High, Marjon A. van Slegtenhorst, Grazia M.S. Mancini, Candice R. Finnila, Arie van Haeringen, Nicolette den Hollander, Claudia Ruivenkamp, Sakkubai Naidu, Sonal Mahida, Elizabeth E. Palmer, Lucinda Murray, Derek Lim, Parul Jayakar, Michael J. Parker, Stefania Giusto, Emanuela Stracuzzi, Corrado Romano, Jennifer S. Beighley, Raphael A. Bernier, Sébastien Küry, Mathilde Nizon, Mark A. Corbett, Marie Shaw, Alison Gardner, Christopher Barnett, Ruth Armstrong, Karin S. Kassahn, Anke Van Dijck, Geert Vandeweyer, Tjitske Kleefstra, Jolanda Schieving, Marjolijn J. Jongmans, Bert B.A. de Vries, Rolph Pfundt, Bronwyn Kerr, Samantha K. Rojas, Kym M. Boycott, Richard Person, Rebecca Willaert, Evan E. Eichler, R. Frank Kooy, Yaping Yang, Joseph C. Wu, James R. Lupski, Thomas Arnesen, Gregory M. Cooper, Wendy K. Chung, Jozef Gecz, Holly A.F. Stessman, Linyan Meng, and Gholson J. Lyon. "Truncating Variants in NAA15 Are Associated with Variable Levels of Intellectual Disability, Autism Spectrum Disorder, and Congenital Anomalies”. Am J Hum Genet. 2018;102(5):985-994.

PubMed | PDF

Marianne Goris*, Robert S. Magin*, Håvard Foyn*, Line M. Myklebust, Sylvia Varland, Rasmus Ree, Adrian Drazic, Parminder Bhambra, Svein I. Støve, Markus Baumann, Bengt Erik Haug, Ronen Marmorstein and Thomas Arnesen. "Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80". Proc Natl Acad Sci U S A. 2018;115(17):4405-4410.

PubMed | PDF

Adrian Drazic*, Henriette Aksnes*, Michaël Marie*, Malgorzata Boczkowska, Sylvia Varland, Evy Timmerman, Håvard Foyn, Nina Glomnes, Grzegorz Rebowski, Francis Impens, Kris Gevaert, Roberto Dominguez and Thomas Arnesen. "NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility".  Proc Natl Acad Sci U S A. 2018;115(17):4399-4404.

PubMed | PDF

Sylvia Varland*, Line M. Myklebust*, Siri Øfsthus Goksøyr, Nina Glomnes, Janniche Torsvik, Jan Erik Varhaug, and Thomas Arnesen. “Identification of an alternatively spliced nuclear isoform of human N-terminal acetyltransferase Naa30”. Gene. 2018;644:27-37.

PubMed | PDF 

Sylvia Varland*, Camilla Osberg*, and Thomas Arnesen. “N-terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects”. Proteomics. 2018; 15(14):2385-401.

PubMed | PDF

 

* contributed equally ** corresponding // Updated June 13, 2019.

Vitenskapelig artikkel
  • 2018. Truncating variants in NAA15 are associated with variable levels of intellectual disability, autism spectrum disorder, and congenital anomalies. American Journal of Human Genetics. 985-994.
  • 2018. Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80. Proceedings of the National Academy of Sciences of the United States of America. 4405-4410.
  • 2018. NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. Proceedings of the National Academy of Sciences of the United States of America. 4399-4404.
  • 2018. N-terminal acetylation levels are maintained during acetyl-CoA deficiency in Saccharomyces cerevisiae. Molecular & Cellular Proteomics. 2309-2323.
  • 2018. Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae. BMC Research Notes.
  • 2018. Identification of an alternatively spliced nuclear isoform of human N-terminal acetyltransferase Naa30. Gene. 27-37.
Faglig foredrag
  • 2015. Metabolic Regulation of N-Terminal Acetylation in Saccharomyces cerevisiae.
Vitenskapelig foredrag
  • 2020. Exploring N-terminal acetyltransferases using functional genomics.
  • 2018. Protein N-terminal acetylation: when the start matters.
Leserinnlegg
  • 2016. Forskere og modellorganismer i skjønn forening. NBS-nytt. 34-36.
Mastergradsoppgave
  • 2012. Investigating Potential Functional Effects of Glucose- Dependent Dynamic N-Terminal Acetylation in Saccharomyces cerevisiae.
Doktorgradsavhandling
  • 2016. Regulation of protein N-terminal acetylation.
Poster
  • 2019. NAA80 – a novel regulator of cytoskeleton dynamics.
  • 2019. Mechanism of actin N-terminal acetylation by NAA80-profilin.
  • 2018. N-terminal acetylation of actin by NAA80 impacts cell migration.
  • 2018. Discovery of NAA80 as actin’s N-terminal acetyltransferase – a novel regulator of cytoskeleton dynamics.
  • 2018. Actin Acetylation.
  • 2018. A Yeast Model for Genetic Variants in Human NAA15 associated with Autism Spectrum Disorder.
  • 2016. Dynamic aspects of protein N-terminal acetylation in response to changes in nutrient availability.
  • 2015. The N-terminal acetyltransferase NatC has a role in cellular stress response in yeast.
  • 2015. Metabolic Regulation of Protein N-terminal Acetylation.
  • 2012. GLUCOSE DEPENDENT DYNAMIC N-TERMINAL ACETYLATION IN SACCHAROMYCES CEREVISIAE.
  • 2012. Dynamicity and functional implications of N-terminal acetylation in S. cerevisiae.
Vitenskapelig oversiktsartikkel/review
  • 2019. Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control . 1-15.
  • 2018. Spotlight on protein N-terminal acetylation. 13 sider.
  • 2015. N-terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects. 2385-2401.

Se fullstendig oversikt over publikasjoner i CRIStin.

Sylvia Varland er prosjektleder for det NFR finansierte prosjektet "NatFUGE: Exploring N-terminal acetyltransferases with FUnctional GEnomics"

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