Molecular signaling and bioenergetics

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Compartmentalization of NAD

Most biological processes require energy and are tightly regulated. Energy is extracted from food supplies and eventually transformed into ATP, the universal energy carrier of the cell. These pathways consist of many reactions which involve NAD or NADP, small molecules which serve as intermediate energy transmitters.

Vitamin B3 is essential for the synthesis of the nucleotides NAD and NADP. Interestingly, the key molecules in energy transduction also have important roles in the regulation of all vital cellular activities.

Our current work is aimed at further dissecting the molecular mechanisms of this network connecting cellular energy and signalling transmission.

The group is part of the research unit Systems Biology and Translational Cell Signaling.

News | Research
spergillus fumigatus vokser på en petriskål.

New discoveries on deadly fungus – might be a key for treatment

Scientists at the University of Bergen (UiB) have discovered a new enzyme on the deadly fungus Aspergillus fumigatus that might unlock new treatment. The fungus kills around one million people per year worldwide, and is found “everywhere”.

News | Research
Marc Niere og Mathias Ziegler

Discovered a shuttle that brings the "batteries" into the cell's power houses

Researchers at the University of Bergen have made a major contribution to the discovery of a protein that plays a fundamental role in human energy metabolism.

International research collaboration
Crystal structure of an enzyme. Background animal and plant shapes

Why evolution invented a paradoxical enzyme that eats up vitamin B3

Mathematical modeling and systems biology explain the evolutionary transition from a four-step to a two-step pathway for the synthesis of NAD from vitamin B3.

Portrett av Mathias Ziegler

Principal Investigator: Mathias Ziegler (personal page)