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Molecular and Computational Biology Research School

John Manak on specialized microarray techniques

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The use of tiling microarrays to annotate genomes

When: 5.2.2010 11.00-12.00

Where: Seminarrommet (rom 520B1, "N-terminalen), 5. etasje, Høyteknologisenteret (Bioblokken), Thormølensgate 55

Contact: Eric Thompson

The use of tiling microarrays to annotate genomes: Identification of novel transcript isoforms, mapping mutations to genes, mapping binding sites of chromatin proteins and histone modifications.

The use of specialized microarrays to identify mutations associated with disease

When: 5.2.2010 13.15

Where: Seminarrommet (rom 520B1, "N-terminalen"), 5. etasje, Høyteknologisenteret (Bioblokken), Thormølensgate 55

Contact: Eric Thompson

The use of specialized microarrays to identify mutations associated with disease: array-based Comparative Genomic Hybridization to identify Copy Number Variants, sequence (exon) capture and mismatch endonuclease strategies to identify disease-causing mutations down to a single altered DNA base pair.

About

These lectures provides an excellent opportunity to get an up-to-date introduction to some very useful strategies utilizing microarray technology. The lectures are given by John Manak, University of Iowa, one of the foremost experts with respect to the use high-throughput microarray technology in biological research. Dr. Manak has extensive experience in array technology, having previously held research and development positions at Affymetrix and Roche NimbleGen. Among his significant achievements was the development of a strategy to identify a large number of novel transcript isoforms and to subsequently map uncharacterized mutations to their corresponding genes. Currently he uses microarray technologies combined with molecular genetics in flies to study the modulation of chromatin structure and to help find mutations that cause human disease. Recently he has established links with the Sars centre in the application of whole genome tiling arrays to genome assembly and annotation and comprehensive developmental expression profiling in marine model organisms.