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The eukaryotic NAT-machinery

Protein N-terminal acetylation

From molecular mechanisms to human disease

Most proteins are chemically modified in the cell and such modifications are often crucial for the protein’s ability to carry out a function. N-terminal acetylation one of the most common modifications in eukaryotes. It is catalyzed by N-terminal acetyltransferases (NATs) which are linked to cancer, genetic syndromes, and regulation of human metabolism.

The Arnesen lab is part of the Translational Cell Signaling and Metabolism research group at the Department of biomedicine.

New research
Impact of N-terminal acetylation in yeast

Removing protein N-terminal acetylation increases the turnover of ribosomal proteins

The impact of the most common protein modification, N-terminal acetylation, has remained a conundrum in the field since its very origin. A new UiB article adds a piece to this puzzle.

New research
Feil ved NAA20 genet fører til at NatB komplekset av proteinene NAA20 og NAA25 ikke dannes optimalt. Derved blir NatB sin evne til å utføre acetylering av cellulære proteiner redusert og dette fører til sykdom.

Pathogenic variants of novel gene causative of developmental delay

Variants in different genes may cause developmental delay and various syndromes. Researchers from USA, Saudi Arabia and Norway recently uncovered pathogenic gene variants causing developmental delay and intellectual disabilities in a gene not previously linked to genetic disease.

New research
melissa-labellarte unsplash

New gene variants linked to congenital heart disease

Around 600 children are born with congenital heart disease in Norway each year. Little is known about the causes of congenital heart defects. A new international study involving researchers from University of Bergen and Haukeland University Hospital shows that the NAA15 protein can play an important...

News
PFN2 co-operates with NAA80 to acetylate actin

The cell motility regulator NAA80 is assisted by Profilin 2

Actin is modified by N-terminal acetylation which regulates its role in steering cellular architecture and cell motility. Now the machinery performing this acetylation is uncovered.

Cell biology
Cryo-EM structures of the NatE complex with/without HYPK bound

The structure of an enzyme complex upregulated in cancer

In human cells, N-terminal acetylation is among the most common protein modifications. Now, researchers at the University of Pennsylvania and the University of Bergen have revealed the structural and biochemical properties of the major molecular machine involved in this process. Cancer cells require...