CCBIO-seminar – Marcus Buschbeck
Velkommen til CCBIOs seminarserie for vårsemesteret 2025. Åpent for alle i auditorium 4, BBB. Ikke nødvendig med påmelding. Foreleser er Marcus Buschbeck, Josep Carreras Leukaemia Research Institute, Barcelona, Spania.
Hovedinnhold
Foreleser: Marcus Buschbeck, Josep Carreras Leukaemia Research Institute, Barcelona, Spania.
Tittel: Mining the chromatin regulatory space for drug targets in myeloid malignancies
Vert: Carina Strell, Mathias Ziegler
Sted: Auditorium 4, BB-bygget
Når: 22. mai 2025 kl. 14.30-15.30
Påmelding er ikke nødvendig.
Sammendrag:
Epigenetic information is written in chromatin. But how exactly do epigenetic mechanisms operate at the molecular level? How does the environment influence these processes? How does nuclear metabolism impact chromatin structure and the cell’s epigenetic memory?
These are the questions we address in the lab. We combine basic research and applied research. In our basic research, we like to dissect molecular mechanisms of chromatin regulation and evaluate if this knowledge has an application in cancer. We have a long-standing interest in histone variants with macrodomains. In our more applied projects, we screen for novel drug targets for blood cancers and to understand their molecular mode of action. I will divide my talk into two halves and first present results showing how we identified CBP as sensitizer for azacytidine-based therapy. In the second part, I will present novel data that establish a histone variant as novel first-of-its-kind drug target in acute myeloid leukemia.
Keywords: histone variants, drug targets, combinatorial therapies, leukemia, 3D genome, chromatin regulation, myelodysplastic syndromes.
More information at: https://buschbecklab.org